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      • A Method for Embedding Information into Printed Documents using Dot Pattern Watermarking

        Junichi MATSUDA,Tomoya MIWA,Ken MATSUDA,Yoshiki MIZUKAMI,Katsumi TADAMURA 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7

        We propose a method for embedding information into printed documents. The method is using dot pattern watermarking based on illustration so that impression of documents is natural. Since random dots are used for conventional dot pattern, documents with dot pattern often give strange impression to readers. Our method is to use dot pattern image transformed from illustration image. We developed two key techniques; one is a method for transforming illustration image to dot pattern image suitable for watermarking; another one is a method for embedding information that can reduce noise caused by errors when printing and scanning documents. We verified the impression of printed documents with dot pattern generated by the proposed method by subjective experiments.

      • Verification of Wisteria floribunda agglutinin-positive glycoproteins as a cholangiocarcinoma marker

        Atsushi Matsuda,Atsushi Kuno,Hideki Matsuzaki,Toru Kawamoto,Toshihide Shikanai,Yasuni Nakanuma,Masakazu Yamamoto,Nobuhiro Ohkohchi,Yuzuru Ikehara,Junichi Shoda,Jun Hirabayashi,Hisashi Narimatsu 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1

        Cholangiocarcinoma (CC) is a lethal malignancy which exhibits asymptomatic growth infiltrating the surrounding structures, and thus,CC is usually detected at an advanced stage. The mainstay of treatment for CC is complete resection with negative surgical margins. Therefore, its diagnosis at a relatively early stage is demanded for performing the surgical resection. Since the definitive CC diagnosis relies on invasive methods such as biliary cytology and biopsy, a noninvasive assay with high diagnostic accuracy is keenly required. In the previous meeting, we reported that Wisteria floribunda agglutinin (WFA) is the best probe lectin which reliably distinguishes between CC and normal bile duct epithelia in tissue sections. Moreover, L1 cell adhesion molecule (L1CAM), CA125, and maspin were assigned as the reliable CC marker candidates by WFA-assisted glycoproteomics and immunohistochemistry. In this meeting, we will introducethe verification and validation process in one of the above candidates, L1CAM. Since the serum concentration of L1CAM was low as described in other reports (< 5 ng/mL), we firstly constructed a highly-sensitive detection system to confirm the existence of L1CAM in both bile and serum of CC patients with immunoprecipitation and western blotting. We then performed highly-sensitive glycan profiling with antibody-assisted lectin microarray (limit of detection: 25 pg) and confirmed WFA-positivity of biliary L1CAM from the CC patients. The subsequent validation study using bile samples from CC patients (n = 29) and patients with benign bile duct diseases (n = 29) showed that WFA-positive L1CAM distinguished CC from the benigndiseases with good specificity (sensitivity = 0.66, specificity = 0.93, overall accuracy = 0.79, area under the receiver operating curve [AUC] = 0.82). The combined use of the L1CAM assay with the highly-sensitive assay detecting WFA-positive sialylated mucin 1 (WFA-sialyl MUC1), a reliable CC marker (Matsuda A., et al., Hepatology, 2010), sufficiently improved the diagnostic accuracy of CC (overall accuracy = 0.84, AUC = 0.93). This combination assay using WFA–L1CAM and WFA–sialyl MUC1 will possibly be a useful serological test with enhanced reliability.

      • SCISCIESCOPUSKCI등재

        Mechanical Properties of Injection Molded Fe-6% Ni-0.4% C Steels with Varying Mo Contents of 0.5 to 2 %

        Matsuda, Mitsuhiro,Miura, Hideshi 대한금속재료학회 2003 METALS AND MATERIALS International Vol.9 No.6

        In our previous studies, sintered and heat-treated alloy steels (Fe-6Ni-0.5Mo-0.4C (mass%)) produced by a MIM process showed excellent mechanical properties of 2000 MPa tensile strength and 5 % elongation. This was attributed to the solid solution strengthening and the mezzo-heterogeneous microstructure, which consisted of martensite or retained austenite (Ni and Mo rich phases) surrounded by a network of tempered martensite. This study has been performed to clarify the effect of Mo on the mezzo-heterogeneous microstructure and the mechanical properties of MIM processed and sintered alloy steels (Fe-6Ni-0.4C) with varying Mo content (0.5~2 mass%). The tensile properties of the heat-treated steels with added 2 mass% Mo were lower than those of the steels with added 0.5 mass% Mo. The reduction in the tensile properties, particularly the appearance of large pores formed at the original location of Mo powder through the transient liquid phase formation and the low hardness of the matrix, was due to the low sintered density. By using mechanically milled fine Ni and Mo powders, the heat-treated steel (Fe-6Ni-2Mo-0.4C) showed excellent properties, including tensile strength of 1800 MPa and ductility of 2.2 % elongation.

      • SCOPUSSCIEKCI등재

        Glioblastoma Multiforme in the Pineal Region with Leptomeningeal Dissemination and Lumbar Metastasis

        Matsuda, Ryosuke,Hironaka, Yasuo,Suigimoto, Tadashi,Nakase, Hiroyuki The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.58 No.5

        We report a case of a 31-year-old woman with glioblastoma multiforme (GBM) in the pineal region with associated leptomeningeal dissemination and lumbar metastasis. The patient presented with severe headache and vomiting. Magnetic resonance imaging (MRI) of the brain showed a heterogeneously enhanced tumor in the pineal region with obstructive hydrocephalus. After an urgent ventricular-peritoneal shunt, she was treated by subtotal resection and chemotherapy concomitant with radiotherapy. Two months after surgery, MRI showed no changes in the residual tumor but leptomeningeal dissemination surrounding the brainstem. One month later, she exhibited severe lumbago and bilateral leg pain. Thoracico-lumbar MRI showed drop like metastasis in the lumbar region. Finally she died five months after the initial diagnosis. Neurosurgeons should pay attention to GBM in the pineal region, not only as an important differential diagnosis among the pineal tumors, but due to the aggressive features of leptomeningeal dissemination and spinal metastasis.

