Simulation of Impact from Stratospheric Ozone on Global Tropospheric Ozone Distribution with a Chemistry Transport Model: A Case Study during the 1990-1991 Period

Kuo-Ying Wang,Wen-Shung Kau 한국기상학회 2015 Asia-Pacific Journal of Atmospheric Sciences Vol.51 No.2

In this work we examine the effect of ozone (O3) from the stratosphere on the O3 levels in the troposphere. The tropopause is defined according to the potential vorticity (PV) and potential temperature distribution. Annual simulations were performed with and without stratospheric O3 in the model to access the impact of stratospheric O3 on tropospheric O3 distribution. Our results show that surface O3 over the tropical marine boundary layer is dominated by in-situ photochemistry in the troposphere. The maintenance of the inter-hemispheric asymmetry in ozone over the extra-tropical marine boundary layer is dominated by the transport of O3 from the stratosphere. Comparisons between the model and the surface measurements show that the model without stratospheric O3 exhibits a hemispheric summer maximum, emphasizing the contributions of transport of O3 and O3 producing precursors from continental regions during the summer months, whilst no clear spring O3 maximum is found. About 50%-80% of O3 in the lower troposphere over the northern hemisphere mid-latitudes are photochemically produced during the northern hemisphere summer. About 20%-40% is due to tropospheric photochemistry in the lower troposphere during the northern hemisphere spring. We conclude that O3 transported from the stratosphere is the dominating factor for the spring O3 maximum over the extra-tropical latitudes, while the photochemical ozone production is the dominating factor for O3 over the tropical marine boundary layer environments and over the land surface emission areas.

Long-term Multiple Chemical Exposure Assessment for a Thin Film Transistor Liquid Crystal Display (TFT-LCD) Industry

Wang, Ying-Fang,Wang, Shih-Min,Kuo, Yu-Chieh,Yoon, Chungsik,Wang, Ya-Fen,Tsai, Perng-Jy Taiwan Association for Aerosol Research 2017 Aerosol and air quality research Vol.17 No.11

Susceptibility Loci Associations with Prostate Cancer Risk in Northern Chinese Men

Wang, Na-Na,Xu, Yong,Yang, Kuo,Wei, Dong,Zhang, Yao-Guang,Liu, Ming,Shi, Xiao-Hong,Liang, Si-Ying,Sun, Liang,Zhu, Xiao-Quan,Yang, Yi-Ge,Tang, Lei,Zhao, Cheng-Xiao,Wang, Xin,Chen, Xin,Hui, Juan,Zhang, Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: KLK3 gene products, like human prostate-specific antigen (PSA), are important biomarkers in the clinical diagnosis of prostate cancer (PCa). G protein-coupled receptor RFX6, C2orf43 and FOXP4 signaling plays important roles in the development of PCa. However, associations of these genes with PCa in northern Chinese men remain to be detailed. This study aimed to investigate their impact on occurrence and level of malignancy. Methods: All subjects were from Beijing and Tianjin, including 266 cases with prostate cancer and 288 normal individuals as controls. We evaluated associations between clinical covariates (age at diagnosis, prostate specific antigen, Gleason score, tumor stage and aggressive) and 6 candidate PCa risk loci, genotyped by PCR- high resolution melting curve and sequencing methods. Results: Case-control analysis of allelic frequency of PCa associated with PCa showed that one of the 6 candidate risk loci, rs339331 in the RFX6 gene, was associated with reduced risk of prostate cancer (odds ratio (OR) = 0.73, 95% confidence interval (CI) =0.57-0.94, P = 0.013) in northern Chinese men. In addition, subjects with CX (CC+TC) genotypes had a decreased risk for prostrate cancer compared to those carrying the TT homozygote (OR =0.64, 95% CI = 0.45- 0.90, P = 0.008). The TT genotype of 13q22 (rs9600079, T) was associated with tumor stage (P=0.044, OR=2.34, 95% CI=0.94-5.87). Other SNPs were not significantly associated with clinical covariates in prostate cancer (P > 0.05). Conclusions. rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus in northern Chinese men.

