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      • Implementation of DSTFCs in MIMO MB-IR-UWB System

        Zheng Dou,Zijing Jin,Yun Lin,Zhiqiang Wu,Zhiping Zhang 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.3

        This paper implements differential space-time-frequency codes (DSTFCS) to multiple-input multiple-output (MIMO), multi-band impulse radio ultra-wideband (MB-IR-UWB) system. Four scenarios of the system operating mode have been put forward and combination of DSTFCs and the system has been studied in this paper. Through simulation, a comparison of BER performance among different scenarios and channel statements is analyzed. In addition, considered inter-symbol interference (ISI), the simulation on system with ISI and without ISI is given. Finally the conclusion that scenario 3 is more suitable to the proposed MIMO MB-IR-UWB system for it being less sensitive to ISI has been drawn.

      • Genetic Analysis of Generalized S-Transform

        Yun Lin,Xiaowan Yu,Chunguang Ma,Zheng Dou,Zhiqiang Wu,Zhiping Zhang 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.4

        This text starts with the short time Fourier transform and continuous wavelet transform to deduce the generalized S-transformation. From the point of generation views, we analyzed a relative relationship between generalized S-transformation and the short time Fourier transform, and the other relative relationship between generalized S transform and continuous wavelet transform. The article gives the definition of “the gene mutation of formula” and “the genetic restructuring of formula”, and introduces the deriving process of the two core concept. Theoretical analyses show that generalized S-transformation inherited the desirable characteristics in short time Fourier transform which use the window function to select suitable signal. Through genome sequencing of specific parameters, generalized S-transformation has a stronger adaptation that the time-frequency window could make real-time adjusting of frequency. Moreover, generalized S-transformation breaks out limitation that the wavelet function has to content the admissible conditions. From the point of gene mutation, we give the definition of “the gene mutation of formula”. Based on the structure form of wavelet functions, we define the generalized S-transformation with a wider domain of definition. Generalized S-transformation inherited the desirable characteristics of the short time Fourier transform and continuous wavelet transform. It has great utility and flexibility in analyzing non-stationary signals.

      • KCI등재

        Glioma-Associated Oncogene Homolog1 (Gli1)-Aquaporin1 pathway promotes glioma cell metastasis

        ( Zheng Qiang Liao ),( Ming Ye ),( Pei Gen Yu ),( Chun Xiao ),( Feng Yun Lin ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.7

        Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulated in glioma tissues, as in comparison to in normal tissues. These up-regulation phenomena were also observed in glioma U251 and U87 cells. It was demonstrated that Gli1 positively regulated the AQP1 expression. By luciferase reporter gene and ChIP assay, we observed that this modulation process was realized by combination of Gli1 with AQP1 promotor. In addition, knock down of Gli1 by siRNA interference reduced the viability of glioma cells as well as suppressed cell metastasis. Also, the inhibitory effects of cell survival by silenced Gli1 were abrogated by AQP1 overexpression. In summary, glioma cell survival is a regulatory process and can be mediated by Gli1-AQP1 pathway. [BMB Reports 2016; 49(7): 394-399]

      • KCI등재

        Study on molten salt oxidation process of simulated Co doped cation exchange resins

        Yun Xue,Yue-Lin Wang,Yu Li,Wen-Da Xu,Fu-Qiu Ma,Yang-Hai Zheng,Qing-Guo Zhang,Zhi Zhang,Mi-lin Zhang,Yong-De Yan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-

