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Kim, Sang Hee,Kim, Yongmo,Kim, Moonil,Kim, Dae Shick,Lee, Sang Chul,Chi, Seung-Wook,Lee, Do Hee,Park, Sung Goo,Park, Byoung Chul,Bae, Kwang-Hee,Kang, Sunghyun Pergamon Press 2009 Oncology Research Vol.17 No.11
<P>Metastasis is a complex, multistep process by which a cancer cell leaves the primary tumor, travels to a distant site via the circulatory system, and establishes a secondary cancer. A deeper understanding of the molecular events underlying metastasis will provide information that will be useful for the development of new diagnostic and therapeutic strategies. The B16 and B16F10 mouse melanoma cell lines are widely used as model system for studying many aspects of cancer biology including metastasis. Compared with B16, which has a low metastatic potential, the highly metastatic cell line B16F10 displayed a higher metastatic ability along with higher expression levels of the metastasis-associated phosphatase of regenerating liver-3 (PRL-3). B16 cells transfected with PRL-3 cDNA (B16-PRL3) had metastatic abilities comparable to those of Bl16F10 cells. To study the molecular mechanisms that underlie metastasis, the proteomes of the B16, B16F10, and B16-PRL3 cell lines were compared using two-dimensional differential in-gel electrophoresis. Proteins that varied significantly in levels between these cell lines were selected and identified using mass spectrometry. Interestingly, many proteins, especially those present in membrane fractions, were similarly up- or downregulated in both the Bl16F10 and B16-PRL3 cells lines compared to B16 cell lines. The list of similarly regulated proteins included heat shock protein 70, fascin-1, septin-6, ATP synthase beta subunit, and bone morphogenic protein receptor type IB. These proteins may play a causal role in PRL-3-mediated metastasis. These investigations open an avenue for the further characterization of the molecular mechanisms that underlie metastasis.</P>
Production and Characterization of a Novel Microbial Transglutaminase from Actinomadura sp.T-2
Kim, Hyun Soo,Jung, Sang Hoon,Lee, In Seon,Yu, Tae Shick 한국미생물 · 생명공학회 2000 Journal of microbiology and biotechnology Vol.10 No.2
An actinomycetes strain, T-2, which produces transglutaminase (EC 2.3.2.13), was isolated from soil and identified as belonging to the Actinomadura sp., based on taxonomic studies. The conditions for the transglutaminase production and its enzymatic properties were investigated. The optimum components for the transglutaminase production were 2% glucose, 1% polypeptone and soytone, and 0.1% MnCl_2. The optimum pH and temperature of the enzyme reaction were pH 8.0 and 45℃, respectively. The enzyme was stable within the pH range of 5.0-9.0 and 30℃-45℃. The novel enzyme required no calcium ions for its activity. This enzyme polymerized various proteins such as casien, soy protein, hemoglobin, egg white, gelatin, and soybean milk.
Antimicrobial and antifungal effects of a green tea extract against vaginal pathogens
( Sang Hee Kim ),( Lan Sook Lee ),( Su Mi Bae ),( Sei Jun Han ),( Byung Rai Lee ),( Woong Shick Ahn ) 대한산부인과학회 2008 Journal of Womens Medicine Vol.1 No.1
Objective: Green tea extract (GTEs), including catechins and caffeine, have strong anti-microbial activity. Methods: We determined the anti-microbial and anti-fungal effects of a GTE on the vaginal pathogens, Proteus mirabilis (KCTC 2510), Streptococcus pyogenes (KCTC 3096), and Candida albicans (KCTC 7270). Results: The growth inhibitory effects of a GTE and the ethyl acetate fraction against P. mirabilis and S. pyogenes were stronger compared to the anti-microbial activity of the H2O fraction. Among the catechins, epigallocatechin gallate had the strongest anti-microbial activity. The growth of C. albicans was strongly inhibited by the methylene chloride fraction and caffeine; the anti-fungal activity of a GTE was due to caffeine. We also evaluated whether the in vitro activity of a GTE included purified solvent fractions stable to heat and pH changes. The stability of transtype catechins increased following heat treatment, but this did not significantly affect the anti-microbial activity. A GTE were stable over the pH range 4-10. The most active anti-microbial activity of a GTE occurred in an alkaline, rather than an acid environment, except for the anti-microbial activity against S. pyogenes and C. albicans, which was not influenced by pH. Conclusions: Taken together, the results of this study indicate that a GTE may be a valuable therapeutic agent for the treatment of vaginal pathogens.