Detrital zircon evidence for the antiquity of Taiwan

Ching-Ying Lan,Tadashi Usuki,Kuo-Lung Wang,Tzen-Fu Yui,Kazuaki Okamoto,Yuan-Hsi Lee,Takafumi Hirata,Yoshitaka Kon,Yuji Orihashi,Juhn G. Liou,Chun-Sun Lee 한국지질과학협의회 2009 Geosciences Journal Vol.13 No.3

In-situ U–Pb geochronology and Hf isotopic studies of zircons from the Pre-Tertiary basement complex and Eocene rocks of the Central Range of Taiwan were carried out to elucidate the history of detrital zircons older than 2.3 Ga. Zircons from the eastern Backbone Range and Eastern Central Range show Paleoproterozoic to late Neoarchean ages (2.3 –³2.5 Ga), whereas those from the Hsuehshan Range yield Neoarchean to Mesoarchean ages (2.6–3.2 Ga). The εHf(T) for the Paleoproterozoic to late Neoarchean zircons varies from –7.4 to +5.1, implying both juvenile crustal growth and reworking of old crusts. This dual origin could extend back to Mesoarchean–Paleoarchean (3.0–3.4 Ga) based on Hf isotopic model ages. Consistent but narrower εHf(T) values and Hf crustal model ages for zircons from Taiwan compared to Cathaysia suggest a possible common origin for these zircons, although Taiwan has a generally younger crustal evolution history than SE China.

Factors associated with future commitment and past history of human papilloma virus vaccination among female college students in northern Taiwan

Ping-Fen Kuo,Ying-Tse Yeh,Shuh-Jen Sheu,Tze-Fang Wang 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.3

Objective: To investigate factors influencing commitment to human papilloma virus (HPV) vaccination and prior vaccination among female college students in northern Taiwan. Methods: A quota sample of 400 female college students was recruited from nine colleges in northern Taiwan during March 2013. Of these, 398 completed the self administered questionnaire which was designed based on the health promotion model. Results: The results showed that factors associated with prior vaccination behavior were family history of gynecologic malignancy, ever being advised to get HPV vaccination, perceived barriers of action and perceived self-efficacy. Predictors for commitment to HPV vaccination in the next 6 months were the cost of vaccination, ever being advised to get HPV vaccination, perceived self-efficacy and situational influences. Perceived self-efficacy was significantly influenced by relationship status, past receipt of a recommendation for HPV vaccination and level of knowledge about HPV. Conclusion: When formulating vaccination policies, governmental or medical institutions should include these factors to promote vaccination Objective: To investigate factors influencing commitment to human papilloma virus (HPV) vaccination and prior vaccination among female college students in northern Taiwan. Methods: A quota sample of 400 female college students was recruited from nine colleges in northern Taiwan during March 2013. Of these, 398 completed the self administered questionnaire which was designed based on the health promotion model. Results: The results showed that factors associated with prior vaccination behavior were family history of gynecologic malignancy, ever being advised to get HPV vaccination, perceived barriers of action and perceived self-efficacy. Predictors for commitment to HPV vaccination in the next 6 months were the cost of vaccination, ever being advised to get HPV vaccination, perceived self-efficacy and situational influences. Perceived self-efficacy was significantly influenced by relationship status, past receipt of a recommendation for HPV vaccination and level of knowledge about HPV. Conclusion: When formulating vaccination policies, governmental or medical institutions should include these factors to promote vaccination.

High-speed Rotor’s Mechanical Design and Stable Suspension Based on Inertia-ratio for Gyroscopic Effect Suppression

Jiqiang Tang,Shaopu Zhao,Ying Wang,Kuo Wang 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.4

The rotor’s stable suspension is one of significant requirements for a magnetically suspended control momentum gyroscope (MSCMG), the gyroscopic effect is one of rotor’s prominent characteristics. To find out the relationship between rotor’s structure and gyroscopic effect, the inertia-ratio is originally presented and the relationship between the inertia-ratio and gyroscopic effects is researched. To improve the rotor’s suspension stability, the cross feedback control (CFC) method is researched based on modeling the suspension system of rotor and point out that only distributed PID control cannot make rotor’s suspension be stable due to the whirling. To suppress the gyroscopic effects more effectively and sustain the stable suspension within a wider speed range, a CFC method with pre-modulated gains is presented. All research results verify that this presented CFC method can effectively suppress the rotor’s vibration caused by its gyroscopic effects. Experimental results also indicate that a large inertiaratio is helpful to suppress rotor’s gyroscopic effect and can enhance the suspension stability to some extent. In addition, a rotor with angular momentum 200 Nms is designed for a MSCMG by optimizing its inertia-ratio. This paper will provide helpful hint for the research of high-speed rotor’s mechanical design and stable suspension.

