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- 저자 : Mitchell, Rich (검색결과 350 건)
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( Edward Gane ),( Amoreena C Corsa ),( Yang Liu ),( Ben C Mitchell2 ),( John F Flaherty ),( Michael D Miller ),( Kathryn M Kitrinos ),( Scott Fung ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aim: To evaluate amino acid changes within HBV pol/RT after 96 weeks of treatment with TDF or FTC/ TDF and determine their potential association with TDF resistance. Methods: In Study GS-US-174-0121, 280 patients receiving lamivudine (LAM) with detectable LAM-resistance mutations in HBV pol/RT (LAM-R: rtM204V/I±rtL180M) were randomized 1:1 to receive blinded treatment with TDF or FTC/TDF for 96 weeks. Virologic breakthrough (VB) was defined as confirmed HBV DNA >1 log10 increase from nadir or HBV DNA ≥400 copies/mL (69 IU/mL) after <400 copies/mL. Resistance genotyping by HBV pol/RT sequencing was attempted for all patients at baseline and if viremic (HBV DNA ≥400 copies/ mL) at Week 96/study discontinuation. Results: Overall, 18 patients (9 TDF, 9 FTC/TDF) were viremic viremic at Week 96/last visit. The mean baseline HBV DNA was significantly higher for viremic patients (8.04 log10 copies/mL) compared to patients who did not qualify for genotyping (6.39 log10 copies/mL). In the TDF arm, 3 patients had conserved site changes/reversions (1 with VB), 1 had unique polymorphic site changes, 2 had no change, and 3 were unable to be genotyped. In the FTC/TDF arm, 2 patients had conserved site changes/reversions, 1 had unique polymorphic site changes, 4 had no change, and 2 were unable to be genotyped. No phenotypic resistance to TDF was observed. Four of eight (50%) patients had LAM-R reversions (rtV/I204M±rtM180L) on TDF while 1/8 (12.5%) patients on FTC/TDF had LAM-R reversions. Thirteen patients (4.6%) with prior entecavir (ETV) exposure and 25 patients (8.9%) with baseline ETV-R were enrolled; neither had an impact on viral kinetics. Conclusions: No TDF resistance has been detected through 96 weeks of treatment with either TDF or FTC/TDF in LAM-R patients. The presence of ETV-R or ETV exposure did not impact viral kinetics through 96 weeks. Resistance surveillance in this population will continue through Year 5.
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Are the Distribution of Einstein Crossing Times of Galactic Microlensing Events Bimodal?
Mitchell F. Struble,Thulsi Wickramasinghe 한국우주과학회 2012 Journal of Astronomy and Space Sciences Vol.29 No.2
The observed distribution of a blending-corrected sample of Einstein ring crossing times, tE, for microlensing events toward the galactic bulge/bar are analyzed. An inspection of the distribution of crossing times suggests that it may be bimodal, indicating that two populations of lenses could be responsible for observed microlensing events. Given the possibility that microlensing in this direction can be due to the two most common classes of stars, main-sequence and white dwarf, we analyze and show via Monte Carlo simulations that the observed bimodality of tE can be derived from their accepted mass functions, and the density distributions of both stellar populations in the galactic disk and bulge/bar, with a transverse velocity distribution that is consistent with the density distribution. Kolmogorov-Smirnov (KS) one sample tests shows that a white dwarf population of about 25% of all stars in the galaxy agrees well with the observed bimodality with a KS significance level greater than 97%. This is an expanded and updated version of a previous investigation (Wickramasinghe, Neusima, & Struble, in Mao 2008). A power-point version of the talk, with introductory figures, is found at: https://sites.google.com/site/rhkochconference/agenda-1/program.
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The Domestic Origins of the Second Korean War: New Evidence from Communist Bloc Archives
( Mitchell Lerner ) 서울대학교 규장각한국학연구원 2018 Seoul journal of Korean studies Vol.31 No.1
In the late 1960s, the Korean Peninsula suddenly exploded with a violence not seen since the end of the Korean War, driven by a sudden wave of North Korea aggression that culminated in January 1968 with the attempted assassination of Park Chung Hee and the capture of the USS Pueblo. For decades, scholars have struggled to understand this crisis, as they lacked access to materials that could open a window into DPRK policy. Only now, with the recent release of new materials collected from the archives of the Communist bloc nations, can we begin to understand the critical events of the Second Korean War and the larger environment that surrounded it. This paper integrates the most recent materials from former Communist bloc states to revisit our understanding of this dangerous situation, and to suggest that it was driven above all else by domestic political and economic circumstances inside North Korea.
