Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats

Mohammad Khaksari,Gholamreza Asadikaram,Amir Rahnema,Mehdi Mahmoodi,Gholamhosein Hasanshahi,Mohammad Hashemi,Mohammad Khaksari 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.6

It has been shown that some opium derivatives promote cell death via apoptosis. This study was designed to examine the influence of opium addiction on brain and liver cells apoptosis in male and female diabetic and non-diabetic Wistar rats. This experimental study was performed on normal, opium-addicted, diabetic and diabetic opium-addicted male and female rats. Apoptosis was evaluated by TUNEL and DNA fragmentation assays. Results of this study showed that apoptosis in opium-addicted and diabetic opium-addicted brain and liver cells were significantly higher than the both normal and diabetic rats. In addition, we found that apoptosis in brain cells of opium-addicted and diabetic opium-addicted male rats were significantly higher than opium-addicted and diabetic opium-addicted female, whereas apoptosis in liver cells of opium-addicted and diabetic opium-addicted female rats were significantly higher than opium-addicted and diabetic opium-addicted male. Overall, these results indicate that opium probably plays an important role in brain and liver cells apoptosis, therefore, leading neurotoxicity and hepatotoxicity. These findings also in away possibly means that male brain cells are more susceptible than female and interestingly liver of females are more sensitive than males in induction of apoptosis by opium.

Biological Treatment of Wastewater Containing an Azo Dye Using Mixed Culture in Alternating Anaerobic/Aerobic Sequencing Batch Reactors

Mohammad Hakimelahi,Mohammad Reza Alavi Moghaddam,Seyed Hossein Hashemi 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.4

The performance of one stage anaerobic/aerobic processes for the biological treatment of synthetic wastewaters containing Acid Red 18 was studied. In addition, a method for evaluating dye mineralization using lumped parameters was investigated. The selected initial dye concentrations were 0, 35, 70, 140, and 280 mg/L, in reactors R1 ~ R5,respectively. This study showed that average COD removal was not lower than 85% while the remaining COD originated from Acid Red 18 and its degradation products. The majority of the dye removal occurred in the anaerobic phases and the aerobic phase contributions were insignificant. The kinetics data of dye removal showed that the increase in initial dye concentration (35 ~ 280 mg/L) caused a decrease in first-order kinetic rate constants (0.0593 ~ 0.0384/h). The overall mineralization of AR 18 dye was at least 44,35, 13, and 0% in R2 ~ R5, respectively. Increase in initial dye concentrations had no significant effect on sludge characteristics.

Association of lnc-LAMC2-1:1 rs2147578 and CASC8 rs10505477 Polymorphisms with Risk of Childhood Acute Lymphoblastic Leukemia

Hashemi, Mohammad,Bahari, Gholamreza,Naderi, Majid,Bojd, Simin Sadeghi,Taheri, Mohsen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.11

Long non-coding RNAs (lncRNAs) are a novel class of non-protein coding RNAs that are involved in a wide variety of biological processes. There are limited data regarding the impact of lnc-LAMC2-1:1 rs2147578 as well as CASC8 rs10505477 T>C polymorphisms on cancer development. Here we examined for the first time whether rs2147578 and rs10505477 polymorphisms are associated with childhood acute lymphoblastic leukemia (ALL) in a total of 110 cases and 120 healthy controls. Genotyping was achieved by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The rs2147578 variant increased the risk of ALL in codominant (OR=4.33, 95%CI=2.00-9.37, p<0.0001, CG vs CC, and OR=5.81, 95%CI=2.30-14.69, p=0.0002, GG vs CC), dominant (OR=4.63, 95%CI=2.18-9.86, p<0.0001, CG+GG vs CC), overdominant (OR=1.74, 95%CI=1.02-2.97, p=0.0444, CG vs CC+GG) and allele (OR=1.91, 95%CI=1.32-2.77, p=0.0008, G vs C) inheritance models tested. No significant association was found between the CASC8 rs10505477 T>C variant and risk of childhood ALL. In conclusion, the present study revealed that the lnc-LAMC2-1:1 rs2147578 polymorphism may be a risk factor for developing childhood ALL. Further studies with larger sample sizes with different ethnicities are now required to confirm our findings.

