http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Youngjo,Kim, Hyung-Jun,Cha, Sun Joo,Choi, Hyun-Jun,Kim, Hayoung,Lee, Sanghyun,Jeon, Yu-Mi,Lee, Mihye,Lee, Seongsoo,Kim, Kiyoung Elsevier 2019 NEUROBIOLOGY OF AGING Vol.73 No.-
<P><B>Abstract</B></P> <P>Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that is characterized pathologically by the loss of motor neurons. Mutations in the <I>TAF15</I> gene have been implicated in the pathogenesis of ALS. TATA-binding protein associated factor 15 (TAF15) accumulates as cytoplasmic aggregates in neuronal cells, the clearance of which may be a therapeutic strategy for ALS. However, the identification of a novel regulator for protection against a TAF15-induced proteinopathy and the exact pathogenic mechanism of TAF15-induced neurodegeneration remain to be elucidated. Here, we show that parkin directly binds to TAF15 and that parkin overexpression can suppress the defective phenotypes, including the life span and locomotive activity of a TAF15-induced proteinopathy. We also found that overexpression of parkin in neuronal cells leads to a reduction in TAF15 levels, because of the E3 ubiquitin ligase activity of parkin. Our study provides in vivo evidence supporting the use of parkin for neuroprotection in a TAF15-induced proteinopathy and offers new insights into the pathogenic mechanisms underlying TAF15-induced ALS.</P>
Kim, Kiyoung,Lee, Gyeonghweon,Thanh, Hien Dang,Kim, Jong-Hwa,Konkit, Maytiya,Yoon, Seokmin,Park, Miri,Yang, Siyoung,Park, Eunsup,Kim, Wonyong Elsevier 2018 Journal of dairy science Vol.101 No.7
<P><B>ABSTRACT</B></P> <P>We aimed to determine the effects of <I>Lactobacillus</I> strains against rotaviral infections. Rotaviruses are the major causative agent of acute gastroenteritis in infants and children worldwide. However, to date, no specific antiviral drugs for the treatment of rotavirus infection have been developed. We identified 263 <I>Lactobacillus</I> strains from 35 samples of the traditional Korean fermented vegetable food kimchi. Among them, <I>Lactobacillus plantarum</I> LRCC5310, more specifically the exopolysaccharides produced by these cells, were shown to have an antiviral effect against human rotavirus Wa strain in vitro. In vivo, the oral administration of exopolysaccharides for 2 d before and 5 d after mouse infection with the murine rotavirus epidemic diarrhea of infant mice strain led to a decrease in the duration of diarrhea and viral shedding and prevented the destruction of enteric epithelium integrity in the infected mice. We demonstrated here that the exopolysaccharides extracted from <I>L. plantarum</I> LRCC5310 can be used for the effective control of rotavirus infection.</P>
Kim, Kiyoung,Kim, Song-Hee,Kim, Jaekwang,Kim, Heuijong,Yim, Jeongbin American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.9
<▼1><P><B>Background:</B> Glutathione <I>S</I>-transferase Omega has been shown to be associated with Parkinson disease.</P><P><B>Results:</B><I>Drosophila</I> GSTO1 regulates mitochondrial ATP synthase activity in <I>parkin</I> mutants.</P><P><B>Conclusion:</B><I>Drosophila</I> GSTO1 plays a protective role in a <I>Drosophila</I> model of Parkinson disease.</P><P><B>Significance:</B> These findings may lead to a better understanding of the molecular mechanism of neuroprotection due to GSTO in Parkinson disease.</P></▼1><▼2><P>A loss-of-function mutation in the gene <I>parkin</I> causes a common neurodegenerative disease that may be caused by mitochondrial dysfunction. Glutathione <I>S</I>-transferase Omega (GSTO) is involved in cell defense mechanisms, but little is known about the role of GSTO in the progression of Parkinson disease. Here, we report that restoration of <I>Drosophila</I> GSTO1 (DmGSTO1), which is down-regulated in <I>parkin</I> mutants, alleviates some of the <I>parkin</I> pathogenic phenotypes and that the loss of <I>DmGSTO1</I> function enhances <I>parkin</I> mutant phenotypes. We further identified the ATP synthase β subunit as a novel <I>in vivo</I> target of DmGSTO1. We found that glutathionylation of the ATP synthase β subunit is rescued by DmGSTO1 and that the expression of DmGSTO1 partially restores the activity and assembly of the mitochondrial F<SUB>1</SUB>F<SUB>0</SUB>-ATP synthase in <I>parkin</I> mutants. Our results suggest a novel mechanism for the protective role of DmGSTO1 in <I>parkin</I> mutants, through the regulation of ATP synthase activity, and provide insight into potential therapies for Parkinson disease neurodegeneration.</P></▼2>
Kiyoung Kim,Dongsun Kim,Kyu-Nam Kim 대한가정의학회 2019 Korean Journal of Family Medicine Vol.40 No.2
Background: The blood level of alanine aminotransferase (ALT) is associated with increased coronary heart dis-ease (CHD) risk. However, its use as an independent factor for CHD risk prediction remains unclear in Asian popu-lations. The purpose of this study was to examine the association between serum ALT levels and CHD risk in Kore-ans.Methods: This was a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011). The ALT levels of 3,215 individuals were analyzed. The Framingham Risk Score (FRS) modified by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) was used to compute the 10-year CHD risk prediction.Results: Positive correlations were established between log-transformed ALT concentration and FRS (r=0.433, P<0.001). After adjusting for body mass index, low-density lipoprotein cholesterol, the amount of alcohol intake, and gamma-glutamyl transferase, the odds ratio (95% confidence interval) for intermediate or greater risk of 10-year CHD prediction (10-year risk ≥10%) for the lowest quartile of participants was 2.242 (1.405–3.577) for the sec-ond quartile, 2.879 (1.772–4.679) for the third quartile, and 3.041 (1.789–5.170) for the highest quartile.Conclusion: In Koreans, a higher serum ALT concentration was significantly correlated with 10-year CHD risk pre-diction according to NCEP ATP III guidelines.
