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Establishment of Spray Standards for Major Pest Control of Chinese Cabbage Using Drones
Duck-Soo Choi,Kyung-Cheol Ma,Hyo-Jeong Kim,Jin-Hee Lee,Sang-A Oh,Sun-Gon Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04
드론을 이용한 밭작물 병해충 방제기준을 설정하기 위하여 드론의 살포높이(3, 4, 5m), 진행속도(3m/sec, 4m/sec) 에 따른 하향풍 속도, 살포 폭, 약량별 감수지에서 입자크기, 살포조건별 낙하입자수 등 드론의 농약 살포특성을 조사하였다. 또, 배추의 주요해충인 배추좀나방, 파밤나방, 담배거세미나방에 대하여 항공방제용 농약 4종을 대상으로 치사농도와 약량을 검정하였다. 드론 표면별 평균 낙하입자비율은 표면 80.5%, 사면 14.8%, 밑면 4.7%였으며, 살포높이별 평균낙하입자수는 3m=53개/㎠, 4m=40개/㎠, 5m=39개/㎠였고, 진행속도별 평균낙하 입자수는 3m/sec=62개/㎠, 4m/sec는 25개/㎠였다. 약제별 배추좀나방 치사농도와 치사량은 승승장구 (10배, 2㎕), 포워드(15배, 1㎕), 섹큐어(20배, 0.5㎕), 레이서((25배, 0.5㎕)였으며, 파밤나방에 대하여는 섹큐어(20배, 1㎕), 레이서((20배, 1㎕), 담배거세미나방은 섹큐어(20배, 1㎕), 레이서((20배, 0.5㎕)였다. 따라서 배추 주요해충 방제를 위한 농약살포방법은 섹큐어액상수화제, 레이서액상수화제를 20배액으로 희석하여 3m 높이에서 3m/sec속도로 살포시 낙하 입자수 72개/㎠로 해충방제에 효과적이었다.
Sung, Jae Hyuck,Kim, Choong Yong,Yang, Seoung Oh,Khang, Hyun Soo,Cheong, Hae Kwan,Lee, Jong Seong,Song, Chang-Woo,Park, Jung Duck,Han, Jeong Hee,Chung, Yong Hyun,Choi, Byung Sun,Kwon, Il Hoon,Cho, Myu Informa Healthcare 2007 Inhalation toxicology Vol.19 No.1
<P> Welders are at risk of being exposed to high concentrations of welding fumes and developing pneumoconiosis or other welding-fume exposure-related diseases. Among such diseases, manganism resulting from welding-fume exposure remains a controversial issue, as although the movement of manganese into specific brain regions has been established, the similar movement of manganese presented with other metals, such as welding fumes, has not been clearly demonstrated as being similar to that of manganese alone. Meanwhile, the competition between Mn and iron for iron transporters, such as transferrin and DMT-1, to the brain has also been implicated in the welding-fume exposure. Thus, the increased signal intensities in the basal ganglia, including the globus pallidus and subcortical frontal white matter, based on T1-weighted magnetic resonances in welders, require further examination as regards the correspondence with an increased manganese concentration. Accordingly, to investigate the movement of manganese after welding-fume exposure, 6 cynomolgus monkeys were acclimated for 1 mo and assigned to 3 dose groups: unexposed, low dose of (total suspended particulate [TSP] 31 mg/m3, 0.9 mg/m3 of Mn), and high dose of total suspended particulate (62 mg/m3 TSP, 1.95 mg/m3 of Mn). The primates were exposed to manual metal-arc stainless steel (MMA-SS) welding fumes for 2 h/day in an inhalation chamber system equipped with an automatic fume generator for 6 mo. Magnetic resonance imaging (MRI) studies of the basal ganglia were conducted before the initiation of exposure and thereafter every month. During the exposure, the blood chemistry was monitored every 2 wk and the concentrations of metal components in the blood were measured every 2 wk and compared with ambient manganese concentrations. The manganese concentrations in the blood did not show any significant increase until after 2 mo of exposure, and then reached a plateau after 90 days of exposure, showing that an exposure period of at least 60 days was required to build up the blood Mn concentration. Furthermore, as the blood Mn concentration continued to build, a continued decrease in the MRI T1 relaxation time in the basal ganglia was also detected. These data suggested that prolonged inhalation of welding fumes induces a high MRI T1 signal intensity with an elevation of the blood manganese level. The presence of a certain amount of iron or other metals, such as Cr and Ni, in the inhaled welding fumes via inhalation was not found to have a significant effect on the uptake of Mn into the brain or the induction of a high MRI T1 signal intensity.</P>
Lee, Jaemin,Kang, Tae Heung,Yoo, Wonbeak,Choi, Hyunji,Jo, Seongyea,Kong, Kyungsu,Lee, Sang-Rae,Kim, Sun-Uk,Kim, Ji-Su,Cho, Duck,Kim, Janghwan,Kim, Jeong-Yoon,Kwon, Eun-Soo,Kim, Seokho AMERICAN ASSOCIATION FOR CANCER RESEARCH 2019 CANCER IMMUNOLOGY RESEARCH Vol.7 No.2
