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Nissen, Mark S,Kumar, G N Mohan,Youn, Buhyun,Knowles, D Benjamin,Lam, Ka Sum,Ballinger, W Jordan,Knowles, N Richard,Kang, Chulhee American Society of Plant Physiologists 2009 The Plant cell Vol.21 No.3
<P>Potato (Solanum tuberosum) multicystatin (PMC) is a crystalline Cys protease inhibitor present in the subphellogen layer of potato tubers. It consists of eight tandem domains of similar size and sequence. Our in vitro results showed that the pH/PO(4)(-)-dependent oligomeric behavior of PMC was due to its multidomain nature and was not a characteristic of the individual domains. Using a single domain of PMC, which still maintains inhibitor activity, we identified a target protein of PMC, a putative Cys protease. In addition, our crystal structure of a representative repeating unit of PMC, PMC-2, showed structural similarity to both type I and type II cystatins. The N-terminal trunk, alpha-helix, and L2 region of PMC-2 were most similar to those of type I cystatins, while the conformation of L1 more closely resembled that of type II cystatins. The structure of PMC-2 was most similar to the intensely sweet protein monellin from Dioscorephyllum cumminisii (serendipity berry), despite a low level of sequence similarity. We present a model for the possible molecular organization of the eight inhibitory domains in crystalline PMC. The unique molecular properties of the oligomeric PMC crystal are discussed in relation to its potential function in regulating the activity of proteases in potato tubers.</P>
Contamination and Bioconcentration of Perfluorinated Compounds in Main River Ecosystems of Korea
N. H. Lam,C.R. Cho,M.S. Chang,B.C. Lee,P.J. Kim,K. Sasaki,H.S. Cho 한국해양환경·에너지학회 2012 한국해양환경공학회 학술대회논문집 Vol.2012 No.11
Water, sediment, plankton, blood and liver of crucian carp (Carassius carassius) and mandarin fish (Siniperca cherzeri) samples from 5 freshwater ecosystems in 3 major rivers of Korea including Nam Han River, Nakdong River and Yeongsan River were collected together with medaka fish (Oryzias latipes) and water in their 5 natural habitats. The samples were analyzed to determine the occurrence and contamination level of perfluorinated compounds (PFCs). The mean total concentration of detected PFCs was in the ascending order of water, sediment, plankton, crucian carp and mandarin fish. Longchain PFCs (≥C8) was widely detected and occupied 99.32% of total PFCs concentration. Perfluorooctane sulfonate (PFOS) was the dominant PFC in most of the ecosystem components with a maximum concentration in water of 6.25 ng/L and in fish of 273 ng/g wet wt. The results also demonstrated that concentration of PFOS and total PFCs in blood of crucian carp and mandarin fish were higher than those in their liver. PFOS concentrations detected in water samples were lower than the water quality criteria values for aquatic organisms protection, which were reported in Giesy et al., 2010. A positive linear regression (r²=0.99, p<0.05) and a trophic magnification factor of 28.25 were observed between PFOS concentrations and trophic levels of collected biota. The mean bioconcentration factor (BCF) of PFOS were extended from 14,745±21,366 (in plankton) to 517,476±705,036 (in crucian carp blood). According to the method of Moermond et al., 2010 and the received BCF of sensitive medaka fish in this study, we suggested the MPCsp,water of 0.083 ng/L for PFOS in Korea freshwater ecosystems.
Bioconcentration of Perfluorinated Compounds in Freshwater Fish in Korea Rivers
N. H. Lam,C. R. Cho,M. S. Chang,B. K. Min,H. S Cho 해양환경안전학회 2012 해양환경안전학회 학술발표대회 논문집 Vol.2012 No.11
Water, plankton, blood and liver of crucian carp (Carassius auratus) and mandarin fish (Siniperca cherzeri) samples from 5 freshwater ecosystems in 3 major rivers of Korea including Nam Han River, Nakdong River and Yeongsan River were collected.
