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Li Ma,Xin'an Wu,Yuhui Wei,Yan Zhou,Xiaohua Ma 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
The aim of this study was to investigate the effects of Pluronic F68 and Labrasol on the intestinal absorption and pharmacokinetics of rifampicin. Intestinal permeability of rifampicin with or without excipients was evaluated by an in situ single-pass perfusion method. A highperformance liquid chromatographic method was applied to study the pharmacokinetics of rifampicin with or without excipients. Labrasol or Pluronic F68 (0.1% and 0.05%, v/v), co-perfused with rifampicin (60 μg/mL), significantly increased in situ permeability. Similarly, verapamil (a typical P-gp inhibitor) also increased in situ permeability, but to a lesser extent. In vivo, the oral administration of rifampicin with or without Pluronic F68, Labrasol or verapamil resulted in statistically significant effect on t1/2 (4.83 to 7.75, 6.42 and 7.46 h) and total body clearance (0.46 to 0.26, 0.28, 0.24 L/h/kg). In addition, Pluronic F68, Labrasol and verapamil produced minor changes in AUC_0-t, which improved 1.55-, 1.54-, and 1.73-fold in comparison to control group, respectively. These results showed that Labrasol and Pluronic F68 might inhibit the function of P-gp in the intestine, thereby increasing intestinal absorption and changing the pharmacokinetic parameters of rifampicin. Therefore, excipient selection is an important factor to consider in rational formulation design.
Method to Estimate Lateral Earth Pressure on High-Filled Cut-and-Cover Tunnels
Li Ma,Sheng Li,I-Hsuan Ho,Qicai Wang,Bentian Yu 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.3
High-filled cut-and-cover tunnels (HFCCTs) can be used in northwestern China to reclaim usable land. Because of the ultra-high backfill used in HFCCTs, the stress on the cut-and-cover tunnel (CCT) will change. However, The calculation method adopted at present for earth pressure usually result in either overestimation or underestimation. Different from vertical earth pressure, lateral earth pressure (LEP) can help stabilize the structure of HFCCTs. The current methods for estimating LEP rely mainly on Rankine’s theory or empirical formulas. Using conventional methods has led to errors between actual values and estimated values, and such deviation increases with an increase in the backfill height over the CCT. Due to the complex soil-arching effect, the current methods used for calculating LEP for HFCCTs need to be modified. These modifications need to consider characteristics of the CCT, mechanical properties of the backfill soil, and the geometry of the landform. In this work, several influential factors were identified through numerical analysis using the finite element method and propose four corresponding coefficients of modification: k0, the cross-sectional shape of the CCT; k1, the mechanical properties of the backfill; k2, the width of the CCT; and k3, the coupled effect of the slope angle and ratio of the width of the valley floor to the width of the CCT. Because current methods and specifications may overestimate the LEP for HFCCTs in valleys, a general equation was formulated for modifying the LEP coefficient. Also, this general modification equation was verified that agrees well with the numerical analysis results for different cases.
MRG-DBSCAN: An Improved DBSCAN Clustering Method Based on Map Reduce and Grid
Li Ma,Lei Gu,Bo Li,Shouyi Qiao,Jin Wang 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.2
DBSCAN is a density-based clustering algorithm. This algorithm clusters data of high density. The traditional DBSCAN clustering algorithm in finding the core object, will use this object as the center core, extends outwards continuously. At this point, the core objects growing, unprocessed objects are retained in memory, which will occupy a lot of memory and I/O overhead, algorithm efficiency is not high. In order to ensure the high efficiency of DBSCAN clustering algorithm, and reduce its memory footprint. In this paper, the original DBSCAN algorithm was improved, and the G-DBSCAN algorithm is proposed. G-DBSCAN algorithm reduces the number of query object as a starting point. Put the data into the grid, with the center point of the data in the grid to replace all the grid points as the algorithm input. The query object will be drastically reduced, thus improving the efficiency of the algorithm, reduces the memory footprint. In order to make the G-DBSCAN algorithm can adapt to large data processing, we will parallelize the G-DBSCAN algorithm, and combining it with Map Reduce framework. The results prove that G-DBSCAN and MRG-DBSCAN algorithm are feasible and effective.
Simulation and Optimization Study on Layout Planning of Plant Factory Based on WITNESS
Li Ma,Meiqiong Ma,Chao Ma,Jingwen Deng,Xingluo Liu,Lijun Zhao 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.5
The emergence of plant factory has solved great restriction problem of natural environment in the traditional agriculture. Therefore, it has been the research concentrate on the facility agriculture in recent years. However, the reasonability of factory's production process and layout determines quality of the product, production efficiency and economic benefits. This paper took Wuchang Jingtian Plant Factory as an example, analyzed the production process and layout and provided a corresponding improvement scheme which was verified by the WITNESS simulation software. An optimal solution was determined from the evaluation index of production efficiency, busy rate, production cycle etc.. Besides, the simulation analysis of production cost before and after the improvement verified the improved plant factory operation is effective and feasible. This improvement scheme not only improved efficiency of production system of the plant factory, but also reduced the operating cost.