Performance Analysis of Entropy-based Multi-Robot Cooperative Systems in a MANET
Sang-Chul Kim,Kee Hyun Shin,Chong-Woo Woo,Yun Shick Eom,Jae Min Lee 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.5
This paper proposes two novel algorithms enabling mobile robots to cooperate with each other in a reliability-based system and a time-critical system. In the reliability-based cooperative system, the concepts of a mobile ad hoc network (MANET) and an object entropy are adopted in order to coordinate a specific task. A logical robot group is created based on the exchange of request and reply messages in a robot communication group whose organization depends on transmission range. In the time-critical cooperative system, relational entropy is used to define the relationship between mobile robots. A group leader is selected based on optimizing power consumption. The proposed algorithm has been verified based on the computer-based simulation and soccer robot experiment. The performance metrics are defined. The metrics include the number of messages needed to make a logical robot group and to obtain the relationship of robots and the power consumption to select a group leader. They are verified by simulation and experiment.
Kim, Yong_Duk,Yang, Young_Taek,Kim, Kyung_Ho,Kim, Sung_Taek,Kang, Hyoung_Shick 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Jeju islanders consume soybean leaves as a wrapping for slices of raw fish and pork, eating mainly the young, raw, but fully extended leaf. These leaves are known to contain several kinds of functioning compounds, such as amino acids, isoflavones, flavonoids and pterocarpans. Farmers grow soybean leaves, but different soybean varieties and their characteristics for soybean leaf production have not been studied. Therefore, this study compared agronomic characteristics and iso flavones among varieties grown in a green house and in an open field. The results were as follows: There were differences in agronomic characteristics among the varieties and between places grown; generally, indoor growing produced bigger and more abundant leaves of higher quality. There were also differences in isoflavone contents in soybean leaves. Soybean leaves harvested earlier contained higher amounts in total concentration. Plants grown outside showed slightly higher but, different concentrations of the compunds studied. These results indicate that it is possible to control the isoflavone levels with varieties used, and harvest time and place.
Utilization of lacZ to Isolate Regulatory Genes from Corynebacterium glutamicum
KIM, HYUNG-JOON,PARK, JOON-SUNG,LEE, HEUNG-SHICK,KIM, YOUNHEE 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.2
A total of 100 Corynebacterial clones exerting a regulatory effect on the aceB promoter of Corynebacterium glutamicum were isolated by utilizing a reporter carrying the enteric lacZ gene fused to the promoter. The isolated clones were classified into 3 groups of A, B, and C, according to their color of colonies. Escherichia coli cells carrying clones in groups A and B showed a 90% and 50% reduction in β-galactosidase activity, respectively. The introduction of group A clones into C. glutamicum also resulted in an almost complete reduction in the expression of the aceA and aceB genes, suggesting that the clones express repressor-like proteins for the genes. Although white colonies were formed on plates containing X-gal, E. coli cells carrying one of the clones in group C exhibited intact β-galactosidase activity. The result suggests that the clone may encode proteins that prevent the cells from accumulating the chromogenic compound, X-gal.
Importance of the Porcine ADAM3 Disintegrin Domain in Sperm-Egg Interaction
KIM, Ekyune,PARK, Ki-Eun,KIM, Ji-Su,BAEK, Dong Chul,LEE, Jae-Woong,LEE, Sang-Rae,KIM, Myeong-Su,KIM, Sang-Hyun,KIM, Chan-Shick,KOO, Deog-Bon,KANG, Han-Seok,RYOO, Zae-Young,CHANG, Kyu-Tae Society for Reproduction and Development 2009 Journal of Reproduction and Development Vol.55 No.2
<P>In the mouse, ADAM3, a well-characterized testis-specific protein of the A disintegrin and metalloprotease (ADAM) family, has a crucial role in fertilization by mediating sperm binding to the egg zona pellucida. However, little is known about ADAM3 in other species, such as domestic pigs. We have identified porcine ADAM3 and analyzed the protein. RT-PCR and trypsinization of sperm surface proteins revealed that porcine ADAM3 is expressed at high levels in the testis and on the sperm surface. Furthermore, an IVF inhibition assay with a recombinant porcine ADAM3 disintegrin domain showed that treatment of the disintegrin domain effectively prevented pig sperm-egg interactions. In the present study, we demonstrated the presence of ADAM3a and ADAM3b molecules in the pig and examined their roles in fertilization.</P>