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Miki, Daiki,Kubo, Michiaki,Takahashi, Atsushi,Yoon, Kyong-Ah,Kim, Jeongseon,Lee, Geon Kook,Zo, Jae Ill,Lee, Jin Soo,Hosono, Naoya,Morizono, Takashi,Tsunoda, Tatsuhiko,Kamatani, Naoyuki,Chayama, Kazuak Nature Publishing Group, a division of Macmillan P 2010 Nature genetics Vol.42 No.10
Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 ? 10<SUP>??11</SUP>, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 ? 10<SUP>??12</SUP>, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.
Prompt gamma detection for range verification in proton therapy
Shunsuke Kurosawa,Hidetoshi Kubo,Kazuki Ueno,Shigeto Kabuki,Satoru Iwaki,Michiaki Takahashi,Kojiro Taniue,Naoki Higashi,Kentaro Miuchi,Toru Tanimori,김도균,김종원 한국물리학회 2012 Current Applied Physics Vol.12 No.2
It is an on-going challenge to verify the proton range in situ during proton therapy. Since the protons stop in target tissue, measurement of gamma-rays emitted either promptly from nuclear de-excitation or in pair from positron annihilation is the feasible method to monitor the proton range in-vivo. Using the technique of gamma collimation, we empirically demonstrated that the proton range and prompt gamma distribution are well correlated in the therapy energy range, and that measuring prompt gammas is a viable method for the clinical application. However, this collimation technique appears not to be applicable to passively scattered proton beams. The device chosen for gamma imaging in 2D is an electron tracking Compton camera, which images single-emission photons employing a gas chamber to induce Compton scattering. Images of prompt gammas were attained at the proton beam energy of 140 MeV. Measurements showed that gamma image in the energy range of 800e2000 keV provides a better match with the proton range compared to the image by lower energy gammas.
Kim, Yun Kyoung,Oh, Ji Hee,Kim, Young Jin,Hwang, Mi Yeong,Moon, Sanghoon,Low, Siew-Kee,Takahashi, Atsushi,Matsuda, Koichi,Kubo, Michiaki,Lee, Juyoung,Kim, Bong-Jo Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>Hematological traits are important health indicators and are used as diagnostic clinical parameters for human disorders. Recently, genome-wide association studies (GWAS) identified many genetic loci associated with hematological traits in diverse ethnic groups. However, additional GWAS are necessary to elucidate the breadth of genetic variation and the underlying genetic architecture represented by hematological metrics. To identify additional genetic loci influencing hematological traits (such as hematocrit, hemoglobin concentration, white blood cell count, red blood cell count, and platelet count), we conducted GWAS and meta-analyses on data from 12,509 Korean individuals grouped into population-based cohorts. Of interest is EGF, a factor plays a role in the proliferation and differentiation of hematopoietic progenitor cells. We identified a novel EGF variant, which associated with platelet count in our study (<I>P</I><SUB>combined</SUB> = 2.44 × 10<SUP>−15</SUP>). Our study also replicated 16 genetic associations related to five hematological traits with genome-wide significance (<I>P</I> < 5 × 10<SUP>−8</SUP>) that were previously established in other ethnic groups. Of these, variants influencing platelet count are distributed across several genes and have pleiotropic effects in coronary artery disease and dyslipidemia. Our findings may aid in elucidating molecular mechanisms underlying not only hematopoiesis but also inflammatory and cardiovascular diseases.</P>