Nguyen, Lam N.,Lim, Yun-Sook,Pham, Long V.,Shin, Hae-Young,Kim, Yong-Sun,Hwang, Soon B. American Society for Microbiology 2014 Journal of virology Vol.88 No.21
<P>The hepatitis C virus (HCV) life cycle is tightly regulated by lipid metabolism of host cells. In order to identify host factors involved in HCV propagation, we have recently screened a small interfering RNA (siRNA) library targeting host genes that control lipid metabolism and lipid droplet formation using cell culture-grown HCV (HCVcc)-infected cells. We selected and characterized the gene encoding stearoyl coenzyme A (CoA) desaturase 1 (SCD1). siRNA-mediated knockdown or pharmacological inhibition of SCD1 abrogated HCV replication in both subgenomic replicon and Jc1-infected cells, while exogenous supplementation of either oleate or palmitoleate, products of SCD1 activity, resurrected HCV replication in SCD1 knockdown cells. SCD1 was coimmunoprecipitated with HCV nonstructural proteins and colocalized with both double-stranded RNA (dsRNA) and HCV nonstructural proteins, indicating that SCD1 is associated with HCV replication complex. Moreover, SCD1 was fractionated and enriched with HCV nonstructural proteins at detergent-resistant membrane. Electron microscopy data showed that SCD1 is required for NS4B-mediated intracellular membrane rearrangement. These data further support the idea that SCD1 is associated with HCV replication complex and that its products may contribute to the proper formation and maintenance of membranous web structures in HCV replication complex. Collectively, these data suggest that manipulation of SCD1 activity may represent a novel host-targeted antiviral strategy for the treatment of HCV infection.</P><P><B>IMPORTANCE</B> Stearoyl coenzyme A (CoA) desaturase 1 (SCD1), a liver-specific enzyme, regulates hepatitis C virus (HCV) replication through its enzyme activity. HCV nonstructural proteins are associated with SCD1 at detergent-resistant membranes, and SCD1 is enriched on the lipid raft by HCV infection. Therein, SCD1 supports NS4B-mediated membrane rearrangement to provide a suitable microenvironment for HCV replication. We demonstrated that either genetic or chemical knockdown of SCD1 abrogated HCV replication in both replicon cells and HCV-infected cells. These findings provide novel mechanistic insights into the roles of SCD1 in HCV replication.</P>
Synthetic Bacteria for Therapeutics
( Phuong N. Lam Vo ),( Hyang-mi Lee ),( Dokyun Na ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.6
Synthetic biology builds programmed biological systems for a wide range of purposes such as improving human health, remedying the environment, and boosting the production of valuable chemical substances. In recent years, the rapid development of synthetic biology has enabled synthetic bacterium-based diagnoses and therapeutics superior to traditional methodologies by engaging bacterial sensing of and response to environmental signals inherent in these complex biological systems. Biosynthetic systems have opened a new avenue of disease diagnosis and treatment. In this review, we introduce designed synthetic bacterial systems acting as living therapeutics in the diagnosis and treatment of several diseases. We also discuss the safety and robustness of genetically modified synthetic bacteria inside the human body.
Ho, T. A.,Phan, M. H.,Phuc, N. X.,Lam, V. D.,Phan, T. L.,Yu, S. C. Springer Science + Business Media 2016 Journal of electronic materials Vol.45 No.5
<P>The Ti-substitution influence on the magnetic and magnetocaloric properties of La0.7Ba0.3Mn1-x Ti (x) O-3 (x = 0.05 and 0.1) was investigated. Based on Banerjee's criteria and Franco's universal curves, we proved the existence of a second-order magnetic phase transition in the samples. Using the modified Arrott plot method, we determined the critical parameters T (C) a parts per thousand 245 K, beta = 0.374 +/- A 0.013, gamma = 1.228 +/- A 0.045, and delta = 4.26 +/- A 0.03 for x = 0.05, and T (C) a parts per thousand 169 K, beta = 0.339 +/- A 0.001, gamma = 1.307 +/- A 0.003, and delta = 4.78 +/- A 0.02 for x = 0.1. With these critical values, the predictable scaling behavior of the M(H) data above and below T (C) proves that the calculated exponents are unambiguous and intrinsic. The values beta = 0.374 for x = 0.05 and beta = 0.339 for x = 0.1 suggest that the magnetic phase transition of the samples falls into the three-dimensional (3D) Heisenberg and 3D Ising universality classes, respectively, corresponding to short-range ferromagnetic (FM) order due to FM clusters in a wide temperature range even above T (C), as confirmed by electron spin resonance studies. In reference to the magnetocaloric effect around T (C), the magnetic entropy change reaches maximum values (|Delta S-max|) of about 4 and 3 J kg(-1) K-1 for x = 0.05 and 0.1, respectively, for a magnetic field change 50 kOe. Magnetic field dependencies of |Delta S-max| obey a power function |Delta S-max(H)| ae H (n) , where exponent values n = 0.59 and 0.61 for x = 0.05 and 0.1, respectively, were determined from the relation n = 1 + (beta-1)/(beta + gamma). The difference between the experimental n values and the theoretical value n = 2/3 of the mean field model is due to the presence of short-range FM order in the samples.</P>
Lam, V D,Tung, N T,Cho, M H,Park, J W,Jang, W H,Lee, Y P Institute of Physics [etc.] 2009 Journal of physics. D, applied physics Vol.42 No.11
<P>This report investigates the effect of the dielectric layer thickness on both magnetic and electric resonances of cut-wire-pair (CWP) structures in the microwave frequency regime. It was found that the resonances are sensitive to the thickness of the dielectric layer. As the thickness increases, the bandwidth of the magnetic resonance is slightly extended to a higher frequency, while the low-frequency edge of the electric-resonance band is remarkably shifted to a lower frequency. It was also found that the dependence of the magnetic resonance frequency on the dielectric layer thickness follows the trend of the closed formula based on the cavity model for the coupled metallic elements (Cai <I>et al</I> 2007 <I>Opt. Express</I> <B>15</B> 3333). In addition, we also studied the effect of the dielectric layer thickness on the left-handed behaviour of a combined structure consisting of CWP and continuous wire. The actual measurements are compared with the numerical simulation values to show a good coincidence.</P>