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최영래,이의린,조남기 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6
The purpose of this study vacs to investigate the relationship between communication and group cohesion in high school baseball team. How the communication-related factors such as an athlete's communication with director, coaches, and other athletes, individual feedback organizational socialization, and the level of information influence the cohesion based factors like individual and goup centered socially oriented cohesion{ individual and goup centered task oriented cohesion was examined in this study. 251 high school baseball athletes registered in Seoul and Kyonggi-Do participated in this study, and self-assessment was adapted in the survey, The collected data were analyzed with one-way ANOVA, Correlation, and Multiple Regression Analysis. The results of the study are as follow; First, it was revealed that the relationship between individual feedback and communication with peers was significant. Communication with peers according to positions was analyzed significant. However, the relationship between communication with the director according to the level of game participation and the level of information was insignificant. Secondly, in the analysis of the relationship between individual characteristics and group cohesion, individual centered task oriented cohesion differ from position to position, In addition, all the independent variables have significant relationships with the level of game participation. Thirdly, positive relationships were come out significant between individual feedback and individual centered task oriented cohesion, between communication with the coach and group cohesion, individual and goup centered task oriented choesion and group centered socially oriented cohesion between communication with peers and group cnetered taks oriented sochesion and individual centered socially oriented choesion. However, it was revealed that the relationship between the level of information and group and indivisual cohesion were insignificant.
Lin, Chunmei,Choi, Yun Seok,Park, Seul Gi,Gwon, Lee Wha,Lee, Jong Geol,Yon, Jung-Min,Baek, In-Jeoung,Lee, Beom Jun,Yun, Young Won,Nam, Sang-Yoon Hindawi Publishing Corporation 2016 BioMed research international Vol.2016 No.-
<P>Scrotal hyperthermia leads to oxidative stress and apoptosis in spermatogenic cells, which subsequently causes male infertility. In this study, we examined the effects of <I>β</I>-carotene and/or curcumin on heat-stress- (HS-) induced testicular injuries in mice. ICR male mice (8 weeks old) were consecutively treated with <I>β</I>-carotene (10 mg/kg) and/or curcumin (20 mg/kg) orally once a day for 14 days and then subjected to single exposure with scrotal HS at 43°C for 15 min on day 7. HS induced a significant reduction in testicular weight, appearance of multinucleated giant cells, and desquamation of germ cells in destructive seminiferous tubules, as well as degenerative Leydig cells. Moreover, HS reduced the superoxide dismutase (SOD) activity and mRNA levels of mitochondrial SOD, phospholipid hydroperoxide glutathione peroxidase, B-cell lymphoma-extra-large, and 3<I>β</I>-hydroxysteroid dehydrogenase, with increases in lipid peroxidation levels and mRNA levels of BCL2-associated X protein and caspase-3 relative to those of the control group. However, these changes were significantly recovered by combined treatment with <I>β</I>-carotene and curcumin after HS. These findings indicate that the combined treatment with <I>β</I>-carotene and curcumin might be a valuable protective agent to ameliorate hyperthermic spermatogenic disorders via its potent antioxidative, antiapoptotic, and androgen synthetic effects.</P>
Anti-postmenopausal Effects of the Newly-Developed Phytoestrogen, FGF271, in vitro and in vivo
Nam-Jin Lee,Geun-Soo Kim,Bo-Yeon Kwak,Kwon-Taek Yi,Jae-Kyung Lee,Yu-Ri Jeong,Chun Mei Lin,Jae Soo Kim,Jong-Koo Kang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
Based on 1 year-long randomized double-blind placebo-controlled clinical study at one of Korean reputed hospitals, the combined test material (Estromon<SUP>®</SUP>) of the new phytoestrogen FGF271 (the extract of the three mixed herbs), amino acid, vitamins and minerals has been significantly effective to improve such menopausal symptoms as vaginal dryness and hot flush, serum osteocalcin level and bone mineral density (BMD) of femoral bone. This in vitro research was done to find out the phytoestrogen effect of FGF271 while in vivo research was designed to investigate the sole effect of FGF271 by comparing with Estromon<SUP>®</SUP>. In result, cell proliferation and alkaline phosphatase (ALP) induction study of MCF-7, Ishikawa, and SaOS-2 cell shows that Cynanchum wilfordii, Phlomis umbrosa, Angelica gigas, and FGF271 have phytoestrogenic effect, respectively and FGF271 has higher phytoestrogenic effect than the individual herbal extract. In ovariectomized (OVX) animal experiment to investigate the sole effect of FGF271 by comparing it with Estromon<SUP>®</SUP>, the oral administration of 100 ㎎/㎏ of FGF271 per day for 12 weeks significantly increased BMD of femoral bone of rats compared to ovariectomised control group (P<0.05) while the group of 100 ㎎/㎏ of Estromon<SUP>®</SUP> did not show significant difference statistically. In conclusion, it was revealed that the improvement of menopausal symptoms and BMD of femoral bone in the clinical study was caused solely by the phytoestrogenic effect of FGF271 in the Estromon<SUP>®</SUP>.
