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REVIEW: Footpad dermatitis (FPD) in chickens
AMER, Mohamed M. Korea FoodHealth Convergence Association 2020 식품보건융합연구 (KJFHC) Vol.6 No.4
Footpad dermatitis (FPD) can be considered as a threat for poultry production due to it causes losses due to condemnation in slaughterhouse. The prevalence and the severity of FPD in broiler breeders increase over time with development of poultry industry. The condition is produced by multifactorial including include drinker design and management, diet composition, house (temperature and humidity levels), litter (type, quality, and quantity) and gut health. Bacterial infections can be associated. FPD lesions can develop in less than a week. FPD is a variable size of inflammatory lesion of the footpad in commercial poultry characterized by necrotic lesions on the plantar surface of the footpad of poultry. These lesions can be exposed after removal of fecal mass and litter stuck on it. There are considerable and numerous interactions between the environment and the genetic traits. Prevention depends mainly on improvement of litter condition. Genetic selection against footpad dermatitis must be contributed to reduce pain and suffering for particular bird experiencing contact dermatitis as well as to avoid economic losses. The objective of this review is to collect different literature written about FPD to be available to students, researchers and veterinarian in poultry practical.
Anti-cancer Effect of Hyoscyamus muticus Extract via Its Activation of Fas/FasL-ASK1-p38 Pathway
Amer Ali Abd El-Hafeez,Hala Mohamed M. Marzouk,Mohamed A. A. Abdelhamid,Hazim O. Khalifa,Tamer H. A. Hasanin,Ahmed G. K. Habib,Fatma Mahmoud Abdelwahed,Fatma M. Barakat,Eslam M. Bastawy,Eman M. B. Abd 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.5
Hyoscyamus muticus L. is a traditional medicine used as antispasmodic and sedative. Herein, we aimed to determine the phytochemical constituents and for the first time its anti-cancer activities. The phytochemical constituents of the different extracts were evaluated by calorimetric methods. The anti-cancer activities of the extracts were tested against leukemia, breast, renal, and prostate cancers cell lines. 4, 6-Diamidino-2-phenylindole (DAPI) staining, flow cytometric analysis, knockdown of ASK1, and reactive oxygen species (ROS) production were evaluated to clarify the mechanism of action. Phytochemical screening confirmed the presence of wide range of phytoconstituents. Hyoscyamus muticus methanolic extracts (HMME) showed the highest anti-cancer activities against leukemia, breast, renal, and prostate cancers as compared to ethanol and aqueous extracts. Specifically, HMME exerted cytotoxic effect against the MDA-MB-231 and MDA-MB-468 triple-negative breast cancer (TNBC) cell lines with IC50 values of 8.75 and 7.25 μg/mL, respectively. Mechanistically, DAPI staining and flow cytometric analysis revealed that HMME induces apoptosis via the death receptor, FAS, but not the mitochondrial pathway. Moreover, ASK1 and p38 were rapidly activated in response to HMME, and knockdown of ASK1 by a small interference of RNA specific to Ask1 attenuated p38 and caspase-3 activation and suppressed apoptosis, implying that HMME-induced apoptosis relies on the ASK1-p38-caspase-3 pathway. Furthermore, we confirmed that cellular ROS generation was a critical mediator in HMME-induced apoptosis because the ROSscavenger N-acetyl cysteine significantly decreased the phosphorylation of ASK1 and HMME-induced apoptosis. Our results confirmed HMME cytotoxic effects in TNBCs via ROS-dependent activation of the Fas/FasL-ASK1-p38 axis.
Ductile damage prediction of AA 5754 sheet during cold forming condition
Mohamed Amer,Mostafa Shazly,Mohamed Mohamed,Abdel Aziz Hegazy 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.10
Aluminium sheet parts manufactured by cold-forming processes are subjected to ductile damage due to the plastic deformation. Tool design based on the experience and failure prediction using simple criteria in sheet metal forming can cause high cost of material scrap and tools modifications. Consequently, the ability to predict ductile damage gives full control of the forming process. This work was conducted to evaluate the predictive capability of different damage models for AA 5754 under cold forming condition. The models are calibrated using published tensile and forming limit diagram data for AA 5754. A set of experimental cup tests for AA 5754 sheet were conducted to validate the selected models. An FE model was developed to simulate the cup test process using LS-DYNA software. The selected models used were the Johnson-Cook, continuum damage model (CDM), Gurson model and the generalized incremental stress state-dependent model (GISSMO) model. The experimental results of the cup tests were compared with the simulation results from different damage models concluding that the Gissmo model was able to show a good agreement with the experimental results.
Cellulitis in Broiler Chickens
AMER, Mohamed M.,MEKKY, Hoda M.,FEDAWY, Hanaa S.,AMER, Aziza M.,ELBAYOUMI, Khalid M. Korea FoodHealth Convergence Association 2020 식품보건융합연구 (KJFHC) Vol.6 No.5
Cellulitis in broiler chickens is one of the economically important problems that facing the broiler industry due to the presence of the lesion leads to condemnation of part of /or the entire carcasses. Broiler with cellulitis lesions showed lower body weight. Cellulitis was recorded on different body regions including the head, dorsum, thighs, breast, legs, and abdomen. Cellulitis results from the invasion of subcutaneous (s.c.) tissues by bacteria through disruption of skin integrity. Lesions revealed the existence of the characteristic s.c colored exudate varies from yellowish to green, which were either serosanguineous, fibrinous s.c exudate yellowish, greenish or suppurative. Many bacterial isolates including E. coli, Staphylococci, Clostridia, Aeromonas spp., Enterobacter spp., Proteus mirabilis, P. aeruginosa, and Streptococci were isolated from the lesion. Chickens exposed to immunosuppression proved to have a greater probability of developing cellulitis. The condition was experimentally induced by s.c inoculation of 25-day-old broiler chickens with E. coli, S. aureus and clostridia. Usually, bacterial isolates were multidrug-resistant. The usage of Bifidobacterium bifidum or antibiotic with avoiding immunosuppression can reduce lesion and condemnation rate resulted from cellulitis. The objective of this review is to collect different literature written about cellulitis to be available to students, researchers, and veterinarians in poultry practical.
