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Eudesmols Induce Apoptosis through Release of Cytochrome c in HL-60 Cells
Duc Manh Hoang,Trinh Nam Trung,Long He,Do Thi Ha,이명숙,김보연,Hoang Van Luong,안종석,배기환 한국생약학회 2010 Natural Product Sciences Vol.16 No.2
We verified that the apoptosis activities were examined by DNA fragmentation, flow cytometric analysis with annexin V staining, activation of caspase-3, and cytochrome c release. In the result, a- and b-eudesmol induced DNA fragmentation in HL-60 cells at a concentration of 80 mM, respectively. Additionally, pro-apoptotic cells sorted by flow cytometry analysis were detected in HL-60 cells to 31.77 and 29.67% with a- and b-eudesmol of 80 mM. Thus, both a- and b-eudesmol exerted caspase-3 activation and cytochrome c release at 80 mM in HL-60 cells. These results are firstly reported that the sesquiterpenes, a- and b-eudesmol are apoptosis inducers through mitochondria-dependent caspase cascade in HL-60 cells.
Duc Manh Hoang,Trinh Nam Trung,Phan Thi Thu Hien,Do Thi Ha,Hoang Van Luong,이명숙,배기환 한국생약학회 2010 Natural Product Sciences Vol.16 No.4
Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling, has served as a potential drug target for the treatment of type 2 diabetes. The MeOH extracts of twenty-nine medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for PTP1B inhibitory activity in vitro. The results indicated that, most materials showed moderate to strong inhibitory activity with IC50 values ranging from 3.4 mg/mL to 35.1 mg/mL; meanwhile, eleven extracts (37.9%) could demonstrate PTP1B activity with IC50 values less than 15.5 mg/mL; sixteen extracts (55.2%) could demonstrate PTP1B activity with IC50 values ranging from 15.5 mg/mL to 35.1 mg/mL. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants.
( Ha Phuong Linh ),( Hoang Van Tiep ),( Dinh Cong Dang ),( Nguyen Khac Hung Manh ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Background: Tenofovir disoproxil fumarate (TDF) is one of the first optimal choices to be used in the treatment of chronic hepatitis B. FibroScan is non-invasive methods to assess liver fibrosis. Aims: To evaluate the therapeutic effect of TDF on fibrosis via FibroScan after treatment. Methods: This study was conducted in 63 chronic hepatitis B patients who had the indication of antiviral therapy at 103 Cam Khe Clinic from March 2019 to March 2020. All patients with chronic hepatitis B treated with TDF during 6 months. Liver fibrosis stages was appreciated using transient hepatic elastography by Fibroscan before and after 6 months treatment. Results: The average age of patients was 46 years, with men accounted for 69% of the total. After treatment, normalization of ALT 71.26%, viral response of 90.23%, HBV DNA below the detection level was 66.3%. Liver fibrosis evaluated by FibroScan before and after 6 months treatment were 7.15 ± 1.56 kPa, and 3.58 ± 1.19 kPa eveluated by FibroScan. Conclusions: TDF was effective for patients after treatment on liver fibrosis assessed by FibroScan in chronic hepatitis B patients.
Hoang, Van Minh,Le, Hong Chung,Kim, Bao Giang,Duong, Minh Duc,Nguyen, Duc Hinh,Vu, Quynh Mai,Nguyen, Manh Cuong,Pham, Duc Manh,Ha, Anh Duc,Yang, Jui-Chen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1
Two years after implementation of the graphic health warning intervention in Vietnam, it is very important to evaluate the intervention's potential impact. The objective of this paper was to predict effects of graphic health warnings on cigarette packages, particularly in reducing cigarette demand and smoking-associated deaths in Vietnam. In this study, a discrete choice experiment (DCE) method was used to evaluate the potential impact of graphic tobacco health warnings on smoking demand. To predict the impact of GHWs on reducing premature deaths associated with smoking, we constructed different static models. We adapted the method developed by University of Toronto, Canada and found that GHWs had statistically significant impact on reducing cigarette demand (up to 10.1% through images of lung damage), resulting in an overall decrease of smoking prevalence in Vietnam. We also found that between 428,417- 646,098 premature deaths would be prevented as a result of the GHW intervention. The potential impact of the GHW labels on reducing premature smoking-associated deaths in Vietnam were shown to be stronger among lower socio-economic groups.
