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Guo, Lu,Wang, Dong,Gu, Fei,Li, Yazheng,Wang, Yezhu,Zhou, Rongting 서울대학교 교육연구소 2021 Asia Pacific Education Review Vol.22 No.3
Intelligent tutoring systems (ITSs) are a promising integrated educational tool for customizing formal education using intelligent instruction or feedback. In recent decades, ITSs have transformed teaching and learning and associated research. This study examined the evolution and future trends of ITS research with scientometric methods. First, a dataset comprising 1173 relevant publications was compiled from the Web of Science Core Collection databases (including the Science Citation Index Expanded and the Social Science Citation Index). Then, the publication distributions by time, author, institution, country/ region, and knowledge sources were analyzed to reveal the multidisciplinary integration paths. Dataset co-occurrence and co-citation analyses were conducted to identify the most popular research issues, the research chronology, and the emerging trends. It was found that: (a) ITS research has been growing in recent years. According to the Price literature exponential growth curve, this feld is still in its initial stage while has high potential; (b) computer science, education, psychology, and engineering were the main ITS research knowledge sources, with ITS social science publications since 2007 being higher than ITS natural sciences publications; (c) interactive learning environments, student modeling, teaching/learning strategies, and machine learning have been the most popular research foci; and (d) the Coh-Metrix, problem-centered instruction, and STEM are the current research trends.
Treating urban dredged silt with ethanol improves settling and solidification properties
Guo-Lu Yang,Zhao-Hui Chai,Meng Chen 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.1
The organic matter content in urban dredged silt is high for the indraft of municipal sewage, and it seriously influences the utilization of urban dredged silt. It is necessary to find a method to solve this problem. This paper presents a method of treating the silt with ethanol (STE), considering that ethanol is a good organic solvent which can dissolve many kinds of organic matter, and optimizes the treatment conditions through Box-Benhnken design (BBD) experiment with organic matter removal efficiency as the response. The ideal conditions were as follows: action time, 47 min; ethanol concentration, 41%; ratio of ethanol to silt, 54 : 1 ml/g with organic matter removal efficiency of 51.12%. Then, settling and solidification properties of raw silt and STE were explored through laboratory experiments. The results show treating urban dredged silt improved the settling and solidification properties of silt.
The Simulation Study of Circulating Tumor Cells Collection using Electrophoresis Method
( Guo-hao Lu ),( Deng-chyang Wu ),( Chao-wang Young ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Cancer is one of the leading causes of morbidity and mortality worldwide. The most method in the treatment of cancer is early detection, and the concentration of circulating tumor cells (CTCs) in the peripheral blood is the important factor. CTCs are cells that have shed into the vasculature or lymphatic from a primary cancer cells and are carried around the body in the circulation system. CTCs thus constitute seeds for the subsequent growth of additional tumors in vital distant organs, triggering a mechanism that is responsible for the vast majority of cancer-related deaths. CTCs also have the potential to provide a mechanism for early patient prognoses and to determine appropriate tailored treatments. In this study, the technologies of electrophoresis and micro-flow channel were used to separate two different size (20μm, 10μm) particles (simulate as CTCs and normal cells), for collecting sufficient concentration of CTCs from the patient peripheral blood. Results show that this electrophoresis method can separate effectually two different size particles, under the field of dielectric electrophoresis (1MHz, 10V<sub>pp</sub>),theinjectionflow(0.5μl/min) and solution conductivity (430μs/cm) in self-made micro-flow channel.
Lu-Lu Zhang,Guo-Hong Li,Yi-Yang Li,Zhen-Yu Qi,Ai-Hua Lin,Ying Sun 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3
Purpose The incidence, risk factors and survival impact of secondary primary malignancies (SPMs) among survivors of nasopharyngeal carcinoma (NPC) treated with definitive intensity-modulated radiation therapy (IMRT) with or without chemotherapy are poorly characterized. Materials and Methods Consecutive patients (n=6,377) from the big-data intelligence platform at Sun Yat-sen University Cancer Center, China (in a high-incidence area) with newly diagnosed non-metastatic pathologically proven non-keratinizing undifferentiated NPC treated with IMRT±chemotherapy between January 2003 and June 2013 were retrospectively analyzed. Cumulative incidence of SPMs was calculated using the Kaplan-Meier method. Cox proportional hazards model was used to identify potential risk factors for SPMs and assess whether SPMs affect overall survival. Results Of the 6,377 patients, 189 (3.0%) suffered SPMs (median follow-up, 62 months). One-, 2-, 3-, 4-, and 5-cumulative risks of SPMs were 0.4%, 0.9%, 1.6%, 2.2%, and 2.6%, respectively. Latency from start of IMRT to SPMs diagnosis was 37 months (range, 6 to 102 months). In patients with SPMs, 14.3% suffered SPMs within 1 year post-IMRT: 1-3 years, 38.1%; 3-5 years, 33.9%; and > 5 years, 13.7%. Lung cancer was the most common SPM (50/6,377, 0.78%). Multivariate analysis demonstrated sex (male, 64% increase), age (! 50 years, 68% increase), and smoking history (41% increase) were significant risk factors for SPMs, and SPMs were associated with poorer overall survival. Conclusion This large cohort study confirms SPMs a dreadful complication for long-term survivors of NPC treated with IMRT. SPMs negatively impact overall survival in NPC. Close follow-up is recommended for older male survivors with a smoking history.
