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Kim, Sang-Cheol,Park, Soo-Young,Hyoun, Jae-Hee,Cho, Hee-Yeong,Lee, Young-Jae,Kang, Ji-Hoon,Lee, Young-Ki,Park, Doek-Bae,Yoo, Eun-Sook,Kang, Hee-Kyoung Korean Society of ToxicologyKorea Environmental Mu 2004 Toxicological Research Vol.20 No.4
The present study was undertaken to investigate the effects of mistletoe (Viscum album var. coloratum) growing on Carpinus laxiflora BL. on proliferation and differentiation of HL-60 acute promyelocytic leukemia cells. Aqueous extract and its $(NH_2)_2SO_4$ saturated fractions of the mistletoe exhibited potent anti-proliferation activity against HL-60 cells. Moreover, when HL-60 cells were treated with 0~30% and 30~70% $(NH_2)_2SO_4$ saturated fractions of the mistletoe, HL-60 expressed CD 66b or CD 14 cell surface antigens and showed activity to reduce nitroblue tetrazolium, indicating that mistletoe induces the differentiation of HL-60 into granulocytes or monocytes. To understand how mistletoe induces the differentiation, we investigated the expression of molecules for modulating the proliferation and differentiation of leukemia cells, such as c-Myc and myeloblastin. The 0~30% $(NH_2)_2SO_4$ saturated fraction of the mistletoe reduced the mRNA levels of c-Myc and myeloblastin in a time-dependent manner. The results indicate that the mistletoe induces the differentiation of HL-60 cells via the decrease of c-Myc and myeloblastin expressions. Thus, it is suggested that mistletoe has a therapeutic potential for the treatment of acute promyelocytic leukemia.
Effect of KIOM-79 against mitochondrial damage induced by streptozotocin in pancreatic beta-cells.
Kang, Kyoung Ah,Kim, Jin Sook,Zhang, Rui,Piao, Mei Jing,Ko, Dong Ok,Wang, Zhi Hong,Heo, Young Jun,Park, Doek Bae,Maeng, Young Hee,Hyun, Jin Won Taylor Francis 2009 Journal of toxicology and environmental health. Pa Vol.72 No.20
<P>The present study examined the effects of KIOM-79 on streptozotocin (STZ)-induced mitochondrial oxidative stress in rat pancreatic beta-cells (RINm5F). KIOM-79 is a mixture of plant extracts from parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix, and Euphorbiae radix. A marked increase in mitochondrial reactive oxygen species (ROS) was observed in STZ induced diabetic cells, which returned to control conditions after KIOM-79 treatment. Mitochondrial manganese superoxide dismutase (Mn SOD) activity and its protein expression were downregulated by STZ treatment but upregulated by KIOM-79 treatment. In addition, KIOM-79 treatment restored the loss of the mitochondrial membrane potential (Deltapsi) produced by STZ treatment. KIOM-79 induced an increase in Bcl-2 and a decrease in phospho Bcl-2 and Bax, which are related to permeability of the mitochondrial membrane. Further, KIOM-79 inhibited the translocation of cytochrome c from the mitochondria to the cytosol and elevated the ATP level, which was reduced by STZ treatment. These results suggest that KIOM-79 exhibits a protective effect through activation of antioxidant defense mechanisms and by attenuation of mitochondrial dysfunction in STZ-induced diabetic cells.</P>
Sang-Cheol Kim,Soo-Young Park,Jae-Hee Hyoun,Hee-Yeong Cho,Young-Jae Lee,Ji-Hoon Kang,Young-Ki Lee,Doek-Bae Park,Eun-Sook Yoo,Hee-Kyoung Kang 한국독성학회 2004 Toxicological Research Vol.20 No.4
The present study was undertaken to investigate the effects of mistletoe (Viscum album var. coloratum) growing on Carpinus laxiflora BL. on proliferation and differentiation of HL-60 acute promyelocytic leukemia cells. Aqueous extract and its (NH₄)₂SO₄ saturated fractions of the mistletoe exhibited potent anti-proliferation activity against HL-60 cells. Moreover, when HL-60 cells were treated with 0~30% and 30~70% (NH₄)₂SO₄ saturated fractions of the mistletoe, HL-60 expressed CD 66b or CD 14 cell surface antigens and showed activity to reduce nitroblue tetrazolium, indicating that mistletoe induces the differentiation of HL-60 into granulocytes or monocytes. To understand how mistletoe induces the differentiation, we investigated the expression of molecules for modulating the proliferation and differentiation of leukemia cells, such as c-Myc and myeloblastin. The 0~30% (NH₄)₂SO₄ saturated fraction of the mistletoe reduced the mRNA levels of c-Myc and myeloblastin in a time-dependent manner. The results indicate that the mistletoe induces the differentiation of HL-60 cells via the decrease of c-Myc and myeloblastin expressions. Thus, it is suggested that mistletoe has a therapeutic potential for the treatment of acute promyelocytic leukemia.