Manh Hung Do,비엣 흥 응웬(Viet Hung Nguyen),투하 응웬 티(Thu Ha Nguyen Thi),한 호앙 티(Hanh Hoang Thi),프엉 투 응웬 티(Phuong Thu Nguyen Thi) 영남대학교 박정희새마을연구원 2018 새마을학연구 Vol.3 No.2
베트남의 1986년도 정치경제 개혁, 즉 도어머이(Doi Moi)는 베트남의 경제를 개방적 사회주의경제로 전환시켰으며, 이를 계기로 베트남 경제는 획기적으로 근대화되었다. 그러나 이 과정에서 급속한 도시화는 도농 간 불균형을 가져왔으며, 이 도농 간 격차를 줄이기 위해 베트남 정부는 2006년에 새농촌개발(NRD) 프로그램을 도입하기에 이르렀다. 이 프로그램은 농촌 지역의 사회기반시설의 확충과 생활환경의 개선, 생산 활동의 종합적 발전, 소득증대, 농민들의 육체적ㆍ정신적 건강 증진 등을 목표로 하고 있었다. 이 논문의 주된 목적은 NRD 프로그램의 시행이 NRD의 궁극적 목적 중 하나인 농가소득 증대에 미치는 영향에 대한 과학적 증거를 제시하는 데 있다. 또한 이와 더불어 새마을운동의 시범사업을 실시한 지역과 그렇지 않은 지역 간에 소득 증대에서 차이가 있는가를 다중회귀분석을 통해 밝혀보고자 한다. 분석 결과는 NRD의 시행이 상당히 긍정적 결과를 가져왔으며 코민 수준에서 농가소득 증대와 생활환경의 개선에 중요한 영향을 미쳤다는 것을 보여주었다. 또한 도로 건설, 전기 도입, 주민 역량 강화, 제도의 발전 등이 농가소득 증대에 큰 영향을 미쳤음을 확인했다. 회귀분석의 결과는 또한 새마을 사업을 시행하고 있는 코뮌들이 그렇지 않은 코뮌에 비해 연소득이 1200만 동(미화530달러) 더 많다(또는 41.8% 더 높다)는 것을 보여주었다. The economic and political reform of Vietnam in 1986 (the Doi Moi) has transformed its economy positively and significantly into an open socialist-oriented market economy. This caused a dramatic change of Vietnam’s economy towards modernization. However, the urbanization process created an unbalanced development between the urban and rural regions. To solve the gaps between these regions, the government of Vietnam firstly introduced the New Rural Development (NRD) program in 2006 to encourage and mobilize a revolutionary and campaign to improve local infrastructure, living condition, comprehensive development of related-production activities in rural regions, as well as increase income, and improve physical and mental health of people living in rural communities. One of the main purposes of this research paper is aimed at providing a scientific evidence for justifying whether the NRD implementation could have an impact on rural households’ income, one of the ultimate goals of the NRD, and examining the difference of incomes between Saemaul Undong (SU)-piloted provinces with the other provinces by employing a multiple regression model. The analysis results show that the NRD implementation has shown positive results and significant impacts on increasing rural households’ income and improving living conditions at the communal levels. Criteria such as road development, access to electricity, capacity building, and institutional development have significantly influenced on the households’ income. The regression model also indicates that the communes currently implementing SU pilots have a better annual income of 12 million VND (~US$ 530) or 41.8% higher than the other communes.
Hoang, Van-Hai,Ngo, Van T. H.,Cui, Minghua,Manh, Nguyen Van,Tran, Phuong-Thao,Ann, Jihyae,Ha, Hee-Jin,Kim, Hee,Choi, Kwanghyun,Kim, Young-Ho,Chang, Hyerim,Macalino, Stephani Joy Y.,Lee, Jiyoun,Choi, S American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.17
<P>Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor <B>1</B>, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogues, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational analysis of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.</P> [FIG OMISSION]</BR>
( Ha Phuong Linh ),( Hoang Van Tiep ),( Dinh Cong Dang ),( Nguyen Khac Hung Manh ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Chronic hepatitis C is a major infectious disease which is mainly cause of morbidity worldwide in patients with liver disease, and liver transplantation. Raised ferritin levels play an important role of intervening the process which is associated with hepatic injury. Screening with non-invasive strategies can detect the disease at early stage and intervention could be initiated. To determine correlation between serum ferritin levels and liver stiffness values in patients of chronic hepatitis C. Methods: A cross-sectional study was conducted at 103 Cam Khe Clinic from May 2019 to April 2020. 93 patients with chronic hepatitis C fulfilling inclusion criteria were included in this study. Liver fibrosis stages was appreciated using transient hepatic elastography by Fibroscan, the activities of serum liver function biomarker enzymes and serum ferritin levels were determined by automated analyser. Results: The average age of patients was 48 years, with men accounted for 78% of the total. The mean serum ferritin value was 148.19 ng/ml, liver stiffness measurements range from 12.5 to 75.5 kPa, with a median value of 17.39 ± 15.98 kPa. Significantly elevated levels of serum ferritin (P<0.001), were detected in patients with severe fibrosis compared to mild fibrosis. Concentration of serum ferritin was increased with the evolution of fibrosis in all stages from F0 to F4 and this increase was significant (P<0.01) in cirrhotic patients (F4). There was a positive correlation between serum level of ferritin and progression of fibrosis (0.979391) (r = 0.976). Conclusions: There is significant correlation between serum ferritin and liver stiffness. Serum ferritin concentration may be used as liver fibrosis biomarkers.
HA, Son Tung,TRAN, Manh Linh,HOANG, Huy Viet,TRAN, Van Hung Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.6
This paper investigates the potential impact of external factors on bid/no-bid decision for supervision consultant service on construction project in Hanoi, the capital of Vietnam. The data used in this study are secondary data taken from annual reports and sourced from the Department of Public Procurement, Ministry of Planning and Investment in Hanoi. Besides, to identify the impact of external factors on bid/no-bid decision for supervision consultant service on construction project in Hanoi, the study collected data from 272 qualified questionnaires from bidders doing business in Hanoi. Cronbach's Alpha, EFA and regression model are used to explore the impact of each independent variable on bid/no-bid decision for supervision consultant service on construction project. The results show that three external determinants, including Project characteristic (PC), Legal codes (LC) and Competition (C) are affecting bid/no-bid decision for supervision consultant service on construction project in Hanoi. Among them, Project characteristic (PC) and Legal codes (LC) have positive relationships with bid/no-bid decision for supervision consultant service on construction project, whereas Competition (C) negatively affects bid/no-bid decision for supervision consultant service on construction project. It means the more contractors actually participate in a bid, the less bid/ no-bid decisions are made.