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노선숙,문미혜 이화여자대학교 사범대학 교과교육연구소 2004 교과교육학연구 Vol.7 No.3
Modern society is a society of knowledge and information putting much emphasis on information-processing skills and information-producing abilities. As teachers serve as agents to select ICT-used class as one of teaching and learning methods, their roles are of great importance. Therefore, this study is designed to look into the actual conditions of ICT-used training to math teachers and to present improving measures. The following are the survey on the actual conditions of math ICT-used training contents. First, math ICT-used training contents don't contribute to the qualitative improvement of in-service teaching and learning methods. Second, ICT-used training is lopsided by focusing on elementary knowledge. Third, there was a significant difference in teachers being able to counter on ICT-used areas, elementary attainments, attitudes towards training and its perception by sex, teaching career and working school. The following are the survey on the actual conditions of operation First, training opportunities are very limited in relation to math ICT-utilized teaching and learning and that training period is very short when compared with the contents of training. Second, ICT-used training is conducted in a way that lectures are dominated. Third, post-training instruction is hardly given.
Noh, Eun-Mi,Park, Jinny,Song, Hwa-Ryung,Kim, Jeong-Mi,Lee, Minok,Song, Hyun-Kyung,Hong, On-Yu,Whang, Pyoung H.,Han, Myung-Kwan,Kwon, Kang-Beom,Kim, Jong-Suk,Lee, Young-Rae Hindawi Publishing Corporation 2016 Oxidative medicine and cellular longevity Vol.2016 No.-
<P>Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin aging through their damaging effect on cellular constituents. However, the origins of ROS have not been fully elucidated. We investigated that ROS generation of replicative senescent fibroblasts is generated by the modulation of phosphatidylinositol 3,4,5-triphosphate (PIP3) metabolism. Reduction of the PTEN protein, which dephosphorylates PIP3, was responsible for maintaining a high level of PIP3 in replicative cells and consequently mediated the activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway. Increased ROS production was blocked by inhibition of PI3K or protein kinase C (PKC) or by NADPH oxidase activating in replicative senescent cells. These data indicate that the signal pathway to ROS generation in replicative aged skin cells can be stimulated by reduced PTEN level. Our results provide new insights into skin aging-associated modification of the PI3K/NADPH oxidase signaling pathway and its relationship with a skin aging-dependent increase of ROS in human dermal fibroblasts.</P>
( Eun Mi Noh ),( Dong Hyu Cho ),( Young Rae Lee ),( Young Ju Jeong ),( Jong Hyeon Kim ),( Hee Suk Chae ),( Jin Ny Park ),( Won Seok Jung ),( Sung Joo Park ),( Jong Suk Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.11
Heme oxygenase-1 (HO-1), an inducible enzyme with broad tissue expression, is wel1-regulated in response to hematopoietic stress and preserves vascular homeostasis. We investigated the involvement of HO-1 in HL-60 cell differentiation. Dimethyl sulfoxide (DMSO) completely decreased HO-1 expression in a time-dependent manner, but clearly induced HL-60 cell differentiation, as evidenced by a marked increase in CD11b expression. Interestingly, zinc protoporphyrin (ZnPP), a strong inhibitor of HO-1, induced HL-60 cell differentiation. In contrast, treatment with cobalt protoporphyrin (CoPP), an activator of HO-1, decreased CD11b expression. Additionally, ZnPP downregulated HO-1 protein expression in HL-60 cells, whereas CoPP induced upregulation. These results suggest that HO-1 might have a negative function in DMSO-induced HL-60 cell differentiation. This study provides the first evidence that HO-1 plays an important role in DMSO-induced HL-60 cell differentiation. [BMB reports 2011; 44(11): 753-757]
( Bo Mi Hwang ),( Hee Suk Chae ),( Young Ju Jeong ),( Young Rae Lee ),( Eun Mi Noh ),( Hyun Zo Youn ),( Sung Hoo Jung ),( Hong Nu Yu ),( Eun Yong Chung ),( Jong Suk Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.11
The expression of matrix metalloproteinases (MMPs) produced by cancer cells has been associated with the high potential of metastasis in several human carcinomas, including breast cancer. Several pieces of evidence demonstrate that protein tyrosine phosphatases (PTP) have functions that promote cell migration and metastasis in breast cancer. We analyzed whether PTP inhibitor might control breast cancer invasion through MMP expression. Herein, we investigate the effect of 4-hydroxy- 3,3-dimethyl-2H benzo[g]indole-2,5(3H)-dione (BVT948), a novel PTP inhibitor, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. The expression of MMP-9 and cell invasion increased after TPA treatment, whereas TPA-induced MMP-9 expression and cell invasion were decreased by BVT948 pretreatment. Also, BVT948 suppressed NF-kB activation in TPA-treated MCF-7 cells. However, BVT948 didn`t block TPA-induced AP-1 activation in MCF-7 cells. Our results suggest that the PTP inhibitor blocks breast cancer invasion via suppression of the expression of MMP-9. [BMB Reports 2013; 46(11): 533-538]
