Reliability Analysis of COTS-based Software System

Zhang Nan,Wei Jiamin 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.8

Mode Analysis of Cascaded Four-Conductor Lines Using Extended Mixed-Mode S-Parameters

Nan Zhang,Wansoo Nah 한국전자파학회JEES 2016 Journal of Electromagnetic Engineering and Science Vol.16 No.1

In this paper, based on the mode analysis of four-conductor lines, the extended mixed-mode chain-parameters and S-parameters of fourconductor lines are estimated using current division factors. The extended mixed-mode chain-parameters of cascaded four-conductor lines are then obtained with mode conversion. And, the extended mixed-mode S -parameters of cascaded four-conductor lines can be predicted from the transformation of the extended chain-parameters. Compared to the extended mixed-mode S-parameters of fourconductor lines, the cross-mode S-parameters are induced in the extended mixed-mode S -parameters of cascaded four-conductor lines, due to the imbalanced current division factors of cascaded two sections. The generated cross-mode S-parameters make the equivalent different- and common-mode conductors not independent from each other again. In addition, a new mode conversion, which applies the imbalanced current division factors, between the extended mixed-mode S-parameters and standard S-parameters is also proposed in this paper. Finally, the validity of the proposed extended mixed-mode S-parameters and mode conversion is confirmed by a comparison of the simulated and estimated results of shielded cable.

The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability

Zhang Nan,Shen Yan,Li Huan,Chen Ying,Zhang Ping,Lou Shifeng,Deng Jianchuan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

N6-methyladenosine (m6A) is the most abundant posttranscriptional modification of mRNA in eukaryotes. Recent evidence suggests that dysregulated m6A-associated proteins and m6A modifications play a pivotal role in the initiation and progression of diseases such as cancer. Here, we identified that IGF2BP3 is specifically overexpressed in acute myeloid leukemia (AML), a subtype of leukemia associated with poor prognosis and high genetic risk. IGF2BP3 is required for maintaining AML cell survival in an m6A-dependent manner, and knockdown of IGF2BP3 dramatically suppresses the apoptosis, reduces the proliferation, and impairs the leukemic capacity of AML cells in vitro and in vivo. Mechanistically, IGF2BP3 interacts with RCC2 mRNA and stabilizes the expression of m6A-modified RNA. Thus, we provided compelling evidence demonstrating that the m6A reader IGF2BP3 contributes to tumorigenesis and poor prognosis in AML and can serve as a target for the development of cancer therapeutics.

Finite Server Queuing Model with Change-Point and Imperfect Debugging for Software Reliability Assessment

Zhang Nan 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.12

Most software reliability growth models (SRGMs) take software faults detected that may be removed immediately into consideration. In fact, it costs often considerable resources to identify the root causes of faults detected and to remove them. In additional, detection effort and correction effort have the great effect on software debugging process. The detection effort function and correction effort function are defined as resource expenditures spent on software debugging process, respectively. In this paper, we investigate software debugging process using the queue theory. We propose finite server queuing models with resource and change-point under imperfect debugging environment. A real software failure project is demonstrated the effectiveness of proposed models, and numerical results demonstrate that new models can provide better fit and prediction.

Theory, Simulation, and Experiment on Extended Mixed-Mode S-Parameters in Three-Conductor Lines

Zhang, Nan,Kim, Kwangho,Lee, Hosang,Nah, Wansoo [Institute of Electrical and Electronics Engineers 2017 IEEE transactions on electromagnetic compatibility Vol.59 No.6

<P>This paper proposes novel mixed-mode S-parameters, which are dubbed as 'extended mixed-mode S-parameters.'The extended mixed-mode S-parameters were applied to three-conductor transmission lines, resulting in the independent differential and common modes using the current division factor of three-conductor transmission lines. By contrast to the conventional mixed-mode S-parameters, there are no cross-mode S-parameters in the extended mixed-mode S-parameters, even in the asymmetrical conductor transmission lines. In addition, two new mode conversion matrices, which contain the current division factor, are also proposed to convert the extended mixed-mode S-parameters to the standard S-parameters. The validity of the proposed extended mixed-mode S-parameters and the mode conversion method were confirmed by comparing the S-parameters from the theory, EM-simulation, and experiment as well.</P>

The four models for forecasting the peak period of Dendrolimus punctatus (Lepidoptera: Lasiocampiade) for the second generation egg

Zhang Nan,Qian Guangjing,Zhang Lin,Song Xueyu,Zou Yunding,Bi Shoudong 한국곤충학회 2021 Entomological Research Vol.51 No.7

To improve the accuracy of forecasting the peak period of Dendrolimus punctatus, stationary time series, periodic distance method, stepwise regression model and the Bayes discriminant analysis were used. RSME value, kappa coefficient and accuracy were used as evaluation criteria to predict the peak period for the second generation egg of D. punctatus with over 33 years from 1983 to 2016 in Qianshan County, Anhui Province. The predictions of these models were verified in 2017 and 2018. The prediction of the stationary time model and Bayes discriminant analysis for 2017 was one level lower than the actual result and for 2018 was one level higher than the actual result, while the prediction of the periodic distance method was identical to the actual result for 2017 and greatly different from the actual result for 2018. The accuracy for stationary time series (RMSE = 0.92 kappa = 0.76) and periodic distance method (RMSE = 2.96, kappa = 0.81) from 1983 to 2018 were 87.88% and 85.71%, respectively. When taking into consideration the standard error was based on differential, the accuracy for the prediction of stepwise regression model (RMSE = 0.25, kappa = 1.00) from 1983 to 2018 was 100%. The accuracy of Bayes discriminant method (RMSE = 0.71, kappa = 0.96) was 97.14%. Comparatively speaking, the stepwise regression model and Bayes discriminant analysis method were better than the stationary time series and periodic distance method in RMSE value, kappa coefficient and accuracy. So they were relatively ideal forecast methods.