Bending and Twisting Measurement of Spent Fuel
Kiyoung Kim,Donghee Lee,Beomgyu Kim,Kyungho Roh,Yongdeog Kim 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
More than 20,000 bundles of spent nuclear fuel are stored in the spent nuclear fuel storage pool of domestic nuclear power plants, and the dry storage facility project in the nuclear power plant site is being promoted as the saturation of the wet storage pool is imminent. Since bending or twisting of spent nuclear fuel is an important item in order to load spent nuclear fuel into a dry storage cask, PSE (Pool Side Examination) was performed to verify this. This paper describes whether it can be safely loaded into a dry storage cask based on the measurement results of bending or twisting of spent nuclear fuel. The nuclear fuel assembly is designed to prevent excessive assembly bending and twisting because it can cause interference during dry storage and handling due to factors such as differences in depletion of nuclear fuel rods, irradiation growth, and coolant flow during reactor operation. The bending of the nuclear fuel assembly is measured by establishing a Plumb Line to photograph the nuclear fuel assembly based on it, and calculating a pixel that images the distance between the support grid and the Plumb Line. The twisting of the nuclear fuel assembly is measured by forming a virtual vertical plane with two Plumb Lines, and based on this, the twisting angle of the lower fixed compared to the upper fixed. As a result of the measurement, the bending of spent nuclear fuel was about 0.0-10.2 mm, much lower than the reactor loading criteria of 15.0 mm, and in the case of twisting, about 0.0~2.2° much lower than the reactor loading criteria of 5.0°. Therefore, it was confirmed that spent nuclear fuel at domestic nuclear power plants was not affected by bending and twisting when loading into dry storage cask.
김기영(KIM, Kiyoung),이승준(LEE, Seungjun),김덕녕(KIM, Ducknyung),이은탁(LEE, Euntak),김태완(KIM, Taewan),손봉수(SON, Bongsoo) 대한교통학회 2022 대한교통학회지 Vol.40 No.3
고속도로 엇갈림구간은 합류, 분류, 엇갈림 교통류가 서로 상충하여 교통혼잡과 교통사고 발생 가능성이 높은 구간이다. 한국도로용량편람에서는 단순히 길이만을 기준으로 엇갈림구간을 합류부 및 분류부와 구분하고 있으며, 엇갈림구간에서의 교통류 특성으로 인해 발생할 수 있는 교통문제를 완화시키는 적정 길이기준은 제시되어있지 않다. 본 연구에서는 엇갈림유형별 주행행태모형을 구축하고 엇갈림구간을 효율적으로 운영할 수 있는 길이기준 산정 모형을 개발하였다. 다양한 교통조건에 대해 미시시뮬레이션 교통분석 프로그램 VISSIM을 적용하여 고속도로 기본구간에서의 밀도-기반 서비스수준이 엇갈림구간에서 지속될 수 있는 엇갈림유형별 길이 설계기준을 제시하였다. 연구결과는 엇갈림유형과 길이기준을 지역별 교통상황에 따라 다르게 적용해야 할 필요성을 제시하고 있다. 길이기준의 적정성은 도로주행 시뮬레이터 실험으로 검증하였다. On freeway weaving sections, traffic congestion and accidents occur frequently due to the disturbance generated by merging or diverging vehicles. To reduce the disturbance and accordingly improve Level-of-Service (LOS), an appropriate length of weaving section should be provided. According to the KHCM, the weaving section density, which is a surrogate for LOS, is determined by weaving length, traffic volume, and weaving volume ratio. However, it is not yet clear whether the KHCM accurately estimates the density for various traffic conditions. The purpose of this study is to evaluate the effects of weaving length on various traffic conditions applying microscopic traffic simulation model VISSIM. Genetic algorithm optimization method is applied to build the car-following and lane-changing models in VISSIM. The results show that weaving length is a critical determinant of LOS and short weaving length significantly increases traffic congestion. Increasing the length of the weaving section is a good countermeasure for managing traffic congestion. The amendment of KHCM regarding freeway weaving section length is suggested for future study.