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Ahn, Dong-Kuk,Kim, Kyo-Han,Yang, Eun-Kyung,Kim, Hyung-Jin,Park, Jae-Sik,Lee, Won-Jung The Official Publication of Korean Academy of Oral 1996 International Journal of Oral Biology Vol.20 No.1
This study was performed to investigate the mechanisms of the nucleus tractus solitarius (NTS)-induced pain modulation in the orofacial area and a possible interrelationship between the antinociceptive and cardiovascular responses in rats. After 15 nM glutamate or 160 pM acetylcholine was microinjected into the NTS, arterial pressure was decreased in 57±3 and 45±2 mmHg, and heart rate was also decreased in 78±7 and 33±4 beats/min, respectively. Digastric electromyogram (dEMG) evoked by noxious electrical stimulation in the palatal mucosa was suppressed by the NTS application of glutamate to 20±4% of the control. However, aCSF and acetylcholine did not affect the dEMG. Pentolinium blocked the depressor response resulting from the microinjection of 15 nM glutamate into the NTS, but had no significant effect on the suppression of dEMG response to NTS stimulation. Methysergide and phentolamine, but not naloxone, significantly inhibited the suppression of dEMG response to microinjection of glutamate into the NTS. These results suggest that the NTS is effective in the modulation of nociceptive transmission in orofacial area and have an interrelationship between antinociception and cardiovascular responses. The NTS-induced antinociception seems to be mediated by serotonergic and adrenergic pathways but not by opioid pathway.
Ahn, Jun-Ku,Kim, Hae-Won,Ahn, Kyung-Chan,Yoon, Soon-Gil,Son, Seung-Hyun,Jung, Hyung-Mi,Moon, Jin-Suck,Jin, Hyun-Joo,Lee, Seung-Eun,Lee, Jeong-Won,Chung, Yeoul-Kyo,Oh, Yong-Soo Taylor Francis 2007 Integrated ferroelectrics Vol.95 No.1
<P> B2Mg2/3Nb4/3O7 (BMN) thin films were deposited at low temperature (< 200°C) on Copper Clad Laminates (CCL) with various Ar/O2 flow ratios and film thicknesses by sputtering system. 200 nm-thick BMN thin films were deposited at Ar/O2 = 10: 10 had rms roughness of 54.3 ÅA, capacitance density of 155 nF/cm2 at 100 kHz, dissipation factor of 0.017 and leakage current density of ∼10- 5 at 3 V. Surface roughness of the BMN thin films increased a little with increasing the film thickness. However leakage current density decreased and the dielectric constant of that was maintained at 40.</P>
“Turn-on” fluorescent sensing with “reactive” probes
Eun Jun, Mi,Roy, Basab,Han Ahn, Kyo Royal Society of Chemistry 2011 Chemical communications Vol.47 No.27
<P>Chemical probes are valuable tools for the investigation of biochemical processes, diagnosis of disease markers, detection of hazardous compounds, and other purposes. Therefore, the development of chemical probes continues to grow through various approaches with different disciplines and design strategies. Fluorescent probes have received much attention because they are sensitive and easy-to-operate, in general. To realize desired selectivity toward a given analyte, the recognition site of a fluorescent probe is designed in such a way to maximize the binding interactions, usually through weak molecular forces such as hydrogen bonding, toward the analyte over other competing ones. In addition to such a supramolecular approach, the development of fluorescent probes that sense analytes through chemical reactions has witnessed its usefulness for achieving high selectivity, in many cases, superior to that obtainable by the supramolecular approach. Creative incorporations of the reactive groups to latent fluorophores have provided novel chemical probes for various analytes. In this feature article, we overview the recent progress in the development of turn-on fluorescent probes that are operating through chemical reactions triggered by target analytes. Various chemical reactions have been implemented in the development of many reactive probes with very high selectivity and sensitivity toward target analytes. A major emphasis has been focused on the type of chemical reactions utilized, with the hope that further explorations can be made with new chemical reactions to develop reactive probes useful for various applications.</P> <P>Graphic Abstract</P><P>The reaction-based approach has demonstrated to be valuable in the development of turn-on type fluorescent probes for various target analytes with high selectivity and sensitivity. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc00014d'> </P>
Determination of Eperisone in Human Plasma by Liquid Chromatography-ESI-Tandem Mass Spectrometry
Min Kyo Jeoung,Eun Sook Jeong,Nam Hee Kim,Chang-Soo Kim,Youn-Bok Chung,이영문,Su-Youn Ahn,Hwang-Eui Cho,Yong Hwa Lee,홍진태,문동철 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
A sensitive and selective method for the determination of 4’-ethyl-3-methyl-3-piperidinopropiophenone hydrochloride (eperisone hydrochloride) in human plasma was developed and validated. The procedure employed an internal standard and a solvent extraction step followed by chromatography on a Xterra C18 minibore column. Detection was by electrospray ionization tandem mass spectrometry with multiple reaction monitoring. The mass transitions of eperisone and tolperisone (IS) were m/z 260 → 98 and m/z 246 → 98, respectively. The method has a limit of detection of 0.1 pg/mL for eperisone based on the three times signal-tonoise value with a linear range from 0.01 to 10.0 ng/mL for the analyte. Extraction recovery was on average 98.6±7.2% (SD) for eperisone. The Intra- and inter-day assay accuracy ranged from 93 to 114% and precision (RSD) was better than 8.5%. The method was successfully employed to analyze plasma samples and evaluate pharmacokinetics of eperisone in healthy male volunteers.
( Shin Kyo Yoon ),( Jeong Eun Kim ),( Jin Hee Ahn ),( Kyung Hae Jung ),( Sung Bae Kim ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Everolimus (EVE) combined with an exemestane (EXE) have shown improved progression-free survival (PFS) in patients with hormone receptor-positive (HR+) advanced breast cancer (ABC) following treatment with nonsteroidal aromatase inhibitors. The aim of this study is to investigate the incidence and time course of EVE-related adverse events (AEs) in treatment with EVE+EXE for postmenopausal HR+ABC patients. Methods: A total 56 patients were retrospectively reviewed between Jan 2013 - Jun 2014. Primary end point was to demonstrate incidence and time course of EVE-related AEs. Secondary end points was to analysis for objective response rate (ORR) and factors associated with PFS. Results: The median follow-up duration was 3.4 months (0.47-15.0). The median age was 56 years (35-78), 73% of patients showed sensitivity to previous endocrine therapy. The most frequently reported all-grade AEs included class-effect related hyperglycemia (73.2%), hypercholesterolemia (69.6%), and stomatitis (57.1%). None of patients experienced non-infectious pneumonitis. The cumulative risks of stomatitis, rash, fatigue, and anorexia at 2 weeks and 6 weeks are shown at fi gure 1. Overall, there were 25.0% of dose reduction and 17.9% of dose interruption. The most common cause of dose reduction or interruption was stomatitis. The median PFS was 10.2 months and ORR was 23.2%. Factors associated with PFS were duration of most recent hormonal, positive status for progesterone receptor and lines of chemotherapy between EVE and EVE+EXE (fi gure 2). AEs such as stomatitis, rash, fatigue, and anorexia showed no association with PFS. Conclusions: Hyperglycemia, stomatitis, and fatigue were the most common AEs and stomatitis was the most common cause of dose reduction or interruption. Understanding the time course of class-effect AEs will help inform preventive and monitoring strategies as well as patient education.