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Eco-Friendly Manufacturing of Nano-TiO2 Coated Cotton Textile with Multifunctional Properties
Mirele Horsth de Paiva Teixeira,Luís Antônio Lourenço,Wagner Artifon,Celso Junior de Castro Vieira,Sergio Yesid Gómez González,Dachamir Hotza 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1
In this work, multifunctional cotton fabrics were developed by immobilizing TiO2 nanoparticles (TiO2-NPs) usingan eco-friendly bath through a highly-scalable technique. The effects of TiO2-NPs, cross-linking agent, catalyst and curingtemperatures were assessed by analysis of variance and surface response methodology. The results disclose an excellentperformance of treated textiles for various applications: flame-retardant (char content enhanced by 1000 %), photocatalyticdecontamination (>90 % of contaminant abatement and feasibility for multiple reuses), self-cleaning of intense stains (up to80 % of stain vanishing), bacterial inhibition without TiO2 UV-activation (≈25 % of bacteria growth reduction). Moreover,those properties were durable for at least five domestic laundering cycles.
Endoscopy Timing in Patients with Acute Upper Gastrointestinal Bleeding
Gonçalo Alexandrino,Tiago Dias Domingues,Rita Carvalho,Mariana Nuno Costa,Luís Carvalho Lourenço,Jorge Reis 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.1
Background/Aims: The role of very early (≤12 hours) endoscopy in nonvariceal upper gastrointestinal bleeding is controversial. We aimed to compare results of very early and early (12–24 hours) endoscopy in patients with upper gastrointestinal bleedingdemonstrating low-risk versus high-risk features and nonvariceal versus variceal bleeding. Methods: This retrospective study included patients with nonvariceal and variceal upper gastrointestinal bleeding. The primaryoutcome was a composite of inpatient death, rebleeding, or need for surgery or intensive care unit admission. Endoscopy timing wasdefined as very early and early. We performed the analysis in two subgroups: (1) high-risk vs. low-risk patients and (2) variceal vs. nonvariceal bleeding. Results: A total of 102 patients were included, of whom 59.8% underwent urgent endoscopy. Patients who underwent very earlyendoscopy received endoscopic therapy more frequently (p=0.001), but there was no improvement in other clinical outcomes. Furthermore, patients at low risk and with nonvariceal bleeding who underwent very early endoscopy had a higher risk of thecomposite outcome. Conclusions: Very early endoscopy does not seem to be associated with improved clinical outcomes and may lead to poorer outcomesin specific populations with upper gastrointestinal bleeding. The actual benefit of very early endoscopy remains controversial andshould be further clarified.
Sensory neurons and osteoblasts: close partners in a microfluidic platform
Neto, Estrela,Alves, Cecí,lia J.,Sousa, Daniela M.,Alencastre, Inê,s S.,Lourenç,o, Ana H.,Leitã,o, Luí,s,Ryu, Hyun R.,Jeon, Noo L.,Fernandes, Rui,Aguiar, Paulo,Almeida, Ra Oxford University Press 2014 Integrative biology Vol.6 No.6
<P>Innervation has proven to be critical in bone homeostasis/regeneration due to the effect of soluble factors, produced by nerve fibers, associated with changes in the activity of bone cells. Thus, in this study, we have established and characterized a coculture system comprising sensory neurons and osteoblasts to mimic the <I>in vivo</I> scenario where nerve fibers can be found in a bone microenvironment. Embryonic or adult primary dorsal root ganglion (DRG) and MC3T3-E1 osteoblastic cells were cocultured in compartmentalized microfluidic platforms and morphological and functional tests were performed. The time of adhesion and readout of axonal outgrowth were improved by the alignment of DRG with the axis of microgrooves, which showed to be a crucial step for the designed experiments. Cocultures of entire DRG from adult origin with osteoblasts were performed, showing extended DRG projections towards the axonal compartment, reaching osteoblastic cells. Immunocytochemistry showed that the neurites present within the osteoblastic compartment were immunoreactive to synapsin and calcitonin gene-related peptide suggesting the presence of specialized structures involved in this crosstalk. This evidence was further confirmed by electron microscopy where varicosities were detected as well as electron dense structures in neurite membranes. Aiming to mimic the properties of tissue extracellular matrices, MC3T3-E1 cells were seeded in the axonal side upon laminin, collagen or within 3D functionalized alginate matrices and axonal outgrowth was clearly observed. In order to analyze and quantify data with reproducible image analysis, a semi-automated algorithm was also developed. The collagen and laminin substrates displayed a higher amount of axons reaching the axonal side. Overall, the established method revealed to be a suitable tool to study the interaction between the peripheral nervous system and bone cells in different contexts mimicking the <I>in vivo</I> scenario.</P>