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MINIMALLY INVASIVE METHOD ORTHOTOPIC LUNG CANCER MOUSE MODEL FOLLOWED DIFFERENT CELL VOLUME
Jinsoo Lee,Young-Su Yang,Heung-Sik Seo,Soo-Nam Kim,Min-Sung Kang,Hyo-Seon Yang,Soonjin Kwon,Jae-Hwan Kim,Young-Ah Han,Seong-Jin Choi,Byeong-Chan Lee,Jin-Hee Lee,Hee-Jin Yu,Jeong-Ah Song,Kyung Jin Jung 한국환경독성학회 2009 한국독성학회 심포지움 및 학술발표회 Vol.2009 No.11
Processing SPARQL queries with regular expressions in RDF databases
Lee, Jinsoo,Pham, Minh-Duc,Lee, Jihwan,Han, Wook-Shin,Cho, Hune,Yu, Hwanjo,Lee, Jeong-Hoon BioMed Central 2011 BMC bioinformatics Vol.12 No.suppl2
<P><B>Background</B></P><P>As the Resource Description Framework (RDF) data model is widely used for modeling and sharing a lot of online bioinformatics resources such as Uniprot (dev.isb-sib.ch/projects/uniprot-rdf) or Bio2RDF (bio2rdf.org), SPARQL - a W3C recommendation query for RDF databases - has become an important query language for querying the bioinformatics knowledge bases. Moreover, due to the diversity of users’ requests for extracting information from the RDF data as well as the lack of users’ knowledge about the exact value of each fact in the RDF databases, it is desirable to use the SPARQL query with regular expression patterns for querying the RDF data. To the best of our knowledge, there is currently no work that efficiently supports regular expression processing in SPARQL over RDF databases. Most of the existing techniques for processing regular expressions are designed for querying a text corpus, or only for supporting the matching over the paths in an RDF graph.</P><P><B>Results</B></P><P>In this paper, we propose a novel framework for supporting regular expression processing in SPARQL query. Our contributions can be summarized as follows. 1) We propose an efficient framework for processing SPARQL queries with regular expression patterns in RDF databases. 2) We propose a cost model in order to adapt the proposed framework in the existing query optimizers. 3) We build a prototype for the proposed framework in C++ and conduct extensive experiments demonstrating the efficiency and effectiveness of our technique.</P><P><B>Conclusions</B></P><P>Experiments with a full-blown RDF engine show that our framework outperforms the existing ones by up to two orders of magnitude in processing SPARQL queries with regular expression patterns.</P>
Orthotopic Lung Cancer Mouse Model using the Minimally Invasive Method
Jinsoo Lee(이진수),Young-Su Yang,Heung-Sik Seo,Min-Sung Kang,Soo-Nam Kim,Seong-Jin Choi,Soonjin Kwon,Byeong-Chan Lee,Hyo-Seon Yang,Young-Ah Han,Hee-Jin Yu,Jeong-Doo Heo,Kyu-Hyuk Cho,Kyuhong Lee,Chang-Woo 한국실험동물학회 2009 한국실험동물학회 학술발표대회 논문집 Vol.2009 No.2
Joo, Jinsoo,Lee, Sun Jeong,Park, Dong Hyuk,Kim, Young Soo,Lee, Yeonhee,Lee, Cheol Jin,Lee, Seong-Rae IOP Pub 2006 Nanotechnology Vol.17 No.14
<P>The field emissive, electrical, magnetic, and structural characteristics of nickel (Ni) nanowires synthesized using the electrochemical deposition method with an alumina nanoporous template are reported. The synthesis and formation of Ni nanowires were confirmed by XRD, SEM, and HR-TEM experiments. Ferromagnetic hysteresis curves and the metallic temperature dependence of the current–voltage characteristics were observed for the Ni nanowire systems. The nanotip emitters of the field emission cells of the Ni nanowires after O<SUB>2</SUB> plasma treatment were easily patterned using the solution drop casting (SDC) method, in which the Ni nanowires were homogeneously dispersed in organic solvents, and then dropped and dried on an n-type doped Si substrate as the cathode. For the O<SUB>2</SUB> plasma treated Ni nanowires, we observed that the inhomogeneous oxidized layer on their surface was reduced, that the current density of the field emission cell increased from ∼3.0 × 10<SUP>−9</SUP> to ∼1.0 × 10<SUP>−3</SUP> A cm<SUP>−2</SUP> due to field emission, and that the lowest threshold electric field was ∼4 V µm<SUP>−1</SUP>. The field enhancement factor was estimated as ∼1300 for the O<SUB>2</SUB> plasma treated Ni nanowires. The evolution of the field emission obtained from the phosphor screen was observed at different applied electric fields. </P>
Jinsoo Lee,Young-Ah Han,Hyo-Seon Yang,Jeong-Ah Song,Young-Su Yang,Soonjin Kwon,Min-Sung Kang,Kyuhong Lee,Jeong-Doo Heo,Kyu-Hyuk Cho,Chang Woo Song 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.4
The incidence rate of lung cancer is continually increasing, and lung cancer is the leading cause of cancer-related death worldwide. Nevertheless, few therapeutic methods are available for lung cancer. Therefore, establishing appropriate lung cancer animal models is important to investigate mechanismsand to evaluate new drugs for lung cancer. In the present study, we transplanted non-small cell lung cancer A549 human adenocarcinoma cells (2×10⁴, 2.0×10?, and 2.0×10? cells) into the right lobe of BALB/c nude mice via the intercostal space to develop an orthotopic lung cancer animal model that is minimally invasive and similar to human lung cancer. We then investigated the incidence rate and severity of lung cancer according to the A549 cell number (2×10⁴, 2.0×10?, and 2.0×10? cells) and transplantation periods (4~23 days). Lung cancer development was confirmed with gross examination, which was supported by histopathological examination. These results indicate that the incidence rate and severity of lung cancer was increased depending on the number of transplanted cells and transplantation period which the cell number and duration are increasing risk of lung cancer. Thus, this study can provide appropriate reference data to develop an orthotopic lung cancer animal model using the nonsmall cell lung cancer A549 cell line for researching mechanisms and evaluating candidate drugs, including various approaches for treating lung cancer.
Lee, Jinsoo,Jeong, Ji-Seong,Cho, Kyung-Jin,Moon, Kyeong-Nang,Kim, Sang Yun,Han, Byungcheol,Kim, Yong-Soon,Jeong, Eun Ju,Chung, Moon-Koo,Yu, Wook-Joon The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.2
Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods: This study was conducted to evaluate the potential toxicological effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague-Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague-Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on maternal function and embryo-fetal development. Results and conclusion: No test item-related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have toxicological potential on developmental and reproductive functions. Therefore, no observed adverse effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.