Is there a characteristic pattern of ambulatory blood pressure profile in type 1 diabetic children and adolescents?

Morić Bernardica Valent,Šamija Ivan,Sabolić Lavinia La Grasta,Stipančić Gordana 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.4

Purpose: To examine the characteristics of ambulatory blood pressure (ABP) including blood pressure variability (BPV) and its association with albuminuria in type 1 diabetic (T1D) children and to identify potential predictors of high-normal albuminuria and microalbuminuria. Methods: ABP monitoring was performed in 201 T1D children and adolescents (mean age, 14.7±3.8 years) with T1D duration over 1 year. The level of albuminuria was assessed as the albumin/creatinine ratio (ACR) and patients were further classified as low-normal, high-normal or microalbuminuria. Results: Fifteen T1D children (7.5%) were hypertensive using office blood pressure (BP) and 10 (5%) according to ABP. T1D subjects had elevated 24-hour systolic BP (SBP) and diastolic BP (DBP) (+0.2 and + 0.3 standard deviation score [SDS]) and nighttime SBP and DBP (+0.6 and +0.8 SDS) compared to reference values. Patients with microalbuminuria had significantly higher 24-hour, daytime and nighttime DBP compared to normoalbuminuric subjects. There was a high percentage of nondippers (74.1%). Nighttime diastolic BPV was significantly higher in subjects with high-normal compared to low-normal albuminuria (P=0.01). A weak correlation was found between ACR and daytime DBP SDS (r=0.29, P<0.001 and nighttime DBP SDS (r=0.21, P=0.003). Age and nighttime diastolic BPV were predictors of high-normal albuminuria while nighttime DBP was a strong predictor for microalbuminuria. Conclusion: T1D children have impaired BP regulation although most of them do not fulfill the criteria for sustained hypertension. There is an association between diastolic ABP and diastolic BPV with rising levels of albuminuria pointing to a clear connection between BP and incipient diabetic nephropathy.

Is there a characteristic pattern of ambulatory blood pressure profile in type 1 diabetic children and adolescents?

Morić Bernardica Valent,Šamija Ivan,Sabolić Lavinia La Grasta,Stipančić Gordana 대한소아내분비학회 2022 Apem Vol.27 No.4

Purpose: To examine the characteristics of ambulatory blood pressure (ABP) including blood pressure variability (BPV) and its association with albuminuria in type 1 diabetic (T1D) children and to identify potential predictors of high-normal albuminuria and microalbuminuria.Methods: ABP monitoring was performed in 201 T1D children and adolescents (mean age, 14.7±3.8 years) with T1D duration over 1 year. The level of albuminuria was assessed as the albumin/creatinine ratio (ACR) and patients were further classified as low-normal, high-normal or microalbuminuria.Results: Fifteen T1D children (7.5%) were hypertensive using office blood pressure (BP) and 10 (5%) according to ABP. T1D subjects had elevated 24-hour systolic BP (SBP) and diastolic BP (DBP) (+0.2 and + 0.3 standard deviation score [SDS]) and nighttime SBP and DBP (+0.6 and +0.8 SDS) compared to reference values. Patients with microalbuminuria had significantly higher 24-hour, daytime and nighttime DBP compared to normoalbuminuric subjects. There was a high percentage of nondippers (74.1%). Nighttime diastolic BPV was significantly higher in subjects with high-normal compared to low-normal albuminuria (<i>p</i>=0.01). A weak correlation was found between ACR and daytime DBP SDS (<i>r</i>=0.29, <i>p</i><0.001 and nighttime DBP SDS (<i>r</i>=0.21, <i>p</i>=0.003). Age and nighttime diastolic BPV were predictors of high-normal albuminuria while nighttime DBP was a strong predictor for microalbuminuria.Conclusion: T1D children have impaired BP regulation although most of them do not fulfill the criteria for sustained hypertension. There is an association between diastolic ABP and diastolic BPV with rising levels of albuminuria pointing to a clear connection between BP and incipient diabetic nephropathy.

