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Chiou, C.M.,Yang, T.S.,Yeh, S.P.,Tsai, M.Z.,Cheng, S.P.,Huang, M.C. Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.12
The follicles (1.8 to 7.8 mm in diameter) were recovered from the ovaries in marketed pigs and the number of granulosa cells, the diameter of oocytes obtained from different development stages of the follicles and follicular fluid levels were determined. Correlations between size measurements and cell counts as well as the diameter of antral follicles and oocytes were also investigated. The results indicated that, while expanding in size, follicle numbers decreased with a greater atretic proportion. Granulosa cells increased in numbers continuously and remained unchanged beyond the size of 200 ${mm}^3$ in non-atretic follicles, whereas a sudden drop of granulosa counts was observed in atretic follicles. Follicular fluid, on the other hand, linearly increased its volume with follicle size and differed little between those of non-atretic and atretic follicles. Diameters of oocytes in non-atretic follicles increased to its maximum when follicles expanded to 150 ${mm}^3$ and maintained its size during later follicular expansion. It is concluded that, for in vitro culture, the optimal size of porcine follicle should be between 150 to 180 ${mm}^3$if they are collected from pre-pubertal gilts of marketing size slaughtered in an abattoir.
( C. J. Tsai ),( T. K. Yeh ),( M. Y. Wang ) 한국부식방식학회(구 한국부식학회) 2019 Corrosion Science and Technology Vol.18 No.1
A high-temperature gas-cooled reactor (HTGR) is recognized as the best candidate reactor for next generation nuclear reactors. Helium is used to be the coolant in the core of the HTGR with temperature expected to exceed 900 °C at the core outlet. Several iron- and nickel-based superalloys, including Alloy 800H, Hastelloy X, and Alloy 617, are potential structural materials for intermediate heat exchanger (IHX) in an HTGR. Oxidation behaviors of three selected alloys (Hastelloy X, Alloy 800H, and Alloy 617) were investigated at four different temperatures from 650℃ to 950 ℃ under helium environments with various concentrations of O<sub>2</sub> and H<sub>2</sub>O. Preliminary results showed that chromium oxide as the primary protective layer was observed on surfaces of the three tested alloys. Based on results of mass gain and SEM analyses, Hastelloy X alloy exhibited the best corrosion resistance in all corrosion tests. Further details on the oxidation mechanism of these alloys are presented in this study.
Zhang, J.,Tsai, T.F.,Lee, M.G.,Zheng, M.,Wang, G.,Jin, H.,Gu, J.,Li, R.,Liu, Q.,Chen, J.,Tu, C.,Qi, C.,Zhu, H.,Ports, W.C.,Crook, T. Elsevier ; Elsevier Science Pub. Co 2017 JOURNAL OF DERMATOLOGICAL SCIENCE Vol.88 No.1
Background: Tofacitinib is an oral Janus kinase inhibitor. Objective: This study assessed tofacitinib efficacy and safety vs placebo in Asian patients with moderate to severe chronic plaque psoriasis. Methods: Patients from China mainland, Taiwan, and Korea were randomized 2:2:1:1 to tofacitinib 5mg (N=88), tofacitinib 10mg (N=90), placebo→5mg (N=44), or placebo→10mg (N=44), twice daily (BID) for 52 weeks. Placebo-treated patients advanced to tofacitinib at Week 16. Co-primary efficacy endpoints: proportions of patients achieving Physician's Global Assessment (PGA) response ('clear' or 'almost clear') and proportion achieving ≥75% reduction from baseline Psoriasis Area and Severity Index (PASI75) at Week 16. Results: At Week 16, more patients achieved PGA and PASI75 responses with tofacitinib 5mg (52.3%; 54.6%) and 10mg (75.6%; 81.1%) BID vs placebo (19.3%; 12.5%; all p<0.0001). Of patients with a Week 16 response, 73.6% and 75.0% maintained PGA response, and 76.8% and 84.9% maintained PASI75 to Week 52 with tofacitinib 5mg and 10mg BID, respectively. Over 52 weeks, 2.2-4.5% of patients across treatment groups experienced serious adverse events, and 1.1-6.8% discontinued due to adverse events. Conclusion: Tofacitinib demonstrated efficacy vs placebo at Week 16 in Asian patients with moderate to severe plaque psoriasis; efficacy was maintained through Week 52. No unexpected safety findings were observed. [NCT01815424]
