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Kim, Sung-Eun,Jang, Eun Sun,Ki, Moran,Gwak, Geum-Youn,Kim, Kyung-Ah,Kim, Gi-Ae,Kim, Do Young,Kim, Dong Joon,Kim, Man Woo,Kim, Yun Soo,Kim, Young Seok,Kim, In Hee,Kim, Chang Wook,Kim, Ho Dong,Kim, Hyun The Korean Academy of Medical Sciences 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.42
<P><B>Background</B></P><P>Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study.</P><P><B>Methods</B></P><P>A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m<SUP>2</SUP> or proteinuria as at least grade 2+ of urine protein.</P><P><B>Results</B></P><P>HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m<SUP>2</SUP> (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, <I>P</I> < 0.001, and 14.1%, <I>P</I> < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m<SUP>2</SUP> along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m<SUP>2</SUP>.</P><P><B>Conclusion</B></P><P>Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m<SUP>2</SUP> and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.</P>
( Sung Eun Kim ),( Eun Sun Jang ),( Moran Ki ),( Geum-youn Gwak ),( Kyung-ah Kim ),( Gi-ae Kim ),( Do Young Kim ),( Dong Joon Kim ),( Man Woo Kim ),( Yun Soo Kim ),( Young Seok Kim ),( In Hee Kim ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study aimed to investigate the association between CKD and HBV infection in a population-based, nationwide multicenter study. Methods: A total of 268,422 subjects who underwent health-check examination in nationwide 33 hospitals from Jan 2015 to Dec 2015, were enrolled. We identified 10,473 adults who had chronic HBV infection by hepatitis B surface antigen (HBsAg) positivity (cases), and 41,892 age-and sex-matched HBsAg negative people (controls) in the same dataset. CKD is defined as GFR<60ml/min/1.73<sup>2</sup> (GFR categories G3a-G5), according to KDIGO 2010 clinical practice guideline. Proteinuria was defined as the presence of urine protein of at least grade 2+. Results: HBsAg positive cases showed significantly higher frequency of CKD (3.3%) than in controls (2.7%) (P=0.006). Also, the prevalence of proteinuria in HBV cases (18.4%) was significantly higher than in controls (13.9%) (P<0.001). Multivariable logistic regression analysis for associated factors of CKD revealed that age, serum protein, serum albumin, hemoglobin, hemoglobinA1c and HBsAg positivity were independent predictors (P<0.05). Also, age, sex, HBsAg positivity, serum protein, hemoglobin, hemoglobinA1c and platelet were independent predictors of the proteinuria (P <0.05). Conclusions: HBV infection was significantly associated with GFR<60 ml/min/1.73<sup>2</sup> and proteinuria (≥2+). Therefore, in the era of effective antiviral therapy, clinical concern on the extrahepatic manifestations including kidney disease is warranted.
( Sung Eun Kim ),( Eun Sun Jang ),( Moran Ki ),( Geum-Youn Gwak ),( Kyung-Ah Kim ),( Gi-Ae Kim ),( Do Young Kim ),( Dong Joon Kim ),( Man Woo Kim ),( Yun Soo Kim ),( Young Seok Kim ),( In Hee Kim ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatitis C virus (HCV) entry and replication is associated with interruption of lipid metabolism. We aimed to investigate the association between anti-HCV positivity and serum lipid profiles in a nationwide, multicenter study. Methods: A total of 268,422 subjects who underwent health-check examination in nationwide 33 hospitals from Jan 2015 to Dec 2015 were enrolled. Data on the anti-HCV positivity, and biochemical laboratory results including serum levels of total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol were obtained and analyzed. Among the subjects, 1,360 anti-HCV antibody positive cases (0.6%), and 5,440 anti-HCV negative controls matched for age and sex to the cases were identified in same dataset. Results: Though body mass index (BMI) was not different between case and control group, the mean serum levels of total cholesterol (185 mg/dL), triglyceride (111.8 mg/dL), LDL cholesterol (117.4 mg/dL), and HDL cholesterol (54.5 mg/dL) were all significantly lower in anti-HCV positive group than in controls (192.5, 119.1, 125.1, and 55.8 mg/dL, respectively). By multivariable analyses using logistic regression, the independent factors associated with elevated serum total cholesterol (≥200 mg/dL) were age, male sex, anti-HCV positivity or HCV-RNA positivity. In addition, the independent factors associated with elevated serum triglyceride(≥150 mg/dL) were age, male sex, BMI (≥25kg/m2) HbA1C (≥5.5%), ALT (≥40IU/L), anti-HCV positivity or HCV-RNA positivity. Moreover, the independent factors associated with elevated LDL-cholesterol (≥130 mg/dL) were age, male sex, and anti-HCV positivity or HCV-RNA positivity. Conclusions: In this large population-based data, HCV infection independently associated with lower serum total cholesterol level, lower triglyceride level and lower LDL cholesterol level.
