Adaptive Neural Finite-time Trajectory Tracking Control of MSVs Subject to Uncertainties

Qiang Zhang,Meijuan Zhang,Renming Yang,Namkyun Im 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.6

This paper provides two finite-time trajectory tracking control schemes for marine surface vessels (MSVs) which are influenced by dynamic uncertainties and unknown time-varying disturbances. Neural networks (NNs) are applied to reconstruct the vehicle’s dynamic uncertainties, and the sum of upper bound of approximation error and external unknown disturbances is estimated by designing an adaptive law. According to the backstepping technique and finite-time stability theory, a finite-time trajectory tracking control scheme is presented. Further, to decrease the conservatism of the presented control scheme caused by estimating the upper bound, a multivariate sliding mode finite-time disturbance observer (MSMFTDO) is designed to estimate the unknown external disturbances and the part that is not completely reconstructed by NNs, and then a MSMFTDO-based adaptive neural finite-time trajectory tracking control law is designed. Rigorous theoretical analyses are provided to prove that,owing to the developed finite-time trajectory tracking control strategies, all the signals of the closed-loop trajectory tracking control system are bounded, and that the actual trajectory of MSVs is able to track the reference trajectory in finite time. Simulation results illustrate the effectiveness of the developed schemes.

Combination of High-Density Lipoprotein Cholesterol and Lipoprotein(a) as a Predictor of Collateral Circulation in Patients With Severe Unilateral Internal Carotid Artery Stenosis or Occlusion

Shuyin Ma,Meijuan Zhang,Huiyang Qu,Yuxuan Cheng,Shuang Du,Jiaxin Fan,Qingling Yao,Xiao Dong Zhang,Mengying Chen,Nan Zhang,Kaili Shi,Yizhou Huang,Shuqin Zhan 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.1

Background and Purpose Collateral circulation is considered an important factor affecting the risk of stroke, but the factors that affect collateral circulation remain unclear. This study was performed to identify the factors associated with collateral circulation, especially blood lipids. Methods The study involved patients who had undergone digital subtraction angiography and were confirmed as having severe unilateral stenosis or occlusion of the internal carotid artery (ICA). We classified the collateral circulation status of each patient as good (Grade 3 or 4) or poor (Grade 0, 1, or 2) according to the grading system of the American Society of Interventional and Therapeutic Neuroradiology/American Society of Interventional Radiology. We collected data on patients’ characteristics and identified the factors that affect collateral circulation. Results This study included 212 patients. The multivariate logistic regression analysis showed that the high-density lipoprotein cholesterol (HDL-C) concentration and a complete anterior half of the circle of Willis were independent protective factors for good collateral circulation, whereas elevated lipoprotein(a) [Lp(a)] and serum creatinine concentrations were independent risk factors for good collateral circulation. The area under the receiver operating characteristics curve (AUC) was 0.68 (95% confidence interval [CI], 0.61–0.76) for HDL-C and 0.69 (95% CI, 0.62–0.76) for Lp(a). A binary logistic regression model analysis of the joint factor of HDL-C and Lp(a) yielded an AUC of 0.77 (95% CI, 0.71–0.84). Conclusions In patients with severe unilateral ICA stenosis or occlusion, the combination of HDL-C and Lp(a) is a useful predictor of collateral circulation.

Frequency Analysis of Wing-Rotor System Considering Flexibility in Capsule Based on High-Accurate Method

Zhang, Xiayang,Zhu, Ming,Zhao, Meijuan,Wu, Zhe The Korean Society for Aeronautical Space Sciences 2018 International Journal of Aeronautical and Space Sc Vol.19 No.2

Based on a typical wing-rotor thrust model on the airship, the dynamic influence of the gyroscopic effects from the tip rotor acting on the overall coupled system has been analyzed. Meanwhile, the flexibility at the capsule boundary has been studied, as well. Hamilton's principle is employed to derive the general governing equations and the numerical Rayleigh-Ritz method is finally chosen in actual frequency computations. A new set of shape functions are put forward and verified which take most of the couplings among dimensions into account. The parameter studies are also conducted to make deep investigations. The results demonstrate that the inherent frequencies are significantly affected by the rotor speed and the flexible capsule condition. When rotor revolves, the modal shapes have reached into complex states and the components of each mode will change with the increment of rotor speed. The flexibility will also greatly reduce the entire frequencies compared with the rigid case. It is also demonstrated that the inherent property will be significantly affected by the mounting geometry, rotor inertia, the structural stiffness, and rotor speed.

