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RISS 인기검색어
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- 저자 : Kook Myeong‐ (검색결과 2 건)
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Bae, Jeong Mo,Shin, So‐,Hyun,Kwon, Hyeong‐,Ju,Park, Seog‐,Yun,Kook, Myeong Cherl,Kim, Young‐,Woo,Cho, Nam‐,Yun,Kim, Nayoung,Kim, Tae‐,You,Kim, Donguk,Kang, Gyeong H Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.131 No.6
<P><B>Abstract</B></P><P>Focal CpG island hypermethylation and diffuse genomic hypomethylation signify the changes in the DNA methylation status in cancer cells. <I>ALU</I> and <I>LINE‐1</I> repetitive DNA elements comprise ∼28% of the human genome. PCR‐based measurements of these repetitive DNA elements can be used as a surrogate marker of the genomewide methylation content. Our study aimed to identify the timing of <I>ALU</I> and <I>LINE‐1</I> hypomethylations during multistep gastric carcinogenesis and their prognostic implications in gastric cancer (GC). In our study, we analyzed the methylation statuses of <I>ALU</I> and <I>LINE‐1</I> in 249 cases of gastric biopsy samples and another independent set of 198 cases of advanced GC by pyrosequencing. Regardless of the <I>Helicobacter pylori</I> infection status, a significant decrease in the <I>ALU</I> methylation levels was noted during the transitions from chronic gastritis to intestinal metaplasia and from gastric adenoma to GC. <I>LINE‐1</I> methylation decreased during the transition from intestinal metaplasia to gastric adenoma and no further decrease occurred during the transition from gastric adenoma to GC. A low <I>LINE‐1</I> methylation status was strongly associated with poor prognosis in GC. A multivariate analysis revealed that <I>LINE‐1</I> methylation status was an independent prognostic factor. Our findings suggest that <I>ALU</I> and <I>LINE‐1</I> hypomethylations are early events during multistep gastric carcinogenesis. Furthermore, the <I>LINE‐1</I> methylation status can be used as a molecular biomarker to define a subset of GC patients with poor prognosis.</P>
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Nam, Ji Hyung,Choi, Il Ju,Cho, Soo‐,Jeong,Kim, Chan Gyoo,Lee, Jong Yeul,Nam, Su Youn,Park, Sook Ryun,Kook, Myeong‐,Cherl,Nam, Byung‐,Ho,Kim, Young‐,Woo Blackwell Publishing Asia 2011 Journal of gastroenterology and hepatology Vol.26 No.7
<P><B>Abstract</B></P><P><B>Background and Aim: </B> <I>Helicobacter pylori</I> infection is a risk factor for gastric cancer. We evaluated whether <I>H. pylori</I> infection and premalignant histological changes are more prevalent in siblings of young gastric cancer patients.</P><P><B>Methods: </B> Young (age ≤ 40) gastric cancer patients (<I>n</I> = 185), their young siblings (<I>n</I> = 130), and young control participants (<I>n</I> = 287) were recruited. <I>H. pylori</I> infection and histological changes were assessed using the updated Sydney system in biopsy specimens from three regions. We analyzed the association of <I>H. pylori</I> infection and histological changes with gastric cancer using logistic regression analysis.</P><P><B>Results: </B> The <I>H. pylori</I> infection rate was significantly higher in young cancer patients than their siblings (odds ratio [OR] = 2.42, <I>P</I> = 0.001) or control participants (OR = 3.60, <I>P</I> < 0.001). In <I>H. pylori</I>‐infected subjects, corpus gastritis and premalignant changes of the corpus lesser curvature (LCv) were also more prevalent in patients than in siblings or controls. In terms of the antrum, intestinal metaplasia was more prevalent in <I>H. pylori</I>‐infected patients than in siblings or controls, while atrophy was not affected. Siblings also had a higher <I>H. pylori</I> infection rate (OR = 1.60, <I>P</I> = 0.046) and higher prevalence of intestinal metaplasia at the corpus LCv (OR = 2.88, <I>P</I> = 0.027) than control participants.</P><P><B>Conclusions: </B> Even in young adults, <I>H. pylori</I> infection is a risk factor for gastric cancer. Young adults with histological findings including corpus predominant gastritis, corpus atrophy, or intestinal metaplasia are at increased risk. Since young siblings share risk factors, screening and treatment should be considered for these family members.</P>
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