Optimized Assembly of Micro-/Meso-/Macroporous Carbon for Li–S Batteries

Qiong Tang,Heqin Li,Min Zuo,Jing Zhang,Yiqin Huang,Peiwen Bai,Jiaqi Xu,Kuan Zhou 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.2

In order to explore the effect of hierarchical porous carbon on the performances of Li–S batteries, we synthesized three kinds of micro-/meso-/macroporous carbon materials with different pore properties by facile hard-template method. Different from the majority of reports on porous carbon ensuing large specific surface area (SSA) and total pore volume, it was found that in the case of identically high sulfur content, the pore size distribution substantially influences the performances of Li–S batteries rather than the SSA and total pore volume. Furthermore, in the assembly of micro-/meso-/macropores, the micropore volume ratio to the total pore volume is dominant to the capabilities of batteries. Among the samples, the porous carbon carbonized with the precursor of sucrose at 950℃ presents the highest initial discharge specific capacity of 1327 mAh/g and retention of 630 mAh/g over 100 cycles at 0.2C rate along with the best rate capability. This sample possesses the largest micropore volume ratio of 47.54% but a medium SSA of 1217 m2 /g and inferior total pore volume of 0.54 cm3 /g. The abundant micropores effectively improve the conductivity of dispersed sulfur particles, inhibit the loss of sulfur series and enable the cathode to exhibit superior electrochemical performances.

Caged xanthones displaying protein tyrosine phosphatase 1B (PTP1B) inhibition from <i>Cratoxylum cochinchinense</i>

Li, Zuo Peng,Lee, Hyeong-Hwan,Uddin, Zia,Song, Yeong Hun,Park, Ki Hun Elsevier 2018 Bioorganic chemistry Vol.78 No.-

<P><B>Abstract</B></P> <P>Four new caged xanthones (<B>1</B>–<B>4</B>) and two known compounds (<B>5</B>, <B>6</B>) were isolated from the roots of <I>Cratoxylum cochinchinense</I>, a polyphenol rich plant, collected in China. The structures of the isolated compounds (<B>1</B>–<B>6</B>) were characterized by obtaining their detailed spectroscopic data. In particular, compounds <B>1</B> and <B>6</B> were fully identified by X-ray crystallographic data. The isolated compounds (<B>1</B>–<B>6</B>) were evaluated against protein tyrosine phosphatase 1B (PTP1B), which plays an important role in diabetes, obesity, and cancer. Among these compounds, <B>3</B>, <B>4</B>, and <B>6</B> displayed significant inhibition with IC<SUB>50</SUB> values of 76.3, 43.2, and 6.6 µM, respectively. A detailed kinetic study was conducted by determining <I>K</I> <SUB>m</SUB>, <I>V</I> <SUB>max</SUB>, and the ratio of <I>K</I> <SUB>ik</SUB> and <I>K</I> <SUB>iv</SUB>, which revealed that all the compounds behaved as competitive inhibitors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Six caged xanthones including four new ones were isolated from the roots of <I>Cratoxylum cochinchinense.</I> </LI> <LI> Structural elucidations of all compounds were performed with detailed spectroscopic data including 2D NMR and HREIMS analyses. </LI> <LI> PTP1B inhibitory activities were investigated, among them compound <B>6</B> displayed the most potent inhibition (IC<SUB>50</SUB> = 6.6 μM). </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Human neutrophil elastase (HNE) inhibitory polyprenylated acylphloroglucinols from the flowers of <i>Hypericum ascyron</i>

Li, Zuo Peng,Kim, Jeong Yoon,Ban, Yeong Jun,Park, Ki Hun Elsevier 2019 Bioorganic chemistry Vol.90 No.-

