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Muhammad Ajaz Hussain,Khawar Abbas,Muhammad Sher,Muhammad Nawaz Tahir,Wolfgang Tremel,Mohammad Saeed Iqbal,Muhammad Amin,Munair Badshah 한국고분자학회 2011 Macromolecular Research Vol.19 No.12
This article presents the synthesis of novel hydroxypropylmethylcellulose (HPMC)-aspirin (ASP) conjugates,i.e. macromolecular prodrugs, through the reaction of HPMC with ASP after its in situ activation by 4-methylbenzenesulfonyl chloride. The highly pure ASP prodrugs obtained by this homogeneous and elegant esterification method were characterized using different spectroscopic and chromatographic techniques. Nanoparticulate drug design was successfully achieved by the conversion of free hydroxyls of the polymer into acetates. Transmission electron microscopy and scanning electron microscopy showed nanoparticle formation with the major population size distribution of around 450 nm. Nevertheless, the pharmacokinetics of the HPMC conjugates were studied using high performance liquid chromatography. The pharmacokinetic data indicated that a single dose of 132.6 mg of HPMC-ASP was well tolerated in animal studies without any adverse effects. The maximum plasma concentration (C_max) of HPMC-ASP was found to be 14.6 μg·L^-1 with a t_max of 1 h. The plasma half-life and clearance and the volume of HPMC-ASP distribution were 4.6 h, 3.23 L·h^-1, and 21.8 L·kg^-1, respectively. The elimination of HPMC-ASP followed first-order kinetics with r^2 of 0.9643. The results presented in this paper show the great potential of HPMCASP as a more effective, safe, and stable prodrug.
Muhammad Shabbir Shakir,Muhammad Kaleem Khosa,Khalid Mahmood Zia,Muhammad Saeed,Tanveer Hussain Bokhari,Muhammad Abid Zia 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.11
The Present study deals with synthesis of PVC/ABS/ZnO nanocomposites with Zinc oxide nanoparticles of particle size less than 50 nm by sonication and solution casting techniques. After characterization, such nanocomposite materials were subjected to thermal study, antibiofilm, antibacterial and antioxidant screening. Nanocomposites films showed higher thermal stability than pure polymer matrix loaded with different ZnO-Nps concentration with homogeneous distribution. Antibacterial studies were carried out against selected gram-positive bacteria: Staphylococcus aureus and gram-negative bacteria: Pseudomonas aeruginosa. Selective antibiofilm activity was studied against Staphylococcus aureus and Pseudomonas aeruginosa, which showed a higher to lower activity as a model pathogenic strains (~93 and ~89 at 160 g/ml concentration, respectively), while free radical scavenging capacity was assessed by DPPH, ABTH·+ and FRAP methods. PVC/ABS/ZnO nanocomposite showed larger zones of inhibition and higher antibiofilm and antioxidant activity than PVC/ABS polymer matrix. PVC/ABS/ZnO nanocomposite showed enhanced thermal stability and biological properties that qualify them for different biomedical and industrial applications.
Muhammad SAEED,Laiba ASIF,Bassma AKHRIF,Abdul Wajid MOROOJO Korea Distribution Science Association 2023 Asian journal of business environment Vol.13 No.3
Purpose: The purpose of this research was to examine the implementation of Customer Relationship Management (CRM) and its impact on customer-centric factors such as customer satisfaction, customer acquisition, customer retention, and customer loyalty within the restaurant sector of Istanbul, Turkey. Research design, data, and methodology: The questionnaire was used to collect information using a descriptive methodology. Using a " stratified sampling method," 520 customer responses were gathered. The questionnaire was written clearly and concisely, and responses were marked on a 5-point Likert scale. Results: Based on the data, it is clear that CRM has a significant positive effect on the customer-centric characteristics that contribute to organizations' successful and sustainable performance in the modern, competitive market. We found that CRM has positive effects on customer satisfaction (β=0.362, p=0.000), customer acquisition (β=0.310, p=0.000), customer retention (β=0.246, p=0.000), and customer loyalty (β=0.292, p=0.000). Conclusion: This paper makes a noteworthy contribution by addressing the gap in knowledge through its focus on CRM and other relevant factors. It will aid marketing managers and customer relationship officers in effectively administering the CRM system to uphold customer loyalty, retention, and acquisition.
