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Surgical Treatment of Gastroesophageal Junction Cancer
Hashimoto, Tadayoshi,Kurokawa, Yukinori,Mori, Masaki,Doki, Yuichiro The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.3
Although the incidence of gastroesophageal junction (GEJ) adenocarcinoma has been increasing worldwide, no standardized surgical strategy for its treatment has been established. This study aimed to provide an update on the surgical treatment of GEJ adenocarcinoma by reviewing previous reports and propose recommended surgical approaches. The Siewert classification is widely used for determining which surgical procedure is used, because previous studies have shown that the pattern of lymph node (LN) metastasis depends on tumor location. In terms of surgical approaches for GEJ adenocarcinoma, a consensus was reached based on two randomized controlled trials. Siewert types I and III are treated as esophageal cancer and gastric cancer, respectively. Although no consensus has been reached regarding the treatment of Siewert type II, several retrospective studies suggested that the optimal treatment strategy includes paraaortic LN dissection. Against this background, a Japanese nationwide prospective trial is being conducted to determine the proportion of LN metastasis in GEJ cancers and to identify the optimal extent of LN dissection in each type.
Surgical Treatment of Gastroesophageal Junction Cancer
Tadayoshi Hashimoto,Yukinori Kurokawa,Masaki Mori,Yuichiro Doki 대한위암학회 2018 Journal of gastric cancer Vol.18 No.3
Although the incidence of gastroesophageal junction (GEJ) adenocarcinoma has been increasing worldwide, no standardized surgical strategy for its treatment has been established. This study aimed to provide an update on the surgical treatment of GEJ adenocarcinoma by reviewing previous reports and propose recommended surgical approaches. The Siewert classification is widely used for determining which surgical procedure is used, because previous studies have shown that the pattern of lymph node (LN) metastasis depends on tumor location. In terms of surgical approaches for GEJ adenocarcinoma, a consensus was reached based on two randomized controlled trials. Siewert types I and III are treated as esophageal cancer and gastric cancer, respectively. Although no consensus has been reached regarding the treatment of Siewert type II, several retrospective studies suggested that the optimal treatment strategy includes paraaortic LN dissection. Against this background, a Japanese nationwide prospective trial is being conducted to determine the proportion of LN metastasis in GEJ cancers and to identify the optimal extent of LN dissection in each type.
Takashi Muramatsu,Sadamitsu Hashimoto,Takashi Inoue,Takahiko Shibahara,김진,Masaki Shimono 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.5
A rare case of primary intraosseous squamous cell carcinoma(PISCC) arising from lining epithelium of a dentigerous cyst is described. The case occurred at the left mandibular 3rd molar region in a 56-year-old Japanese woman. Clinical observation revealed cyst formation with an impacted 3rd molar, a common finding in dentigerous cyst, in the left mandible. Histopathologically, the lining epithelium of the cyst demonstrated transition from epithelial dysplasia to invasive squamous cell carcinoma(SCC). This case was diagnosed as PISCC arising from lining epithelium of a dentigerous cyst.
Dysplastic Odontogenic Cyst with the Manifestation of Inflammatory Radicular Cyst
Takashi Muramatsu,유미현,Sadamitsu Hashimoto,이상휘,김진,Masaki Shimono 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.3
This report describes a case of odontogenic cyst with keratinization and dysplastic change of lining epithelium, which showed the manifestation of inflammatory radicular cyst, clinically. A 28-year-old man complained of dull pain in the right mandibular molar region. Radiographically a well-defined oval cystic lesion with non-vital teeth, a common finding in radicular cyst, was observed. Microscopically, the lining epithelium of the cyst demonstrated both keratinization and severe epithelial dysplasia. Atypical findings such as hyperchromatic nuclei, increase of N/C ratio and drop shaped rege ridge were observed in the lining epithelium. However,definite invasion into fibrous connective tissue was not found. Immunohistochemically, the dysplastic lining epithelium was highly positive for proliferative marker, Ki-67. Based on the dysplastic changes of lining epithelium, this periapical lesion would be considered to be signs of malignant change. From this case, we conclude that definitive diagnosis by microscopical examination should be made,even if the periapical lesion would be clinically considered as inflammatory radicular cyst.
Takashi Muramatsu,유미현,Sadamitsu Hashimoto,이상휘,김진,Masaki Shimono 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.3
This report describes a case of odontogenic cyst with keratinization and dysplastic change of lining epithelium, which showed the manifestation of inflammatory radicular cyst, clinically. A 28-year-old man complained of dull pain in the right mandibular molar region. Radiographically a well-defined oval cystic lesion with non-vital teeth, a common finding in radicular cyst, was observed. Microscopically, the lining epithelium of the cyst demonstrated both keratinization and severe epithelial dysplasia. Atypical findings such as hyperchromatic nuclei, increase of N/C ratio and drop shaped rege ridge were observed in the lining epithelium. However, definite invasion into fibrous connective tissue was not found. Immunohistochemically, the dysplastic lining epithelium was highly positive for proliferative marker, Ki-67. Based on the dysplastic changes of lining epithelium, this periapical lesion would be considered to be signs of malignant change. From this case, we conclude that definitive diagnosis by microscopical examination should be made, even if the periapical lesion would be clinically considered as inflammatory radicular cyst.
( Kazutami Sakamoto ),( Yuji Yamashita ),( Hiroyasu Ohtaka ),( Yosuke Hashimoto ),( Masaki Takemura ),( Yoshikazu Uchida ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Trans-Urocanic acid (t-UCA) is recognized as an end metabolite of filaggrin via histidine which is a part of NMF amino acids in the stratum corneum (SC). As an intrinsic chromophore in SC under UV exposure, t-UCA converts to cis isomer (c-UCA) which initiates UV-induced immunosuppression. There are controversial discussions about c-UCA whether its immunosuppressive function is for the protection of body or rather to trigger carcinogenic reactions. Even though, existence of t-UCA in SC and conversion to c-UCA by UV radiation is real events evolved in Nature for the mammalian skin especially in human. The objective of this study is to investigate the transient isomerization of t-UCA in SC to c-UCA during the course of seasonal solar UV Index change in order to better understand the role of UCA for the skin physiology. Ten volunteers with age 21 to 34 are recruited and UCA isomer ratio was measured twice a week for six weeks (Sep 14th through Oct 19 in 2012). SC samples were tape stripped from the inner upper arm and UCA isomers are analyzed by HPLC. Average cis/trans ratio decreased gradually from c.a. 2.0 to 0.2. Solar UV Index reported for the area of experiment also decreased by the duration of days during the 6 weeks test period and there are good correlation found between isomer ratio and Solar UV Index. As a result, dynamic photo-isomerization of UCA in response to the solar UV radiation was confirmed. This finding would lead us further investigation of the functional roles of UCA in the skin especially for the Filaggrin mutation and Atopic Dermatitis, which is one of the hot topics in skin science.