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( Lilian Yan Liang ),( Hye Won Lee ),( Vincent Wai-sun Wong ),( Terry Cheuk-fung Yip ),( Yee-kit Tse ),( Vicki Wing-ki Hui ),( Grace Chung-yan Lui ),( Henry Lik-yuen Chan ),( Grace Lai-hung Wong ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.3
Background/Aims: Serum fibrosis scores comprised of common laboratory tests have high utility to assess severity of liver fibrosis. We aimed to derive and validate a hepatocellular carcinoma (HCC) risk score based on serum fibrosis scores to predict HCC in treatment-naive chronic hepatitis B (CHB) patients. Methods: Fifteen thousand one hundred eighty-seven treatment-naive adult CHB patients were identified to form the training cohort in this retrospective study. Individual fibrosis score was included to construct a new HCC prediction score. The score was externally validated in an independent treatment-naive Korean CHB cohort. Results: 180/15,187 patients (1.2%) in training cohort and 47/4,286 patients (1.1%) in validation cohort developed HCC during a mean follow-up of 52 and 50 months, respectively. The newly developed HCC risk score, Liang score, is composed of gender, age, hepatitis B virus DNA, fibrosis-4 (FIB-4) index, and ranges from 0 to 22. Area under the time-dependent receiver operating characteristic curve of Liang score was 0.79 (95% confidence interval, 0.70-0.89). A cutoff value of nine provided an extremely high negative predictive value of 99.9% and high sensitivity of 90.0% at 5 years in the validation cohort. Patients with Liang score ≤9 had HCC incidence <0.2% per year in both training and validation cohorts, in whom HCC surveillance might be exempted. Conclusion: A novel HCC risk score, Liang score, based on FIB-4 index, is applicable and accurate to identify treatment-naive CHB patients with very low risk of HCC to be exempted from HCC surveillance. (Clin Mol Hepatol 2021;27:499-509)
Liang Sun,Guang Sun 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.11
This paper investigates the robust adaptive relative pose control design for spacecraft rendezvous and docking missions in the presence of parametric uncertainty, matched and mismatched disturbances, actuator saturation and faults. An adaptive saturated fault-tolerant controller is developed by incorporating the anti-windup compensator to adaptive backstepping technique. In contrast to traditional saturated fault-tolerant controllers for the spacecraft systems, the advantage of the proposed control approach can deal with the mismatched disturbances in the model. Also this approach does not require exact knowledge of the actuator faults and is implemented with uncertain value of fault information. Lyapunov analysis is employed to prove the ultimately uniformly bounded stability of the closed-loop system, where relative pose and velocities converge to adjustable small neighborhoods of zero. Numerical simulation results demonstrate the effectiveness of the proposed control approach.
Parthenolide-Induced Apoptosis, Autophagy and Suppression of Proliferation in HepG2 Cells
Sun, Jing,Zhang, Chan,Bao, Yong-Li,Wu, Yin,Chen, Zhong-Liang,Yu, Chun-Lei,Huang, Yan-Xin,Sun, Ying,Zheng, Li-Hua,Wang, Xue,Li, Yu-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Purpose: To investigate the anticancer effects and underlying mechanisms of parthenolide on HepG2 human hepatocellular carcinoma cells. Materials and Methods: Cell viability was assessed by MTT assay and cell apoptosis through DAPI, TUNEL staining and Western blotting. Monodansylcadaverin(MDC) and AO staining were used to detect cell autophagy. Cell proliferation was assessed by Ki67 immunofluorescence staining. Results: Parthenolide induced growth inhibition in HepG2 cells. DAPI and TUNEL staining showed that parthenolide could increase the number of apoptotic nuclei, while reducing the expression of the anti-apoptotic protein Bcl-2 and elevating the expression of related proteins, like p53, Bax, cleaved caspase9 and cleaved caspase3. Parthenolide could induce autophagy in HepG2 cells and inhibited the expression of proliferation-related gene, Ki-67. Conclusions: Parthenolide can exert anti-cancer effects by inducing cell apoptosis, activating autophagy and inhibiting cell proliferation.
Robust Adaptive Backstepping Control for Autonomous Spacecraft Proximity Maneuvers
Liang Sun,Wei Huo 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.3
The control problem of autonomous proximity phase during rendezvous and docking is studied for achaser spacecraft subject to parametric uncertainty and unknown external disturbance approaching to a tumblingnon-cooperative space target. A coupled relative motion model is established for the autonomous spacecraft proximitymissions based on the relative motion information and chaser’s motion information. Based on the cascadedstructure of the six degrees-of-freedom coupled model, the backstepping technology combined with element-wiseand norm-wise adaptive control methods is used to design a relative position controller firstly, then the same methodis also applied to the design of the relative attitude controller. Asymptotic stability is proven uniformly for the sixdegrees-of-freedom closed-loop system, and the performance of the controlled overall system is demonstrated viaa representative numerical example.
