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Kei Matsumoto,Shinwa Tanaka,Takashi Toyonaga,Nobuaki Ikezawa,Mari Nishio,Masanao Uraoka,Tomoatsu Yoshihara,Hiroya Sakaguchi,Hirofumi Abe,Tetsuya Yoshizaki,Madoka Takao,Toshitatsu Takao,Yoshinori Morit 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.1
Background/Aims: The anastomotic site after distal gastrectomy is the area most affected by duodenogastric reflux. Differentreconstruction methods may affect the lesion characteristics and treatment outcomes of remnant gastric cancers at the anastomoticsite. We retrospectively investigated the clinicopathologic and endoscopic submucosal dissection outcomes of remnant gastriccancers at the anastomotic site. Methods: We recruited 34 consecutive patients who underwent endoscopic submucosal dissection for remnant gastric cancer at theanastomotic site after distal gastrectomy. Clinicopathology and treatment outcomes were compared between the Billroth II and non-Billroth II groups. Results: The tumor size in the Billroth II group was significantly larger than that in the non-Billroth II group (22 vs. 19 mm;p=0.048). More severe gastritis was detected endoscopically in the Billroth II group (2 vs. 1.33; p=0.0075). Moreover, operation timewas longer (238 vs. 121 min; p=0.004) and the frequency of bleeding episodes was higher (7.5 vs. 3.1; p=0.014) in the Billroth IIgroup. Conclusions: Compared to remnant gastric cancers in non-Billroth II patients, those in the Billroth II group had larger lesions with abackground of severe remnant gastritis. Endoscopic submucosal dissection for remnant gastric cancers in Billroth II patients involvedlonger operative times and more frequent bleeding episodes than that in patients without Billroth II.
Matsumoto, Takahiro,Ohkubo, Kei,Honda, Kaoru,Yazawa, Akiko,Furutachi, Hideki,Fujinami, Shuhei,Fukuzumi, Shunichi,Suzuki, Masatatsu American Chemical Society 2009 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.131 No.26
<P>A (mu-eta(2):eta(2)-peroxo)dicopper(II) complex, [Cu(2)(H-L)(O(2))](2+) (1-O(2)), supported by the dinucleating ligand 1,3-bis[bis(6-methyl-2-pyridylmethyl)aminomethyl]benzene (H-L) is capable of initiating C-H bond activation of a variety of external aliphatic substrates (SH(n)): 10-methyl-9,10-dihydroacridine (AcrH(2)), 1,4-cyclohexadiene (1,4-CHD), 9,10-dihydroanthracene (9,10-DHA), fluorene, tetralin, toluene, and tetrahydrofuran (THF), which have C-H bond dissociation energies (BDEs) ranging from approximately 75 kcal mol(-1) for 1,4-CHD to approximately 92 kcal mol(-1) for THF. Oxidation of SH(n) afforded a variety of oxidation products, such as dehydrogenation products (SH((n-2))), hydroxylated and further-oxidized products (SH((n-1))OH and SH((n-2))=O), dimers formed by coupling between substrates (H((n-1))S-SH((n-1))) and between substrate and H-L (H-L-SH((n-1))). Kinetic studies of the oxidation of the substrates initiated by 1-O(2) in acetone at -70 degrees C revealed that there is a linear correlation between the logarithms of the rate constants for oxidation of the C-H bonds of the substrates and their BDEs, except for THF. The combination of this correlation and the relatively large deuterium kinetic isotope effects (KIEs), k(2)(H)/k(2)(D) (13 for 9,10-DHA, approximately > 29 for toluene, and approximately 34 for THF at -70 degrees C and approximately 9 for AcrH(2) at -94 degrees C) indicates that H-atom transfer (HAT) from SH(n) (SD(n)) is the rate-determining step. Kinetic studies of the oxidation of SH(n) by cumylperoxyl radical showed a correlation similar to that observed for 1-O(2), indicating that the reactivity of 1-O(2) is similar to that of cumylperoxyl radical. Thus, 1-O(2) is capable of initiating a wide range of oxidation reactions, including oxidation of aliphatic C-H bonds having BDEs from approximately 75 to approximately 92 kcal mol(-1), hydroxylation of the m-xylyl linker of H-L, and epoxidation of styrene (Matsumoto, T.; et al. J. Am. Chem. Soc. 2006, 128, 3874).</P>
Progressive Relapse of Ligamentum Flavum Ossification Following Decompressive Surgery
Kei Ando,Shiro Imagama,Zenya Ito,Kazuyoshi Kobayashi,Junichi Ukai,Akio Muramoto,Ryuichi Shinjo,Tomohiro Matsumoto,Hiroaki Nakashima,Naoki Ishiguro 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.6
Thoracic ossification of the ligamentum flavum (T-OLF) is a relatively rare spinal disorder that generally requires surgical intervention, due to its progressive nature and the poor response to conservative therapy. The prevalence of OLF has been reported at 3.8%–26%, which is similar to that of cervical ossification of the posterior longitudinal ligament (OPLL). The progression of OPLL after cervical laminoplasty for the treatment of OPLL is often shown in long-term follow-up. However, there have been no reports on the progression of OLF following surgery. We report a case of thoracic myelopathy secondary to the progressive relapse of OLF following laminectomy.
