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Seo, Yelim,Kim, Young-Won,Lee, Donghee,Kim, Donghyeon,Kim, Kyoungseo,Kim, Taewoo,Baek, Changyeob,Lee, Yerim,Lee, Junhyeok,Lee, Hosung,Jang, Geonwoo,Jeong, Wonyeong,Choi, Junho,Hwang, Doegeun,Suh, Jung The Korean Society of Pharmacology 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.2
Far-infrared rays (FIR) are known to have various effects on atoms and molecular structures within cells owing to their radiation and vibration frequencies. The present study examined the effects of FIR on gene expression related to glucose transport through microarray analysis in rat skeletal muscle cells, as well as on mitochondrial biogenesis, at high and low glucose conditions. FIR were emitted from a bio-active material coated fabric (BMCF). L6 cells were treated with 30% BMCF for 24 h in medium containing 25 or 5.5 mM glucose, and changes in the expression of glucose transporter genes were determined. The expression of GLUT3 (Slc2a3) increased 2.0-fold (p < 0.05) under 5.5 mM glucose and 30% BMCF. In addition, mitochondrial oxygen consumption and membrane potential (ΔΨm) increased 1.5- and 3.4-fold (p < 0.05 and p < 0.001), respectively, but no significant change in expression of Pgc-1a, a regulator of mitochondrial biogenesis, was observed in 24 h. To analyze the relationship between GLUT3 expression and mitochondrial biogenesis under FIR, GLUT3 was down-modulated by siRNA for 72 h. As a result, the ΔΨm of the GLUT3 siRNA-treated cells increased 3.0-fold (p < 0.001), whereas that of the control group increased 4.6-fold (p < 0.001). Moreover, Pgc-1a expression increased upon 30% BMCF treatment for 72 h; an effect that was more pronounced in the presence of GLUT3. These results suggest that FIR may hold therapeutic potential for improving glucose metabolism and mitochondrial function in metabolic diseases associated with insufficient glucose supply, such as type 2 diabetes.
자율주행용 고정밀 지도를 위한 차로단위 교통정보 제공방안에 관한 연구
백창엽(Changyeob Baek),박수홍(Soohong Park),강우빈(Woobin Kang),이은일(Eunin Lee) 한국자동차공학회 2018 한국자동차공학회 부문종합 학술대회 Vol.2018 No.6
This paper propose a method to provide lane-based traffic information by improving the previously constructed node-link system. The link structure set along the centerline of the road has limitations to support the route planning and route guidance of lane level for autonomous driving. Therefore, this study analyzes domestic and international standards and research cases, and applied the method to add / expand lane links to the existing node-link so as to be compatible with the existing node-link system. The additional and extended feature consists of seven attributes: LANE_ID, LINK_ID, F_NODE, T_NODE, GROUP_ID, LANE_NO, and LANES. It can be linked with previous node-link system through by foreign key. Moreover, additional and extended can be possible to provide traffic information of lane level.
Kim Mi-Yeon,Kim Mi Jeong,Lee Changyeob,Lee Juwon,Kim Sang Seong,Hong Sungho,Kim Hyoung Tae,Seo Jinsoo,Yoon Ki-Jun,Han Sungho 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Enhancing adult neurogenesis in the brain has been suggested as a potential therapeutic strategy for AD. We developed a screening platform, ATRIVIEW®, for molecules that activate neuronal differentiation of adult mouse NSCs. The most potent hit from an FDA-approved drug library was SNR1611 (trametinib), a selective MEK1/2 inhibitor. We found that trametinib increases the levels of P15INK4b and Neurog2, suggesting a mechanism by which MEK1/2 inhibition induces neuronal differentiation. Oral administration of trametinib increased adult neurogenesis in the dentate gyrus and subventricular zone of the 5XFAD AD mouse model. Surprisingly, we also found that trametinib enhanced adult neurogenesis in the cortex. Consequently, trametinib rescued AD pathologies such as neuronal loss and cognitive impairment in 5XFAD mice. Finally, trametinib induced neurogenic differentiation of NSCs derived from AD patient iPSCs, which suggests its potential therapeutic application. Altogether, we suggest that restoration of endogenous adult neurogenesis by trametinib may be a promising therapeutic approach to AD.