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RISS 인기검색어
- 검색키워드
- 저자 : Mohamed F. Amira (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Synthesis of Some New Cytidine and Inosine Derivatives
Youssif, Shaker,Mohamed, Enaiat K.,Sayed Ahmed, Ahmed F.,Ghoneim, Amira A. Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.12
The oxidation of cytidine 1 and inosine 5 by sodium metaperiodate followed by the reaction of the product with $CH_3I$ in NaOH afforded 2',4'-dihydroxyhexopyranosyl derivatives 2 and 14 respectively. The reaction of thiophene-2-carboxylic acid or furfural with cytidine were taken place via cycloaddition afforded adducts 3 and 4 respectivily. The bromination of inosine 5 or its 2',3'-O-isopropylidine inosine 6 led to the formation of 8-bromoanalogue 7 and 8, respectively. The reaction of 8-bromo-2',3'-O-isopropylidine inosine (8) with ethylglycinate hydrochloride afforded 8-ethoxycarbonylmethylaminoinosine 9. The alkylation of the compound 6 with urea led to the formation of 3-carbonylaminoinosine 10. The oxidation of 6 with DCC afforded 4'-formyl derivative 11, which on reaction with ethyl glycinate hydrochloride followed by reaction with sodium cyanoborohydride afforded 12, while the treatment of dialdehyde inosine 13 with ethyl cyanoacetate in the presence of 0.5 N NaOH afforded compound 15.
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Synthesis of Some New Cytidine and Inosine Derivatives
Shaker Youssif,Enaiat K. Mohamed,Ahmed F. Sayed Ahmed,Amira A. Ghoneim 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.12
The oxidation of cytidine 1 and inosine 5 by sodium metaperiodate followed by the reaction of the product with CH3I in NaOH afforded 2',4'-dihydroxyhexopyranosyl derivatives 2 and 14 respectively. The reaction of thiophene-2-carboxylic acid or furfural with cytidine were taken place via cycloaddition afforded adducts 3 and 4 respectivily. The bromination of inosine 5 or its 2',3'-O-isopropylidine inosine 6 led to the formation of 8-bromoanalogue 7 and 8, respectively. The reaction of 8-bromo-2',3'-O-isopropylidine inosine (8) with ethyl glycinate hydrochloride afforded 8-ethoxycarbonylmethylaminoinosine 9. The alkylation of the compound 6 with urea led to the formation of 3-carbonylaminoinosine 10. The oxidation of 6 with DCC afforded 4'-formyl derivative 11, which on reaction with ethyl glycinate hydrochloride followed by reaction with sodium cyanoborohydride afforded 12, while the treatment of dialdehyde inosine 13 with ethyl cyanoacetate in the presence of 0.5 N NaOH afforded compound 15.
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Mohamed E. Mahmoud,Mohamed F. Amira,Seleim M. Seleim,Magda E. Abouelanwar 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.77 No.-
Nitroaromatic compounds are classified as toxic-carcinogenic pollutants and explosives. The removal ofthese compounds represents a great challenge. Therefore, the adsorption behaviors of 4-nitrobenzoicacid and 4-nitroaniline onto a fabricated nanocomposite were researched via a green functionalization ofzirconium silicate with nano-polyaniline (ZrSiO4–NPANI and 7.22–22.09 nm). Optimization of removalprocess was examined by different experimental conditions. The adsorption mechanism of nitro-compounds onto ZrSiO4–NPANI wasfitted with the pseudo-second-order and both Langmuir andFreundlich models. Excellent recovery of nitrocompounds from tap water (95.4%), industrial wastewater(97.67%) and sea water (95.77%) were established using 25 mg L 1 and 100 1 mg.
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El-Gendy Fady Mohamed,Shehata Amira M.F.,El-Kawy Esam Awad Abd,El-Hawy Mahmoud Ahmed 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.3
Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by abnormalities of T cells subsets. Programmed death-1 (PD-1) is a co-signaling inhibitory molecule in T cells that is involved in many autoimmune diseases.Purpose: Here we aimed to measure changes in PD-1 expression and serum interferon-γ (IFN-γ) levels before and 1 month after treatment in pediatric patients with newly diagnosed ITP.Methods: We measured PD-1<sup>+</sup> CD4<sup>+</sup> T cells percentages using flow cytometry and the serum IFN-γ levels by enzyme-linked immunosorbent assay in 40 pediatric patients with ITP and 20 healthy controls.Results: Compared with healthy controls, the PD-1<sup>+</sup> CD4<sup>+</sup> T cells percentages and serum IFN-γ levels were significantly higher in ITP patients before and 1 month after therapy. A correlation study revealed that PD-1<sup>+</sup> CD4<sup>+</sup> T cells percentage was negatively associated with platelet count and positively associated with IFN-γ level in patients with ITP. Furthermore, serum IFN-γ levels were significantly decreased in patients after treatment, but no significant change was detected in the percentage of PD-1<sup>+</sup> CD4<sup>+</sup> T cells before or 1 month after therapy.Conclusion: PD-1<sup>+</sup> CD4<sup>+</sup> T cells expression and IFN-γ levels were increased in patients with ITP. These preliminary data suggest a potential role of PD-1<sup>+</sup> CD4<sup>+</sup> T cells as mediators of ITP. We also found a correlation between PD-1<sup>+</sup> CD4<sup>+</sup> T cells and both platelet counts and IFN-γ levels. These findings suggest a potential role of PD-1<sup>+</sup> CD4<sup>+</sup> T cells and IFN-γ in the pathogenesis of ITP. Further studies investigating PD-1 expression in different T-cell subsets, serum IFN-γ concentrations, and antiplatelet antibodies levels over a longer duration after therapy initiation could delineate the precise role of PD-1 in ITP pathogenesis. Consequently, novel nontraditional therapeutic strategies for ITP patients may become available.
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