Effect of Inverted-V Bracing on Retrofitting Against Progressive Collapse of Steel Moment Resisting Frames

Farshad Hashemi Rezvani,Mohammad Ali Mohammad Taghizadeh,Hamid Reza Ronagh 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.3

The effect of inverted-V bracing on enhancing progressive collapse resistance of steel Moment Resisting Frames (MRF) were investigated in this study. A series of nonlinear static and dynamic analyses were performed to determine the resistance of four generic MRFs retrofitted by ten inverted-V bracing element. These structures were subjected to an exterior column loss and had a different number of stories and span lengths in order to study the effect of these variations on the structural response. Both force-controlled and deformation-controlled actions were implemented to determine if the column loss would lead to a failure progression. Results showed that structural configuration affects the structural resistance against failure progression and hence the appropriate brace element to retrofit it. Also, it was shown that for the studied 4-story frames, by increasing the span length by 20%, the structural resistance decreases by 42% on average. Finally, it was observed that by decreasing the span length, the Dynamic Increase Factor (DIF) suggested by the UFC, will lead to underestimating the required cross-sectional area of the brace for strengthening the unbraced structures.

Smoking and Associated Factors Among the Population Aged 40-64 in Shahroud, Iran

Hamrah, Mohammad Shoaib,Harun-Or-Rashid, Md.,Hirosawa, Tomoya,Sakamoto, Junichi,Hashemi, Hassan,Emamian, Mohammad Hassan,Shariati, Mohammad,Fotouhi, Akbar Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: Smoking is known as a major risk factor for different types of cancer, as well as cardiovascular disease. Its prevalence is increasing in developing countries. The aims of this study were to determine the prevalence of smoking and its associated factors among the population aged 40-64 years in the city of Shahroud which is a representative urban population in Iran. Materials and Methods: A cross-sectional population-based study with stratified random cluster sampling was conducted in 2009 as the first phase of Shahroud Eye Cohort Study. Of 6,311 people, 5,190 participated (82.2%). Information about smoking habit was obtained by face-to-face interview. Results: The overall prevalence of current tobacco smoking was 11.3% (95%CI: 10.5-12.3). It was significantly higher among males than females (25.7% and 0.71%, P<0.001). The prevalence of current cigarette smoking was 10.8% and 1.75% were past smokers. The smoking rate of water-pipe was 0.67%. Unemployed people smoked more than employed (OR=2.66, 95%CI: 1.38-5.14). Conclusions: The prevalence of smoking is low in Shahroud compared with other parts of Iran and other countries. Age, sex, job and marital status were associated with smoking. The low smoking rate among women may be attributed to cultural and social reasons.

New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women

Poorhosseini, Seyed Mohammad,Hashemi, Mohammad,Olyaei, Nasrin Alipour,Izadi, Amir,Moslemi, Elham,Ravesh, Zeinab,Hashemi-Gorji, Feyzollah,Kheiri, Hamid Reza,Yassaee, Vahid Reza Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3

Breast cancer (BC) is the second most common cancer in the world and by far the most frequent cancer among women, with an estimated 1.67 million new cancer cases diagnosed in 2012 (25% of all cancers). Polygene expression analysis is used to predict the prognosis and determine the most appropriate treatment regimen. The objective of this study was to examine the gene expression profiles of SIRT3, HRAS, LSP1, SCUBE2 and AP2A2 in Iranian women with BC.A total of 136 patients including healthy controls were categorized into three groups based on the relapse of the disease. Expression of desired genes in formalin-fixed, paraffin embedded tissues collected from all groups of participants was analyzed via the RT PCR method. RNA extraction and cDNA synthesis were performed then real-time quantitative PCR was carried out. Gene expression analysis revealed that the expression of SIRT3 was equal among patient and control groups. LSP1 was down regulated in all patient groups relative to controls but reduced expression in the metastatic group relative to the non-metastatic one was not significant. HRAS was significantly overexpressed in total and metastatic tumor samples versus normal but not in non-metastatic cases. SCUBE2 expression showed significant over-expression in both overall tumor samples and the non-metastatic group as compared to normal tissues. Gene expression level of AP2A2 in all groups was not detectable. Our data are compatible with a tumor suppressor role of LSP1 related to potential prognostic factor for tumor recurrence and outcome. This study for the first time assayed the prognostic value and changes in the expression of SIRT3, LSP1, HRAS, SCUBE2 and AP2A2 genes in women with breast cancer in the Iranian population and findings confirmed potential biomarker and prognostic capability of these genes. Such expression profiling data can critically improve prognosis and treatment decisions in cancer patients.