<P><B>Abstract</B></P> <P>In the course of an investigation of human neutrophil elastase (HNE) associated with inflammation, the extract of the flower parts of <I>Hypericum ascyron</I> showed a significant influence to HNE. The responsible metabolites to HNE inhibition were found to be eight polyprenylated acylphloroglucinols, PPAPs (<B>1</B>–<B>8</B>) which showed IC<SUB>50</SUB> ranges between 2.4 and 19.9 μM. This is the first report to demonstrate that PPAP skeleton exhibits potent HNE inhibition. The compounds <B>1</B>–<B>3</B> were characterized and newly named as ascyronone E (IC<SUB>50</SUB> = 4.3 μM), ascyronone F (IC<SUB>50</SUB> = 19.9 μM), ascyronone G (IC<SUB>50</SUB> = 4.5 μM) based on 2D-NMR spectroscopic data. In the kinetic analysis of double reciprocal plots, all the compounds showed noncompetitive behaviors to HNE enzyme with the remaining of <I>K</I> <SUB>m</SUB> and the increase of <I>V</I> <SUB>max</SUB>. The binding affinity levels (<I>K</I> <SUB>SV</SUB>) by using fluorescence were sufficient to be able to prove that PPAPs (<B>1</B>–<B>8</B>) had compliant interaction with inhibitory potencies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Eight human neutrophil elastase (HNE) inhibitors were isolated from the flowers of <I>Hypericum ascyron.</I> </LI> <LI> Ascyronones E-G were identified as new polycyclic polyprenylated acylphloroglucinols (PPAPs). </LI> <LI> The isolated acylphloroglucinols showed a significant HNE inhibition with noncompetitive behavior. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Competitive neutrophil elastase inhibitory isoflavones from the roots of <i>Flemingia philippinensis</i>

Kim, Jeong Yoon,Wang, Yan,Uddin, Zia,Song, Yeong Hun,Li, Zuo Peng,Jenis, Janar,Park, Ki Hun Elsevier 2018 Bioorganic chemistry Vol.78 No.-

<P><B>Abstract</B></P> <P> <I>Flemingia philippinensis</I> has been used throughout history to cure rheumatism associated with neutrophil elastase (NE). In this study, we isolated sixteen NE inhibitory flavonoids (<B>1</B>–<B>16</B>), including the most potent and abundant prenyl isoflavones (<B>1</B>–<B>9</B>), from the <I>F. philippinensis</I> plant. These prenyl isoflavones (<B>2</B>, <B>3</B>, <B>5</B>, <B>7</B>, and <B>9</B>) competitively inhibited NE, with IC<SUB>50</SUB> values of 1.3–12.0 μM. In addition, they were reversible, simple, slow-binding inhibitors according to their respective parameters. Representative compound <B>3</B> had an IC<SUB>50</SUB> = 1.3 μM, <I>k</I> <SUB>3</SUB> = 0.04172 μM<SUP>−1</SUP> min<SUP>−1</SUP>, <I>k</I> <SUB>4</SUB> = 0.0064 min<SUP>−1</SUP>, and <I>K</I> <SUB>i</SUB> <SUP>app</SUP> = 0.1534 μM. The <I>K</I> <SUB>ik</SUB>/<I>K</I> <SUB>iv</SUB> ratios (18.5 ∼ 24.6) for compound <B>3</B> were consistent with typical competitive inhibitors. The prenyl functionality of isoflavones significantly affected inhibitory potencies and mechanistic behavior by shifting the competitive mode to a noncompetitive one. The remaining flavonoids (<B>10</B>–<B>16</B>) were confirmed as mixed type I inhibitors that preferred to bind free enzyme rather than the enzyme-substrate complex. Fluorescence quenching analyses indicated that the inhibitory potency (IC<SUB>50</SUB>) closely followed the binding affinity (<I>K</I> <SUB>SV</SUB>).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phenolic isolates from <I>Flemingia philippinensis</I>. </LI> <LI> <I>In vitro</I> neutrophil elastase inhibitory activity. </LI> <LI> Characterization of kinetics based on structure. </LI> <LI> Binding affinity between inhibitor and enzyme. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Transcatheter Arterial Chemoembolization Combined with Interferon-α is Safe and Effective for Patients with Hepatocellular Carcinoma after Curative Resection

