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RISS 인기검색어
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- 저자 : Keiichi Kawano (검색결과 4 건)
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Yutaka Fukui,Tsuneo Kawano,Keiichi Shirase,Nobuhiro Sugimura (사)한국CDE학회 2010 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8
The purpose of this study is to develop a digital human model for evaluating the operations involving the rotation movements of the upper limb in hand-operated screw driving tasks. Experiments were carried out to derive the equations for estimating the maximum torque applied by the movements of the forearm and/or wrist about a screwdriver axis from the working posture of the upper limb. The applied maximum torque and arm posture were measured at each of 22 positions of the screwdriver for 8 participants. The results demonstrated that the measured torques varied with the arm postures. A torque-producing index was defined among the rotational axes and the height of the arm so as to correlate well with the measured torques. Finally, software was developed to estimate the applied maximum torque about screwdriver axis from the torque-producing index of any digital human’s posture.
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Isamu Nishida,Masato Maeda,Tsuneo Kawano,Keiichi Shirase (사)한국CDE학회 2010 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8
Factory automation and efficiency-oriented unmanned factories have become the major trend in manufacturing systems in recent years. However, human-centered manufacturing is gaining attention because of the flexibility it offers to manufacturing systems in terms of both product variety and volume. Although some digital human models capable of estimating the power generated by human muscles during various manufacturing-related tasks have been developed, a more effective method of analyzing muscle power is required to better estimate human muscle power. In the present study, a new musculoskeletal model taking the function of bi-articular muscles into consideration is applied to estimate the power generated by human muscles. The purpose of this study is to optimize working conditions that satisfy both the height of subjects and their maximum muscle power during a lifting operation. Results indicate the model is able to predict the heaviest weight and maximum height that this weight can be lifted to keep muscle power of the upper limb of a subject under 70% of the maximum muscle power. Moreover, the analyzed muscle power of the upper limb from experimental lifting operations is in good agreement optimized environments where humans can work efficiently and safely considering their physical characteristics.
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Structure and Activity of Insect Cytokine GBP which Stimulates the EGF Receptor
Tomoyasu Aizawa,Yoichi Hayakawa,Katsutoshi Nitta,Keiichi Kawano 한국분자세포생물학회 2002 Molecules and cells Vol.14 No.1
Growth-blocking peptide (GBP) is an insect cytokine that possesses diverse biological activities such as lar-val growth regulation, cell proliferation, and stimula-tion of immune cells. GBP is a 25-amino acid peptide with one disulfide bond. It has been revealed that the tertiary structure of GBP consists of an N- and C- terminal disordered region and a well-structured core. Although there is only a slight similarity between the primary structures of GBP and EGF and the molecu-lar weight of GBP is about half that of EGF, GBP di-rectly binds and activates the EGF receptor of human keratinocyte cells. Furthermore, the tertiary structure of the well-defined region of GBP is similar to that of the C-terminal domain of EGF. This review will focus on the tertiary structure of GBP and its activities, as compared with those of EGF.
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Yoshiaki Yamanaka,Kunitaka Menuki,Yukichi Zenke,Satoshi Ikeda,Eiji Hatakeyama,Kimiaki Kawano,Satoshi Nishida,Hiroaki Tanaka,Keiichi Yumisashi,Akinori Sakai 대한골다공증학회 2019 Osteoporosis and Sarcopenia Vol.5 No.4
Objectives: To assess the vitamin D status in postmenopausal women with osteoporotic fractures, determine its concentration by fracture site at the clinical setting, and compare the proportion of vitamin D deficiency with that reported in literature. Methods: The prospective study included 317 postmenopausal women with osteoporotic fractures who were treated consecutively from 2016 to 2018. After obtaining informed consent for participation in the seamless treatment of osteoporosis against fractures study, which is our initiative to prevent secondary osteoporotic fractures, we registered the patients, examined bone mineral density (BMD) at the unfractured femoral neck and lumbar spine, serum 25-hydroxyvitamin D (25(OH)D) concentration, blood chemistry, and bone turnover markers. Results: The mean age of the patients was 80.7 years. Moreover, 78% of patients of all fractures had 25(OH)D concentration < 20 ng/mL, whereas 12% of patients had 25(OH)D concentration 30 ng/mL 25(OH)D concentration in hip fractures was significantly lower than that in vertebral or distal radius fractures (P < 0.05). Multiple regression analysis revealed that 25(OH)D concentration is significantly associated with femoral neck BMD (b ¼ 0.16; 95% confidence interval [CI], 0.78e12.17, P ¼ 0.03) and serum albumin concentration (b ¼ 0.21; 95% CI, 0.62e2.96, P < 0.001) in patients with 25(OH)D concentration < 30 ng/mL. Conclusions: The results of this study show that the proportion of postmenopausal women with osteoporotic fractures who had vitamin D deficiency was higher than the proportion in previous reports that examined general postmenopausal women (35.2%e52.0%).
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