Kim, Jeong-Mi,Noh, Eun-Mi,Kwon, Kang-Beom,Hwang, Bo-Mi,Hwang, Jin-Ki,You, Yong-Ouk,Kim, Min Seuk,Lee, Wan,Lee, Jeong-Ho,Kim, Hye-Jung,Kim, Jong-Suk,Lee, Young-Rae BlackWell Publishing Ltd 2013 Experimental dermatology Vol.22 No.11
<P>Ultraviolet B (UVB) radiation induces photoageing by upregulating the expression of matrix metalloproteinases (MMPs) in human skin cells. Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component in oats. Although anti-inflammatory, anti-atherosclerotic and antioxidant effects have been reported, the antiphotoageing effects of DHAvD are yet to be understood. In this study, we investigated the inhibitory effects of DHAvD on UVB-induced production of reactive oxygen species (ROS) and expression of MMPs, and its molecular mechanism in UVB-irradiated human dermal fibroblasts. Western blot and real-time PCR analyses revealed that DHAvD inhibited UVB-induced MMP-1 and MMP-3 expression. It also significantly blocked UVB-induced ROS generation in fibroblasts. Additionally, DHAvD attenuated UVB-induced phosphorylation of MAPKs, activation of NF-κB and AP-1. DHAvD regulates UVB-irradiated MMP expression by inhibiting ROS-mediated MAPK/NF-κB and AP-1 activation. DHAvD may be a useful candidate for preventing UV light-induced skin photoageing.</P>
Hwang, Bo-Mi,Noh, Eun-Mi,Kim, Jong-Suk,Kim, Jeong-Mi,Hwang, Jin-Ki,Kim, Hye-Kyung,Kang, Jae-Seon,Kim, Do-Sung,Chae, Han-Jung,You, Yong-Ouk,Kwon, Kang-Beom,Lee, Young-Rae D.A. Spandidos 2013 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.31 No.2
<P>Decursin, a coumarin compound, was originally isolated from the roots of Angelica gigas almost four decades ago, and it was found to exhibit cytotoxicity against various types of human cancer cells and anti-amnesic activity in vivo through the inhibition of AChE activity. However, the anti-skin photoaging effects of decursin have not been reported to date. In the present study, we investigated the inhibitory effects of decursin on the expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human dermal fibroblast (HDF) cells. Western blot analysis and real-time PCR revealed that decursin inhibited the ultraviolet (UV)B-induced expression of MMP-1 and MMP-3 in a dose-dependent manner. Decursin significantly blocked the UVB-induced activation of nuclear factor-κB (NF-κB). However, decursin showed no effect on MAPK or AP-1 activity. In this study, decursin prevented the UVB-induced expression of MMPs via the inhibition of NF-κB activation. In conclusion, decursin may be a potential agent for the prevention and treatment of skin photoaging.</P>
Noh, Eun-Mi,Youn, Hyun Jo,Jung, Sung Hoo,Han, Ji-Hey,Jeong, Youg-Ju,Chung, Eun-Yong,Jung, Ji-Youn,Kim, Byeong-Soo,Lee, Sung-Ho,Lee, Young-Rae,Kim, Jong-Suk D.A. Spandidos 2010 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.25 No.2
<P>Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in breast cancer cell invasion. NF-kappa B and AP-1 are known to induce MMP-9 expression. We investigated whether cordycepin, an NF-kappa B or AP-1 inhibitor, can modulate MMP-9 expression and cell invasion in MCF-7 cells. Toxicity of cordycepin was determined by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. MMP-9 expression was determined by real-time PCR, Zymography, and Western blot analysis. AP-1 activation was assayed by electrophoretic mobility shift assay (EMSA). MAPK signaling was evaluated by Western blotting with specific p-ERK, and ERK, p-p38, p38, p-JNK, JNK antibodies. Cordycepin suppressed AP-1 activation, but not NF-kappa B activation in 12-O-tetradecanoylpho-bol-13-acetate (TPA)-treated MCF-7 cells. Cordycepin inhibits TPA-induced MMP-9 expression and cell invasion by suppressing AP-1 activation. Also, cordycepin suppressed the MAPK signaling pathway. Cordycepin is a potent inhibitor of TPA-induced MMP-9 expression and blocks strongly the ability of AP-1 activation via MAPK signaling pathway in MCF-7 cells.</P>
Noh, Eun-Mi,Lee, Young-Rae,Chay, Kee-Oh,Chung, Eun-Yong,Jung, Sung Hoo,Kim, Jong-Suk,Youn, Hyun Jo D. A. Spandidos 2011 MOLECULAR MEDICINE REPORTS Vol.4 No.2
<P>Estrogen receptor α (ERα) mediates most of the biological effects of estrogen in mammary epithelial cells and stimulates growth signals involving phosphoinositide-3-OH kinase (PI3K)/Akt in breast cancer cells. Phosphatase and tensin homologue (PTEN) is a critical counter-regulator of PI3K signaling and is thus one of the major tumor suppressors in breast cancer. Inhibition of PI3K with an inhibitor, wortmannin, increased the level of PTEN protein in ERα-positive MCF-7 cells, while levels in ERα-negative MDA-MB 231 cells were not altered. In addition, the level of PTEN protein in MCF-7 cells was significantly lower than that in MDA-MB 231 cells, which correlated with high levels of phospho-Akt and phosphatidylinositol-3,4,5,-trisphosphate (PIP3). However, PTEN mRNA expression as measured by real-time PCR showed no differences in either cell line. Notably, the levels of casein kinase 2 (CK2) and phospho-PTEN (Ser380/Thr382/383) in MCF-7 cells were lower than those in MDA-MB 231 cells, indicating that the down-regulation of PTEN protein in MCF-7 cells is caused by low levels of CK2 expression, leading to accelerated PTEN degradation. Collectively, these results suggest that ERα induces the down-regulation of PTEN through PI3K activation in breast cancer cells.</P>