Zuo, Chaohui,Xia, Man,Liu, Jingshi,Qiu, Xiaoxin,Lei, Xiong,Xu, Ruocai,Liu, Hanchun,Li, Jianliang,Li, Yongguo,Li, Qinglong,Xiao, Hua,Hong, Yuan,Wang, Xiaohong,Zhu, Haizhen,Wu, Qunfeng,Burns, Michael,Li Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Objectives: Intrahepatic recurrence is the major cause of death among patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative surgical resection. Several approaches have been reported to decrease the recurrence rate. The objective of our study was to compare the clinical effects of transcatheter arterial chemoembolization (TACE) combined with interferon-alpha (IFN-${\alpha}$) therapy on recurrence after hepatic resection in patients with HBV-related HCC with that of TACE chemotherapy alone. Methods: We retrospectively analyzed the data from 228 patients who were diagnosed with HBV-related HCC and underwent curative resection between January 2001 to December 2008. The patients were divided into TACE (n = 126) and TACE-IFN-${\alpha}$ (n = 102) groups for postoperative chemotherapy. The TACE regimen consisted of 5-fluorouracil (5-FU), cisplatin (DDP), and the emulsion mixed with mitomycin C (MMC) and lipiodol. The recurrence rates, disease-free survival (DFS), overall survival (OS), and risk of recurrence were evaluated. Results: The clinicopathological parameters and adverse effects were similar between the 2 groups (P > 0.05). The median OS for the TACE-IFN-${\alpha}$ group (36.3 months) was significantly longer than that of the TACE group (24.5 months, P < 0.05). The 3-and 5-year OS for the TACE-IFN-${\alpha}$ group were significantly longer than those of the TACE group (P < 0.05) and the recurrence rate was significantly lower (P < 0.05). The TACE and IFN-${\alpha}$ combination therapy, active hepatitis HBV infection, the number of tumor nodules, microvascular invasion, liver cirrhosis, and the BCLC stage were independent predictors of OS and DFS. Conclusions: The use of the TACE and IFN-${\alpha}$ combination chemotherapy after curative hepatic resection safely and effectively improves OS and decreases recurrence in patients with HBV-related HCC who are at high risk. Our findings can serve as a guide for the selection of postoperative adjuvant chemotherapy for patients with HBV-related HCC who are at high risk of recurrence.

How the International Cooperation in “Sci-tech +Industry” Model Working in Developing Mango as “One Village and One Product”: Citing the Industrial Upgrading Experience in Baihua Village as An Example

Yanxiu Zuo(Yanxiu Zuo),Junxiang Qian(Junxiang Qian),Lichi Li(Lichi Li),Zhangguan Ni(Zhangguan Ni),Jun Wu(Jun Wu),Huiyun Zhang(Huiyun Zhang),Yufu Chen(Yufu Chen),Huiyun Zhang(Huiyun Zhang),Li Yao(Yao L 아시아사회과학학회 2022 Jornal of Asia Social Science Vol.9 No.1

Baihua Village is a typical mountainous village in the southwest part of Lujiang county, Longyang District, Baoshan City, Yunnan Province. Residents there made a living on the land, including growing sugarcane and planting maize, whose annual income was no more than 2000 yuan before 2006. Since then when a research institute has set it as one of the pilot villages for mango growing impetus with sci-tech. For the sake of “One village and One Product”, mango breeding and relevant techniques have been applied to daily work. Within years, the developed model of has been explored: simply “villages are the main carriers facilitated by the specialized cooperative for mango growing, back-up by science and technology. Technical trainings serve as the driving force for the leading growers, meanwhile, sellers work as the bridge link the producing-end and the markets”.

ACOX1 destabilizes p73 to suppress intrinsic apoptosis pathway and regulates sensitivity to doxorubicin in lymphoma cells

( Fei-meng Zheng ),( Wang-bing Chen ),( Tao Qin ),( Li-na Lv ),( Bi Feng ),( Yan-ling Lu ),( Zuo-quan Li ),( Xiao-chao Wang ),( Li-ju Tao ),( Hong-wen Li ),( Shu-you Li ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.9

Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid β-oxidation. Deregulation of ACOX1 has been linked to peroxisomal disorders and carcinogenesis in the liver. Currently, there is no information about the function of ACOX1 in lymphoma. In this study, we found that upregulation of ACOX1 promoted proliferation in lymphoma cells, while downregulation of ACOX1 inhibited proliferation and induced apoptosis. Additionally, overexpression of ACOX1 increased resistance to doxorubicin, while suppression of ACOX1 expression markedly potentiated doxorubicin-induced apoptosis. Interestingly, downregulation of ACOX1 promoted mitochondrial location of Bad, reduced mitochondrial membrane potential and provoked apoptosis by activating caspase-9 and caspase-3 related apoptotic pathway. Overexpression of ACOX1 alleviated doxorubicin-induced activation of caspase-9 and caspase-3 and decrease of mitochondrial membrane potential. Importantly, downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. Also, overexpression of ACOX1 significantly reduced stability of p73 protein thereby reducing p73 expression. Thus, our study indicated that suppression of ACOX1 could be a novel and effective approach for treatment of lymphoma. [BMB Reports 2019; 52(9): 566-571]

Preparation and Photoelectrocatalytic Performance Study of Au-RGO/TiO2 NTs Photoelectrode

Zuo Jin Long,ShaoDong Yang,YiWen Li,Chong Tan,Zhi Xia,SiYing Yuan,ShiYou Yu,JunSheng Li 한국고분자학회 2022 Macromolecular Research Vol.30 No.11

In our research, The Au-reduced graphene oxide (RGO)/TiO2 nanotubes (NTs) photoelectrode was prepared by electrodeposition, and was characterized and analyzed by scanning electron microscope, X-ray energy scattering spectroscopy, X-ray diffraction, photoluminescence spectroscopy, and photoelectrochemical methods. The results show that the best preparation conditions is setting deposition voltage as 0.2 V and deposition time as 30 s. At the same time, the nano-gold is well supported on RGO/TiO2 NTs without changing the original nanotube array structure. After a 35 W mercury lamp and a 15 V bias are applied, the photoelectric degradation efficiency of methylene blue is 72%, slightly higher thanthose of the other two electrodes. which show demonstrate that the photocatalytic activity of Au-RGO/TiO2 NTs photoelectrodes under visible light is improved effectively.

Moisture Sorption and Thermodynamic Properties of Vacuum Dried Capsosiphon fulvescens Powders (초)

( Li Zuo ),( Sun Hui Kim ),( Jun Ho Lee ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2010 한국식품저장유통학회 학술대회 Vol.2010 No.-

The Influence of Construction Scheme of Asymmetric Three-Cabin Utility Tunnelling on the Surface Settlement Behaviour

Zuo Chun Li,Gui He Wang,Jun Wei Hao,Yao Zhou,Xiao Yang Wang,Heng Xuan,Feng Huang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.9

The asymmetric three-cabin structure is one of the favourite choices in urban utility tunnel engineering, as it can provide a higher space utilization and clearer classification for pipelines. However, few work has been done on utility tunnel in such special cross-section during undercutting construction until now. Besides, as the loose soil layers such as sand and silt are often encountered during the utility tunnelling, its influence on surface settlement become one of the main concerns. This study focuses on the influence of the construction scheme on the surface settlement details for an asymmetric three-cabin utility tunnel. A 3D finite element method (FEM) model was established including both the stratum and a utility tunnel based on the Beijing Daxing International Airport (BDIA) Expressway Urban Utility Tunnel project. With this model, the behaviour of the surface settlement with the undercutting construction of the utility tunnel was investigated, and the causes and values of surface settlement in five construction stages were analyzed. By changing the construction spacing and sequence of mid and side cabins, the surface settlement and structural deformation were compared. The numerical results demonstrated a strong correlation between the cross-section shape and surface settlement characteristics. And the symmetry line of the surface settlement trough was offset by 1 m to the side with the larger cross-section. The second (excavation of upper bench in mid-cabin) and fourth (excavation of upper bench in side-cabin) stages caused the largest surface settlement, which were 41.9% and 18.07% of the total settlement, respectively. In addition, after optimizing the field tunnelling scheme, the surface settlement was reduced by 31.9% using the side-tunnel first construction sequence. The proposed numerical model is able to predict the settlement characteristics in each construction stage, which is important and provides a basis for further studies on the surface settlement mechanism and optimal design of the asymmetric three-cabin utility tunnelling scheme.