( Kei Yane ),( Hiroyuki Maguchi ),( Akio Katanuma ),( Kuniyuki Takahashi ),( Manabu Osanai ),( Toshifumi Kin ),( Ryo Takaki ),( Kazuyuki Matsumoto ),( Katsushige Gon ),( Tomoaki Matsumori ),( Akiko To The Editorial Office of Gut and Liver 2015 Gut and Liver Vol.9 No.2
Background/Aims: Several studies have shown the usefulness of endoscopic nasogallbladder drainage (ENGBD) in patients with acute cholecystitis. However, the procedure is difficult, and factors that affect technical success have not yet been clarified. We conducted a prospective study to evaluate the technical feasibility, efficacy, and predictive factors for the technical success of ENGBD in patients with acute cholecystitis. Methods: All patients with moderate or severe acute cholecystitis who were enrolled underwent ENGBD between April 2009 and April 2011. Patients with surgically altered anatomy or pancreatobiliary malignancies were excluded. The primary outcomes included technical success, clinical success, and complications. Factors that could affect the technical success were also examined. Results: Of the 27 patients who underwent ENGBD during the study period, technical success was achieved in 21 (78%) and clinical improvement was achieved in 20 (95%). Early complications were encountered in four patients (15%). Gallbladder wall thickness (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.08 to 2.47) and age (OR, 1.16; 95% CI, 1.00 to 1.35) were effective predictors of technical failure. Conclusions: ENGBD was effective in resolving acute cholecystitis; however, this modality was technically challenging and had a limited success rate. Because of technical difficulties, ENGBD should be reserved for limited indications. (Gut Liver, 2015;9:239-246)
Kei Ando,Shiro Imagama,Norimitsu Wakao,Kenichi Hirano,Ryoji Tauchi,Akio Muramoto,Hiroki Matsui,Tomohiro Matsumoto,Yukihiro Matsuyama,Naoki Ishiguro 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.3
Purpose: Thoracic dumbbell tumors are relatively rare, usually arising from neurogenic elements. Methods for surgical removal thereof remain controversial. The purpose of this study was to evaluate the surgical results of a single-stage posterior approach with laminectomy and costotransversectomy only for the management of thoracic dumbbell tumors. Materials and Methods: Eight cases of thoracic large dumbbell tumor were analyzed retrospectively: seven men and one woman (mean age, 49 years). Pathologic findings included schwannoma in five patients, neurofibroma in two patients (Recklinghausen in one patient), and ganglioneuroma in one patient. All patients underwent single-stage removal of dumbbell tumors by a posterior approach followed by laminectomy and costotransversectomy combined with instrumentation. Clinical and radiologic outcomes were reviewed, thereafter. Results: Operative time ranged from 185 to 420 minutes (mean, 313 minutes), with estimated blood loss ranging from 71 to 1830 mL (mean, 658 mL). Postoperative complications included atelectasis in one case. All patients had tumors successfully removed with no neurological deterioration. Spinal deformities were not observed in any patients at the last follow-up (mean, 52 months), with instrumentation. Conclusion: Single-stage surgery with laminectomy and costotransversectomy may be useful for removing thoracic dumbbell tumors without a combined anterior approach.
