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MONTE CARLO SIMULATION FOR CORRECTION OF IONIZATION CHAMBER WALL
Kurosawa, Tadahiro,Takata, Nobuhisa,Koyama, Yasuji Korean Association for Radiation Protection 2001 방사선방어학회지 Vol.26 No.3
In precise measurement of air kerma with cavity ionization chambers, the effect of wall attenuation and scatter are corrected by Kwall and that of nonuniformity by Knu. Using the EGS4 code, we calculated these two correction factors. Correction factors calculated for two different-sized cylindrical ionization chamber differ by up to 0.7% from those obtained by measurements.
Promotion of grain growth in NiFe<sub>2</sub>O<sub>4</sub> by annealing with oleic acid
Kurosawa, R.,Suzuki, T.,Nakayama, T.,Suematsu, H.,Niihara, K.,Jeong, Y.K.,Kim, K.H. Elsevier 2012 Current Applied Physics Vol.12 No.suppl2
For investigation of the grain-size dependence on magnetization, NiFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles were heated at 440 <SUP>o</SUP>C, 600 <SUP>o</SUP>C, 800 <SUP>o</SUP>C, and 1000 <SUP>o</SUP>C with and without oleic acid. It was recognized that the median diameter (D<SUB>50</SUB>) increased from 5.9 to 145.9 nm by the heat treatments from 440 to 1000 <SUP>o</SUP>C. In addition, it was confirmed that NiFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles after the heat treatment with oleic acid at 600 <SUP>o</SUP>C have higher grain growth rate than that after only heat treatment without oleic acid. It was deduced that NiFe<SUB>2</SUB>O<SUB>4</SUB> was dissolved in oleic acid, so that sintering speed became fast. From these results, it was concluded that the formally observed saturation magnetization increase in heat treated NiFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles with oleic acid was caused partly by grain growth enhancement with the presence of oleic acid.
Kurosawa, Yoshikazu The Korean Association of Immunobiologists 2009 Immune Network Vol.9 No.1
Although the success of trastuzumab and rituximab for treatment of breast cancer and non-Hodgkins lymphoma, respectively, suggests that monoclonal antibodies(mAbs) will become important therapeutic agents against a wider range of cancers, useful therapeutic Abs are not yet available for the majority of the human cancers because of our lack of knowledge of which antigens (Ags) are likely to become useful targets. We established a procedure for comprehensive identification of such Ags through the extensive isolation of human mAbs that may be therapeutic. Using the phage-display Ab library we isolated a large number of human mAbs that bind to the surface of tumor cells. They were individually screened by immunostaining, and clones that preferentially and strongly stained the malignant cells were chosen. The Ags recognized by those clones were isolated by immunoprecipitation and identified by mass spectrometry(MS). We isolated 2,114 mAbs with unique sequences and identified 25 distinct Ags highly expressed on several carcinomas. Of those 2,114 mAbs 434 bound to specifically to one of the 25 Ags. I am going to discuss how we could select proper target Ags for therapeutic Abs and candidate clones are therapeutic agents.
Prompt gamma detection for range verification in proton therapy
Shunsuke Kurosawa,Hidetoshi Kubo,Kazuki Ueno,Shigeto Kabuki,Satoru Iwaki,Michiaki Takahashi,Kojiro Taniue,Naoki Higashi,Kentaro Miuchi,Toru Tanimori,김도균,김종원 한국물리학회 2012 Current Applied Physics Vol.12 No.2
It is an on-going challenge to verify the proton range in situ during proton therapy. Since the protons stop in target tissue, measurement of gamma-rays emitted either promptly from nuclear de-excitation or in pair from positron annihilation is the feasible method to monitor the proton range in-vivo. Using the technique of gamma collimation, we empirically demonstrated that the proton range and prompt gamma distribution are well correlated in the therapy energy range, and that measuring prompt gammas is a viable method for the clinical application. However, this collimation technique appears not to be applicable to passively scattered proton beams. The device chosen for gamma imaging in 2D is an electron tracking Compton camera, which images single-emission photons employing a gas chamber to induce Compton scattering. Images of prompt gammas were attained at the proton beam energy of 140 MeV. Measurements showed that gamma image in the energy range of 800e2000 keV provides a better match with the proton range compared to the image by lower energy gammas.
