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Size and Shape Selectivity of Host Networks Built Based on Tunable Secondary Building Units
Moon, Dohyun,Lah, Myoung Soo American Chemical Society 2005 Inorganic chemistry Vol.44 No.6
<P>By modulating the secondary building units derived from the primary building units, N-acylsalicylhydrazides (H3 xshz), we have been able to construct isostructural but tunable host networks, [Mn6(xshz)6(dmf)2(bpea)2], with different cavity sizes and shapes where the secondary building units, [Mn6(xshz)6], were linked through exo-bidentate bridging ligand, 1,2-bis(pyridyl)ethane (bpea) to form 3-D networks. With a short length linear N-acyl side chain at the primary building unit, the host networks have a 3-D network with three-dimensional cavities. With an appropriate length linear N-acyl side chain at the primary building unit, the host network keeps the isostructural 3-D network but with two types of one-dimensional channels of reduced cavity volume. The tuned host networks showed not only size selectivity for the guest molecules but also shape selectivity. While the three-dimensional channeled host showed selectivity depending on the length of the podal guests, the one-dimensional channeled host showed selectivity depending on both the length and/or the podality of the guest molecules.</P>
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Moon, Dohyun,Choi, Jong-Ha Elsevier 2019 Journal of molecular structure Vol.1177 No.-
<P><B>Abstract</B></P> <P>A new double complex, [<I>trans</I>-Cr(N<SUB>3</SUB>)<SUB>2</SUB>(Me<SUB>2</SUB>tn)<SUB>2</SUB>]<SUB>3</SUB>[Cr(N<SUB>3</SUB>)<SUB>4</SUB>(Me<SUB>2</SUB>tn)]<SUB>2</SUB>ClO<SUB>4</SUB> (Me<SUB>2</SUB>tn = 2,2-dimethylpropane-1,3-diamine), was prepared, and its structure determined through single-crystal X-ray diffraction at 100 K. The complex crystallizes in the space group <I>C</I>2/<I>c</I> of the monoclinic system with <I>a</I> = 34.255 (7), <I>b</I> = 11.067 (2), <I>c</I> = 24.137 (5) Å, and <I>β</I> = 120.64 (3)<SUP>o</SUP>. The asymmetric unit contains one half of a centrosymmetric <I>trans</I>-<I>anti</I>-[Cr(N<SUB>3</SUB>)<SUB>2</SUB>(Me<SUB>2</SUB>tn)<SUB>2</SUB>]<SUP>+</SUP> cation, one independent <I>trans</I>-<I>syn</I>-[Cr(N<SUB>3</SUB>)<SUB>2</SUB>(Me<SUB>2</SUB>tn)<SUB>2</SUB>]<SUP>+</SUP> cation, one <I>cis</I>-[Cr(N<SUB>3</SUB>)<SUB>4</SUB>(Me<SUB>2</SUB>tn)]<SUP>-</SUP> anion, and one half of a perchlorate anion. In two independent complex cations, the Cr<SUP>III</SUP> ions are each coordinated by four N atoms of two chelating Me<SUB>2</SUB>tn and two N atoms of the azido group in a distorted octahedral geometry, whereas the Cr<SUP>III</SUP> ion in <I>cis</I>-[Cr(N<SUB>3</SUB>)<SUB>4</SUB>(Me<SUB>2</SUB>tn)]<SUP>-</SUP> has a distorted octahedral coordination with two N atoms of one Me<SUB>2</SUB>tn and four N atoms of the azido group. Interestingly, the six-membered rings in two <I>trans</I>-[Cr(N<SUB>3</SUB>)<SUB>2</SUB>(Me<SUB>2</SUB>tn)<SUB>2</SUB>]<SUP>+</SUP> cations adopt <I>anti</I> and <I>syn</I> chair-chair conformations, independently. The CrN (Me<SUB>2</SUB>tn) bond lengths vary from 2.0556 (15) to 2.0992 (19) Å, whereas the CrN (azido) bond lengths range from 2.0205 (16) to 2.0428 (16) Å. The perchlorate anion is disordered over two sets of sites, and has a distorted tetrahedral geometry. The crystal lattice is stabilized through hydrogen bonding interactions between the nitrogen of N<SUB>3</SUB> <SUP>−</SUP> and the NH groups of the Me<SUB>2</SUB>tn ligand. The IR and electronic absorption spectral properties are also discussed herein.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesis of a new double chromium (III) complex with azido groups. </LI> <LI> Structural determination from synchrotron X-ray radiation data. </LI> <LI> Description of spectral properties by IR and electronic absorption spectroscopy. </LI> </UL> </P>
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Moon, Dohyun,Tanaka, Shinnosuke,Akitsu, Takashiro,Choi, Jong-Ha Elsevier 2018 Journal of molecular structure Vol.1154 No.-