Estimation of Radioactive Inventory for a major component of Reactor in Decommissioning
Hak-soo Kim,Ki-doo Kang,Kyoung-doek Kim,Chan-Woo Jeong 한국방사성폐기물학회 2004 방사성폐기물학회지 Vol.2 No.1
고리 1호기 원자로압력용기의 중성자속과 방사화생성물 재고량을 계산하기 위하여 DORT 코드와 ORIGEN2 코드를 사용하였다. DORT 코드를 이용해 중성자속을 계산하기 위하여 노심을 중앙부터 원자로압력용기까지 방위각 방향으로 94 mesh로 분할하였다. 원자로압력용기 영역의 중성자속을 이용하여 주요 핵종의 단면적을 재계산하였다. 원자로압력용기의 경우, Fe, Co, Ni 및 Ni의 핵종이 총 방사능의 약 95%를 차지하였으며, 해체 후 50년 이상 냉각후의 총 방사능은 정지시점과 비교하여 약 0.2% 이하로 감소하는 것으로 평가되었다. 총 중량이 210 ton인 원자로압력용기의 총 방사능은 5.25GBq이었다. ORIGEN2 계산 결과를 검증하기 위하여 고리 1호기 원자로압력용기의 계산값과 실측값에 대한 비교 검증을 수행하였으며, 그 결과는 서로 일치함을 확인할 수 있었다. DORT and ORIGEN2 code were used for calculation of neutron flux and inventory in reactor pressure vessel(RPV) of Kori unit-1, To calculate neutron flux using DORT code, the reactor was divided into 94 mesh from the center of core to RPV and from 0 to 45 degree along the azimuth. The cross-sections of main nuclides were recalculated using neutron flux in the RPV region. The results showed that 95% of the total activity in RPV came from the nuclides of Fe, Co, Ni and Ni. And the total activity with cooling of more than 50 years after decommissioning was no more than 0.2% of at the time of shutdown. Considering the weight of RPV is 210 tons, the initial total activity of RPV reached 5.2510 GBq. To verify results of ORIGEN2 calculation, comparison between calculated and measured value at RPV of Kori unit-1 was peformed. The comparison results showed a good agreement.
Hyun, Jae-Hee,Kang, Jung-Il,Kim, Sang-Cheol,Kim, Elvira,Kang, Ji-Hoon,Kwon, Jung-Mi,Park, Doek-Bae,Lee, Young-Jae,Yoo, Eun-Sook,Kang, Hee-Kyoung Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol. No.
The present study investigated the anti-proliferative and chemosensitizing effects of Crinum asiaticum var. japonicum against multi-drug resistant (MDR) cancer cells. The 80% methanol extract, chloroform ($CHCl_3$) fraction and butanol (BuOH) fraction of C. asiaticum inhibited the growth of mitoxantrone (MX) resistant HL-60 (HL-60/MX2) cells. When HL-60/MX2 cells were treated with the $CHCl_3$ and BuOH fractions, DNA ladder and sub-G1 hypodiploid cells were observed. Furthermore, the fractions reduced BcI-2 mRNA levels, whereas Bax mRNA levels were increased. These results suggest that the inhibitory effect of C. asiaticum on the growth of the HL-60/MX2 cells might arise from the induction of apoptosis. Treatment of HL-60/MX2 cells with the fractions markedly decreased the mRNA levels of the multi-drug resistance protein-1 and breast cancer resistance protein. The $CHCl_3$ fraction and hexane fraction increased MX accumulation in HL-60/MX2 cells. These results imply that the $CHCl_3$ fraction of C. asiaticum plays a pivotal role as a chemosensitizer. We suggest that components of C. asiaticum might have a therapeutic potential for the treatment of MDR leukemia.