      • SCOPUSKCI등재

        An extension plan of Yakushima Biosphere Reserve as a case study of consensus building of islanders

        Matsuda, Hiroyuki,Yumoto, Takakazu,Okano, Takahiro,Tetsuka, Kenshi,Fujimaki, Aomi,Shioya, Katsunori The Ecological Society of Korea 2015 Journal of Ecology and Environment Vol.38 No.2

        A participatory approach of local stakeholders is important to create a balance between nature protection and the sustainable use of natural resources in a nature reserve and its vicinity area. The zoning and management policy of biosphere reserves (BRs) is a good example of this idea, especially for island reserves. Yakushima was inscribed as a World Natural Heritage (WH) in 1993. Almost all of its residents did not remember that Yakushima was a BR. In addition, Yakushima has some problems in nature reserve management. Overabundance of the deer population is a critical threat to both agriculture and natural vegetation in the world heritage site. There are too many tourists visiting the WH site and Nagata-hama beach. The beach is a Ramsar site and one of the most important spawning grounds of sea turtles in the north Pacific. Now, residents and the municipality have decided to reactivate the Yakushima BR. Although the Ministry of the Environment of Japan has an initiative to manage the WH and the Ramsar site, the BR is managed by the municipality and local stakeholders. Local activities of both nature conservation and the sustainable use of natural resources are encouraged in the BR site. The islanders willingly included all areas of the island into the BR site. Scientists who have participated in the Society of Yakushimaology have played a significant role to build trust between local stakeholders and to seek feasible policies on the nature reserves. The concept of the "Yakushima Environmental Culture Village" is a good model for the extension plan of the Yakushima and Kuchinoerabujima BRs.

      • KCI등재
      • Surface and Electronic Properties of Hydrogen Terminated Si [001] Nanowires

        Matsuda, Yuki,Tahir-Kheli, Jamil,Goddard , William A. American Chemical Society 2011 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.115 No.25

        <P>The calculated band gaps reported previously for silicon nanowires (SiNW) have disagreed with the experimental values both in magnitude and in the behavior with radius. We resolve this discrepancy here. We report ab initio quantum mechanical calculations of hydrogen terminated Si [001] nanowires (H–SiNWs) as a function of diameter (<I>d</I>) and hydrogen coverage using the B3LYP density functional. For smaller diameters (<I>d</I> ≤ 1.9 nm) we find that the most stable surface is fully saturated with hydrogen leading to direct band gaps. For larger diameters, the surface dangling bonds are not saturated, leading to surface LUMO and HOMO states that lower the gap and lead to an indirect band gap. This transition from direct to indirect gap resolves the previous disagreement in the scaling of band gap with diameter. We conclude that the electronic properties of Si NW depend sensitively on controlling the diameter and surface hydrogen coverage.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2010/jpccck.2010.115.issue-25/jp106048u/production/images/medium/jp-2010-06048u_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp106048u'>ACS Electronic Supporting Info</A></P>

      • SCISCIESCOPUS

        Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA

        Matsuda, Daiki,Hosoda, Nao,Kim, Yoon Ki,Maquat, Lynne E Nature Publishing Group 2007 Nature Structural and Molecular Biology Vol.14 No.10

        Nonsense-mediated mRNA decay (NMD) generally eliminates messenger RNAs that prematurely terminate translation and occurs in all eukaryotes that have been studied, although with mechanistic variations. In mammals, NMD seems to be restricted to newly synthesized mRNA that is bound by the cap-binding heterodimer CBP80-CBP20 (CBP80/20) and typically has at least one exon junction complex (EJC) situated downstream of the nonsense codon and added post-splicing. However, mammalian NMD can also target spliced mRNA lacking an EJC downstream of the nonsense codon. Here we provide evidence that this additional pathway, known as failsafe NMD, likewise seems to be restricted to CBP80/20-bound mRNA and does not detectably target its subsequently remodeled product, eIF4E-bound mRNA. Our studies, including analyses of factor dependence, reveal important shared features of the two mammalian-cell NMD pathways as well as fundamental differences between NMD in mammals and Saccharomyces cerevisiae.

      • Avian colibacillosis caused by an intestinal pathogenic <i>Escherichia coli</i> isolate from calf diarrhea

        Matsuda, Kiku,Chaudhari, Atul A.,Lee, John Hwa Elsevier 2010 Research in veterinary science Vol.89 No.2

        <P><B>Abstract</B></P><P>An intestinal pathogenic <I>Escherichia coli</I> isolate from calf diarrhea, containing the <I>iutA</I>, <I>f17A</I>, <I>afa</I>-<I>8D</I>, and <I>cnf2</I> genes, was able to cause avian colibacillosis after experimental infection in chickens. Intra-tracheal inoculation and spray of this strain caused 10% of mortality and gross lesions, including airsacculitis, pericarditis, and perihepatitis. These results suggest that some bovine pathogenic <I>E. coli</I> can cause extra-intestinal infections in other animal species.</P>

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