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Risk Assessment Principle for Engineered Nanotechnology in Food and Drug
Myungsil Hwang,Eun Ji Lee,Se Young Kweon,Mi Sun Park,Ji Yoon Jeong,Jun Ho Um,Sun Ah Kim,Bum Suk Han,Kwang Ho Lee,Hae Jung Yoon 한국독성학회 2012 Toxicological Research Vol.28 No.2
While the ability to develop nanomaterials and incorporate them into products is advancing rapidly worldwide, understanding of the potential health safety effects of nanomaterials has proceeded at a much slower pace. Since 2008, Korea Food and Drug Administration (KFDA) started an investigation to prepare “Strategic Action Plan” to evaluate safety and nano risk management associated with foods, drugs, medical devices and cosmetics using nano-scale materials. Although there are some studies related to potential risk of nanomaterials, physical-chemical characterization of nanomaterials is not clear yet and these do not offer enough information due to their limitations. Their uncertainties make it impossible to determine whether nanomaterials are actually hazardous to human. According to the above mention, we have some problems to conduct the human exposure risk assessment currently. On the other hand, uncertainty about safety may lead to polarized public debate and to businesses unwillingness for further nanotechnology investigation. Therefore, the criteria and methods to assess possible adverse effects of nanomaterials have been vigorously taken into consideration by many international organizations: the World Health Organization, the Organization for Economic and Commercial Development and the European Commission. The object of this study was to develop risk assessment principles for safety management of future nanoproducts and also to identify areas of research to strengthen risk assessment for nanomaterials. The research roadmaps which were proposed in this study will be helpful to fill up the current gaps in knowledge relevant nano risk assessment.
Antimetastatic Effects of Capsaicin in Murine B16 Melanoma Cell Lines
MyungSil Hwang,YoungNa Yum,Hoil Kang,Ok-Hee Kim 한국환경성돌연변이발암원학회 2005 한국환경성돌연변이·발암원학회지 Vol.25 No.1
The present work was undertaken to evaluate the antimetastatic potential of capsaicin (8-methyl-N-vanillyl-6-nonenamide) by measuring its effects on matrix metalloproteinase activity, cell invasion and lung metastasis. Significant inhibition of matrix metalloproteinase-2 activity by capsaicin (100 μM) was detected by gelatin zymography. In vitro invasion assay showed capsaicin (50, 100 μM) reduced tumor cell invasion (28-40%). Capsaicin (i.p., 2.5 mg/kg) inhibited development of lung colonization (58%). These results suggest that capsaicin prevents metastasis in part through suppression of invasion of B16F10 melanoma cells by inhibiting matrix metalloproteinase-2 responsible for degradation of extracellular matrix.
Kim, MeeKyung,Lee, Gunyoung,Lim, Ho Soo,Yun, Sang Soon,Hwang, Myungsil,Hong, Jin-Hwan,Kwon, Hoonjeong Informa UK (TaylorFrancis) 2017 Food additives & contaminants. Part A. Chemistry, Vol.34 No.9
<P>A sweetener is a food additive that imparts a sweet taste to food products. Sweeteners have been increasingly used in Korea since the approval of sodium saccharin and d-sorbitol in 1962. Unlike food contaminants, humans are exposed to food additives only through the consumption of processed food products. For exposure assessments of sweeteners, the dietary intakes of food products containing acesulfame-K, aspartame, saccharin-Na, and sucralose were determined, and the resulting calculated estimated daily intake (EDI) values were compared directly with each additive's ADI. The poundage method was used to calculate the daily intake per capita for 12 additional sweeteners, such as lactitol, for which appropriate analytical methods for food products do not exist. The risk, as evaluated by comparing the EDI with the ADI, was determined to be 2.9% for acesulfame-K, 0.8% for aspartame, 3.6% for saccharin-Na, 4.3% for steviol glycosides, and 2.1% for sucralose. No hazardous effect was predicted for the other 11 sweeteners, including lactitol.</P>