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RISS 인기검색어
- 검색키워드
- 저자 : Manish Kaushal (검색결과 3 건)
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Minal Vaish,Anjali Mishra,Manish Kaushal,Saroj K Mishra,Balraj Mittal 생화학분자생물학회 2004 Experimental and molecular medicine Vol.36 No.2
Thyroid tumors display diverse spectrum of his-topathological groups with geographic variation in its prevalence. Influence of iodine deficiency (a major causative factor) in its etiology, prevalence, or aggressiveness is debatable which reflects the existence of various genetic events in pathoge-nesis. The present study was undertaken to study the role of Microsatellite instability (MSI) or LOH (loss of heterozygosity), an indicator of defective mismatch repair system as a genetic change and tumors. Tumor tisues from total thyroidectomy surgical specimens and blood (matched control) of 36 patients from iodine deficient areas (10 benign; 26 malignant) were obtained after their consent. Urinary iodine analysis was done by alkali ash method for which 10 ml of urine was colected from 18 patients before surgery. Genomic DNA, isolated from tumor tissue and blod was am-plified by polymerase chain reaction (PCR) using mono and dinucleotide markers - BAT-26, BAT-40, TGF(RII, IGFIIR, hMSH3, BAX, D2S123, D9S283, on 8% denaturing polyacrylamide gel folowed by autoradiography. Of total, 66.6% of tumors [70% (7/10) benign and 65.4% malignant cases (17/26)] showed MSI/LOH. Strong asociation of MSI/LOH with low iodine (P = 0.01) and with AMES risk groups i.e. age (P= 0.02), tumor size (P= 0.04) and metastases (P = 0.002) in thyroid tumors was observed. This may help in predicting the biolo-gical behaviour and strengthening the hypothesis thyroid tumors. Our results further substantiate the risk group clasification and help in deciding the treatment modality in particular patient.
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( Harshal Surendra Mandavdhare ),( Vishal Sharma ),( Kaushal K Prasad ),( Amit Kumar ),( Manish Rathi ),( Surinder S Rana ) 대한장연구학회 2017 Intestinal Research Vol.15 No.3
Recent studies have identified sprue-like illness associated with the use of the antihypertensive agent olmesartan medoxomil. However, whether this condition is specific to the use of olmesartan or is associated with the use of drugs belonging to the class of “sartans” remains to be clarified. A 45-year-old woman with chronic kidney disease along with hypothyroidism and hypertension presented with chronic diarrhea and significant weight loss. Endoscopy of the upper gastrointestinal tract showed scalloping and grooving of the duodenum, and histopathological examination showed subtotal villous atrophy. She was on telmisartan for hypertension, which was discontinued. Subsequently, diarrhea ameliorated dramatically, and she regained weight. To our knowledge, this is the first study to report telmisartan-associated sprue-like enteropathy. Further, we have reviewed the cases of patients with sprue-like enteropathy caused by valsartan, irbesartan, and eprosartan. (Intest Res 2017;15:419-421)
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Endoscopic Ultrasound-Guided Fine-Needle Aspiration of the Adrenal Glands: Analysis of 21 Patients
Rajesh Puri,Ragesh Babu Thandassery,Narendra S. Choudhary,Hardik Kotecha,Smruti Ranjan Misra,Suraj Bhagat,Manish Paliwal,Kaushal Madan,Neeraj Saraf,Haimanti Sarin,Mridula Guleria,Randhir Sud 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.2
Background/Aims: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) cytology of adrenal masses helps in etiological diagnosis. The aim of this study was to evaluate the diagnostic yield of EUS-FNA of adrenal masses in cases where other imaging methods failed and/or were not feasible. Methods: Twenty-one consecutive patients with adrenal masses, in whom adrenal FNA was performed because conventional imaging modalities failed and/or were not feasible, were prospectively evaluated over a period of 3 years. Results: Of the 21 patients (mean age, 56±12.2 years; male:female ratio, 2:1), 12 had pyrexia of unknown origin and the other nine underwent evaluation for metastasis. The median lesion size was 2.4×1.6 cm. Ten patients were diagnosed with tuberculosis (shown by the presence of caseating granulomas [n=10] and acid-fast bacilli [n=4]). Two patients had EUS-FNA results suggestive of histoplasmosis. The other patients had metastatic lung carcinoma (n=6), hepatocellular carcinoma (n=1), and adrenal lipoma (n=1) and adrenal myelolipoma (n=1). EUS results were not suggestive of any particular etiology. No procedure-related adverse events occurred. Conclusions: EUS-FNA is a safe and effective method for evaluating adrenal masses, and it yields diagnosis in cases where tissue diagnosis is impossible or has failed using conventional imaging modalities.
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