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Evaluation of 131I (monoiodide) BSP for Clinical Studies
Ueda, Hideo,Iro, Masahiro,Kurata, Kunio,Yamada, Hideo,Iwase, Tohru,Migita, Tohru,Kameda, Haruo,Kato, Sadatake,Sato, Noboru,Ide, Kazuko,Wakebayashi, Takao 대한핵의학회 1971 핵의학 분자영상 Vol.5 No.1
"In 1925 Rosenthal and White introduced a bromosulfophthalein (BSP) dye retention test as a sensitive indicator of liver function. Even now it is regared as one of the most sensitive agents for the detection of non-icteric liver disease (liver cirrhosis, early stage of acute-hepatitis and hepatic tumor). BSP accumulates in the liver cells, conjugates with glutathione and is excreted into the bile. Therefore, a disorder in its excretion is due to a disturbance of one of these processes. Since bilirubin and BSP compete for uptake by the liver and increased serum bilirubin interferes with the colorimetric determination of BSP, it has been considered that BSP test is inappropriate for the differential diagnosis of jaundice conditions. It has been generally said that when jaundice is present, the BSP test is useless and should not be performed. In 1955, Taplin et al. labeled rose bengal, a dye similarly metabolized in the liver as BSP, with 131I and measured the hepatic excretion of this dye by external monitoring. Laster, Blahd et al. applied this method to the determination of the peripheral pool, succeeding in the diagnosis of chronic and subacute hepatic diseases without colorimetry. In 1968, Yamada, Taplin et al. suggested the possibility of differentiating so-called medical jaundice from surgical jaundice by scanning the subjects during 24 to 48 hours following intravenous injection of 131I-labeled rose bengal. As mentioned before, many authorities hold the opinion that BSP is not proper for the differential diagnosis of jaundice states. Some have tried to diagnose biliary tract obstruction by a malignant tumor by measuring BSP excretion into duodenal fluid and others by quantitating changes in serum levels of conjugated and free BSP. Furthermore, Burton et al. reported that in patients with extrahepatic obstructive jaundice, BSP retention was observed for 24 days after its administration. From a consideration of all these finding we came to a conclusion that the differential diagnosis of various jaundice states, (medical, surgical and constitutional) is possible by sequential scanning with radioisotope-labeled BSP, as with rose bengal, in accordance with procedures described by Yamada, Taplin et al. The evidence suggested that labeled BSP might make a more important contribution than rose bengal. "
일본 기수호 (Lake Obuchi)에서 생태계 모델의 개발과 적용
( Ueda Shinji ),( Kunio Kondo ),( Jiro Inaba ),( Masahiro Hosoda ),( Hiroshi Kutsukake ),( Yasushi Seike ),( Kisaburo Nakata ) 한국하천호수학회 2004 생태와 환경 Vol.37 No.4
In order to evaluate the water quality (N, P and C) and the biological mass balance of semi-enclosed brackish Lake Obuchi, Japan, an ecosystem model was developed and applied to the lake, using the flow field calculated by a hydrodynamic model. The time series data of the observed tide level, river discharge and meteorological parameters from January 2001 to December 2002 were incorporated as the parameters of the hydrodynamic model. Water quality and biomass balance were estimated by the ecosystem model, and simulated fluctuations in water quality agreed with our observations. The carbon contents of POC, phytoplankton and zooplankton in the lake were calculated by the model at an average 7200, 1500 and 22 ㎏, respectively, which somewhat agreed with our observations of POC (5900 ㎏), phytoplankton (3800 ㎏), and zooplankton (150 ㎏).
Diagnosis of Constitutional Hyperbilirubinemias by Sequential Scanning with I-131-BSP
Iio, Masahiro,Ueda, Hideo,Iuchi, Masahiko,Yamada, Hideo,Kameda, Haruo,Ishiwa, Mamoru 대한핵의학회 1971 핵의학 분자영상 Vol.5 No.1
Sequential liver scanning was introduced for the diagnosis of medical and surgical jaundices by Yamada and Taplin(1) using I-131-Rose Bengal. Following this trial authors have reevaluated the I-131-BSP (monoiodide)(2) and applied this dye successfully for the same purpose as well as for hepatic function study(2). In this paper, taking note of the fact that I-131-BSP sequential scanning method makes visible the mechanism of liver uptake, intrahepatic transport and biliary excretion of this dye, the authors aimed to make clear the classification of constitutional hyperbilirubinemias and the pathophysiology of this disease subjects, which are still controversial among researchers.