<P>The homing of natural killer (NK) cells is often inhibited by pancreatic cancer tumors. A mesothelin-directed antibody conjugated to a cleavable NK cell—recruiting chemokine increased NK-cell infiltration of PDAC tumors, reduced tumor burden, and improved survival.</P><P>Natural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer. Despite the usefulness of NK cells, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antitumor immune response. One approach to successful cancer immunotherapy is to increase trafficking of NK cells to tumor tissues. Here, we developed an antibody-based NK-cell–homing protein, named NK-cell–recruiting protein-conjugated antibody (NRP-body). The effect of NRP-body on infiltration of NK cells into primary and metastatic pancreatic cancer was evaluated <I>in vitro</I> and in murine pancreatic ductal adenocarcinoma models. The NRP-body increased NK-cell infiltration of tumors along a CXCL16 gradient (CXCL16 is cleaved from the NRP-body by furin expressed on the surface of pancreatic cancer cells). CXCL16 induced NK-cell infiltration by activating RhoA via the ERK signaling cascade. Administration of the NRP-body to pancreatic cancer model mice increased tumor tissue infiltration of transferred NK cells and reduced the tumor burden compared with that in controls. Overall survival of NRP-body–treated mice (even the metastasis models) was higher than that of mice receiving NK cells alone. In conclusion, increasing NK-cell infiltration into tumor tissues improved response to this cancer immunotherapy. The combination of an NRP-body with NK-cell therapy might be useful for treating pancreatic cancer.</P>
Sang-Yong Son,Nam-Joon Yi,Geun Hong,Hyeyoung Kim,Min Su Park,Young Rok Choi,Kyung-Suk Suh,Duck-Woo Kim,Seung-Yong Jeong,Kyu-Joo Park,Jae-Gahb Park,Kuhn-Uk Lee 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.4
Backgrounds/Aims: Hepatic resection has only guaranteed long-term survival in patients with colorectal liver metastasis (CRLM) even in the era of effective chemotherapy. The definite role of neoadjuvant chemotherapy (NCT) is to improve outcomes of unresectable CRLMs, but it its role has not been defined for initially resectable CRLMs (IR-CRLMs). Methods: We reviewed the medical records of 226 patients, who had been diagnosed and treated for IR-CRLM between 2003 and 2008; the patients had the following pathologies: 10% had more than 4 nodules, 11% had tumors larger than 5 cm, and 61% had synchronous CRMLs. Among these patients, 20 patients (Group Y) were treated with NCT, and 206 (Group N) did not receive NCT according to their physician’s preference. The median follow-up time was 34.1 months. Results: The initial surgical plans were changed after NCT to further resection in 20% and to limited resection in 10% of 20 patients. Complication rates of Groups Y (30%) were indifferent from Group N (23%) (p=0.233), but intraoperative transfusions were more frequent in Group N (15%) than in Group Y (5%) (p=0.006). There was one case of hospital mortality (0.44%). Disease-free survival rates in Groups Y and N were 23% and 39%, respectively, and patient survival rates were 42% and 66% (p>0.05). By multivariate analysis, old age (≥60 years), differentiation of primary tumor (poorly/mucinous), resection margin involvement, and no adjuvant chemotherapy were associated with poor patient survival; the number of CRLMs (≥4) was associated with poor disease-free survival. Conclusions: NCT had neither a positive impact nor a negative impact on survival, even with intraoperative transfusion, as observed on operative outcomes for patients with IR-CRLM. Further study is required to elucidate the role of NCT for treatment of patient with IR-CRLMs. (Korean J Hepatobiliary Pancreat Surg 2011;15:206-217)
Impact of Family History on Prognosis of Patients with Sporadic Colorectal Cancer
Lee, Soo Young,Kim, Duck-Woo,Kang, Sung Il,Ihn, Myong Hoon,Oh, Heung-Kwon,Kang, Sung-Bum,Kim, Chang Hyun,Kim, Hyeong Rok,Kim, Young Jin,Ju, Jae Kyun Springer - Society of Surgical Oncology 2019 Annals of Surgical Oncology Vol.26 No.4
A Study on Breeding Ecology of Oystercatcher (Haematopus ostralegus) at Yubu Island
Sang-Duck Lee,Sun-Gyeum Kim,Sun-Ho No,Heui-Young Kang,Chung-Yeol Baek,Sam-Rae Cho 한국조류학회II 2014 한국조류학회지 Vol.21 No.2
A survey of the breeding ecology of Oystercatcher (Haematopus ostralegus) inhabiting in the Youbu Island was conducted from February to August 2006. The maximum number of Oystercatcher was 2,500 in February and the minimum 150 in July. The nests had outer diameter of 191.7±6.14 mm, inner diameter of 127.3±3.90 mm, depth of 34.2±16.2 mm, and had far from high tide of 617.2±302.0 cm. The laying of eggs starts at the early April with average incubation of 29 days. The total number of eggs laid was 168, and the clutch size was 2.47±0.89. The eggs had a major axis of 57.51±0.06 mm, minor axis of 39.15±0.34 mm, and the weight was 44.30±0.26 g. The hatching success rate among 168 eggs was 78.6% (132 eggs), and the fledgling success rate was 9.8% (13 eggs). During the period of study, there were disturbance factors on 105 occasions and it was accounted for 54.3% by other birds, 14.3% by fishermen, 10.5% by fish boat and 20.9% by other causes.