MRT letter: Recovering weak-textured surfaces using image focus
Muhammad, Mannan Saeed,Choi, Tae-Sun Wiley Subscription Services, Inc., A Wiley Company 2009 Microscopy research and technique Vol.72 No.10
<P>In nature, objects have partially weak texture and their shape reconstruction using focus based passive methods like shape from focus (SFF), is difficult. This article presents a new SFF algorithm which can compute precise depth of dense as well as weak textured objects. Segmentation is applied to discard wrong depth estimate and then later interpolating them from accurate depth values of their neighbors. The performance of the proposed method is tested, using different image sequences of synthetic and real objects, with varying textures. Microsc. Res. Tech., 2009. © 2009 Wiley-Liss, Inc.</P>
Muhammad Saeed,Zoya Afzal,Fatima Afzal,Rifat Ullah Khan,Shaaban S. Elnesr,Mahmoud Alagawany,Huayou Chen 한국축산식품학회 2023 한국축산식품학회지 Vol.43 No.6
Health-promoting preparations of inanimate microorganisms or their components are postbiotics. Since probiotics are sensitive to heat and oxygen, postbiotics are stable during industrial processing and storage. Postbiotics boost poultry growth, feed efficiency, intestinal pathogen reduction, and health, making them acceptable drivers of sustainable poultry production. It contains many important biological properties, such as immunomodulatory, antioxidant, and anti-inflammatory responses. Postbiotics revealed promising antioxidant effects due to higher concentrations of uronic acid and due to some enzyme’s production of antioxidants, e.g., superoxide dismutase, glutathione peroxidase, and nicotinamide adenine dinucleotide oxidases and peroxidases. Postbiotics improve intestinal villi, increase lactic acid production, and reduce Enterobacteriaceae and fecal pH, all of which lead to a better immune reaction and health of the gut, as well as better growth performance. P13K/AKT as a potential target pathway for postbiotics-improved intestinal barrier functions. Similarly, postbiotics reduce yolk and plasma cholesterol levels in layers and improve egg quality. It was revealed that favorable outcomes were obtained with various inclusion levels at 1 kg and 0.5 kg. According to several studies, postbiotic compounds significantly increased poultry performance. This review article presents the most recent research investigating the beneficial results of postbiotics in poultry.
STRONG CONVERGENCE OF NEW VISCOSITY RULES OF NONEXPANSIVE MAPPINGS
Muhammad Saeed Ahmad,Waqas Nazeer,Mobeen Munir,Sayed Fakhar Abbas Naqvi,강신민 한국전산응용수학회 2017 Journal of applied mathematics & informatics Vol.35 No.5
The aim of this paper is to present two new viscosity rules for nonexpansive mappings in Hilbert spaces. Under some assumptions, the strong convergence theorems of the purposed new viscosity rules are proved. Some applications are also included.
Muhammad Waqas,Imad-ud-din Saqib,Muhammad Imran Jamil,Mohammad Ayaz Khan,Saeed Akhter 대한비뇨의학회 2018 Investigative and Clinical Urology Vol.59 No.1
Purpose: To evaluate the impact of various computed tomography scan-based parameters of renal stones on the outcome of extracorporeal shock wave lithotripsy (ESWL). Materials and Methods: We conducted a retrospective study of patients who underwent ESWL for renal stones (sized 5–20 mm) from January 2013 to December 2016. We evaluated body mass index, location of the stone, skin-to-stone distance (SSD), stone attenuation value (SAV), stone diameter, Hounsfield density, stone area, and stone volume. Statistical analysis was done and significance was confirmed by multivariate logistic regression analysis. Results: Of the 203 patients 122 (60.1%) had successful clearance of the stone. The presence of a double J stenting, a lower pole location, a higher SAV, higher Hounsfield density, larger stone area, larger stone diameter, and higher stone volume were negative predictors of ESWL outcome. When these parameters were analyzed with multivariate logistic regression analysis, stone location, SSD, and SAV were the only significant independent predictors of the outcome of ESWL. Conclusions: Stone location, SSD, and SAV are reliable and strong predictors of ESWL outcome for the treatment of renal stones.
Saeed Zaman Jamali,Muhammad Omer Khan,Syed Basit Ali Bukhari,Muhammad Mehdi,Gi-Hyeon Gwon,Chul-Ho Noh,Chul-Hwan Kim 한국조명·전기설비학회 2017 조명·전기설비학회논문지 Vol.31 No.10
Low voltage DC (LVDC) distribution systems are gaining attention as customer loads are shifting towards power electronics-based equipment. The DC distribution system has the advantage of supplying power to these power electronic-based loads with high efficiency and without undergoing an energy conversion process. However, the power electronic components used in the LVDC distribution system are vulnerable during short-circuit faults. These components must be protected during the short-circuit faults for a safe and reliable operation. Therefore, this paper proposes a protection technique based on DC short-circuit fault current behavior. The fault is detected via a superposition principle. A fault current limiter (FCL) is used to suppress DC fault strength and reduce the stress from the circuit breaker. Finally, a solid state circuit breaker (SSCB) is used to isolate the fault point. The simulation results show that the proposed protection Scheme operates quickly enough as per expectations to avoid damage to sensitive power electronic devices.
Muhammad Omer Khan,Saeed Zaman,Muhammad Mehdi,Chul-Ho Noh,Gi-Hyeon Gwon,Chul-Hwan Kim 한국조명·전기설비학회 2017 조명·전기설비학회논문지 Vol.31 No.10
Conventional AC power networks in recent decades have been in a process of continuous overhaul due to the development of power electronic devices and distributed energy resources (DER). This development has demonstrated great potential for the implementation of DC power networks and numerous effects on the employment of integrated AC/DC systems based on Voltage Source Converter (VSC) technology are underway. On the other hand, the integration of DER in a distribution network has emerged as a durable choice for fulfilling future energy need. In this study, a load flow analysis is performed on a Voltage Source Converter-Multi terminal DC (VSC-MTDC) based AC/DC Distribution system incorporated with DERs. An IEEE 14 bus distribution network was modified to include a VSC-MTDC network model for the implementation of the Newton-Raphson load flow algorithm. This paper also discussed the mathematical models for VSC, AC and DC networks along with the load flow study of the steady-state change in the AC/DC network as a result of converter and DC line outage.