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Changhao Wang,Yu Luo,Jinru Luo,Xiao Song,Wei Zhang,Pinghuai Wang,Zhenghao Liu,Maoyin Wang,Xinghui He,Linjiang Chai 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.4
Titanium alloys are one of the most important structural materials for the aerospace applications, which bring active studyon microstructural and mechanical optimization of the alloys. In the present study, commercial TA2 titanium sheets withdifferent initial textures were rolled to a strain of 4% at liquid nitrogen temperature. Microstructures of the rolled sheets werecharacterized using a scanning electron microscope equipped with an EBSD detector and their mechanical properties weretested through quasi-static uniaxial tension tests at room temperature. The influence of the initial texture on the microstructureand mechanical performance of the cryorolled sheet were discussed. Twinning is found to occur in the TA2 sheets after rollingeven at a small strain. Initial texture is an important factor affecting both numbers and types of the twins. {11–22} contractiontwinning is always the dominating type of twins for all three sheets having different initial textures. A lot of {11–22}and {11–24} twins can be found in the sheets with the initial texture of C-axes//ND, while the sheet with an initial texture ofC-axes away from the ND contains few twins, with a high density of dislocations developed instead. Along with contractiontwinning, many {10–12} and {11–21} twins are detected in the sheet with the initial texture of C-axes⊥ND. The cryorolledsheet having the densest twins shows the best mechanical properties, indicating a beneficial effect of a small pre-strain.
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Xiaohu Su,Bingwu Wang,Zhaoyun Zhou,Zixian Li,Song Tong,Simin Chen,Nan Zhang,Su Liu,Maoyin Zhang 대한통증학회 2023 The Korean Journal of Pain Vol.36 No.1
Background: The purpose of this research was to assess the role of heparanase (HPSE)/syndecan1 (SDC1)/nerve growth factor (NGF) on cancer pain from melanoma. Methods: The influence of HPSE on the biological function of melanoma cells and cancer pain in a mouse model was evaluated. Immunohistochemical staining was used to analyze HPSE and SDC1. HPSE, NGF, and SDC1 were detected using western blot. Inflammatory factors were detected using ELISA assay. Results: HPSE promoted melanoma cell viability, proliferation, migration, invasion, and tumor growth, as well as cancer pain, while SST0001 treatment reversed the promoting effect of HPSE. HPSE up-regulated NGF, and NGF feedback promoted HPSE. High expression of NGF reversed the inhibitory effect of HPSE down-regulation on melanoma cell phenotype deterioration, including cell viability, proliferation, migration, and invasion. SST0001 down-regulated SDC1 expression. SDC1 reversed the inhibitory effect of SST0001 on cancer pain. Conclusions: The results showed that HPSE promoted melanoma development and cancer pain by interacting with NGF/SDC1. It provides new insights to better understand the role of HPSE in melanoma and also provides a new direction for cancer pain treatment.
ScienceON
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