Lin, Chunmei,Kim, Saet Byeol,Yon, Jung-Min,Park, Seul Gi,Gwon, Lee Wha,Lee, Jong-Geol,Baek, In-Jeoung,Lee, Beom Jun,Yun, Young Won,Nam, Sang-Yoon The Korean Society of Veterinary Science 2017 大韓獸醫學會誌 Vol.57 No.4
Temporal and subcellular distributions of hyaluronic acid (HA) as a degradable nanoparticle (NP) in animals were investigated to determine if HA-NP could be utilized as an appropriate drug delivery system. After mice were intravenously injected with 5 mg/kg of Cy5.5-labeled HA-NP sized 350-400 nm or larger HA-polymers, the fluorescence intensity was measured in all homogenized organs from 0.5 h to 28 days. HA-NP was greatly detected in spleen, liver and kidney until day 28, while it was maintained at low levels in other organs. HA-polymer was observed at low levels in all organs. HA-NP quantities in spleen and liver were reduced until day 3, but increased sharply between days 3 and 7, then decreased again, while their HA-polymers were maintained at low levels until day 28. In kidneys, both HA-NP and HA-polymer showed high levels after 0.5 h of administration, but steadily decreased until day 28. According to ultrastructural analyses, HA-NP was engulfed in Kupffer cells of liver and macrophages of spleen and kidney at day 1 and was accumulated in the cytoplasm of kidney tubular cells at day 7. Overall, these findings suggest that HA-NP could be considered a desirable drug carrier in the liver, kidney, or spleen.
Lin, Chunmei,Jeong, Ju-Yeon,Yon, Jung-Min,Park, Seul Gi,Gwon, Lee Wha,Lee, Jong-Geol,Baek, In-Jeoung,Nahm, Sang-Soep,Lee, Beom Jun,Yun, Young Won,Nam, Sang-Yoon The Korean Society of Veterinary Science 2017 大韓獸醫學會誌 Vol.57 No.2
Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350-400 nm) and larger HA polymers in mice at intervals after application. $^{177}Lutetium$ (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.
Sang-Yoon Nam, Jong Geol Lee , Jung-Min Yon , Chunmei Lin, A Young Jung, Ki Youn Jung, Beom Jun Lee, Young Won Yun 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1
Neurotoxicity and oxidative injury induced by glutamate cause neuronal degeneration related to various central nervous system diseases. Resveratrol, a polyphenolic compound, is known to have antioxidative and anti-inflammatory effects. The aim of this study was to investigate the question of whether resveratrol has a neuroprotective effect against glutamate-induced toxicity in cultured cortical neurons. Following exposure to glutamate for 15 min, cortical neurons originating from ICR mouse fetuses on embryonic days 15-16 were then treated with resveratrol for 24 h in the post-treatment paradigm. Glutamate induced a significant reduction in cell viability; however, resveratrol induced a significant increase in cell viability. Glutamate induced generation of ROS and apoptotic neuronal death; however, these were decreased by exposure to resveratrol. mRNA expression in antioxidant enzymes, cytoplasmic glutathione peroxidase, copper/zinc superoxide dismutase (SOD), and manganese SOD, and anti-apoptotic regulator Bcl-xL were decreased by exposure to glutamate, however, exposure to resveratrol resulted in a significant increase in their mRNA levels. In addition, mRNA expression of pro-inflammatory cytokines, interleukin-1β and tumor necosis factor-α, was increased by glutamate insult, but significantly reduced by resveratrol. These findings indicate that resveratrol is neuroprotective against glutamate-induced toxicity, suggesting a useful therapeutic application in treatment of neurodegenerative disorders.