<P><B>Abstract</B></P> <P>Two new copper (II) complexes, [Cu(<I>N</I>-Metn)<SUB>2</SUB>Cl]BF<SUB>4</SUB> (<B>1</B>) and [Cu(Me<SUB>2</SUB>tn)<SUB>2</SUB>(N<SUB>3</SUB>)]N<SUB>3</SUB> (<B>2</B>) (<I>N</I>-Metn = <I>N</I>-methyl-1,3-propanediamine; Me<SUB>2</SUB>tn = 2,2-dimethyl-1,3-propanediamine), have been prepared, fully characterized, and their structures established by X-ray single-crystal analysis from synchrotron diffraction data. For these complexes, the Cu(II) ions are five-coordinate in an axially elongated square-pyramidal environment, with the four amine N atoms at the equatorial positions and the Cl atom (<B>1</B>) or N atom of one azide (<B>2</B>) at an apical site. The CuN bond lengths for amine N atoms in the complex <B>1</B> (2.0198(13)–2.0735(12) A°) and complex <B>2</B> (2.0239(9)–2.0489(9) Å) are typical, but the axial ligands are coordinated with a CuCl bond length of 2.5962 (7) Å for complex <B>1</B>, and the CuN (azido) bond length is 2.1990 (10) Å for complex <B>2</B>, adopting square-planar geometry around the Cu(II) with four N atoms from two <I>N</I>-Metn or Me<SUB>2</SUB>tn ligands. The crystals are stabilized by a three-dimensional network of intermolecular hydrogen bonds that are formed between the primary and secondary amine groups of the <I>N</I>-Metn ligands, the Cl ligands, and the F atoms of BF<SUB>4</SUB> <SUP>−</SUP> anion in <B>1</B>, and by the primary amine groups of the Me<SUB>2</SUB>tn ligands and the N atoms of the azido ligand and azide ion in <B>2</B>. Hirshfeld surface analysis with 2D fingerprint plots revealed that the H⋯H, F⋯H, Cl⋯H contacts in <B>1</B> and the H⋯H and N⋯H contacts in <B>2</B> are the main intermolecular interactions. The electronic absorption and IR spectral properties are also discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Syntheses of two new Cu(II) complexes. </LI> <LI> Two Cu(II) complexes are structurally characterized through single crystal X-ray diffraction. </LI> <LI> Spectroscopic and magnetic properties including Hirshfeld surface analysis are also described. </LI> </UL> </P>
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문도현(Dohyun Moon),박홍기(Hongki Park),최은석(Eunseok Choi),김동구(Dong Goo Kim),김민정(Minjung Kim) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.6
목적: 통증을 수반하는 성인의 후천성 편평족의 흔한 원인 질환인 후경골건 기능 장애는 동양인에서는 드문 질환으로 알려져 있다. 저자는 12예의 치료 경험이 있어 임상적 경험을 보고하고자 한다. 대상 및 방법: 2000년 3월부터 2007년 1월까지 후경골건 기능 장애로 진단된 12예의 임상 소견과 치료 결과를 분석하였으며 평균 추시기간은 32개월이다. 결과: 12예 중 8예가 여성, 평균 나이는 45세였으며, 체질량지수 분류상 과체중이 5예, 비만이 5예 있었다. 4예에서 과거 외상력이 있으며 4예는 기존의 유연성 편평족에서 진행하였다. 치료는 Johnson과 Strom의 임상단계에 따라 Ⅰ의 3예에서 건초 절제술을 시행하였고, 임상단계 Ⅱ에서는 장지굴근건 이행술, 종골 내측 전위 절골술을 시행하였고, 임상단계 Ⅰ, Ⅲ, Ⅳ의 각 1예에서 보존적 치료를 시행하였다. 술전 미국정형외과족부족관절학회의 후족부-족관절 수치는 평균 58점, 수술 후 90점이었으며, 보존적 치료군에서 최초 평균 38점에서 추시상 평균 57점으로 증가한 소견을 보였다. 결론: 한국에서도 통증을 수반하는 성인의 후천성 편평족의 감별진단에서 후경골건의 기능 장애를 고려해야 하고, 조기진단과 임상 평가에 의한 적절한 치료가 필요할 것으로 사료된다. Purpose: Posterior tibialis tendon dysfunction (PTTD) is one of the most common causes of acquired flatfoot deformity in western countries. But it was known that they were very rare in eastern countries. So we want to report the clinical features and outcomes of 12 patients with PTTD. Materials and Methods: We evaluated the results of 12 patients using clinical features and results from March 2000 to January 2007 and mean follow up periods is 32 months. Results: Average age was 45 years, 8 of 12 patients were female, 2 patient with hypertension and 1 with rheumatoid arthritis. 5 patients were overweighted and 5 patients were obese. 4 patients has a history of last trauma. 4 patients experienced progression of flatfoot. On behalf of Johnson and Strom classifications 6 cases were grade Ⅰ, 4 cases were grade Ⅱ, grade Ⅲ, and grade Ⅳ was 1 case, relatively. As a treatment we used tenosynovectomy for 3 cases of grade 1, additional FDL transfer was done for 2 cases of grade Ⅰ and 2 cases of grade Ⅱ. For other 2 patients of grade Ⅱ flexor digitorum longus transfer and Medial displacement calcaneal osteotomy was done. Pathologic findings of tendon showed degenerative tendinitis. Lastly conservative treatment group was 3 cases of grade Ⅰ, Ⅲ, Ⅳ each. Average preoperative and postoperative American Orthopedic Foot and Ankle Society's hindfoot/ankle scoreFAS score was 58 and 90. Initial and follow up AOFAS scores of the conservative group was 38 and 57, relatively. Conclusion: As a cause of acquired flatfoot in adult, PTTD is not a rare disease any more in Korea. To prevent the disability and progression of flatfoot, careful clinical evaluation and proper treatment is important.