Sun Liang-Yu,Liu Jing,Li Qin,Fu Di,Zhu Jia-Yun,Guo Jian-Jun,Xiao Rong,Jin Dao-Chao 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1
Pardosa pseudoannulata is the main predatory natural enemy of crop pests in a paddy ecosystem. When P. pseudoannulata is exposed to unfavorable temperature conditions, the response of heat shock proteins could resist the damage, and is therefore, conducive to the organism’s rapid adaptation to the surrounding stress environ ment. In this study, we explored the roles of hsp70 and hsp90 genes in response to heat stress, using the rapid amplification of cDNA ends technique and cloned full-length cDNAs of Pphsp70, Pphsp83, and Pphsp90. The mRNA expression levels of the three genes under different temperature stresses (25, 28, 31, 34, 37, 40, and 43 ◦ C) and with different duration stresses (4, 8, 12, 16, and 20 h) were analyzed by quantitative real-time polymerase chain reaction. The full-length cDNA of Pphsp70, Pphsp83, and Pphsp90 was 2331 base pair (bp), 2466 bp, and 2663 bp, respectively. Phylogenetic analysis of amino acid sequences of Pphsp70, Pphsp83, and Pphsp90 showed that the sequences had high homology with that of other spiders. The mRNA expression of all three genes was extremely significantly up-regulated at 43 ◦ C. Moreover at 43 ◦ C, the expression of all three genes in both female and male spiders at the duration of 4 h was the highest compared to that of other stress duration groups. Therefore, it can be inferred that the three genes of P. pseudoannulata play a crucial protective role in resistance in a high-temperature environment.
Quadrilateral multiblock decomposition via auxiliary subdivision
Sun Liang,Armstrong Cecil G,Robinson Trevor T,Papadimitrakis Dimitrios 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.3
Automatic quadrilateral (quad) or hexahedral (hex) multiblock decomposition has been a topic of research for many years. The key challenges are to automatically determine where to place mesh singularities and how to generate a decomposition based on the mesh singularities to get the desired mesh orientation and distribution. In this work, a new idea of achieving these is proposed based on an auxiliary subdivision of the domain into smaller subdomains, followed by applying an equation, which calculates the net number of mesh singularities of a surface, to locate the quad mesh singularities. Under this idea, two different methods are presented based on the medial axis and the inward boundary offset. Both methods are conformal to the vertex classifications of the original domain, which guarantees a good mesh quality at the boundary. The mesh results are compared with a paving method and a cross-field method.
Liang Sun,Fei Shang,Chang-Qing Duan,Guo-liang Yan 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.7
Transferring the recombinant S. cerevisiae T73-63 from 30 oC to 4 oC resulted in 41.4% increment of β-carotene concentration (3.96mg/g dry cell weight) relative to that of 30 oC, which was accompanied with the accumulation of fatty acid and ergosterol. The comparisons of the transcriptional levels of mevalonate pathway genes indicated that the expressions of HMG1, ERG9, ERG19, ERG20 and IDI1 at 4 oC were all higher than those of 30 oC, respectively. This suggested that increased transcriptions of mevalonate pathway genes contribute to the improvement of β-carotene production at low temperature. We also found that supplementation of 30mg/L triclosan, an inhibitor of fatty acid synthesis, led to further 28.3% enhancement of β-carotene concentration (4.94mg/g DCW), which was 18.8% higher than that of 30 oC with the same concentration of triclosan. The higher expressional levels of HMG, ERG19 and ERG20 and the simultaneous increment of ergosterol content (17.8%) suggested that more carbon source was transferred from fatty acid synthesis to mevalonate pathway under the circumstance of appropriately blocking fatty acid synthesis at low temperature (4 oC), which resulted in a higher increment of β-carotene production compared to that of 30 oC. The results of this study collectively suggest that the combination of reducing temperature and adding fatty acid synthesis inhibitors is a potential approach to improve the production of desirable isoprenoid compounds such as carotenoids.
Convergent Stochastic Differential Evolution Algorithms
Liang Sun,Hongwei Ge,Limin Wang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.7
Differential evolution (DE) algorithms have been extensively and frequently applied to solve optimizationproblems. Theoretical analyses of their properties are important to understand the underlying mechanismsand to develop more efficient algorithms. In this paper, firstly, we introduce an absorbing Markovsequence to model a DE algorithm. Secondly, we propose and prove two theorems that provide sufficientconditions for DE algorithm to guarantee converging to the global optimality region. Finally, we design two DE algorithms that satisfy the preconditions of the two theorems, respectively. The two proposed algorithmsare tested on the CEC2013 benchmark functions, and compared with other existing algorithms.Numerical simulations illustrate the converge, effectiveness and usefulness of the proposed algorithms.