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Mitchell Wendt,허강준 한국실험동물학회 2016 Laboratory Animal Research Vol.32 No.4
Our research sought to characterize the phylogeny of Pseudomonas aeruginosa isolated from pet Chinese stripe-necked turtles (Ocadia sinensis) to better understand its evolutionary relation to other isolates and increase understanding of a potential zoonotic pathogen transmitted through direct contact with pet turtles. Thirty-one Pseudomonas aeruginosa isolates were obtained from both immature and adult turtles sold in pet shops in Korea. To characterize the phylogenic position of Chinese stripe-necked turtle-borne P. aeruginosa relative to other strains, multilocus sequence typing (MLST) analysis was performed due to the accessibility and breadth of MLST databases. Seven housekeeping genes (acsA, aroE, guaA, mutL, nuoD, ppsA, and trpE) were sequenced and the results were compared with data from the MLST database. The genes were further used for phylogenetic analysis of P. aeruginosa using concatenated gene fragments. Both rooted and unrooted phylogenetic trees were generated. Eleven distinct sequence types were present within the isolates among which seven were new. Expanding an unrooted phylogenetic tree to include P. aeruginosa MLST sequences isolated from various other geographic locations and sources revealed a divergent cluster containing the majority of isolates obtained from turtles. This suggests that P. aeruginosa strains particularly well-adapted for inhabiting turtles occupy a distinct phylogenetic position.
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Drifting apart? The U,S, -ROK alliance at risk
( Mitchell B Reiss ) 한국국방연구원 2009 The Korean Journal of Defense Analysis Vol.21 No.1
Given the success of the U.S.-ROK alliance over the past five and half decades, it is far easier to envision that it will remain undisturbed than to imagine major change, let alone the end of the alliance. Yet past history is no guarantee of future success. Major shifts in American foreign policy, new transnational challenges and a changing political, economic, and security environment in Northeast Asia, call into question whether the alliance will last another 10 years, let alone another half century. By the start of the twenty-first century, the United States had increasingly conceptualized the alliance in regional or even global terms, whereas the ROK military, despite some impressive blue-water naval assets, was still wedded to the mission of peninsular defense. Ideally, the United States would like the ROK to join with U.S. forces in addressing regional and global contingencies, in addition to fulfilling its primary missions to deter and, if necessary, defeat North Korea. Yet America`s reorientation of its forces on the Korean peninsula and the ROK`s military transformation were driven more by domestic political concerns than by jointly shared security imperatives. As a result, larger questions about the future of the alliance went begging. With both partners transitioning to new force structures, these measures portended an alliance that was drifting apart, not a maturing alliance that was becoming a more equal and cohesive partnership. Questions remain unanswered, or even unasked, about whether the two partners agree on the strategic environment in the region and the respective roles both should play. Although there have been discussions on the ````future of the alliance,```` these have focused on U.S. base realignment and other details, not on the future security environment in the region and its larger strategic implications. It is these offshore missions, not North Korea, where threat assessments will likely diverge and where alliance disagreements will arise in the future. In short, the two parties have yet to confront the full implications of the military and defense decisions of the past few years, often undertaken unilaterally and attuned more to domestic audiences than to strategic realities. The ability to paper over a lack of common purpose and shared vision may be useful as a temporary placeholder, but it will not provide an adequate foundation for the future viability of the alliance. The good news is that consensus exists in both countries that the alliance needs to be preserved; the bad news is that charting the way ahead is neither easy nor obvious. The risk is that without the development of a clear and common vision of a shared future with defined and mutually agreed-upon roles, the United States and South Korea will gradually drift apart, along with a partnership that has proved so successful over the past half century.
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Mitchell, Robert J,Gu, Man Bock Humana Press ; Humana Press ; OCLC 2005 Applied biochemistry and biotechnology Vol.120 No.3
<P>The NagR protein is a response regulatory protein found in the bacterium Ralstonia sp. U2 that is involved in sensing for salicylic acid and the subsequent induction of the operon just upstream of its gene. The genes encoded for in this operon are involved in the degradation of salicylic acid. Escherichia coli strain RFM443 carrying a fusion of the Photorhabdus luminescens luxCDABE operon with the nagR gene and upstream region of the nagAa gene was constructed and characterized with respect to its optimum temperature, its response time and kinetics, and its ability to detect numerous benzoic acid derivatives. Although capable of detecting 0.5 mM salicylic acid at any temperature between 28 and 40 degrees C, this E. coli strain, labeled DNT5, showed its greatest relative activity at 30 degrees C, i.e., the temperature at which the largest induction was seen. Furthermore, experiments done with numerous benzoic acid derivatives found the NagR protein to be responsive to only a few of the compounds tested, including salicylic acid and 3-methyl salicylic acid, and acetyl salicylic acid was the strongest inducer. The lower limits of detection for these compounds with E. coli strain DNT5 were also established, with the native inducer, salicylic acid, giving the most sensitive response and detectable down to a concentration of about 2 microM. A second lux fusion plasmid was also constructed and transformed into an NahR background, Pseudomonas putida KCTC1768. Within this strain, NAGK-1768, the supplemental activity of the NahR protein on the nagAa promoter, was shown to extend both the range of chemicals detected and the sensitivity.</P>
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