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Ahmed, Qamar U.,Zaidi, S.M.K.R.,Kaleem, M.,Khan, N.U.,Singhal, K.C. Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.2
The effect of aqueous and alcoholic extracts of the fruit, leaf and stem of Melia azedarach Linn. (Meliaceae) on the spontaneous movements of both the whole worm and the nerve-muscle (n.m.) preparation of Setaria (S.) cervi and on the survival of microfilariae in vitro was studied. Alcoholic extracts of fruit, leaf and stem caused inhibition of the spontaneous movements of the whole worm and the n.m. preparation of S. cervi, while only aqueous extract of fruit caused inhibition of the spontaneous movements of the whole worm and the n.m. preparation of S. cervi. The initial stimulatory effect was not observed by the aqueous and alcoholic extracts of fruit on n.m. preparation. The concentrations required to inhibit the movements of the whole worm and n.m. preparation for alcoholic extracts of fruit, leaf and stem were 250, $40\;{\mu}g/ml$; 280, $40\;{\mu}g/ml$ and 270, $25\;{\mu}g/ml$ respectively, whereas an aqueous extract of fruit caused inhibition of whole worm and n.m. preparation at $200\;{\mu}g/ml$ and $40\;{\mu}g/ml$ respectively. Alcoholic extracts of the fruit, leaf and stem and aqueous extract of the fruit of M. azedarach caused concentration related inhibition on the survival of microfilariae (m.f.) of S. cervi. The $LC_{50}$ and $LC_{90}$ as observed after 6 h were found to be 5, 15, 10, 20 ng/ml and 10, 25, 20 and 35 ng/ml, respectively. This work was conducted in view of the exploration of potential antifilarial herbal drug.
Timofeeva, M.N.,Panchenko, V.N.,Prikhod'ko, S.A.,Ayupov, A.B.,Larichev, Yu.V.,Khan, Nazmul Abedin,Jhung, Sung Hwa Academic Press 2017 Journal of catalysis Vol.354 No.-
<P><B>Abstract</B></P> <P>Benzodiazepines and their derivatives are a very important class of nitrogen-containing heterocyclic compounds with biological activity that are widely used in medicine. In this study, we demonstrated synthesis of 1,5-benzodiazepines from 1,2-phenylenediamine and ketones (acetone, cyclohexanone, acetophenone, methyl ethyl ketone) in the presence of isostructural porous metal-benzenetricarboxylates of the families MIL-100(M) (M: V<SUP>3+</SUP>, Al<SUP>3+</SUP>, Fe<SUP>3+</SUP> and Cr<SUP>3+</SUP>) and three porous aluminium trimesates Al-BTCs (MIL-96(Al), MIL-100(Al) and MIL-110(Al)). A combination of catalytic, theoretical and physicochemical methods showed that reaction rates and yields of 1,5-benzodiazepines were adjusted by the type of metal ions and accessibility of active sites. The yield of 1,5-benzodiazepines in the presence of MIL-100(M) was comparable with zeolites, such as HY, H-ZSM−5, β-zeolite and heulandite.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesis of 1,5-benzodiazepines over MIL-100(M), MIL-110 and MIL-96 was studied. </LI> <LI> Effect of Brønsted and Lewis acidity on MIL’s performance was investigated. </LI> <LI> Lewis acidity of MIL-100(Fe, Cr, Al, V) was studied by EPR spectroscopy. </LI> <LI> The type of M<SUP>3+</SUP>(Al, Fe, Cr, V) and structure of MILs affect the yield of product. </LI> <LI> MIL-100(M) samples perform well in compared with zeolites. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Critical Analysis of Density-based Spatial Clustering of Applications with Noise (DBSCAN) Techniques
Said Akbar,M.N.A. Khan 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.5
Clustering is the most used technique in data mining. Clustering maximize the intra-cluster similarity and minimize the inter clusters similarity. DBSCAN is the basic density based clustering algorithm. Cluster is defined as regions of high density are separated from regions that are less dense. DBSCAN algorithm can discover clusters of arbitrary shapes and size in large spatial databases. Beside its popularity, DBSCAN has drawbacks that its worst time complexity reaches to O (n2). Similarly, it cannot deal with varied densities. It is hard to know the initial value of input parameters. In this study, we have studied and discussed some significant enhancement of DBSCAN algorithm to tackle with these problems. We analysed all the enhancements to computational time and output to the original DBSCAN. Majority of variations adopted hybrid techniques and use partitioning to overcome the limitations of DBSCAN algorithm. Some of which performs better and some have their own usefulness and characteristics.