        Cation exchange resins (CERs) are widely applied to purify waste liquids generated during the operationof nuclear reactors. The radioactive nuclides 60Co and 58Co are important corrosion activation products inreactor cooling water. In this study, the simulated Co doped CERs were oxidized with ternary carbonate. According to the thermogravimetric analysis (TG), the decomposition of Co doped CERs includes threeprocesses: 1. Elimination of the osmotic water; 2. Pyrolysis of sulfonic acid group; 3. Destruction of styrene–divinylbenzene copolymer. The X-Ray Diffraction (XRD) patterns indicate that sulfur mainly exists inthe form of sulfate in waste salt. The Co2+ undergoes the path of CoS2 ? Co3O4 with the increase of temperatureand the transition point is 650 C. Combined with Fourier Transform Infrared Spectrometer (FTIR)spectra and X-ray Photoelectron Spectroscopy (XPS) analysis, sulfonic acid groups begin to decomposeat 350 C. During the molten salt oxidation process, most of the sulfur in sulfonic acid groups is entrappedby carbonate as the form of sulfate, and a little of which remains as sulfone group, sulfoxide group andsulfur bridge in residue. When the resins are oxidized at 800 C, the retention rate of Co2+ is 97.3%, indicatingthat the molten salt oxidation can effectively remain Co2+ and convert it into a more stablesubstance.

      • The Recognition Method of Radiation Source Based on Information Entropy and Cloud Model

        Yun Lin,Can Wang,Chunguang Ma,Zheng Dou,Zhiqiang Wu,Zhiping Zhang 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.2

        Information entropy features are often used for radiation source signal recognition, but due to the information entropy is very sensitive to noise, so this method has greater recognition rate changes with the SNR. This paper putting forward a viable recognition based on Entropy and cloud model. using cloud model to extract secondary features of signals, build radiation source signal’s entropy and cloud feature vector. The method uses cloud model description and processing interval fuzzy and observation noise data, better solve the low SNR cases of radiation source signal feature extraction problem. At the same time, putting forward the similar cloud classification recognition algorithm based on cloud model. The simulation results show that Entropy and cloud model has better recognition effect under low SNR, which can improve the signals’ recognition rate under low SNR.

      • Detection Method of Weak Low-Frequency Electromagnetic Signal Based on Multi-layer Autocorrelation

        Zheng Dou,Yu Tao,Yun Lin,Zhiqiang Wu,Dong Li,Zhiping Zhang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.4

        Low frequency electromagnetic signals play an important role in the detection of underground electrical structure. After propagation of long distance, signal will be attenuated to a certain extent and probably buried in noise, make it difficult to extract. In this paper, the method of multi-layer autocorrelation will be used to detect and extract the weak low frequency electromagnetic signal, and its performance will be compared with the narrow-band filter and the method of synchronous accumulation. Simulation results show that the correlation coefficient of signal obtained by multi-layer autocorrelation and source signal can achieve more than 0.8 when SNR is -18dB. However, the value of narrow-band filter and synchronous accumulation is lower than that mentioned above when SNR is only -14dB. Experimental verifies that multi-layer autocorrelation method can suppress noise more effectively and detect weak signals more accurately.

      • KCI등재

        Lentivirus-mediated microRNA-124 gene-modified bone marrow mesenchymal stem cell transplantation promotes the repair of spinal cord injury in rats

        Jia-Lin Song,Wei Zheng,Wei Chen,Yun Qian,Yuan-Ming Ouyang,Cun-Yi Fan 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