Low-cost and low-technology oriented improvement of visual environment at intersections by ergonomic installation of traffic convex mirrors for preventive safety against crossing collisions

Mori Mori,Sadao Horino,Yuji Inomata,Hiroki Sasayama,Yuko Hirota 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-

In Japan, Quarter-million crossing collisions at intersections accounted for one-fourth of the total accidents in 2005. Three-fourths of collisions took place at urban intersections, more than half of them occurred at uncontrolled intersections. Risks of crossing collisions depend on the quality of visual environment at intersection. This study aimed to assess the legibility and effectiveness of 23 traffic convex mirrors installed at 10 urban intersections, after the road management authority inspected and repaired. The legibility of mirror was assessed by means of the photographs of each mirror taken from the drivers’ viewpoint at a legal stop line, entering from the lower priority direction. “Three ergonomics requirements” suggested by the authors were used as the criteria of legibility assessment; (1) Position of road lane, (2) Blind area and (3) Road surface markings. Combining these 3 criteria, the comprehensive assessment of mirror was indicated in 2-grade scale, such as “Good” or “Poor”, namely so dangerous to be improved. A field assessment revealed that 11 among 23 mirrors were still improperly installed. However, simulation analysis showed that 7 among 11 poor mirrors could be improved by adjusting the angle of mirror plate or displacing mirror plate/poles. In conclusion, the present official guideline in regard with installing mirror should be revised to add newly “three ergonomics requirements” for preventive safety. Application of these new guidelines in practice, a typical low-cost and low technology-oriented improvement to reduce crossing collisions, was highly recommended.

Insect-produced Elicitors, Fatty Acid Amino Acid Conjugates:Insights from Physiological Point of View

Naoki Mori,Naoko Yoshinaga 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04

Fatty acid-amino acid conjugates (FACs), first identified from beet armyworm Spodoptera exigua larvae (Alborn et al., 1997), have been found in noctuid as well as sphingid caterpillar oral secretions and especially volicitin [N-(17-hydroxylinolenoyl)- L-glutamine, 17OH-volicitn] and its biochemical precursor, N-linolenoyl- L-glutamine, are known elicitors of induced volatile emissions in corn plants. We conducted FAC screening of 29 lepidopteran species and found FACs in 19 of these species (Yoshinaga & Mori et al., 2010). Thus, FACs are quite commonly synthesized through a broad range of lepidopteran caterpillars. From an evolutionary perspective, it is presumed that volicitin and the other FACs, although consequently unfavorable to the insect in the plant-herbivore interactions, are produced because they are essential part of the primary metabolism of the insects. In this context, we suggested that FACs in Spodoptera litura play an active role in nitrogen assimilation by regulating the amount of glutamine in the larval midgut (Yoshinaga & Mori et al., 2008). The benefits of the physiological function of FACs for the herbivores need to outweigh the costs caused by induction of plant defense

Crop improvement : Original Paper ; Expression of an enhancin gene from the Trichoplusia ni granulosis virus confers resistance to Lepidopterous insect pests to rice

( Mari Mori ),( Harushige Kitamura ),( Atsushi Kondo ),( Koji Dohi ),( Masashi Mori ),( Masanori Kaido ),( Kazuyuki Mise ),( Eiichi Shimojyo ),( Yoshifumi Hashimoto ) 한국식물생명공학회 ( 구 한국식물조직배양학회 ) 2006 Plant Biotechnology Vol.23 No.1

A synthesis method of gene networks based on gene expression by network learning

Yoshihiro Mori,Yasuaki Kuroe,Takehiro Mori 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10

Effect of a dynamic absorber on friction-induced vibration of a rectangular plate

Hiroki Mori,Oleksandr Mikhyeyev,Takuo Nagamine,Mizue Mori,Yuichi Sato 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1

When a plate-like object is rubbed by rubber, friction-induced vibration is generated. To reduce the friction-induced vibration, we experimentally investigate the characteristics of the vibration of a rectangular glass plate. The results show that the frequency of the frictioninduced vibration is almost the same as the natural frequency of a glass plate. The vibration is generated when the natural frequency of a rubbing system is close to that of a glass plate. We then examine the effect of a dynamic absorber mounted on the glass plate. The results demonstrate that the damping of a dynamic absorber is effective for suppressing the friction-induced vibration. Numerical simulation is also performed using a simplified analytical model. The calculated results agree qualitatively with the experimental ones.