Phosphatidylcholine regulates NF-κB activation in attenuation of LPS-induced inflammation: evidence from in vitro study

Meijuan Cheng,Hongying Pan,Yining Dai,Jiajie Zhang,Yongxi Tong,Yicheng Huang,Mingshan Wang,Haijun Huang 한국통합생물학회 2018 Animal cells and systems Vol.22 No.1

Phosphatidylcholine (PC) has been demonstrated as anti-inflammatory and antioxidant/pro-oxidant molecules. In this study, we investigated the protective effects of PC on inflammatory bowel disease (IBD) caused by lipopolysaccharide (LPS)-induced injury in intestinal epithelia cells. The IEC-6 cells (intestinal epithelia cells) were stimulated with LPS (1 μg/mL) for 24 h with or without PC pretreatment, in the next steps: (1) the level of the inflammatory cytokine tumor necrosis factor (TNF)-α was measured with ELISA; (2) the nuclear translocation and phosphorylation of NF-κB was investigated with Western blot, EMSA, immunofluorence assay; (3) the protein phosporylation levels in MAPK signaling pathway were detected with Western blot method. The results showed: (1) compared with the normal group, 10 and 20 μg/mL of PC significantly inhibited the production and activation of TNF-α, (P < 0.01); (2) pretreatment with PC inhibited LPS-induced nuclear translocation and phosphorylation of p65 in IEC-6 cells; (3) pretreatment with PC inhibited the protein phosphorylation levels in MAPK signaling pathway. Our findings indicated that PC had the effect to protect IEC-6 cells from LPS-induced injury and this effect was exerted possibly through inhibiting the TNF-ɑ secretion, down-regulating nuclear translocation and phosphorylation of p65 and inhibiting MAPK signaling pathways.

Long Noncoding RNA MHRT Protects Cardiomyocytes against H₂O₂-Induced Apoptosis

Zhang, Jianying,Gao, Caihua,Meng, Meijuan,Tang, Hongxia The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.1

Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The exploration of new biomarkers with high sensitivity and specificity for early diagnosis of AMI therefore becomes one of the primary task. In the current study, we aim to detect whether there is any heart specific long noncoding RNA (lncRNA) releasing into the circulation during AMI, and explore its function in the neonatal rat cardiac myocytes injury induced by $H_2O_2$. Our results revealed that the cardiac-specific lncRNA MHRT (Myosin Heavy Chain Associated RNA Transcripts) was significantly elevated in the blood from AMI patients compared with the healthy control ($^*p<0.05$). Using an in vitro neonatal rat cardiac myocytes injury model, we demonstrated that lncRNA MHRT was upregulated in the cardiac myocytes after treatment with hydrogen peroxide ($H_2O_2$) via real-time RT-PCR (qRT-PCR). Furthermore, we knockdowned the MHRT gene by siRNA to confirm its roles in the $H_2O_2$-induced cardiac cell apoptosis, and found that knockdown of MHRT led to significant more apoptotic cells than the non-target control ($^{**}p<0.01$), indicating that the lncRNA MHRT is a protective factor for cardiomyocyte and the plasma concentration of MHRT may serve as a biomarker for myocardial infarction diagnosis in humans AMI.

Phosphatidylcholine regulates NF-κB activation in attenuation of LPS-induced inflammation: evidence from in vitro study

Cheng, Meijuan,Pan, Hongying,Dai, Yining,Zhang, Jiajie,Tong, Yongxi,Huang, Yicheng,Wang, Mingshan,Huang, Haijun 한국통합생물학회 2018 Animal cells and systems Vol.22 No.1

Phosphatidylcholine (PC) has been demonstrated as anti-inflammatory and antioxidant/pro-oxidant molecules. In this study, we investigated the protective effects of PC on inflammatory bowel disease (IBD) caused by lipopolysaccharide (LPS)-induced injury in intestinal epithelia cells. The IEC-6 cells (intestinal epithelia cells) were stimulated with LPS ($1{\mu}g/mL$) for 24 h with or without PC pretreatment, in the next steps: (1) the level of the inflammatory cytokine tumor necrosis factor (TNF)-${\alpha}$ was measured with ELISA; (2) the nuclear translocation and phosphorylation of NF-${\kappa}B$ was investigated with Western blot, EMSA, immunofluorence assay; (3) the protein phosporylation levels in MAPK signaling pathway were detected with Western blot method. The results showed: (1) compared with the normal group, 10 and $20{\mu}g/mL$ of PC significantly inhibited the production and activation of TNF-${\alpha}$, (P < 0.01); (2) pretreatment with PC inhibited LPS-induced nuclear translocation and phosphorylation of p65 in IEC-6 cells; (3) pretreatment with PC inhibited the protein phosphorylation levels in MAPK signaling pathway. Our findings indicated that PC had the effect to protect IEC-6 cells from LPS-induced injury and this effect was exerted possibly through inhibiting the TNF-${\alpha}$ secretion, down-regulating nuclear translocation and phosphorylation of p65 and inhibiting MAPK signaling pathways.

