<P><B>Abstract</B></P><P><B>Background and Aim: </B> <I>Helicobacter pylori</I> infection is a risk factor for gastric cancer. We evaluated whether <I>H. pylori</I> infection and p...
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https://www.riss.kr/link?id=A107755957
Nam, Ji Hyung ; Choi, Il Ju ; Cho, Soo‐ ; Jeong ; Kim, Chan Gyoo ; Lee, Jong Yeul ; Nam, Su Youn ; Park, Sook Ryun ; Kook, Myeong‐ ; Cherl ; Nam, Byung‐ ; Ho ; Kim, Young‐ ; Woo
2011
-
SCOPUS,SCIE
학술저널
1157-1163(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P><P><B>Background and Aim: </B> <I>Helicobacter pylori</I> infection is a risk factor for gastric cancer. We evaluated whether <I>H. pylori</I> infection and p...
<P><B>Abstract</B></P><P><B>Background and Aim: </B> <I>Helicobacter pylori</I> infection is a risk factor for gastric cancer. We evaluated whether <I>H. pylori</I> infection and premalignant histological changes are more prevalent in siblings of young gastric cancer patients.</P><P><B>Methods: </B> Young (age ≤ 40) gastric cancer patients (<I>n</I> = 185), their young siblings (<I>n</I> = 130), and young control participants (<I>n</I> = 287) were recruited. <I>H. pylori</I> infection and histological changes were assessed using the updated Sydney system in biopsy specimens from three regions. We analyzed the association of <I>H. pylori</I> infection and histological changes with gastric cancer using logistic regression analysis.</P><P><B>Results: </B> The <I>H. pylori</I> infection rate was significantly higher in young cancer patients than their siblings (odds ratio [OR] = 2.42, <I>P</I> = 0.001) or control participants (OR = 3.60, <I>P</I> < 0.001). In <I>H. pylori</I>‐infected subjects, corpus gastritis and premalignant changes of the corpus lesser curvature (LCv) were also more prevalent in patients than in siblings or controls. In terms of the antrum, intestinal metaplasia was more prevalent in <I>H. pylori</I>‐infected patients than in siblings or controls, while atrophy was not affected. Siblings also had a higher <I>H. pylori</I> infection rate (OR = 1.60, <I>P</I> = 0.046) and higher prevalence of intestinal metaplasia at the corpus LCv (OR = 2.88, <I>P</I> = 0.027) than control participants.</P><P><B>Conclusions: </B> Even in young adults, <I>H. pylori</I> infection is a risk factor for gastric cancer. Young adults with histological findings including corpus predominant gastritis, corpus atrophy, or intestinal metaplasia are at increased risk. Since young siblings share risk factors, screening and treatment should be considered for these family members.</P>
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