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Effects of Isoflavonoids on Mouse Lymphocyte Proliferation In Vitro
Namgoong, Soon-Young,Lee, Chang-Hee,Lim, Hyun-Pyo The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.4
The suppressive activity of isoflavonoids against lymphocyte proliferation in vitro was examined. Isoflabvonoid derivatives tested were isflavones isolated from Pueraia radix and synthesized 7-O-substituted biochanin A derivatives. The certain isoflavones such as biochanin A and 2-carbethoxybiochainin A were found to possess the suppressive activity against concanavaline A (Con A)-induced lymphocyte proliferation from mouse spleen. Against mixed lymphocyte culture reaction, biochanin A, 2-carbethoxybiochainin A, daidzein, formononetin, genistein and 7-O-isopropylbiochaninl A showed the suppressive activity at $10^{-5}$ M. However, all isoflavones tested did not show the suppressive activity against lymphocyte proliferation induced by B-cell mitogen, lipopolysaccharide (LPS). In general, isoflavones were revealed to be less active than flavones/flavonols.
The Prolyl Isomerase Pin1 Induces LC-3 Expression and Mediates Tamoxifen Resistance in Breast Cancer
Namgoong, G.M.,Khanal, P.,Cho, H.-G.,Lim, S.-C.,Oh, Y.K.,Kang, B.S.,Shim, J.-H.,Yoo, J.-C.,Choi, H.S. The American Society for Biochemistry and Molecula 2010 The Journal of biological chemistry Vol.285 No.31
Roles of actin binding proteins in mammalian oocyte maturation and beyond
Namgoong, Suk,Kim, Nam-Hyung Informa UK (TaylorFrancis) 2016 Cell Cycle Vol.15 No.14
<P>Actin nucleation factors, which promote the formation of new actin filaments, have emerged in the last decade as key regulatory factors controlling asymmetric division in mammalian oocytes. Actin nucleators such as formin-2, spire, and the ARP2/3 complex have been found to be important regulators of actin remodeling during oocyte maturation. Another class of actin-binding proteins including cofilin, tropomyosin, myosin motors, capping proteins, tropomodulin, and Ezrin-Radixin-Moesin proteins are thought to control actin cytoskeleton dynamics at various steps of oocyte maturation. In addition, actin dynamics controlling asymmetric-symmetric transitions after fertilization is a new area of investigation. Taken together, defining the mechanisms by which actin-binding proteins regulate actin cytoskeletons is crucial for understanding the basic biology of mammalian gamete formation and pre-implantation development.</P>
Namgoong, S. Y.,Son, K. H.,Chang, H. W.,Kang, S. S.,Kim, H. P. 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-
In this investigation, 34 structurally different flavonoids including derivatives of chalcone, flavanone, flavan-3-ol, flavone, flavonol, and their glycosides were evaluated for in vitro suppression of mitogen-induced lymphocyte proliferation and mixed lymphocyte culture from mouse spleen. Flavonoids, mainly derivatives of flavone and flavonol, clearly demonstrated the suppressive effects on lymphocyte proliferation at higher than 10^(-6) M depending on the structures of flavonoid molecules, although their suppressive activities were less than that of cyclosporin A or prednisolone. Various glycosidic substitutions to A- and/or C-ring of the flavonoid aglycones were found to eliminate the suppressive activities of their aglycones, regardless of sugar compositions and positions of substitutions. In concanavalin A-induced lymphocyte proliferation, derivatives of flavone and flavonol having 2, 3-unsaturation and at least 1 hydroxyl group showed the suppressive activity. In lipopolysaccharide-induced lymphocyte proliferation, only myricetin was active among flavonoids tested at the concentrations up to 10^(-5) M. In mixed lymphocyte culture, some derivatives of flavone and flavonol with 2, 3-unsaturation were active and especially flavone derivatives showed the higher suppressive activities than those of the flavonol derivatives.
Design of cyclotron magnet with tenth harmonics for accelerator mass spectrometry
Namgoong Ho,Choi Hyojeong,Ha Donghyup,Ghergherehchi Mitra,Chai J. S.,Lee Jongchul 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.2
In this study, we developed a carbon-beam cyclotron for accelerator mass spectrometry (AMS). A cyclotron magnet for AMS was developed for particle acceleration systems using cyclotrons rather than the tandem accelerator used in conventional accelerator mass spectrometry systems. Design parameters were selected for the development of cyclotrons for AMS, and the magnetic feld design and equilibrium orbit (EO) analysis beam trajectory were analyzed using the Cyclone and CST Microwave Studio. Additionally, by measuring the magnetic feld of the manufactured cyclotron, magnetic feld optimtableization was performed through shimming, and the beam trajectory was verifed based on the measurement results. The cyclotron magnet was designed with a mass resolution of 2890, with harmonic 10 and turn number 92. The minimum turn separation was optimized at 2 mm to reduce the loss caused by the collision of the beam during acceleration. This cyclotron for AMS could accelerate the 12C−, 13C−, and 14C− particles at 40 keV to obtain a beam of 400 keV.
Two Dimensional Transfer Modes in $CH_2$ Spin System
NamGoong Hyun Korean Magnetic Resonance Society 2006 Journal of the Korean Magnetic Resonance Society Vol.10 No.1
Spin-lattice relaxation pathway of $CH_2$ spin system by two dimensional NOESY sequence has been discussed. Two-dimensional spectra governed by dipolar relaxation mechanism were simulated in term of transfer mode, the generalization of conventionally used magnetization mode in one dimension. The transfer matrix directly related to the Redfield relaxation matrix can be constructed by the multiplet of transfer mode. The observable relaxation transfer modes causes to variation of the off-diagonal signal intensity of phase sensitive NOESY spectra from which variable spectral density can be extracted with simple group theoretical calculation. The variation of the J-coupling peak intensity as a function of the mixing time in 2-D spectra for $n-Undecane-5-^{13}C$ and Bromoacetic $2-^{13}C$ acid has been theoretically traced.
Namgoong, Jin Woong,Chung, Sei-Won,Jang, Hyeyoun,Kim, Young Hoon,Kwak, Moo Sun,Kim, Jae Pil Elsevier 2018 Journal of industrial and engineering chemistry Vol.58 No.-
<P><B>Abstract</B></P> <P>Four synergists were synthesized to enhance pigment nanoparticles dispersion and the contrast ratio. The interaction between the synergist and the dispersant was confirmed by infra-red (IR) spectrometry. We demonstrate that the hydrogen bonds forming between the synergist and the dispersant act as a key factor. To analyze the dispersion properties, dynamic light scattering (DLS), and electron microscopic analysis was examined. The spectral and color characteristics was also measured by UV–vis spectrometry and colorimetry, and the contrast ratio of color filters was evaluated. This study confirms that the prepared synergist can increase the contrast ratio of green color filter.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>