http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Zhi-Ning Huang,Han Liang,Hong Qiao,Bao-Rui Wang,Ning Qu,Hua Li,Run-Run Zhou,Li-Juan Wang,Shan-Hua Li,Fu-Nan Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13 μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.
Juan Qian,Ting Xie,Liqun Chen,Zhijiang Li,Ning Guo,Shaoju Fu,Peihua Zhang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11
Polyethylene is getting tremendous attention in personal thermal management textiles for summer, but there is lackof systematical coolness and thermal-wet comfort research in wearing knitting fabrics. In this work, two group of knittingstructure were designed following a sandwich structure model that consisted of a middle layer of multifilament and twoasymmetric outer layers. Nine bi-layer samples interknitted with polyester were fabricated with one face composed ofpolyester filaments and the other face built of polyethylene and polyester filaments. Textile parameters, such as knittingstructure, polyethylene fractions and distribution in the inner layer, yarn composition and relative porosity, were considered. Breathability, thermal transfer properties, moisture management performance and dynamic cooling performance wasmeasured and evaluated to investigate the thermal-wet and coolness relevant comfort properties of these fabrics. It was foundthat the fabrics knitted with tuck stitches have better air permeability, contact coolness, overall moisture management anddynamic cooling performance in comparison to the fabrics knitted with float stitches. The air permeability became better withthe increasing proportion of polyethylene and the decreasing ratio of tuck stitch. The effective contact area of polyethylenewith skin was beneficial to promote the transient thermal conductivity and dynamic cooling performance of fabric. The resultalso suggested that an asymmetric structure with meshes in the inner layer were beneficial to promote moisture management. Meanwhile, when the proportion of tuck stitch in inner layer was 6.25 %, the air permeability and heat transfer properties offabric were the best. Moreover, independent tests had proved that the performance of transient and steady thermalconductivity of polyethylene/polyester fabric was the best when the mass ratio of polyethylene was 49.3 % in this study.
Bond Distortion and Electron States in Charged $C_{60}{^2-}$
Fu, Rong-Tang,Fu, Rou-Li,Lee, Kee-Hag,Sun, Xin,Ye, Hong-Juan Korean Chemical Society 1993 Bulletin of the Korean Chemical Society Vol.14 No.6
By considering both electron-electron and electron-lattice interactions, the effect of charge transfer on the bond structure and electronic states of $C_{60}$ is studied without configuration limitation. The results show that the electron-electron interaction does not eliminate the layer structure of the bond distortion and the self-trapping of transferred electrons. For charged ${C_{60}}^{2-}$, there exist two localized electronic states, which possess laminar wave functions, and four nonequivalent groups of carbon atoms, which induce a fine-structure in the NMR spectrum line.
A high-efficiency simulation method of wind field and its application on transmission line
Xing Fu,Xing-Heng Zhang,Hong-Nan Li,Gang Li,Hui-Juan Liu 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.33 No.4
Generally, the fluctuating wind is simplified as several independent one-dimensional multivariate stationary Gaussian processes in simulating a natural wind field. The correlation in the lateral, longitudinal and vertical directions should all be considered in the simulation of longitudinal wind field for the large-span spatial structures. In fact, this type of structure has lots of simulation points. The calculation amount of wind field simulation by the harmonic superposition method depends on the scale of cross-spectral density matrix, which is directly related to the number of simulated points, leading to a low efficiency when generating the time-varying wind speed. This paper innovatively proposes a high-efficiency simulation method for the longitudinal wind field based on Taylor’s hypothesis. Subsequently, the effectiveness of the proposed wind field method was verified by the numerical simulation. Finally, the dynamic responses of a transmission tower-line system under the wind loadings generated with the new method and traditional method are calculated and compared. The percentages difference of the mean and maximum axial force at the main tower members are less than 0.02% and 1%, respectively, indicating the effectiveness of the proposed time delay method. The results also show that the proposed simulation method of wind field can not only ensure the simulation accuracy, but also significantly improve the efficiency of wind speed generation, which is suitable for the wind load simulation of large-span spatial structures.