Carroll, WM,Saida, T,Kim, HJ,Kira, J,Kermode, AG,Tsai, CP,Fujihara, K,Kusunoki, S,Tanaka, M,Kim, KK,Bates, D SAGE Publications 2013 Multiple sclerosis journal: clinical and laborator Vol.19 No.10
<P>Definite diagnosis of inflammatory demyelinating disease (multiple sclerosis (MS) and neuromyelitis optica (NMO)) may require time, but early treatment offers the opportunity to maximize patient outcomes. The purpose of this report is to provide guidance to facilitate early treatment decisions for patients with inflammatory demyelinating disease, before definitive diagnosis. Neurology experts reviewed the existing literature and clinical evidence. A treatment decision pathway was developed, defining patients for whom first-line MS disease-modifying therapies (a) are unlikely to be effective, (b) may be effective but require careful monitoring and (c) are likely to provide benefit. This algorithm seeks to ensure that patients, particularly those in Asia, receive appropriate treatment early in inflammatory demyelinating disease.</P>
Effect of Heat Treatment on the Pitting Corrosion Behavior of 347 SS Weld Overlay
Lo, I. H.,Lee, M. C.,Lin, K. Y.,Ho, W.,Yang, G. C. Y.,Tsai, W. T. 한국부식방식학회 2002 Corrosion Science and Technology Vol.31 No.5
The effect of heat treatment on the microstructural change and corrosion performance of 347 SS weld overlay has been investigated. The microstructure and phase changes of he as-weld and post weld heat-treated (PWHT) overlays were examined using optical microscropy (OM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Energy dispersive X-ray analysis (EDS) was also used for intermetallic phase identification. The results showed that delta-ferrite transformation to sigma phase occurred for the as-weld overlay by PWHT at 690℃ for 8 hours. Pitting corrosion resistance of the weld with or without PWHT was evaluated by conducting potentiodynamic polarization tests in 3.5 % NaCl solution. The results showed that the presence of intermetallic phase greatly affected the pitting corrosion resistance of 347 SS weld overlay.
The multiple merger assembly of a hyperluminous obscured quasar at redshift 4.6
Dí,az-Santos, T.,Assef, R. J.,Blain, A. W.,Aravena, M.,Stern, D.,Tsai, C.-W.,Eisenhardt, P.,Wu, J.,Jun, H. D.,Dibert, K.,Inami, H.,Lansbury, G.,Leclercq, F. American Association for the Advancement of Scienc 2018 Science Vol.362 No.6418
<P><B>Mergers drive a powerful dusty quasar</B></P><P>Massive galaxies in the early Universe host supermassive black holes at their centers. When material falls toward the black hole, it releases energy and is observed as a quasar. Astronomers found a population of powerful distant quasars that are obscured by dust, but it has been unclear how they are formed. Díaz-Santos <I>et al.</I> observed the dust-obscured quasar WISE J224607.56-052634.9 at submillimeter wavelengths, finding three small companion galaxies connected to the quasar by bridges of gas and dust. They inferred that galaxy mergers can provide both the raw material to power a quasar and large quantities of dust to obscure it.</P><P><I>Science</I>, this issue p. 1034</P><P>Galaxy mergers and gas accretion from the cosmic web drove the growth of galaxies and their central black holes at early epochs. We report spectroscopic imaging of a multiple merger event in the most luminous known galaxy, WISE J224607.56−052634.9 (W2246−0526), a dust-obscured quasar at redshift 4.6, 1.3 billion years after the Big Bang. Far-infrared dust continuum observations show three galaxy companions around W2246−0526 with disturbed morphologies, connected by streams of dust likely produced by the dynamical interaction. The detection of tidal dusty bridges shows that W2246−0526 is accreting its neighbors, suggesting that merger activity may be a dominant mechanism through which the most luminous galaxies simultaneously obscure and feed their central supermassive black holes.</P>