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- 저자 : Meihua Jiang (검색결과 3 건)
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들쥐 유래의 Glioma 종양세포인 C6 세포에서 톡소포자충 감염에 의한 생존력 및 Interferon-γ와 IL-4의 변화
이광연,최원형,유재영,Meihua Jiang,주종필,박진희,박유신,강주섭,남호우,이윤식 대한암예방학회 2008 Journal of cancer prevention Vol.13 No.3
Toxoplasma gondii, a parasite that infects domestic animals and human, induces toxoplasmosis in the human brain. Despite the importance in the biological proliferation mechanism of T. gondii in the human brain, there are only handful of reports related to the parasite's intrusion process to enter the host and a survival rate of the host brain cell. This research is a pivotal one that studies apoptosis and inhibition of host cell growth in C6 glioma cells infected with the parasites. As a result of T. gondii treatment, activation of caspase-3, IL-4 depression, INF-γ increasement and change of nuclear translocation of STAT signal resulted in mice macrophages and C6 cells. Examining the T. gondii-induced apoptosis of rat glioma C6 cells can aid in developing a preventative treatment for cancer, especially in the elderly through a knowledge of signal suppression, survival rate of the host cell and antigen excretion in a late-onset cancer immunity. (Cancer Prev Res 13, 189-196, 2008)
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C57BL/6 마우스에서 알코올성 간 독성에 대한 DSF의 효과
이윤식,Hai-Dan Yuan,최원형,유재영,Meihua Jiang,Yujing Mi,Han-Hong Xiu,박진희,박유신,강주섭 대한암예방학회 2008 Journal of cancer prevention Vol.13 No.3
The aim of this study was to investigate the effect of disulfiram (tetraethylthiuram disulfide, DSF) on the alcoholic liver diseases in mice. C57BL/6 mice were divided into five groups. Control (normal), ethanol treated, DSF treated, ethanol and DSF treated, DSF treated after ethanol treatment for 3 weeks. We evaluated mice body weight and liver weight. On 1 week, body weight was decreased in ethanol treated mice and the body weight gain was similar in all groups of mice after 2 week. With interests, the body weight was significantly increased after treatment of ethanol and DSF for 3 week. However, in the mice with the treatment of DSF only, there was no change of body weight gain and was similar with that of control group of mice. The liver weight of ethanol treated groups was significantly higher than the other groups. A level of ALT, AST and cholesterol in serum were increased in the ethanol treated mice and the level of cholesterol and LDH were increased in DSF treated mice. By H&E staining, we observed degenerative liver tissue change; periportal lymphocytic infiltration, hepatocytes necrosis, severe imflammatory cell infiltrations in ethanol group, and the liver damage was slightly recovered by the treatment of DSF. These results suggest that drinking ethanol is inducible mouse liver damage and the ethanol-induced liver damage was recovered by the treatment of DSF. (Cancer Prev Res 13, 222-227, 2008)
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Won-Hyung Choi,Jong-Phil Chu,Meihua Jiang,Yun-Sik Lee,Bum-Shik Kim,Deog-Gon Kim,Yong-Koo Park 대한기생충학열대의학회 2010 The Korean Journal of Parasitology Vol.48 No.1
We analyzed parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (KMC) from 1984 to 2005. The total number of parasite infection cases was 150 (0.07%) out of the total 211,859 biopsy specimens submitted for histopathological examinations. They consisted of 62 cysticercosis, 23 sparganosis, 16 paragonimiasis, 15 amebiasis, 11 anisakiasis, 11 clonorchiasis, 3 ascariasis, 2 scabies, 2 enterobiasis, 2 trichuriasis, 1 leishmaniasis, 1 taeniasis, and 1 thelaziasis. Out of 62 cysticercosis cases, 55 were detected in subcutaneous tissues or the central nerve system. Eighteen out of 23 sparganosis cases were involved in muscular and subcutaneous tissues. In most anisakiasis cases, the involved organ was the stomach. The lung and the pleura were the most common site of paragonimiasis. The incidence of parasitic diseases during the first 5 years (1984-1988) was the highest of all observed periods. After 1989, similar incidences were shown throughout the period. Whereas cysticercosis was diagnosed in 34 cases during 1984-1988, no case has been diagnosed since 2000. In the case of sparganosis, the chronological incidence was almost uniform throughout the period 1984-2005. Paragonimiasis showed a similar tendency to cysticercosis. In gender and age distribution of parasitic diseases, men showed higher incidence rates than females, and the age groups of the 40s or older indicated higher infection frequencies than other age groups. Therefore, these results are a significant report to appear the tendency of human parasitic disease diagnosed by tissue biopsy in association with parasitosis at KMC in Seoul.
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