FAST SIMULATED ANNEALING PLACEMENT COMBINED WITH INITIAL PLACEMENT METHOD
Mitsuyasu, Masahiro,Hirashima, Victor,Ueda, Kazuhiro 대한전자공학회 1989 ICVC : International Conference on VLSI and CAD Vol.1 No.1
In this paper, a fast simulated annealing method combined with an initial placement is presented. The simulated annealing method starts with initial placement obtained by the AR placement method. The AR (Attractive and Repulsive force) method is a kind of gravitational placement method based on repulsive forces as well as attractive forces. Three methods have been compared : 1)AR-started SA, 2)Random-started SA, 3)AR-started PI(Pairwise Interchange). The AR-started SA method can obtain better solution than the other, and 2-3 times faster than the Random-started SA method.
Yasunobu Yamashita,Kazuki Ueda,Yuki Kawaji,Takashi Tamura,Masahiro Itonaga,Takeichi Yoshida,Hiroki Maeda,Hirohito Magari,Takao Maekita,Mikitaka Iguchi,Hideyuki Tamai,Masao Ichinose,Jun Kato 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.4
Background/Aims: Transpapillary forceps biopsy is an effective diagnostic technique in patients with biliary stricture. This prospective study aimed to determine the usefulness of the wire-grasping method as a new technique for forceps biopsy. Methods: Consecutive patients with biliary stricture or irregularities of the bile duct wall were randomly allocated to either the direct or wire-grasping method group. In the wiregrasping method, forceps in the duodenum grasps a guidewire placed into the bile duct beforehand, and then, the forceps are pushed through the papilla without endoscopic sphincterotomy. In the direct method, forceps are directly pushed into the bile duct alongside a guide-wire. The primary endpoint was the success rate of obtaining specimens suitable for adequate pathological examination. Results: In total, 32 patients were enrolled, and 28 (14 in each group) were eligible for analysis. The success rate was significantly higher using the wire-grasping method than the direct method (100% vs 50%, p=0.016). Sensitivity and accuracy for the diagnosis of cancer were comparable in patients with the successful procurement of biopsy specimens between the two methods (91% vs 83% and 93% vs 86%, respectively). Conclusions: The wire-grasping method is useful for diagnosing patients with biliary stricture or irregularities of the bile duct wall.
Takashi Tamura,Yasunobu Yamashita,Kazuki Ueda,Yuki Kawaji,Masahiro Itonaga,Shin-ichi Murata,Kaori Yamamoto,Takeichi Yoshida,Hiroki Maeda,Takao Maekita,Mikitaka Iguchi,Hideyuki Tamai,Masao Ichinose,Jun 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.4
Background/Aims: Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been used to diagnose gastrointestinal submucosal tumors (SMTs). Although rapid on-site evaluation (ROSE) has been reported to improve the diagnostic accuracy of EUS-FNA for pancreatic lesions, on-site cytopathologists are not routinely available. Given this background, the usefulness of ROSE by endosonographers themselves for pancreatic tumors has also been reported. However, ROSE by endosonographers for diagnosis of SMT has not been reported. The aim of this study was to evaluate the diagnostic accuracy of EUS-FNA with ROSE by endosonographers for SMT, focusing on diagnosis of gastrointestinal stromal tumor (GIST), compared with that of EUS-FNA alone. Methods: Twenty-two consecutive patients who underwent EUS-FNA with ROSE by endosonographers for SMT followed by surgical resection were identified. Ten historical control subjects who underwent EUS-FNA without ROSE were used for comparison. Results: The overall diagnostic accuracy for SMT was significantly higher in cases with than without ROSE (100% vs. 80%, p=0.03). The number of needle passes by FNA with ROSE by endosonographers tended to be fewer, although accuracy was increased (3.3±1.3 vs. 5.9±3.8, p=0.06). Conclusions: ROSE by endosonographers during EUS-FNA for SMT is useful for definitive diagnosis, particularly for GIST.