Kim, Mal Geum,Kang, Tae Woong,Park, Joon Yeong,Park, Seung Hun,Ji, Yun Bae,Ju, Hyeon Jin,Kwon, Doo Yeon,Kim, Young Sik,Kim, Sung Won,Lee, Bong,Choi, Hak Soo,Lee, Hai Bang,Kim, Jae Ho,Lee, Bun Yeoul,Mi Elsevier 2019 Materials science & engineering. C, Materials for Vol.103 No.-
<P><B>Abstract</B></P> <P>We have designed and characterized an injectable, electrostatically bonded, <I>in situ</I>–forming hydrogel system consisting of a cationic polyelectrolyte [(methoxy)polyethylene glycol-<I>b</I>-(poly(ε-caprolactone)-<I>ran</I>-poly(L-lactic acid)] (MP) copolymer derivatized with an amine group (MP-NH<SUB>2</SUB>) and anionic BMP2. To the best of our knowledge, there have been hardly any studies that have investigated electrostatically bonded, <I>in situ</I>–forming hydrogel systems consisting of MP-NH<SUB>2</SUB> and BMP2, with respect to how they promote <I>in vivo</I> osteogenic differentiation of human turbinate mesenchymal stem cells (hTMSCs). Injectable formulations almost immediately formed an electrostatically loaded hydrogel depot containing BMP2, upon injection into mice. The hydrogel features and stability of BMP2 inside the hydrogel were significantly affected by the electrostatic attraction between BMP2 and MP-NH<SUB>2</SUB>. Additionally, the time BMP2 spent inside the hydrogel depot was prolonged <I>in vivo</I>, as evidenced by <I>in vivo</I> near-infrared fluorescence imaging. Biocompatibility was demonstrated by the fact that hTMSCs survived <I>in vivo</I>, even after 8 weeks and even though relatively few macrophages were in the hydrogel depot. The osteogenic capacity of the electrostatically loaded hydrogel implants containing BMP2 was higher than that of a hydrogel that was simply loaded with BMP2, as evidenced by Alizarin Red S, von Kossa, and hematoxylin and eosin staining as well as osteonectin, osteopontin, osteocalcin, and type 1α collagen mRNA expression. The results confirmed that our injectable, <I>in situ</I>–forming hydrogel system, electrostatically loaded with BMP2, can enhance <I>in vivo</I> osteogenic differentiation of hTMSCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An injectable, electrostatically bonded, <I>in situ</I>–forming hydrogel system consisting of a cationic polyelectrolyte copolymer derivatized with an amine group and anionic BMP2 was prepared. </LI> <LI> The hydrogel features and stability of BMP2 inside the hydrogel were significantly affected by the electrostatic attraction between BMP2 and cationic polyelectrolyte copolymer. </LI> <LI> The electrostatically loaded hydrogel enhanced osteogenic differentiation of human turbinate mesenchymal stem cells better than one with simple loading of BMP2. </LI> </UL> </P>
Success and Failure of Surgical Endodontic Treatment in Molar Teeth
Geum, Yun-Seon,Lee, Jang-Ryeol,Kim, Hyeon-Cheol,Lee, Sang-Cheol,Kim, Yeong-Uk Korean Academy of Dental Science 2010 Journal of korean dental science Vol.3 No.2