Ismail Amer,Mohamed Kohail,M. S. El-Feky,Ahmed Rashad,Mohamed A. Khalaf 한국콘크리트학회 2023 International Journal of Concrete Structures and M Vol.17 No.5
Alkali-activated concrete (AAC) has attained great popularity since finding it as an alternative to Portland cement concrete due to its superior characteristics in terms of mechanical properties and durability, and its low negative environmental impact. This research investigated both experimentally and analytically the bond behavior between alkali-activated slag concrete (AASC) and steel rebars considering some important parameters (rebar diameter and development length-to-diameter ratio) before and after exposure to elevated temperature using beam-end bond testing technique. The obtained experimental results were compared with those obtained from applying the CEB-FIP model and the well-known available equations in the literature. A modified model was proposed for predicting the bond behavior of AASC. Results have showed that the CEB-FIP model provides more conservative values for bond strength compared to the experimentally obtained results which increases the safety level when estimating the bond strength for design purposes. The proposed modified model achieved a higher correlation with the experimental results than the CEB-FIP model at ambient temperature.
Metwally Mohamed Ali,El-Zawahry El-Yamani Ibrahim,Ali Maher Amer,Ibrahim Diaa Farrag,Sabry Shereen Ahmed,Sarhan Omnia Mohamed 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.3
Worldwide, cardiovascular disease is the main cause of death, which accordingly increased by hyperlipidemia. Hyperlipidemia therapy can include lifestyle changes and medications to control cholesterol levels. Statins are the medications of the first choice for dealing with lipid abnormalities. Rosuvastatin founds to control high lipid levels by hindering liver production of cholesterol and to achieve the targeted levels of low-density lipoprotein cholesterol, another lipid lowering agents named ezetimibe may be used as an added therapy. Both rosuvastatin and ezetimibe have low bioavailability which will stand as barrier to decrease cholesterol levels, because of such depictions, formulations of this combined therapy in nanotechnology will be of a great assistance. Our study demonstrated preparations of nanoparticles of this combined therapy, showing their physical characterizations, and examined their behavior in laboratory conditions and vivo habitation. The mean particle size was uniform, polydispersity index and zeta potential of formulations were found to be in the ranges of (0.181–0.72) and (–13.4 to –6.24), respectively. Acceptable limits of entrapment efficiency were affirmed with appearance of spherical and uniform nanoparticles. In vitro testing showed a sustained release of drug exceeded 90% over 24 h. In vivo study revealed an enhanced dissolution and bioavailability from loaded nanoparticles, which was evidenced by calculated pharmacokinetic parameters using triton for hyperlipidemia induction. Stability studies were performed and assured that the formulations are kept the same up to one month. Therefore, nano formulations is a suitable transporter for combined therapy of rosuvastatin and ezetimibe with improvement in their dissolution and bioavailability.
Doaa A. Badr,Mohamed E. Amer,Wagih M. Abd‑Elhay,Mohamed S. M. Nasr,Tamer M. M. Abuamara,Harbi Ali,Aly F. Mohamed,Maha A. Youssef,Nasser S. Awwad,Yi‑Hsu Ju,Ahmed E. Fazary 한국응용생명화학회 2019 Applied Biological Chemistry (Appl Biol Chem) Vol.62 No.5
Cancer is known to be a fierce disease that causes a large percentage of the deaths worldwide. The common cancer treatments; chemotherapy, radiotherapy and surgery are known for their severe side effects; therefore scientists are working on finding solutions to reduce these drawbacks. One of these treatment systems is the sustained released drugs formulations, these systems depend on the encapsulation of the chemotherapy within an emulsifying agent, in order to obtain a slow drug release of low doses over long time intervals. In this study, the anti-cancer effects of free and encapsulated sinapic acid was tested against lung (A549), and colon (CaCo2) cancer cell lines, along with normal fibroblast cells (HFB4) as a negative control. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was performed for IC50 evaluation, also cell cycle assay was performed to detect cell cycle arrest status and related anti-apoptotic and pro-apoptotic; Blc-2, BAX, and P53 gene profile fold changes post cellular treatment. Data recorded revealed that encapsulated SA showed a lower toxicity than the free form to both cell lines and also to the normal cells. The cell cycle analysis showed a cell cycle arrest at the G2/M phase post cell treatment with the free and encapsulated sinapic acid accompanied with up regulation of Bax and P53 and a down regulation of Blc-2 genes in both cell lines. The data suggest a promising anti-cancer and anti-proliferative potential of free and encapsulated sinapic acid. Also they show that the anti-cancer effect of free and encapsulated sinapic acid is quite close.