Ge Fraction Dependence of Al-Induced Crystallization of SiGe at Low Temperatures
Masashi Kurosawa,Yoshitaka Tsumura,Taizoh Sadoh,Masanobu Miyao 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.1
Al-induced crystallization of Si<SUB>1-x</SUB>Ge<SUB>x</SUB> films (x = 0 - 0.5) has been investigated by using amorphous SiGe (a-SiGe)/Al structures to realize polycrystalline SiGe (poly-Si) layers on insulating lms at low temperatures. For the Si sample, poly-Si oriented to the (111) direction was formed after annealing (450 ℃, 20 h) and inversion of Si/Al layers occurred completely. For Si<SUB>1-x</SUB>Ge<SUB>x</SUB> samples (x > 0), the layer exchange occurred in partial areas and poly-SiGe with the (111) orientation was grown only in the exchanged areas. The Ge fractions of the crystallized SiGe were almost the same as those of the initial a-SiGe layers. The diameters of the crystallized areas decreased from ∼100 (x = 0) to ∼30 μm (x = 0.5) with increasing Ge fraction. This technique can be utilized for the formation of high-quality poly-SiGe at low temperatures. Al-induced crystallization of Si<SUB>1-x</SUB>Ge<SUB>x</SUB> films (x = 0 - 0.5) has been investigated by using amorphous SiGe (a-SiGe)/Al structures to realize polycrystalline SiGe (poly-Si) layers on insulating lms at low temperatures. For the Si sample, poly-Si oriented to the (111) direction was formed after annealing (450 ℃, 20 h) and inversion of Si/Al layers occurred completely. For Si<SUB>1-x</SUB>Ge<SUB>x</SUB> samples (x > 0), the layer exchange occurred in partial areas and poly-SiGe with the (111) orientation was grown only in the exchanged areas. The Ge fractions of the crystallized SiGe were almost the same as those of the initial a-SiGe layers. The diameters of the crystallized areas decreased from ∼100 (x = 0) to ∼30 μm (x = 0.5) with increasing Ge fraction. This technique can be utilized for the formation of high-quality poly-SiGe at low temperatures.
Yoshikazu Kurosawa 대한면역학회 2009 Immune Network Vol.9 No.1
Although the success of trastuzumab and rituximab for treatment of breast cancer and non-Hodgkins lymphoma, respectively, suggests that monoclonal antibodies (mAbs) will become important therapeutic agents against a wider range of cancers, useful therapeutic Abs are not yet available for the majority of the human cancers because of our lack of knowledge of which antigens (Ags) are likely to become useful targets. We established a procedure for comprehensive identification of such Ags through the extensive isolation of human mAbs that may be therapeutic. Using the phage-display Ab library we isolated a large number of human mAbs that bind to the surface of tumor cells. They were individually screened by immunostaining, and clones that preferentially and strongly stained the malignant cells were chosen. The Ags recognized by those clones were isolated by immunoprecipitation and identified by mass spectrometry (MS). We isolated 2,114 mAbs with unique sequences and identified 25 distinct Ags highly expressed on several carcinomas. Of those 2,114 mAbs 434 bound to specifically to one of the 25 Ags. I am going to discuss how we could select proper target Ags for therapeutic Abs and candidate clones as therapeutic agents. Although the success of trastuzumab and rituximab for treatment of breast cancer and non-Hodgkins lymphoma, respectively, suggests that monoclonal antibodies (mAbs) will become important therapeutic agents against a wider range of cancers, useful therapeutic Abs are not yet available for the majority of the human cancers because of our lack of knowledge of which antigens (Ags) are likely to become useful targets. We established a procedure for comprehensive identification of such Ags through the extensive isolation of human mAbs that may be therapeutic. Using the phage-display Ab library we isolated a large number of human mAbs that bind to the surface of tumor cells. They were individually screened by immunostaining, and clones that preferentially and strongly stained the malignant cells were chosen. The Ags recognized by those clones were isolated by immunoprecipitation and identified by mass spectrometry (MS). We isolated 2,114 mAbs with unique sequences and identified 25 distinct Ags highly expressed on several carcinomas. Of those 2,114 mAbs 434 bound to specifically to one of the 25 Ags. I am going to discuss how we could select proper target Ags for therapeutic Abs and candidate clones as therapeutic agents.
MONTE CARLO SIMULATION FOR CORRECTION OF IONIZATION CHAMBER WALL
Tadahiro, Kurosawa,Nobuhisa, Takata,Yasuji, Koyama 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.3
In precise measurement of air kerma with cavity ionization chambers, the effect of wall attenuation and scatter are corrected by Kwall and that of nonuniformity by Knu. Using the EGS4 code, we calculated these two correction factors. Correction factors calculated for two different-sized cylindrical ionization chamber differ by up to 0.7% from those obtained by measurements.