Vulnerability assessment of strategic buildings based on ambient vibrations measurements

Mori, Federico,Spina, Daniele Techno-Press 2015 Structural monitoring and maintenance Vol.2 No.2

This paper presents a new method for seismic vulnerability assessment of buildings with reference to their operational limit state. The importance of this kind of evaluation arises from the civil protection necessity that some buildings, considered strategic for seismic emergency management, should retain their functionality also after a destructive earthquake. The method is based on the identification of experimental modal parameters from ambient vibrations measurements. The knowledge of the experimental modes allows to perform a linear spectral analysis computing the maximum structural drifts of the building caused by an assigned earthquake. Operational condition is then evaluated by comparing the maximum building drifts with the reference value assigned by the Italian Technical Code for the operational limit state. The uncertainty about the actual building seismic frequencies, typically significantly lower than the ambient ones, is explicitly taken into account through a probabilistic approach that allows to define for the building the Operational Index together with the Operational Probability Curve. The method is validated with experimental seismic data from a permanently monitored public building: by comparing the probabilistic prediction and the building experimental drifts, resulting from three weak earthquakes, the reliability of the method is confirmed. Finally an application of the method to a strategic building in Italy is presented: all the procedure, from ambient vibrations measurement, to seismic input definition, up to the computation of the Operational Probability Curve is illustrated.

5,20-Bis(α-oligothienyl)-substituted [26]hexaphyrins possessing electronic circuits strongly perturbed by <i>meso</i> -oligothienyl substituents

Mori, Hirotaka,Suzuki, Masaaki,Kim, Woojae,Lim, Jong Min,Kim, Dongho,Osuka, Atsuhiro Royal Society of Chemistry 2015 Chemical science Vol.6 No.3

<▼1><P>A series of [26]hexaphyrins(1.1.1.1.1.1) bearing two α-oligothienyl substituents at 5,20-positions have been synthesised and are shown to have a dumbbell hexaphyrin conformation, to which the α-oligothienyl groups are linked to form an acyclic helix-like conjugated network.</P></▼1><▼2><P>A series of [26]hexaphyrins(1.1.1.1.1.1) bearing two α-oligothienyl substituents at 5,20-positions have been synthesised and are shown to have a dumbbell hexaphyrin conformation, to which the α-oligothienyl groups are linked with small dihedral angles to form an acyclic helix-like conjugated network. While their distinct diatropic ring currents and four reversible reduction waves characteristic of aromatic [26]hexaphyrins indicate that the [26]hexaphyrin aromatic circuits are viable, the absorption spectra and excited state dynamics are significantly perturbed, which becomes increasingly evident with elongation of the oligothienyl substituents. DFT calculations of these hexaphyrins indicated that the LUMO and LUMO + 1 are localised on the hexaphyrin circuit and the HOMO and HOMO – 1 are spread over the acyclic helix-like conjugation network, which can explain the perturbed absorption spectra.</P></▼2>

A new application of photocatalysts: synthesis of nano-sized metal and alloy catalysts by a photo-assisted deposition method

Mori, Kohsuke,Araki, Takashi,Takasaki, Tomoya,Shironita, Sayoko,Yamashita, Hiromi Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.5

Supported Pd catalysts were synthesized using various semiconductor materials by a photo-assisted deposition method under UV-light irradiation. The Pd precursor was deposited and partially reduced by the direct interaction with the photo-excited state of the semiconductor materials, and subsequently transformed into metal particles by $H_2$ reduction. CO adsorption and Pd K-edge XAFS measurements demonstrated that the mean diameter of the deposited Pd particles can be controlled by the type of employed semiconductor materials. The catalytic activities in the direct synthesis of hydrogen peroxide ($H_2O_2$) using $H_2$ and $O_2$ gases under atmospheric pressure were strongly dependent on the type of supports. Here, the use of $TiO_2$ comprising a mixed phase of anatase and rutile was the most efficient based on the amount of Pd. The photo-assisted deposition also provides a simple and straightforward method to synthesize PdAu alloy nanoparticles. For the structural model of PdAu nanoparticles, we suggest that most of the Au atoms are preferentially located in the core region, whereas the Pd atoms are preferentially located in the shell region. The PdAu/$TiO_2$ catalysts prepared by the photo-assisted deposition method were shown to perform significantly better than the pure Pd/$TiO_2$ catalysts.