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Han, Dohyun,Moon, Sungyoon,Kim, Yikwon,Ho, Won-Kyung,Kim, Kyunggon,Kang, Yup,Jun, Heesook,Kim, Youngsoo American ChemicalSociety 2012 JOURNAL OF PROTEOME RESEARCH Vol.11 No.4
<P>Type 2 diabetes results from aberrant regulation of the phosphorylation cascade in beta-cells. Phosphorylation in pancreatic beta-cells has not been examined extensively, except with regard to subcellular phosphoproteomes using mitochondria. Thus, robust, comprehensive analytical strategies are needed to characterize the many phosphorylated proteins that exist, because of their low abundance, the low stoichiometry of phosphorylation, and the dynamic regulation of phosphoproteins. In this study, we attempted to generate data on a large-scale phosphoproteome from the INS-1 rat pancreatic beta-cell line using linear ion trap MS/MS. To profile the phosphoproteome in-depth, we used comprehensive phosphoproteomic strategies, including detergent-based protein extraction (SDS and SDC), differential sample preparation (in-gel, in-solution digestion, and FASP), TiO2 enrichment, and MS replicate analyses (MS2-only and multiple-stage activation). All spectra were processed and validated by stringent multiple filtering using target and decoy databases. We identified 2467 distinct phosphorylation sites on 1419 phosphoproteins using 4 mg of INS-1 cell lysate in 24 LC-MS/MS runs, of which 683 (27.7%) were considered novel phosphorylation sites that have not been characterized in human, mouse, or rat homologues. Our informatics data constitute a rich bioinformatics resource for investigating the function of reversible phosphorylation in pancreatic beta-cells. In particular, novel phosphorylation sites on proteins that mediate the pathology of type 2 diabetes, such as Pdx-1, Nkx2, and Srebf1, will be valuable targets in ongoing phosphoproteomics studies.</P>
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Han, Dohyun,Moon, Sungyoon,Kim, Hyunsoo,Choi, Sung-E,Lee, Soo-Jin,Park, Kyong Soo,Jun, Heesook,Kang, Yup,Kim, Youngsoo American Chemical Society 2011 JOURNAL OF PROTEOME RESEARCH Vol.10 No.2
<P>Type 2 diabetes (T2D) is closely associated with obesity, and it arises when pancreatic β cells fail to achieve β cell compensation. However, the mechanism linking obesity, insulin resistance, and β cell failure in T2D is not fully understood. To explore this association, we carried out a differential proteomics study using the disease models of Zucker Fatty (ZF) and Zucker Diabetic Fatty (ZDF) rats as the rat models for obese/prediabetes and obese/diabetes, respectively. Differentially expressed islet proteins were identified among ZDF, ZF, and Zucker Lean (ZL, control rat) rats using three iTRAQ experiments, where three biological replicates and two technical replicates were examined to assess both the technical and biological reproducibilities. A total of 54 and 58 proteins were differentially expressed in ZDF versus ZL rats and in ZF versus ZL rats, respectively. Notably, the novel proteins involved in impaired insulin secretion (Scg2, Anxa2, and Rab10), mitochondrial dysfunction (Atp5b and Atp5l), extracellular matrix proteins (Lgal-1, Vim, and Fbn1), and microvascular ischemia (CPA1, CPA2, CPB, Cela2a, and Cela3b) were observed for the first time. With these novel proteins, our proteomics study could provide valuable clues for better understanding the underlying mechanisms associated with the dynamic transition of obesity to T2D.</P><P>The immunohistochemistry was performed to accomplish physiological relevance in Zucker rat models, showing islet hyperplasia existed in ZDF and ZF rat islets. Subsequently, differentially expressed islet proteins were identified among ZDF, ZF, and ZL rats using three iTRAQ experiments. Finally, differentially expressed proteins are grouped into 6 clusters using hierarchical clustering and manual grouping to investigate the molecular changes from obese nondiabetes to obese diabetes.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2011/jprobs.2011.10.issue-2/pr100759a/production/images/medium/pr-2010-00759a_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr100759a'>ACS Electronic Supporting Info</A></P>
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