Belt-like VO2(M) with a rectangular cross section: A new route to prepare, the phase transition and the optical switching properties

Yifu Zhang,Meijuan Fan,Fei Niu,Weibing Wu,Chi Huang,Xinghai Liu,Houbin Li,Xin Liu 한국물리학회 2012 Current Applied Physics Vol.12 No.3

Belt-like VO2(M) with a rectangular cross section was first synthesized by the irreversible transformation of VO2(A) at the elevated temperatures under the inert atmosphere to the best of our knowledge. The asobtained samples were characterized by a combination of techniques including XRD, SEM and TEM. The processes of converting VO2(A) to VO2(M) were briefly discussed. The as-obtained VO2(M) has belt-like morphology with a rectangular cross section with typical lengths up to several tens of micrometers,widths ranging from tens of nanometers to several micrometers, and thicknesses about 60e150 nm. The morphology and size of the VO2(M) were dependent on that of the precursor VO2(A). The phase transition properties of VO2(M) were investigated by DSC, indicating that it exhibited a strong phase transition at 67.9 ℃ in the heating cycle and 61.1 ℃ in the cooling cycle. Furthermore, the optical switching property of VO2(M) was studied by the variable-temperature infrared spectra, and it was found that the as-obtained VO2(M) could be used as the optical switch.

Long Noncoding RNA MHRT Protects Cardiomyocytes against H2O2-Induced Apoptosis

( Jianying Zhang ),( Caihua Gao ),( Meijuan Meng ),( Hongxia Tang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.1

Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The exploration of new biomarkers with high sensitivity and specificity for early diagnosis of AMI therefore becomes one of the primary task. In the current study, we aim to detect whether there is any heart specific long noncoding RNA (lncRNA) releasing into the circulation during AMI, and explore its function in the neonatal rat cardiac myocytes injury induced by H2O2. Our results revealed that the cardiac-specific lncRNA MHRT (Myosin Heavy Chain Associated RNA Transcripts) was significantly elevated in the blood from AMI patients compared with the healthy control (*p<0.05). Using an in vitro neonatal rat cardiac myocytes injury model, we demonstrated that lncRNA MHRT was upregulated in the cardiac myocytes after treatment with hydrogen peroxide (H2O2) via real-time RT-PCR (qRT-PCR). Furthermore, we knockdowned the MHRT gene by siRNA to confirm its roles in the H2O2-induced cardiac cell apoptosis, and found that knockdown of MHRT led to significant more apoptotic cells than the non-target control (**p<0.01), indicating that the lncRNA MHRT is a protective factor for cardiomyocyte and the plasma concentration of MHRT may serve as a biomarker for myocardial infarction diagnosis in humans AMI.

Frequency Analysis of Wing–Rotor System Considering Flexibility in Capsule Based on High-Accurate Method

Xiayang Zhang,Ming Zhu,Meijuan Zhao,Zhe Wu 한국항공우주학회 2018 International Journal of Aeronautical and Space Sc Vol.19 No.2

Based on a typical wing–rotor thrust model on the airship, the dynamic influence of the gyroscopic effects from the tip rotor acting on the overall coupled system has been analyzed. Meanwhile, the flexibility at the capsule boundary has been studied, aswell.Hamilton’sprincipleisemployedtoderivethegeneralgoverningequationsandthenumericalRayleigh–Ritzmethod is finally chosen in actual frequency computations. A new set of shape functions are put forward and verified which take mostofthecouplingsamongdimensionsintoaccount.Theparameterstudiesarealsoconductedtomakedeepinvestigations. The results demonstrate that the inherent frequencies are significantly affected by the rotor speed and the flexible capsule condition. When rotor revolves, the modal shapes have reached into complex states and the components of each mode will change with the increment of rotor speed. The flexibility will also greatly reduce the entire frequencies compared with the rigid case. It is also demonstrated that the inherent property will be significantly affected by the mounting geometry, rotor inertia, the structural stiffness, and rotor speed.

Improvement of the electrochemical properties of V_3O_7ㆍH_2O nanobelts for Li battery application through synthesis of V_3O_7@C core-shell nanostructured composites

Yifu Zhang,Min Zhou,Meijuan Fan,Chi Huang,Chongxue Chen,Yuliang Cao,Houbin Li,Xinghai Liu 한국물리학회 2011 Current Applied Physics Vol.11 No.5

V_3O_7ㆍH_2O@C core-shell structured composites have been successfully synthesized using V_3O_7ㆍH_2O nanobelts as the cores and glucose as the source of carbon in the presence of sodium lauryl sulfate (SDS). The as-obtained V_3O_7ㆍH_2O@C core-shell materials were characterized by X-ray powder diffraction (XRD),transmission electron microscopy (TEM), elemental analysis (EA), Fourier transform infrared spectroscopy (FT-IR) and Raman spectrum. The thickness of the carbon shell can be controlled by the hydrothermal reaction time and the quantity of glucose. The surfactants have great influence on fabricating V_3O_7ㆍH_2O@C core-shell composites, which have been discussed in detail. V_3O_7@C composites were subsequently obtained through thermal treatment with V_3O_7ㆍH_2O@C. The electrochemical properties of V_3O_7@C core-shell composites were studied, indicating that the discharge capacity is still 151.2 mAh/g after 45 cycles, which is better than that of pure V_3O_7ㆍH_2O nanobelts.