Optimizing DC Vaccination by Combination With Oncolytic Adenovirus Coexpressing IL-12 and GM-CSF

Zhang, Song-Nan,Choi, Il-Kyu,Huang, Jing-Hua,Yoo, Ji-Young,Choi, Kyung-Ju,Yun, Chae-Ok Nature Publishing Group 2011 MOLECULAR THERAPY Vol.19 No.8

<P>Dendritic cell (DC)-based vaccination is a promising strategy for cancer immunotherapy. However, clinical trials have indicated that immunosuppressive microenvironments induced by tumors profoundly suppress antitumor immunity and inhibit vaccine efficacy, resulting in insufficient reduction of tumor burdens. To overcome these obstacles and enhance the efficiency of DC vaccination, we generated interleukin (IL)-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-coexpressing oncolytic adenovirus (Ad-ΔB7/IL12/GMCSF) as suitable therapeutic adjuvant to eliminate immune suppression and promote DC function. By treating tumors with Ad-ΔB7/IL12/GMCSF prior to DC vaccination, DCs elicited greater antitumor effects than in response to either treatment alone. DC migration to draining lymph nodes (DLNs) dramatically increased in mice treated with the combination therapy. This result was associated with upregulation of CC-chemokine ligand 21 (CCL21<SUP>+</SUP>) lymphatics in tumors treated with Ad-ΔB7/IL12/GMCSF. Moreover, the proportion of CD4<SUP>+</SUP>CD25<SUP>+</SUP> T-cells and vascular endothelial growth factor (VEGF) expression was decreased in mice treated with the combination therapy. Furthermore, combination therapy using immature DCs also showed effective antitumor effects when combined with Ad-ΔB7/IL12/GMCSF. The combination therapy had a remarkable therapeutic efficacy on large tumors. Taken together, oncolytic adenovirus coexpressing IL-12 and GM-CSF in combination with DC vaccination has synergistic antitumor effects and can act as a potent adjuvant for promoting and optimizing DC vaccination.</P>

Staurosporine Induced Apoptosis Rapidly Downregulates TDP-43 in Glioma Cells

Nan, Yi-Nan,Zhu, Jing-Yan,Tan, Yan,Zhang, Qi,Jia, William,Hua, Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

TDP-43 is a ubiquitously expressed DNA/RNA binding protein that has recently attracted attention for its involvement in neurodegenerative diseases. While TDP-43 has been found to participate in various important cellular activities including stress and apoptosis, little is known about its role in cancer cells. Here we report that staurosporine (STS) induced apoptosis in U87 glioma cells is associated with rapid downregulation of TDP-43 at both mRNA and protein levels. The latter is dependent on activation of caspase 3. More importantly, we have shown that knockdown of TDP-43 by specific siRNA dramatically enhanced cytotoxicity of STS. These results suggest that normal level of TDP-43 may be protective for cancer cells under apoptotic insult.

MiR-449a attenuates autophagy of T-cell lymphoma cells by downregulating ATG4B expression

Nan Zhang,Ling Qiu,Tao Li,Xiao Wang,Rui Deng,Hai Yi,Yi Su,Fang-yi Fan 생화학분자생물학회 2020 BMB Reports Vol.53 No.5

Increasing evidence suggests the role of miR-449a in the regulation of tumorigenesis and autophagy. Autophagy plays an important role in the malignancy of T-cell lymphoma. However, it is still unknown whether miR-449a is associated with autophagy to regulate the malignancy of T-cell lymp homa. In this study, we for the first time demonstrated that miR-449a enhanced apoptosis of T-cell lymphoma cells by decreasing the degree of autophagy. Further, miR-449a downregulated autophagy- associated 4B (ATG4B) expression, which subsequently reduced the autophagy of T-cell lymphoma cells. Mechanistically, miR-449a decreased ATG4B protein level by binding to its mRNA 3’UTR, thus reducing the mRNA stability. In addition, studies with nude mice showed that miR-449a significantly inhibited lymphoma characteristics in vivo. In conclusion, our results demonstrated that the “miR-449a/ATG4B/autophagy” pathway played a vital role in the malignancy of T-cell lymphoma, suggesting a novel therapeutic target.

Dynamic analysis of coupled wind-train-bridge system considering tower shielding and triangular wind barriers

Nan Zhang,Guanghui Ge,He Xia,Xiaozhen Li 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.21 No.3

A method for analyzing the coupled wind-vehicle-bridge system is proposed that also considers the shielding effect of the bridge tower with triangular wind barriers. The static wind load and the buffeting wind load for both the bridge and the vehicle are included. The shielding effects of the bridge tower and the triangular wind barriers are incorporated by taking the surface integral of the wind load. The inter-history iteration is adopted to solve the vehicle-bridge dynamic equations with time-varying external loads. The results show that after installing the triangular wind barriers in the area of the bridge tower, the bridge response and the vehicle safety factors change slightly. The peak value of the train car body acceleration is significantly reduced when the wind barrier size is increased.