Existence of solution for impulsive fractional dynamic equations with delay on time scales
Zhi-Juan Gao,Xu-Yang Fu,Qiao-Luan Li 한국전산응용수학회 2015 Journal of applied mathematics & informatics Vol.33 No.3
This paper is mainly concerned with the existence of solution for nonlinear impulsive fractional dynamic equations on a special time scale. We introduce the new concept and propositions of fractional $q$-integral, $q$-derivative, and $\alpha$-Lipschitz in the paper. By using a new fixed point theorem, we obtain some new existence results of solutions via some generalized singular Gronwall inequalities on time scales. Further, an interesting example is presented to illustrate the theory.
Yang, Lishi,Li, Junyang,Fu, Shaozhi,Ren, Peirong,Tang, Juan,Wang, Na,Shi, Xiangxiang,Wu, Jingbo,Lin, Sheng Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.4
The brain is the most common metastatic site of lung adenocarcinoma; however, the mechanism of this selective metastasis remains unclear. We aimed to verify the hypothesis that exposure of tumor cells to the brain microenvironment leads to changes in their gene expression, which promotes their oriented transfer to the brain. A549 and H1299 lung adenocarcinoma cells were exposed to human astrocyte-conditioned medium to simulate the brain microenvironment. Microarray analysis was used to identify differentially expressed genes, which were confirmed by quantitative real-time PCR and western blotting. Knockdown experiments using microRNAs and the overexpression of genes by cell transfection were performed in addition to migration and invasion assays. In vitro findings were confirmed in clinical specimens using immunohistochemistry. We found and confirmed a significant increase in insulin-like growth factor binding protein-3 (IGFBP3) levels. Our results also showed that the up-regulation of IGFBP3 promoted A549 cell epithelial-mesenchymal transition, migration, and invasion, while the knockdown of IGFBP3 resulted in decreased cell motility. We also found that Transforming growth factor-${\beta}$ (TGF-${\beta}$)/Mothers against decapentaplegic homolog 4 (Smad4)-induced epithelial-mesenchymal transition was likely IGFBP3-dependent in A549 cells. Finally, expression of IGFBP3 was significantly elevated in pulmonary cancer tissues and intracranial metastatic tissues. Our data indicate that up-regulation of IGFBP3 might mediate brain metastasis in lung adenocarcinoma, which makes it a potential therapeutic target.
( Bo Xu ),( Fu Ya Yang ),( Cai Yun Xiong ),( Jun Jun Li ),( Xiang Hua Tang ),( Jun Pei Zhou ),( Zhen Rong Xie ),( Jun Mei Ding ),( Yun Juan Yang ),( Zun Xi Huang ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.4
To isolate novel and useful microbial enzymes from uncultured gastrointestinal microorganisms, a fecal microbial metagenomic library of the pygmy loris was constructed. The library was screened for amylolytic activity, and 8 of 50,000 recombinant clones showed amylolytic activity. Subcloning and sequence analysis of a positive clone led to the identification a novel gene (amyPL) coding for α-amylase. AmyPL was expressed in Escherichia coli BL21 (DE3) and the purified AmyPL was enzymatically characterized. This study is the first to report the molecular and biochemical characterization of a novel α-amylase from a gastrointestinal metagenomic library.
EXISTENCE OF SOLUTION FOR IMPULSIVE FRACTIONAL DYNAMIC EQUATIONS WITH DELAY ON TIME SCALES
GAO, ZHI-JUAN,FU, XU-YANG,LI, QIAO-LUAN The Korean Society for Computational and Applied M 2015 Journal of applied mathematics & informatics Vol.33 No.3
This paper is mainly concerned with the existence of solution for nonlinear impulsive fractional dynamic equations on a special time scale.We introduce the new concept and propositions of fractional q-integral, q-derivative, and α-Lipschitz in the paper. By using a new fixed point theorem, we obtain some new existence results of solutions via some generalized singular Gronwall inequalities on time scales. Further, an interesting example is presented to illustrate the theory.