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- 저자 : Kejia Li (검색결과 5 건)
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Shijian Luo,Huiqing Li,Zhihuai Mo,Junjie Lei,Lingjuan Zhu,Yanxia Huang,Ruying Fu,Chunyi Li,Yihuan Huang,Kejia Liu,Wenli Chen,Lei Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluated by flow cytometry and an MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5- diphenyl-2-H-tetrazolium bromide) assay. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis were used to test the expression of MMP9 and the PI3K/Akt signaling pathway-related proteins in human brain microvascular endothelial cells (HBMECs) and tissues. Additionally, the infarct volume after middle cerebral artery occlusion (MCAO) was determined by a TTC (2,3,5-triphenyltetrazolium chloride) assay. The microarray and CMap analyses identified luteolin as a promising compound for future therapies for ischemic stroke. Cytoscape and GSEA showed that the PI3K/Akt signaling pathway was crucial in ischemic stroke. Cell experiments revealed that luteolin enhanced cell viability and downregulated apoptosis via inhibiting MMP9 and activating the PI3K/Akt signaling pathway. Experiments performed in vivo also demonstrated that luteolin reduced the infarct volume. These results suggest that luteolin has potential in the treatment of ischemic stroke through inhibiting MMP9 and activating PI3K/ Akt signaling pathway.
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An experimental study on pool sloshing behavior with solid particles
Songbai Cheng,Shuo Li,Kejia Li,Ting Zhang 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.1
It is important to clarify the mechanisms of molten-fuel-pool sloshing behavior that might be encounteredduring a core disruptive accident of sodium-cooled fast reactors. In this study, motivated byacquiring some evidence for understanding the characteristics of this behavior at more realistic conditions,a number of experiments are newly performed by injecting nitrogen gas into a water pool with theaccumulation of solid particles. To achieve comprehensive understanding, various parameters includingparticle bed height, particle size, density, shape, gas pressure along with the gas-injection duration, wereemployed. It is found that due to the different interaction mechanisms between solid particles and thegas bubble injected, three kinds of regimes, termed respectively as the bubble-impulsion dominantregime, the transitional regime and the bed-inertia dominant regime, could be identified. The performedanalyses also suggest that under present conditions, all our experimental parameters employed can havenoticeable impact on the regime transition and resultant sloshing intensity (e.g. maximum elevation ofwater level at pool peripheries). Knowledge and fundamental data from this work will be used for thefuture verifications of fast reactor severe accident codes in China
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Hailong Yan,Jinbing Cheng,Kejia Zhua,Ao Li,Tao Peng,Yongsong Luo 한국물리학회 2020 Current Applied Physics Vol.20 No.5
Various studies suggest that the performances of TMDs are largely thickness dependent. In this paper, we develop a chemical vapor deposition method to synthesis monolayer and bilayer MoS2 flakes with a solution precursor. The MoS2 phototransistors were prepared to investigate their optoelectronic performance. The MoS2 photodetectors exhibit high detectivity of 2.44 × 1011 and a fast response/recovery time of 97 ms/291 ms. The photoresponsivity of bilayer MoS2 flakes was found up to 7160 A W−1. Our research will pave a pathway to control the layer numbers of other TMDs nanostructures, expand the application of high performance 2D materials.
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Hong Gao,Junying Zhang,Min Li,Kejia Liu,Dong Guo,Yue Zhang 한국물리학회 2013 Current Applied Physics Vol.13 No.5
The surface electric property of Cu2O microcrystal affects the interaction of facets with substance in the aqueous solution, and hence plays a key role in determining the photocatalytic activity. In this paper, the capability of Cu2O microcrystals with exclusive {111}, {110} or both lattice surfaces in reducing Agþ to Ag0were investigated. Ag particles selectively deposited on {111} surfaces of Cu2O, while not on {110} surfaces. The different behaviors of the two surfaces are mainly attributed to their different electric properties:negatively-charged {111} surfaces absorb Agþ ions while positively-charged {110} surfaces repel them. Raman scattering of Cu2O {111} surfaces was enhanced by the photo-deposition of Ag particles.
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Ke Jia,Yu-Han Gao,Xiao-Qin Huang,Rong-Jun Guo,Shi-Dong Li 한국식물병리학회 2015 Plant Pathology Journal Vol.31 No.2
Bacillus subtilis B006 strain effectively suppresses the cucumber fusarium wilt caused by Fusarium oxysporum f. sp. cucumerinum (Foc). The population dynamics of Foc, strain B006 and its surfactin over-producing mutant B841 and surfactin-deficient mutant B1020, in the rhizosphere were determined under greenhouse conditions to elucidate the importance of the lipopeptides excreted by these strains in suppressing Foc. Results showed that B. subtilis strain B006 effectively suppressed the disease in natural soil by 42.9%, five weeks after transplanting, whereas B841 and B1020 suppressed the disease by only 22.6% and 7.1%, respectively. Quantitative PCR assays showed that effective colonization of strain B006 in the rhizosphere suppressed Foc propagation by more than 10 times both in nursery substrate and in field-infected soil. Reduction of Foc population at the cucumber stems in a range of 0.96 log10 ng/g to 2.39 log10 ng/g was attained at the third and the fifth weeks of B006 treatment in nursery substrate. In field-infected soil, all three treatments with B. subtilis suppressed Foc infection, indicated by the reduction of Foc population at a range of 2.91 log10 ng/g to 3.36 log10 ng/g at the stem base, one week after transplanting. This study reveals that the suppression of fusarium wilt disease is affected by the effective colonization of the surfactin-producing B. subtilis strain in the rhizosphere. These results improved our understanding of the biocontrol mechanism of the B. subtilis strain B006 in the natural soil and facilitate its application as biocontrol agent in the field.
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