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Ah Young Lee,Bo Ra Hwang,Myoung Hee Lee,Sanghyun Lee,Eun Ju Cho 대한지역사회영양학회 2016 Nutrition Research and Practice Vol.10 No.3
BACKGROUND/OBJECTIVES: The accumulation of amyloid-β (Aβ) in the brain is a hallmark of Alzheimer’s disease (AD) and plays a key role in cognitive dysfunction. Perilla frutescens var. japonica extract (PFE) and its major compound, rosmarinic acid (RA), have shown antioxidant and anti-inflammatory activities. We investigated whether administration of PFE and RA contributes to cognitive improvement in an Aβ25-35-injected mouse model. MATERIALS/METHODS: Male ICR mice were intracerebroventricularly injected with aggregated Aβ25-35 to induce AD. Aβ25-35-injected mice were fed PFE (50 mg/kg/day) or RA (0.25 mg/kg/day) for 14 days and examined for learning and memory ability through the T-maze, object recognition, and Morris water maze test. RESULTS: Our present study demonstrated that PFE and RA administration significantly enhanced cognition function and object discrimination, which were impaired by Aβ25-35, in the T-maze and object recognition tests, respectively. In addition, oral administration of PFE and RA decreased the time to reach the platform and increased the number of crossings over the removed platform when compared with the Aβ25-35-induced control group in the Morris water maze test. Furthermore, PFE and RA significantly decreased the levels of nitric oxide (NO) and malondialdehyde (MDA) in the brain, kidney, and liver. In particular, PFE markedly attenuated oxidative stress by inhibiting production of NO and MDA in the Aβ25-35-injected mouse brain. CONCLUSIONS: These results suggest that PFE and its active compound RA have beneficial effects on cognitive improvement and may help prevent AD induced by Aβ.
Potter syndrome - Bilateral renal agenesis with club foot : An autopsy case
( Ah-ra Lee ),( Sung-eun Park ),( Ji-young Kim ),( Young-shin Han ),( In-cheol Jung ),( Su-mi Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Potter's syndrome is a rare condition occurring at a frequency of 1:2000 to 1:5000 fetuses. Here we present a case of Potter syndrome with bilateral renal agenesis with low-set abnormal ears, right ventricular hypertrophy with club foot diagnosed on autopsy. A 28 year-old primi-para woman was referred from local clinic at pregnancy 20weeks and 6days for decreased amniotic fluid index. She had no underlying disease or previous operation history except laparoscopic ovarian cystectomy done three years ago. She had never smoked cigarettes and exposed to drinking alcohols during pregnancy. Under transabdominal sonography, the amniotic fluid was nearly absent. On the day of arrival, amniocentesis and 300cc of amnioinfusion was done. The amniotic fluid normalized after amniotic infusion. Chromosomal study was performed by using Giemsa-Trypsin-Leishman Banding technique, it is confirmed to have no numerical or structural chromosome abnormalities under the microscope of 550 resolving power We performed target sonography. Estimated fetal body weight was approximately 323g at the top 20 percentile on the graph. Under doppler sonography, bladder filling and renal arteries were not visible. Lying down adrenal sign with empty renal fossa and right ventricular hypertrophy was seen. The chest was 19weeks sized suggesting pulmonary hypoplasia. For religious reason, she decided to continue pregnancy. One week later, she admitted via emergency department due to labor pain with amniotic membrane rupture. A 350gram weighted stillborn male baby was delivered by spontaneous vaginal delivery. < Autopsy finding > The stillborn baby had no kidney, ureter, bladder and showed low-set ears, suppressed mandible and club foot. When the antenatal sonography shows severely decreased amniotic fluid with intact amnion, we have to suspect urinary anomaly. If severe oligohydramnios, non-visualization of the bladder and empty renal fossa is seen through sonography, it reflects bilateral renal agenesis.
HS 1-Associated Protein X-1 Is Cleaved by Caspase-3 During Apoptosis
Lee, Ah young,Lee, Yoo ra,Park, Yun kyung,Bae, Kwang hee,Cho, Sa yeon,Lee, Do hee,Park, Byoung chul,Kang, Sung hyun,Park, Sung goo Korean Society for Molecular Biology 2008 Molecules and cells Vol.25 No.1
Caspase-3 (CASP3) plays a key role in apoptosis. In this study, HAX-1 was identified as a new substrate of CASP3 during apoptosis. HAX-1 was cleaved by CASP3 during etoposide-(ETO) induced apoptosis, and this event was inhibited by a CASP3-specific inhibitor. The cleavage site of HAX-1, at Asp<sup>127</sup>, was located using N-terminal amino acid sequencing of in vitro cleavage products of recombinant HAX-1. Overexpression of HAX-1 inhibited ETO-induced apoptotic cell death. It also inhibited CASP3 activity. Together, these results suggest that HAX-1, a substrate of CASP3, inhibits the apoptotic process by inhibiting CASP3 activity.
Effects of anesthetic protocol on normal canine brain uptake of 18F-FDG assessed by PET/CT.