Jae-Hee Hyun,Jung-Il Kang,Sang-Cheol Kim,Elvira Kim,Ji-Hoon Kang,Jung-Mi Kwon,Doek-Bae Park,Young-Jae Lee,Eun-Sook Yoo,Hee-Kyoung Kang 한국독성학회 2008 Toxicological Research Vol.24 No.1
The present study investigated the anti-proliferative and chemosensitizing effects of Crinum asiaticum var. japonicum against multi-drug resistant (MDR) cancer cells. The 80% methanol extract, chloroform (CHCl₃) fraction and butanol (BuOH) fraction of C. asiaticum inhibited the growth of mitoxantrone (MX) resistant HL-60 (HL-60/MX2) cells. When HL-60/MX2 cells were treated with the CHCl₃ and BuOH fractions, DNA ladder and sub-G1 hypodiploid cells were observed. Furthermore, the fractions reduced Bcl-2 mRNA levels, whereas Bax mRNA levels were increased. These results suggest that the inhibitory effect of C. asiaticum on the growth of the HL-60/MX2 cells might arise from the induction of apoptosis. Treatment of HL-60/MX2 cells with the fractions markedly decreased the mRNA levels of the multi-drug resistance protein-1 and breast cancer resistance protein. The CHCl₃ fraction and hexane fraction increased MX accumulation in HL-60/MX2 cells. These results imply that the CHCl₃ fraction of C. asiaticum plays a pivotal role as a chemosensitizer. We suggest that components of C. asiaticum might have a therapeutic potential for the treatment of MDR leukemia.
Verification of Pilot Scale Soil Washing Equipment on Nuclear Power Plant Soil
Jung-kwon Son,Ki-doo Kang,Hak-soo Kim,Kyoung-rock Park,Kyoung-doek Kim 한국방사성폐기물학회 2004 방사성폐기물학회지 Vol.2 No.4
원전의 정상운전이나 해체시 발생될 수 있는 토양의 제염을 위한 토양제염장치를 개발하였으며 실증 실험을 수행하였다. 제염장치를 이용한 제염실험을 종합해본 결과 제염조건에 큰 상관없이 이상의 제염율을 얻을 수 있었다. 방사능 준위 및 토양입도에 의한 실험결과를 보면 낮은 방사능 농도 및 고입도의 제염율이 다소 높음을 알 수 있었다. 제염용액과 토양질량의 비에 따른 제염율은 제염제 부피를 두배로 높였을 경우 방사능 농도가 높은 경우에 큰 것으로 나타났다. 반복 제염은 의 다소 작은 입자에 더욱 효과적으로, 제염이 어려운 작은 입자의 반복제염시 방사능 저감 효과가 비교적 크게 나타났다. 본 오염토양 제염장치를 활용하면 원전에서 발생되는 오염토양의 방사능 농도를 줄일 뿐 아니라 처분양을 줄여 저장공간의 확보에 기여할 뿐만 아니라 향후 원전의 해체시에도 유용하게 활용될 수 있으리라 생각된다. Soil washing equipment was developed for decontamination of radioactively contaminated soil generated during normal operation or decommissioning and verification experiments were performed. Decontamination effciency above was achieved. In case of low radiation level and large particle size, decontamination efficiency was higher. According to the ratio of volume of water to soil quantity, decontamination efficiency was higher in case of high radiation level. Re-decontamination using decontaminated soil was effective in case of small particles. Using soil washing equipment, radioactivity of contaminated soil generated in nuclear power plant can be decreased and volume of soil for disposal can be decreased. And this equipment can be used in decommissioning.