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A new anti-Helicobacter pylori juglone from Reynoutria japonica
Atif Ali Khan Khalil,박우성,Jeehoon Lee,김혜진,Kazi Marjahan Akter,Young-Min Goo,Ji-Yeong Bae,Man-Seog Chun,Junghwan Kim,Mi-Jeong Ahn 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.6
A 70% ethanol extract from the root portion of Reynoutria japonica afforded one new and three known juglone derivatives, namely, 2-methoxy-6-acetyl-7-methyljuglone (1), 2-ethoxy-6-acetyl-7-methyljuglone (2), 2-methoxy-7-acetonyljuglone (3), and 3-acetyl-7-methoxy-2-methyljuglone (4) together with two phenolics (5 and 6), an anthraquinone (7), a stilbene (8) and a phthalide (9). Their structures were elucidated on the basis of comprehensive spectroscopic studies including IR, MS, and 1H, 13C, 2D NMR spectra. Compound 3 is a new compound in nature, and compounds 4–6 have been isolated for the first time from R. japonica. The isolates were evaluated for their antibacterial activity against three strains (43504, 51, and 26695) of Helicobacter pylori. The four isolated juglone derivatives (1–4) showed potent growth inhibitory activity. Among them, compounds 1–3 exhibited stronger inhibitory activity than those of the positive controls, juglone and metronidazole, for the three strains and that of another reference, clarithromycin, for the 43504 and 51 strains. Specifically, the new juglone compound 3 displayed the most potent antibacterial activity against all three strains, 43504, 51, and 26695, with MIC values of 0.06, 0.06 and 0.13 μM, respectively, and MIC50 values of 0.14, 0.11 and 0.15 μM, respectively.
Anatomical characterization and LC-MS profiling of <i>Adenophora</i> roots from Korea
Park, Woo Sung,Kim, Hye-Jin,Choe, Su Jin,Khalil, Atif Ali Khan,Akter, Kazi-Marjahan,Shin, Meong Cheol,Chung, Hye-Jin,Park, Jong Hee,Ahn, Mi-Jeong Elsevier 2019 Revista brasileira de farmacognosia Vol.29 No.6
<P><B>Abstract</B></P> <P>“Sasam (沙參)” is a crude drug that is defined in the in Korean Herbal Pharmacopoeia as the root of <I>Adenophora triphylla</I> var. <I>japonica</I> (Regel.) Hara or <I>A. stricta</I> Miq., Campanulaceae. The dried roots of the <I>Adenophora</I> spp. are available in markets, and the roots of various species are similar to each other in shape, making it difficult to distinguish one from another using only the outer morphological appearance. Therefore, the present study aimed to establish quality control parameters for pharmacognostic evaluation and differentiation of five <I>Adenophora</I> species and two varieties grown in Korea. Inner morphological evaluation of the root of these plants was accomplished and preliminary chemical analysis was performed by liquid chromatography-mass spectrometry profiling. As a result, significant differences among samples were found in anatomical characteristics such as number and thickness of cork layer, existence of stone cell in cork layer, frequency of vessels, and area of intercellular space. Significant differences were found among the samples in the content of three components including shashenoside I and a new alkyl glycoside, adenophoroside I. These findings could provide the scientific criteria for the proper identification and establishment of standards for the use of “Sasam”.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>