Lee, Min Su,Ko, Jeff,Lee, Ah Ra,Lee, In Hye,Jung, Mi Ae,Austin, Brenda,Chung, Hyunwoo,Nahm, Sangsoep,Eom, Kidong The College 2010 Veterinary Radiology and Ultrasound Vol.51 No.2
<P>The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane, (2) medetomidine/pentobarbital, (3) xylazine/ketamine, and (4) medetomidine/tiletamine-zolazepam in a randomized cross-over design. The standard uptake value (SUV) of FDG was obtained in the frontal, parietal, temporal and occipital lobes, cerebellum, brainstem and whole brain, and compared within and between anesthetic protocols using the Friedman test with significance set at P < 0.05. Significant differences in SUVs were observed in various part of the brain associated with each anesthetic protocol. The SUV for the frontal and occipital lobes was significantly higher than in the brainstem in all dogs. Dogs receiving medetomidine/tiletamine-zolazepam also had significantly higher whole brain SUVs than the propofol/isoflurane group. We concluded that each anesthetic protocol exerted a different regional brain glucose uptake pattern. As a result, when comparing brain glucose uptake using PET/CT, one should consider the effects of anesthetic protocols on different regions of the glucose uptake in the dog's brain.</P>
Full-Length Genomic Sequence of Subgenotype IIIA Hepatitis A Virus Isolate in Republic of Korea
Lee, Ah-Ra,Lee, Sung-Geun,Kang, Lae-Hyung,Jheong, Weon-Hwa,Paik, Soon-Young Hindawi Publishing Corporation 2013 BioMed research international Vol.2013 No.-
<P>Hepatitis A virus is known to cause acute hepatitis and has significant implications for public health throughout the world. In the Republic of Korea, the number of patients with hepatitis A virus infection has been increasing rapidly since 2006. In this study, the Kor-HAV-F strain was identified as subgenotype IIIA by RT-PCR, and its identity was confirmed by nucleotide sequencing and alignment analysis. Moreover, detailed phylogenetic analysis indicated that the Kor-HAV-F strain clustered into subgenotype IIIA, including strains isolated in Japan, Norway, and India. The entire amino acid sequence of the VP1 and 2A regions was compared with that of the reference strains isolated in various countries. We found 2 amino acid changes (T168A and L96P, resp.) in the VP1 and 2A regions, which had not been found in any other hepatitis A virus strain. To our knowledge, this study is the first to report the full-length sequence of a hepatitis A virus isolated in the Republic of Korea.</P>
( Ah Young Lee ),( Ting Ting Wu ),( Bo Ra Hwang ),( Jaemin Lee ),( Myoung Hee Lee ),( Sanghyun Lee ),( Eun Ju Cho ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.3
Neurodegenerative diseases are often associated with oxidative damage in neuronal cells. This study was conducted to investigate the neuro-protective effect of methanolic (MeOH) extract of Perilla frutescens var. japonica and its one of the major compounds, rosmarinic acid, under oxidative stress induced by hydrogen peroxide (H2O2) in C6 glial cells. Exposure of C6 glial cells to H2O2 enhanced oxidative damage as measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and thiobarbituric acid-reactive substance assays. The MeOH extract and rosmarinic acid prevented oxidative stress by increasing cell viability and inhibiting cellular lipid peroxidation. In addition, the MeOH extract and rosmarinic acid reduced H2O2-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the transcriptional level. Moreover, iNOS and COX-2 protein expression was down-regulated in H2O2-indcued C6 glial cells treated with the MeOH extract and rosmarinic acid. These findings suggest that P. frutescens var. japonica and rosmarinic acid could prevent the progression of neurodegenerative diseases through attenuation of neuronal oxidative stress.
Lee, Ok-Jeong,Kim, Su-Jin,Sohn, Young-Bae,Park, Hyung-Doo,Lee, Soo-Youn,Kim, Chi-Hwa,Ko, Ah-Ra,Yook, Yeon-Joo,Lee, Su-Jin,Park, Sung-Won,Kim, Se-Hwa,Cho, Sung-Yoon,Kwon, Eun-Kyung,Han, Sun-Ju,Jin, Don The Korean Pediatric Society 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.3
Purpose: Mucopolysaccharidosis type II (MPS II or Hunter syndrome) is a rare lysosomal storage disorder caused by iduronate-2-sulfatase (IDS) deficiency. MPS II causes a wide phenotypic spectrum of symptoms ranging from mild to severe. IDS activity, which is measured in leukocyte pellets or fibroblasts, was reported to be related to clinical phenotype by Sukegawa-Hayasaka et al. Measurement of residual plasma IDS activity using a fluorometric assay is simpler than conventional measurements using skin fibroblasts or peripheral blood mononuclear cells. This is the first study to describe the relationship between plasma IDS activity and clinical phenotype of MPS II. Methods: We hypothesized that residual plasma IDS activity is related to clinical phenotype. We classified 43 Hunter syndrome patients as having attenuated or severe disease types based on clinical characteristics, especially intellectual and cognitive status. There were 27 patients with the severe type and 16 with the attenuated type. Plasma IDS activity was measured by a fluorometric enzyme assay using 4-methylumbelliferyl- ${\alpha}$-iduronate 2-sulphate. Results: Plasma IDS activity in patients with the severe type was significantly lower than that in patients with the attenuated type ($p$=0.006). The optimal cut-off value of plasma IDS activity for distinguishing the severe type from the attenuated type was 0.63 $nmol{\cdot}4hr^{-1}{\cdot}mL^{-1}$. This value had 88.2% sensitivity, 65.4% specificity, and an area under receiver-operator characteristics (ROC) curve of 0.768 (ROC curve analysis; $p$=0.003). Conclusion: These results show that the mild phenotype may be related to residual lysosomal enzyme activity.