On some classes of spiral-like functions defined by the Salagean operator

Mohammad Mehdi Shabani,Saeed Hashemi Sababe 강원경기수학회 2020 한국수학논문집 Vol.28 No.1

In this paper, we introduce two subclasses of analytic and Spiral-like functions and investigate convolution properties, the necessary and sufficient condition, coefficient estimates and inclusion properties for these classes.

Coded and Scalar Prefix Trees: Prefix Matching Using the Novel Idea of Double Relation Chains

Mohammad Behdadfar,Hossein Saidi,Massoud Reza Hashemi,Ying-Dar Lin 한국전자통신연구원 2011 ETRI Journal Vol.33 No.3

In this paper, a model is introduced named double relation chains (DRC) based on ordered sets. It is proved that using DRC and special relationships among the members of an alphabet, vectors of this alphabet can be stored and searched in a tree. This idea is general; however, one special application of DRC is the longest prefix matching (LPM) problem in an IP network. Applying the idea of DRC to the LPM problem makes the prefixes comparable like numbers using a pair of w-bit vectors to store at least one and at most w prefixes, where w is the IP address length. This leads to good compression performance. Based on this, two recently introduced structures called coded prefix trees and scalar prefix trees are shown to be specific applications of DRC. They are implementable on balanced trees which cause the node access complexity for prefix search and update procedures to be O(log n) where n is the number of prefixes. As another advantage, the number of node accesses for these procedures does not depend on w. Additionally, they need fewer number of node accesses compared to recent range-based solutions. These structures are applicable on both IPv4 and IPv6, and can be implemented in software or hardware.

An investigation into the shear strength of SFRC beams with opening in web using NFEM

Mohammad Karimi,Seyed Hamid Hashemi 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.5

Making a transverse opening in concrete beams in order to accommodate utility services through the member instead of below or above of that, sometimes may be necessary. It is obvious that inclusions of an opening in a beam decreases its flexural and shear strengths. Fabricated steel bars are usually used to increase the capacity of the opening section, but details of reinforcements around the opening are dense and complex resulting in laborious pouring and setup process. The goal of this study was to investigate the possibility of using steel fibers in concrete mixture instead of complex reinforcement detailing order to strengthen opening section. Nonlinear finite element method was employed to investigate the behavior of steel fiber reinforced concrete beams. The numerical models were validated by comparison with experimental measurements tested by other investigators and then used to study the influence of fiber length, fiber aspect ratio and fiber content on the shear performance of SFRC slender beams with opening. Finally, it was concluded that the predicted shear strength enhancement is considerably influenced by use of steel fibers in concrete mixture but the effect of fiber length and fiber aspect ratio wasn’t significant.

Flotation-Spectrophotometric Determination of Ag(I) at the 10-7 mol L-1 Level Using Iodide and Ferroin as an Ion-associate

Mohammad Saeid Hosseini,Hamid Hashemi-Moghaddam 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.10

A simple and cost effective method for separation and preconcentration of Ag(I) at the 107 mol L1 level in the environmental and mineral samples is present. The method is based on the flotation of Ag(I)-iodide complex as an ion-associate with ferroin in pH of 4 from a large volume of an aqueous solution (500 mL) using n-heptane. The floated layer was then dissolved in dimethylsulfoxide (DMSO) for the subsequent spectrophotometric determination. Beer's law was obeyed over a range of 2.0 × 107-4.0 × 106 mol L1 with the apparent molar absorptivity of 2.67 × 105 L mol1 cm1. The detection limit (n = 5) was 4 × 108 mol L1, and RSD (n = 5) obtained for 2.0 × 106 mol L1 of Ag(I) was 2.2%. The interference effects of a number of elements was studied and found that only Hg2+ at low concentration, and Pb2+, Cd2+, Cu2+, and Fe3+ ions at moderately high concentrations were interfered. To overcome on these interference effects, the solution was treated with EDTA at a buffering pH of 4 and passed through a column containing Amberlite IR-120 ion-exchanger resin, just before the flotation process. The proposed method was applied to determine of Ag(I) in a synthetic waste water, a photographic washing sample and a geological sample and the results was compared with those obtained from the flame atomic absorption spectrometry. The results were satisfactorily comparable with together, so that the applicability of the proposed method was confirmed in encountering with the real samples.