Association of Six Susceptibility Loci with Prostate Cancer in Northern Chinese Men

Zhang, Yu-Rong,Xu, Yong,Yang, Kuo,Liu, Ming,Wei, Dong,Zhang, Yao-Guang,Shi, Xiao-Hong,Wang, Jian-Ye,Yang, Fan,Wang, Xin,Liang, Si-Ying,Zhao, Cheng-Xiao,Wang, Fei,Chen, Xin,Sun, Liang,Zhu, Xiao-Quan,Zh Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background/Aim: Six prostate cancer (PCa) susceptibility loci were identified in a genome-wide association study (GWAS) in populations of European decent. However, the associations of these 6 single-nucleotide polymorphisms (SNPs) with PCa has remained tobe clarified in men in Northern China. This study aimed to explore the loci associated with PCa risk in a Northern Chinese population. Methods: Blood samples and clinical information of 289 PCa patients and 288 controls from Beijing and Tianjin were collected. All risk SNPs were genotyped using polymerase chain reaction (PCR)-high resolution melting curve technology and gene sequencing. Associations between PCa and clinical covariates (age at diagnosis, prostate-specific antigen [PSA], Gleason score, tumor stage, and level of aggressiveness) and frequencies of alleles and genotypes of these SNPs were analyzed using genetic statistics. Results: Among the candidate SNPs, 11p15 (rs7127900, A) was associated with PCa risk (P = 0.02, odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.09-2.46). Genotypes showed differences between cases and controls on 11p15 (rs7127900, A), 11q13 (rs7931342, T), and HNF1B (rs4430796, A) (P = 0.03, P = 0.01, and P = 0.04, respectively). The genotype TG on 11q13 (rs7931342, T) was positively associated with an increased Gleason score (P = 0.04, OR = 2.15, 95% CI = 1.02-4.55). Patients carrying TG on 17q24 (rs1859962, G) were negatively associated with an increased body mass index (BMI) (P = 0.03, OR = 0.44, 95% CI = 0.21-0.92) while those with AG on HNF1B (rs4430796, A) were more likely to have PSA increase (P = 0.002). Conclusion: Our study suggests that 11p15 (rs7127900, A) could be a susceptibility locus associated with PCa in Northern Chinese. Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.

A Novel Monoclonal Antibody Induces Cancer Cell Apoptosis and Enhances the Activity of Chemotherapeutic Drugs

Xu, Heng,Tian, Yan-Na,Dun, Bo-Ying,Liu, Hai-Tao,Dong, Guang-Kuo,Wang, Jin-Hua,Lu, Shang-Su,Chen, Bo,She, Jin-Xiong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.

rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese

Zhang, Lin-Lin,Sun, Liang,Zhu, Xiao-Quan,Xu, Yong,Yang, Kuo,Yang, Fan,Yang, Yi-Ge,Chen, Guo-Qiang,Fu, Ji-Cheng,Zheng, Chen-Guang,Li, Ying,Mu, Xiao-Qiu,Shi, Xiao-Hong,Zhao, Fan,Wang, Fei,Yang, Ze,Wang, Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Aims: Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese. Methods: 749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed. Results: Among the six candidate variants, onlyrs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa ($OR_{recessive}=1.56$, p=0.006); and rs7837328 (A) was associated with PCa ($OR_{dominant}=1.38$, p=0.042/$OR_{recessive}=1.99$, p=0.003). Moreover, we observed a cumulative effects between them ($p_{trend}=2.58{\times}10^{-5}$). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) ($p_{age}=0.046$, $P_{tumorstage}=0.048$). Conclusion: rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.

Beryllium-7 and Lead-210 are Associated with an Increase in the Arctic Oscillation: Evidence from Atmospheric Aerosols in a Remote Tropical Region in East Asia

Xiaoxia Chen,Wuhui Lin,Xianwen He,Liangliang Feng,Kuo-Ying Wang 한국기상학회 2022 Asia-Pacific Journal of Atmospheric Sciences Vol.58 No.1

The Arctic Oscillation (AO) accounts for a large fraction of recent decadal climate trends in Northern Hemisphere (NH) high latitudes. In East Asia, an elevated AO index (AOI) was associated with warmer temperatures in middle- to high-latitude regions, colder temperatures over low-latitude regions, and elevated ozone intrusion from the stratosphere. Elevated beryllium-7 (7Be) is produced in the stratosphere. Few studies have discussed the relationship between 7Be and the AO. Here, we identify the AO signature in 7Be and lead (Pb)-210 observed at a tropical ambient monitoring site in Nanning (22.8°N, 108.5°E) during the December 2014–December 2017 period. Our results show that the 7Be and 210Pb concentrations are positively and significantly correlated with the AOI (P < 0.01). These results show that elevated 7Be and 210Pb are associated with an increase in the AOI, reflecting air masses originating from NH high latitudes and vertically from the high-latitude upper troposphere and lower stratosphere regions to tropical latitudes in East Asia. These results have been verified with ozonesonde data without seasonality and with two meteorological data sets. Our results are also confirmed by observational data over the Pacific regions. We conclude that the AO exerts impacts over the tropical regions in East Asia, and 7Be can be used as a tracer to track the impacts of the AO.