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Eum Da-Young,Lee Chaeyoung,Tran Cong So,Lee Jinyoung,Park Soon Yong,Jeong Mi-So,Jin Yunho,Shim Jae Woong,Lee Seoung Rak,Koh Minseob,Vasileva Elena A.,Mishchenko Natalia P.,Park Seong-Joon,Choi Si Ho,C 한국독성학회 2024 Toxicological Research Vol.40 No.3
Echinochrome A (Ech A), a marine biosubstance isolated from sea urchins, is a strong antioxidant, and its clinical form, histochrome, is being used to treat several diseases, such as ophthalmic, cardiovascular, and metabolic diseases. Cancerassociated fibroblasts (CAFs) are a component of the tumor stroma and induce phenotypes related to tumor malignancy, including epithelial–mesenchymal transition (EMT) and cancer stemness, through reciprocal interactions with cancer cells. Here, we investigated whether Ech A modulates the properties of CAFs and alleviates CAF-induced lung cancer cell migration. First, we observed that the expression levels of CAF markers, Vimentin and fibroblast-activating protein (FAP), were decreased in Ech A-treated CAF-like MRC5 cells. The mRNA transcriptome analysis revealed that in MRC5 cells, the expression of genes associated with cell migration was largely modulated after Ech A treatment. In particular, the expression and secretion of cytokine and chemokine, such as IL6 and CCL2, stimulating cancer cell metastasis was reduced through the inactivation of STAT3 and Akt in MRC5 cells treated with Ech A compared to untreated MRC5 cells. Moreover, while conditioned medium from MRC5 cells enhanced the migration of non-small cell lung cancer cells, conditioned medium from MRC5 cells treated with Ech A suppressed cancer cell migration. In conclusion, we suggest that Ech A might be a potent adjuvant that increases the efficacy of cancer treatments to mitigate lung cancer progression.
Chang Shin Yoon,Hyoung Kyu Kim,Natalia P. Mishchenko,Elena A. Vasileva,Sergey A. Fedoreyev,Olga P. Shestak,Nadezhda N. Balaneva,Vyacheslav L. Novikov,Valentin A. Stonik,한진 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.4
Backgrounds: Echinochrome A (6-ethyl-2,3,5,7,8-pentahydroxy- 1,4-naphthoquinone) is a common naphthoquinone pigment found in the shells, spines, and coelomic fluid of sea urchins. We previously reported that echinochrome A has a cardioprotective function as an antioxidant against reactive oxygen species (ROS) induced by tert-Butyl hydroperoxide and doxorubicin. Methods: In the current study, we evaluated the antioxidant activity, ATP production, and oxygen consumption rate (OCR) of seven echinochrome structural analogs (spinochromes) in AC16 human cardiomyocyte cells. The compounds included in the study had various substituents including hydroxyl (Sp B and Sp E), amino (Echm A), methoxyl (TriMeEch A), pentyl (No. 284), and hydroxypentyl (No. 285). We also investigated the effects of one dimeric spinochrome (Binaphthoquinone). Results: Spinochromes exhibited enhanced antioxidant activity and ATP production. Interestingly, the hydroxylated compounds significantly enhanced the OCR and had a cardiomyocyte protective effect in the presence of doxorubicin. Conclusion: Our findings indicate that echinochrome A structural analogs may have therapeutic potential for cardio-protection.
Jang, A-Rang,Hong, Seokmo,Hyun, Chohee,Yoon, Seong In,Kim, Gwangwoo,Jeong, Hu Young,Shin, Tae Joo,Park, Sung O.,Wong, Kester,Kwak, Sang Kyu,Park, Noejung,Yu, Kwangnam,Choi, Eunjip,Mishchenko, Artem,Wi American Chemical Society 2016 Nano letters Vol.16 No.5
<P>Large-scale growth of high-quality hexagonal boron nitride has been a challenge in two-dimensional-material-based electronics. Herein, we present wafer-scale and wrinkle-free epitaxial growth of multilayer hexagonal boron nitride on a sapphire substrate by using high-temperature and low-pressure chemical vapor deposition. Microscopic and spectroscopic investigations and theoretical calculations reveal that synthesized hexagonal boron nitride has a single rotational orientation with AA' stacking order. A facile method for transferring hexagonal boron nitride onto other target substrates was developed, which provides the opportunity for using hexagonal boron nitride as a substrate in practical electronic circuits. A graphene field effect transistor fabricated on our hexagonal boron nitride sheets shows clear quantum oscillation and highly improved carrier mobility because the ultraflatness of the hexagonal boron nitride surface can reduce the substrate-induced degradation of the carrier mobility of two-dimensional materials.</P>
Strong Light-Matter Interactions in Heterostructures of Atomically Thin Films
Britnell, L.,Ribeiro, R. M.,Eckmann, A.,Jalil, R.,Belle, B. D.,Mishchenko, A.,Kim, Y.-J.,Gorbachev, R. V.,Georgiou, T.,Morozov, S. V.,Grigorenko, A. N.,Geim, A. K.,Casiraghi, C.,Neto, A. H. Castro,Nov American Association for the Advancement of Scienc 2013 Science Vol.340 No.6138
<P><B>Atomic Layer Heterostructures—More Is More</B></P><P>The isolation of stable layers of various materials, only an atom or several atoms thick, has provided the opportunity to fabricate devices with novel functionality and to probe fundamental physics. <B>Britnell <I>et al.</I></B> (p. 1311, published online 2 May; see the Perspective by <B>Hamm and Hess</B>) sandwiched a single layer of the transition metal dichalcogenide WS<SUB>2</SUB> between two sheets of graphene. The photocurrent response of the heterostructure device was enhanced, compared to that of the bare layer of WS<SUB>2</SUB>. The prospect of combining single or several-atom-thick layers into heterostructures should help to develop materials with a wide range of properties.</P>
( Aldar S Bourinbaiar1 ),( Marina V Mezentseva ),( Dmitry A Butov ),( Peter S Nyasulu ),( Yuri V Efremenko ),( Vichai Jirathitikal ),( Vladimir V Mishchenko ),( Galyna A Kutsyna ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Tuberculosis is typically caused by Mycobacterium tuberculosis, a symbiotic bacterium found in one third of the world population. There any many factors triggering overt clinical disease in a small proportion of humans. In our view the major role in this process is played by host`s immune response, especially self-directed, destructive inflammation. Conventional che-motherapy produces bactericidal or bacteriostatic effects, but immunopathological changes can be corrected by immunotherapy only. Various attempts have been made to find the optimal immune intervention. Some have shown promising effect, but many have failed. It is commonly held that the field started in 1890-the year Robert Koch announced his tuberculin therapy. In the P?n Ts`ao Kang Mu - classical Chinese materia medica published during Ming dynasty - Li Shi Chen (1518-1593) recom-mended as a remedy for hemoptysis to collect from the sputum "…blood lumps, roast them till they are black, and take then them as a powder." In retrospect, this is perhaps the earliest recorded reference relating to immunotherapy of TB with heat-kil-led mycobacteria. Modern science is obviously geared toward more palatable approach, but without hindsight from often dis-dained empirical evidence no progress can be made. Clinically tested immunotherapies for tuberculosis recently developed by us will be presented in this talk.