        Our study aims to explore the effects of lentivirus-mediated microRNA-124 (miR-124) gene-modified bone marrow mesenchymal stem cell (BMSC) transplantation on the repair of spinal cord injury (SCI) in rats. BMSCs were isolated from the bone marrow of rats. The target gene miR-124 was identified using a luciferase-reporter gene assay. Seventy-two rats were selected for construction of the SCI model, and the rats were randomly divided into the blank group, sham group, SCI group, negative control (NC) group, overexpressed miR-124 group and si-PDXK group. The mRNA expression of miR-124 and the mRNA and protein expression of pyridoxal kinase (PDXK) were detected by quantitative real-time polymerase chain reaction and western blotting. The locomotor capacity of the rats was evaluated using the Basso, Beattie and Bresnahan (BBB) scale. Brdu, neuron-specific enolase (NSE), neurofilament (NF) and microtubule-associated protein 2 (MAP2) were detected using immunohistochemistry. The expression levels of thyrotropin-releasing hormone (TRH), prostacyclin (PGI2) and gangliosides (GM) were measured using an enzyme-linked immunosorbent assay. PDXK was identified as the target gene of miR-124. The overexpressed miR-124 group exhibited higher miR-124 expression than the SCI, NC and si-PDXK groups. Compared with the SCI and NC groups, the PDXK expression was downregulated in the overexpressed miR-124 and si-PDXK groups, and the BBB scores were significantly increased 7, 21 and 35 days after transplantation. The double-labeled positive cell densities (Brdu+NSE/NF/MAP2) and the expression levels of TRH, PGI2 and GM in the overexpressed miR-124 group were significantly higher than those in the NC and SCI groups. These results indicated that miR-124 targeted PDXK to accelerate the differentiation of BMSCs into neurocytes and promote SCI repair.

      • KCI등재
      • Serum BMP-2 Up-regulation as an Indicator of Poor Survival in Advanced Non-small Cell Lung Cancer Patients

        Fei, Zheng-Hua,Yao, Cheng-Yun,Yang, Xiao-Lei,Huang, Xin-En,Ma, Sheng-Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

        Purpose: High levels of bone morphogenetic protein (BMPs) have been reported in patients with lung cancer. This study was conducted to assess correlations between serum BMP-2 levels and prognostic outcome in patients with non-small-cell lung cancer (NSCLC). Methods: Blood samples from 84 patients with advanced NSCLC and 42 healthy controls were analyzed and quantitated for serum BMP-2 levels before and after two cycles of chemotherapy using a commercially available ELISA kit. Results: The median level of BMP-2 was 146.9 pg/ml in patients with NSCLC vs. 87.7 pg/ml in healthy controls (P<0.01). A significant correlation was observed between pretreatment serum BMP-2 level and ECOG PS, disease stage and number of organs with metastases (P<0.05). Serum BMP-2 level decreased significantly in patients who achieved objective response after two cycles of chemotherapy. Multivariate analysis showed that increased BMP-2 level and advanced clinical stage were significantly correlated with poor prognosis. Conclusion: Thes erum BMP-2 level is positively correlated with clinical stage, ECOG PS and metastatic burden and may serve as an independent negative predictor for prognosis. Decreased BMP-2 after chemotherapy could be a reliable marker for efficacy of treatment.

      • KCI등재

        nonstop glumes (nsg), a novel mutant affects spikelet development in rice

        Nan Wang,Yun-Feng Li,Xian-Chun Sang,Ying-Hua Ling,Fang-Ming Zhao,Zheng-Lin Yang,Guang-Hua He 한국유전학회 2013 Genes & Genomics Vol.35 No.2

        The spikelet is a unique structure of grass plants,and its development involved with complicated molecular regulation network. nsg (nonstop glumes) mutant affecting spikelet development was identified from EMS-treated Jinhui10(Oryza sativa L. ssp. indica.). Mutant plants had normal glumes (inner rudimentary glume, empty glumes and lemma/palea) and pedicel at the early flowering stage, but had longer ones at later stage. An extra glume-like organ was found in 84 %of mutant individuals. The number of stamens decreased in most mutant individuals whereas three stigmas or two carpels were found in some mutant individuals. The mutant phenotype suggests that NSG is involved in the whole rice spikelet development. NSG was mapped to a 15 kb region on the chromosome 4. According to sequence analysis, a gene encoding a protein with C2H2 domain exhibited a 13 bp insertion, causing a frame shift in genomics DNA and cDNA in nsg. This gene was identified as the candidated gene of NSG. The mutation of NSG influenced the transcription level of some floral hometic genes. The expression of OsMADS4, OsMADS16, DL and OsMADS3 decreased distinctly, and OsMADS1 increased in nsg panicle, suggests that NSG affected spikelet development through influencing the expression of floral hometic genes.

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