Filler Effect of Pozzolanic Materials on the Strength and Microstructure Development of Mortar
M. N. N. Khan,M. Jamil,M. R. Karim,M. F. M. Zain,A. B. M. A. Kaish 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.1
The utilization of pozzolans in cementitious system (concrete and mortar) minimizes both cost and energy. It also enhances mechanical strength and durability of the system. The total contribution of pozzolans can be categorized into two: (i) physical or filler effect which is attributed by the fineness of the particles and (ii) chemical or pozzolanic effect which is attributed by the pozzolanic reaction. It is difficult to quantify the strength development of cementitious system caused by the filler and pozzolanic effect separately. Therefore, the individual contribution of pozzolans in cementitious system because of its physical and chemical effects need to be profoundly understood by the scientific community. This paper reviews available literatures to understand the effect of non-reactive fillers that attributed as the microfiller effect of pozzolans in cementitious systems. The previous studies utilized chemically inactive materials that attributed only the microfiller activity of pozzolans for a partial replacement of cement. It was reported that filler effect is equal or sometimes more significant than pozzolanic effect in concrete. A larger range of replacement percentages (like 5%, 10%, 15% or 10%, 20%, 30% etc.) was used in the previous studies. However, probabilities of the optimum compressive strength because of the filler effect may lie in between two larger range of replacement percentages. Therefore, an experimental work is also carried out using natural ground sand of size 7.6-μm at a lower range of cement replacement percentages (like 2.5%, 5%, 7.5% etc.) in mortar. Compressive strength of mortar at different ages and microstructure analysis of mortar at 28 days were performed in this study. Test results showed that the filler effect is more pronounced at a lower replacement percentages of cement (0-10%) while using smaller non-reactive fillers. The maximum strength due to filler effect of ground sand is acheieved at 7.5% replacement of cement. Scanning Electron Microscope (SEM) images also confirmed the effect of fillers on the microstructure development of mortar.
SOME INTEGRALS ASSOCIATED WITH MULTIINDEX MITTAG-LEFFLER FUNCTIONS
KHAN, N.U.,USMAN, T.,GHAYASUDDIN, M. The Korean Society for Computational and Applied M 2016 Journal of applied mathematics & informatics Vol.34 No.3
The object of the present paper is to establish two interesting unified integral formulas involving Multiple (multiindex) Mittag-Leffler functions, which is expressed in terms of Wright hypergeometric function. Some deduction from these results are also considered.
Acetylation of Retinoblastoma Like Protein2 (Rb2/p130) in Tumor Tissues
Khan, Z.N.,Sabir, M.,Kayani, M.A.,Saeed, M. Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation. Acetylation of Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance in cell cycle control and tumorigenesis is still unknown. Efforts are underway to investigate possible interplay between Rb2/p130 phosphorylation and acetylation. Here we hypothesized that Rb2/p130 acetylation, like p53 acetylation, may play a role in development of the tumor phenotype. The proposed hypothesis regarding acetylation of Rb2/p130 in tumor VS normal cells was found to be true in our case study of 36 tumor samples. Statistical analysis of results suggest strong correlation among Rb2/p130 acetylation and cancer phenotype.
CFD simulation of fluidized bed reactors for polyolefin production – A review
M.J.H. Khan,M.A. Hussain,Z. Mansourpour,N. Mostoufi,N.M. Ghasem,E.C. Abdullah 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.6
This literature survey focuses on the application of computational fluid dynamics (CFD) in variousaspects of the fluidized bed reactor. Although fluidized bed reactors are used in various industrialapplications, this first-of-its-kind review highlights the use of CFD on polyolefin production. It is shownthat CFD has been utilized for the following mechanisms of polymerization: governing of bubbleformation, electrostatic charge effect, gas–solid flow behavior, particle distribution, solid–gas circulationpattern, bed expansion consequence, mixing and segregation, agglomeration and shear forces. Heat andmass transfer in the reactor modeling using CFD principles has also been taken under consideration. Anumber of softwares are available to interpret the data of the CFD simulation but only few softwarespossess the analytical capability to interpret the complex flowbehavior of fluidization. In this review, thepopular softwares with their framework and application have been discussed. The advantages andfeasibility of applying CFD to olefin polymerization in fluidized beds were deliberated and the prospectof future CFD applications was also discussed.
Khan, M.S.,Ali, T.,Abid, M.N.,Jo, M.H.,Khan, A.,Kim, M.W.,Yoon, G.H.,Cheon, E.W.,Rehman, S.U.,Kim, M.O. Pergamon Press 2017 Neurochemistry International Vol.108 No.-
Lithium an effective mood stabilizer, primary used in the treatment of bipolar disorders, has been reported as a protective agent in various neurological disorders. In this study, we examined the neuroprotective role of lithium chloride (LiCl) against lipopolysaccharide (LPS) in the cortex and hippocampus of the adult rat brain. We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-<SUB>k</SUB>B (NF-<SUB>K</SUB>B) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1β) and tumour necrosis factor alpha (TNF-α). We also analyzed that LiCl significantly abrogated activated gliosis via attenuation of specific markers for activated microglia, ionized calcium-binding adaptor molecule (Iba-1) and astrocytes, glial fibrillary acidic protein (GFAP) in both the cortex and hippocampus of the adult rat brain. Furthermore, we also observed that LiCl treatment significantly ameliorated the increase expression level of apoptotic neurodegeneration protein markers Bax/Bcl2, activated caspase-3 and poly (ADP-ribose) polymerase-1 (PARP-1) in the cortex and hippocampus regions of the LPS-treated adult rat brain. In addition, the morphological results of the fluoro-jade B (FJB) and Nissl staining showed that LiCl attenuated the neuronal degeneration in the cortex and hippocampus regions of the LPS-treated adult rat brain. Taken together, our Western blot and morphological results indicated that LiCl significantly prevents the LPS-induced neurotoxicity via attenuation of neuroinflammation and apoptotic neurodegeneration in the cortex and hippocampus of the adult rat brain.