Activating Transcription Factor 1 is a Prognostic Marker of Colorectal Cancer
Huang, Guo-Liang,Guo, Hong-Qiang,Yang, Feng,Liu, Ou-Fei,Li, Bin-Bin,Liu, Xing-Yan,Lu, Yan,He, Zhi-Wei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Objective: Identifying cancer-related genes or proteins is critical in preventing and controlling colorectal cancer (CRC). This study was to investigate the clinicopathological and prognostic value of activating transcription factor 1 (ATF1) in CRC. Methods: Protein expression of ATF1 was detected using immunohistochemistry in 66 CRC tissues. Clinicopathological association of ATF1 in CRC was analyzed with chi-square test or Fisher's exact test. The prognostic value of ATF1 in CRC is estimated using the Kaplan-Meier analysis and Cox regression models. Results: The ATF1 protein expression was significantly lower in tumor tissues than corresponding normal tissues (51.5% and 71.1%, respectively, P = 0.038). No correlation was found between ATF1 expression and the investigated clinicopathological parameters, including gender, age, depth of invasion, lymph node status, metastasis, pathological stage, vascular tumoral emboli, peritumoral deposits, chemotherapy and original tumor site (all with P > 0.05). Patients with higher ATF1 expression levels have a significantly higher survival rate than that with lower expression (P = 0.026 for overall survival, P = 0.008 for progress free survival). Multivariate Cox regression model revealed that ATF1 expression and depth of invasion were the predictors of the overall survival (P = 0.008 and P = 0.028) and progress free survival (P = 0.002 and P = 0.005) in CRC. Conclusions: Higher ATF1 expression is a predictor of a favorable outcome for the overall survival and progress free survival in CRC.
Xu, Lu-Lu,Guo, Shu-Liang,Ma, Su-Ren,Luo, Yong-Ai Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Mammalian mediator (MED) is a multi-protein coactivator that has been identified by several research goups. The involvement of the MED complex subunit 19 (MED 19) in the metastasis of lung adenocarcinoma cell line (H1299), which expresses the MED 19 subunit, was here investigated. When MED 19 expression was decreased by RNA interference H1299 cells demonstrated reduced clone formation, arrest in the S phase of the cell cycle, and lowered metastatic capacity. Thus, MED 19 appears to play important roles in the biological behavior of non-small cell lung carcinoma cells. These findings may be important for the development of novel lung carcinoma treatments.
Cloning and Biochemical Characterization of a Hyaluronate Lyase from Bacillus sp. CQMU-D
Wang Lu,Liu Qianqian,Gong Xue,Jian Wenwen,Cui Yihong,Jia Qianying,Zhang Jibei,Zhang Yi,Guo Yanan,Lu He,Tu Zeng 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.2
Hyaluronidase (HAase) can enhance drug diffusion and dissipate edema by degrading hyaluronic acid (HA) in the extracellular matrix into unsaturated HA oligosaccharides in mammalian tissues. Microorganisms are recognized as valuable sources of HAase. In this study, a new hyaluronate lyase (HAaseD) from Bacillus sp. CQMU-D was expressed in Escherichia coli BL21, purified, and characterized. The results showed that HAaseD belonged to the polysaccharide lyase (PL) 8 family and had a molecular weight of 123 kDa. HAaseD could degrade chondroitin sulfate (CS) -A, CS-B, CSC, and HA, with the highest activity toward HA. The optimum temperature and pH value of HAaseD were 40°C and 7.0, respectively. In addition, HAaseD retained stability in an alkaline environment and displayed higher activity with appropriate concentrations of metal ions. Moreover, HAaseD was an endolytic hyaluronate lyase that could degrade HA to produce unsaturated HA oligosaccharides. Together, our findings indicate that HAaseD from Bacillus sp. CQMU-D is a new hyaluronate lyase and with excellent potential for application in industrial production.
Tolerance Constraints on Reliability Analysis of Gear System
Li Guo-wei,Lu Kai-liang,Zhang Wei-guo 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.2
To improve the reliability of a product performance the tolerancing problem may not be neglected especially for miniature precise assembly device. The purpose of this paper is to explore an approach to evaluate the reliability of gear system considering the influence of tolerance constraints. The paper describes the principle and ways of tolerance handling in the finite element control equations, and then introduces the implementation steps based on Monte-Carlo FEA method. The resonance reliability analysis of a gear-tooth system of port-cleaning-equipment gear pump is carried out to illustrate the mentioned method, and a sensitivity analysis is also performed to identify the key tolerances and improve them in order to achieve the anticipated reliability.