( Kazumichi Kawakubo ),( Kei Yane ),( Kazunori Eto ),( Hirotoshi Ishiwatari ),( Nobuyuki Ehira ),( Shin Haba ),( Ryusuke Matsumoto ),( Keisuke Shinada ),( Hiroaki Yamato ),( Taiki Kudo ),( Manabu Onod 대한소화기학회 2018 Gut and Liver Vol.12 No.3
Background/Aims: Although the risk of bleeding after endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is low, the safety of EUS-FNA in patients prescribed antithrombotic agents is unclear. Therefore, this study evaluated the incidence of bleeding after EUS-FNA in those patients. Methods: Between September 2012 and September 2015, patients who were prescribed antithrombotic agents underwent EUS-FNA at 13 institutions in Japan were prospectively enrolled in the study. The antithrombotic agents were managed according to the guidelines of the Japanese Gastrointestinal Endoscopy Society. The rate of bleeding events, thromboembolic events and other complications within 2 weeks after EUS-FNA were analyzed. Results: Of the 2,629 patients who underwent EUS-FNA during the study period, 85 (62 males; median age, 74 years) patients were included in this stduy. Two patients (2.4%; 95% confidence interval [CI], 0.6% to 8.3%) experienced bleeding events. One patient required surgical intervention for hemothorax 5 hours after EUS-FNA, and the other experienced melena 8 days after EUS-FNA and required red blood cell transfusions. No thromboembolic events occurred (0%; 95% CI, 0.0% to 4.4%). Three patients (3.5%; 95% CI, 1.2% to 10.0%) experienced peri-puncture abscess formation. Conclusions: The rate of bleeding after EUS-FNA in patients prescribed antithrombotic agents might be considerable. (Gut Liver 2018;12:353-359)
Clinical Outcomes of Surgical Treatments for Traumatic Spinal Injuries due to Snowboarding
Takahiro Masuda,Kei Miyamoto,Kazuhiko Wakahara,Kazu Matsumoto,Akira Hioki,Tetsuya Shimokawa,Katsuji Shimizu,Shinji Ogura,Haruhiko Akiyama 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.1
Study Design: Retrospective study. Purpose: To assess treatment outcomes of snowboarding-related spinal and spinal cord injuries. Overview of Literature: Snowboarding-related spinal or spinal cord injury have a great impact on social and sporting activities. Methods: A retrospective review of 19 cases of surgically treated snowboard-related injury was done. Analyzed parameters included site of injury, type of fracture, peri- and postoperative complications, pre- and postoperative neurological status, activities of daily living, and participation in sports activities at the final follow-up. Results: The major site of injury was the thoracolumbar junction caused by fracture-dislocation (13/19 cases). The remaining 6 cases had cervical spine injuries. Over 60% of the patients had Frankel A and B paralysis. All patients were surgically treated by posterior fusion with instrumentation. Five underwent additional anterior fusion. Surgical outcome was restoration of ambulatory capacity in 12 patients (63.2%). Ultimately, 15 patients (78.9%) could return to work. Patients with complete paralysis upon admission showed reduced ambulatory capacity compared to those with incomplete paralysis. None of the patients again participated in any sports activities, including snowboarding. Conclusions: Snowboarding-related spinal or spinal cord injury has a great impact on social as well as sports activities. It is necessary to enhance promotion of injury prevention emphasizing the snowboarders’ responsibility code.
Variety of the Wave Change in Compound Muscle Action Potential in an Animal Model
Zenya Ito,Shiro Imagama,Kei Ando,Akio Muramoto,Kazuyoshi Kobayashi,Tetsuro Hida,Kenyu Ito,Yoshimoto Ishikawa,Mikito Tsushima,Akiyuki Matsumoto,Satoshi Tanaka,Masayoshi Morozumi,Yukihiro Matsuyama,Naok 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.6
Study Design: Animal study. Purpose: To review the present warning point criteria of the compound muscle action potential (CMAP) and investigate new criteria for spinal surgery safety using an animal model. Overview of Literature: Little is known about correlation palesis and amplitude of spinal cord monitoring. Methods: After laminectomy of the tenth thoracic spinal lamina, 2–140 g force was delivered to the spinal cord with a tension gage to create a bilateral contusion injury. The study morphology change of the CMAP wave and locomotor scale were evaluated for one month. Results: Four different types of wave morphology changes were observed: no change, amplitude decrease only, morphology change only, and amplitude and morphology change. Amplitude and morphology changed simultaneously and significantly as the injury force increased (p <0.05) Locomotor scale in the amplitude and morphology group worsened more than the other groups. Conclusions: Amplitude and morphology change of the CMAP wave exists and could be the key of the alarm point in CMAP.
MIRIS observation of near-infrared diffuse Galactic light
Onishi, Yosuke,Sano, Kei,Matsuura, Shuji,Jeong, Woong-Seob,Pyo, Jeonghyun,Kim, Il-Jong,Seo, Hyun Jong,Han, Wonyong,Lee, DaeHee,Moon, Bongkon,Park, Wonkee,Park, Younsik,Kim, MinGyu,Matsumoto, Toshio,Ma Astronomical Society of Japan 2018 Publications of the Astronomical Society of Japan Vol.70 No.4