Despite the latest advancement made in its techniques and devices/apparatuses and the resulting rising expectation in the field of dental surgery, apicoectomy performed in the molar teeth remains a technical challenge and lacks evidence substantiated by long-term follow-up studies. This study sought to investigate the treatment outcomes and post-operative success rate in the root-end resected molar teeth accompanied by a high level of surgical risks due to their close proximity to the mandibular canal and maxillary sinus. A total of 68 patients who received treatment at Livingwell Dental Hospital between 2004 and 2010 and underwent apical surgery in the maxillary or mandibular molar area were enrolled in this study. A total of 160 roots collected from 75 molar teeth were subjected to surgical endodontic treatment and subsequently evaluated clinically as well as radiographically. Based on the results of the study, the clinical success rate was found to be 78.8% in cases involving radiological healing. Likewise, 90.7% of the roots recorded a robust clinical survival rate, but with incomplete healing as shown by radiography. The results indicate that the apical procedure involving molar teeth is a prognosis-friendly method that promises positive outcomes and higher success rate based on long-term follow-up observations.
Chemosensitivity testing based on gene expression profiling in patients with ovarian cancer
( Geum Seon Sohn ),( Hyeong Ju Kim ),( Ji Yun Lee ),( Jinkyoung Kong ),( Ji Hee Choi ),( Hanbyoul Cho ),( Eun Ji Nam ),( Sang Wun Kim ),( Sunghoon Kim ),( Jae Hoon Kim ),( Young Tae Kim ),( Doo Byung 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: To evaluate the association between clinical response of treatment agents and results of chemosensitivity testing in ovarian cancer. 방법: Tissue was obtained from 21 ovarian cancer patients and gene expression was evaluated by quantitative real-time polymerase chain reaction (PCR). Selected gene panel with expression of specific genes in the pathways that are related to drug responses in ovarian cancer were analyzed( AKT, Aurora A, BCRP, CD31, ERCC1, GSTpi, HER2, MDR1, Mitosin, PI3 Kinase, RRM1, Survivin, TOP1, TOP2A, TS, VEGF, VEGFR2, XIAP, P73). Gene expression were matched with therapeutic agent including Platinum, Taxanes, Bevacizumab, Gemcitabine, Topoisomerase I Inhibitors, Topoisomerase II Inhibitors, Cyclophosphamide, Herceptin, and 5-fluorouracil for chemosensitivity. 결과: Chemosensitivity testing revealed sensitivity rate of 66%, 81%, 96%, 56% and 61% for Platinum, Taxanes, Topoisomerase I Inhibitors, Topoisomerase II Inhibitors, and Bevacizumab, respectively. Treatment response rate was 70% (Complete Response: 40%, Partial Response: 30%). Treatment response was not significantly increased in the platinum sensitive patients (p=0.613), and overall response rate did not significantly differ according to the chemosensitivity test. 결론: This study may provide useful information in optimizing individual chemotherapy in the treatment of ovarian cancer.
Kim, Seong Soon,Im, So Hee,Yang, Jung Yoon,Lee, Yu-Ri,Kim, Geum Ran,Chae, Jin Sil,Shin, Dae-Seop,Song, Jin Sook,Ahn, Sunjoo,Lee, Hoi,Woo, Jae Chun,Ahn, Jin Hee,Yun, Chang Soo,Kim, Phiho,Kim, Hyoung Ra JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS 2019 DRUG METABOLISM AND PHARMACOKINETICS Vol.34 No.1