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- 저자 : Minglin Zhou (검색결과 2 건)
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Conduction Heating of Boron Alloyed Steel in Application for Hot Stamping
Weikang Liang,Yong Liu,Bin Zhu,Minglin Zhou,Yisheng Zhang 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
In traditional hot stamping process, heating of the sheet by radiation heating occupies most of cycle time, which limits the application of hot stamping in automotive industry. Thus a faster heating method has great significance on the hot stamping. The conduction heating overcomes shortage of the radiation heating because of higher heating rate and greater energy efficiency. It attracts increasing attention in the application of heating blanks in hot stamping. In the present study, a movable conduction heating device on die was designed in terms of the Joule’s Law. Heating experiments of boron alloyed steel were performed using the developed device. Heating rate and uniform temperature region were investigated in the non-heat preservation condition (NHPC) and the heat preservation condition (HPC). The results revealed that in the HPC, the heating rate was improved by 13.1 °C/s. In addition, the length of the uniform temperature region was lengthened by 15 mm. It was demonstrated that the HPC was preferred. Furthermore, it was indicated that the mechanical properties of the blanks in uniform temperature region of the conduction heating were also superior to that of the radiation heating.
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Rongzhen Jiang,Yincheng Teng,Yajuan Huang,Jinghong Gu,Li Ma,Minglin Shi,Yuedi Zhou 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-
In women with preeclampsia (PE), endothelial cell (EC) dysfunction can lead to altered secretion of paracrine factors that induce peripheral vasoconstriction and proteinuria. This study examined the hypothesis that PE sera may directly or indirectly, through human umbilical vein ECs (HUVECs), stimulate phospholipase C-γ1-1,4,5-trisphosphate (PLC-γ1-IP3) signaling, thereby increasing protein kinase C-α (PKC-α) activity, collagen I expression and intracellular Ca2+ concentrations ([Ca2+]i) in human umbilical artery smooth muscle cells (HUASMCs). HUASMCs and HUVECs were cocultured with normal or PE sera before PLC-γ1 silencing. Increased PLC-γ1 and IP3 receptor (IP3R) phosphorylation was observed in cocultured HUASMCs stimulatedwith PE sera (Po0.05). In addition, PE serum significantly increased HUASMC viability and reduced their apoptosis (Po0.05); these effects were abrogated with PLC-γ1 silencing. Compared with normal sera, PE sera increased [Ca2+]i in cocultured HUASMCs (Po0.05), which was inhibited by PLC-γ1 and IP3R silencing. Finally, PE sera-induced PKC-α activity and collagen I expression was inhibited by PLC-γ1 small interfering RNA (siRNA) (Po0.05). These results suggest that vasoactive substances in the PE serum may induce deposition in the extracellular matrix through the activation of PLC-γ1, which may in turn result in thickening and hardening of the placental vascular wall, placental blood supply shortage, fetal hypoxia–ischemia and intrauterine growth retardation or intrauterine fetal death. PE sera increased [Ca2+]i and induced PKC-α activation and collagen I expression in cocultured HUASMCs via the PLC-γ1 pathway.
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